SI3436461T1 - Pirolotriazinske spojine kot tam-inhibitorji - Google Patents

Pirolotriazinske spojine kot tam-inhibitorji

Info

Publication number
SI3436461T1
SI3436461T1 SI201731469T SI201731469T SI3436461T1 SI 3436461 T1 SI3436461 T1 SI 3436461T1 SI 201731469 T SI201731469 T SI 201731469T SI 201731469 T SI201731469 T SI 201731469T SI 3436461 T1 SI3436461 T1 SI 3436461T1
Authority
SI
Slovenia
Prior art keywords
pyrrolotriazine compounds
tam inhibitors
tam
inhibitors
pyrrolotriazine
Prior art date
Application number
SI201731469T
Other languages
English (en)
Inventor
Yun-Long Li
xiaozhao Wang
Joseph Barbosa
David M. Burns
Hao Feng
Joseph Glenn
Chunhong He
Taisheng Huang
Song Mei
Jincong Zhuo
Original Assignee
Incyte Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corporation filed Critical Incyte Corporation
Publication of SI3436461T1 publication Critical patent/SI3436461T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
SI201731469T 2016-03-28 2017-03-27 Pirolotriazinske spojine kot tam-inhibitorji SI3436461T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662314066P 2016-03-28 2016-03-28
US201662362934P 2016-07-15 2016-07-15
US201662438750P 2016-12-23 2016-12-23
EP17715620.5A EP3436461B1 (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors
PCT/US2017/024270 WO2017172596A1 (en) 2016-03-28 2017-03-27 Pyrrolotriazine compounds as tam inhibitors

Publications (1)

Publication Number Publication Date
SI3436461T1 true SI3436461T1 (sl) 2024-03-29

Family

ID=58489114

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201731469T SI3436461T1 (sl) 2016-03-28 2017-03-27 Pirolotriazinske spojine kot tam-inhibitorji

Country Status (28)

Country Link
US (5) US9981975B2 (sl)
EP (2) EP3436461B1 (sl)
JP (3) JP7034084B2 (sl)
KR (3) KR102558066B1 (sl)
CN (3) CN109348715B (sl)
AU (3) AU2017241524B2 (sl)
BR (1) BR112018069612A2 (sl)
CA (1) CA3019145A1 (sl)
CL (1) CL2018002759A1 (sl)
CO (1) CO2018011550A2 (sl)
CR (1) CR20180516A (sl)
DK (1) DK3436461T3 (sl)
EC (2) ECSP18081153A (sl)
FI (1) FI3436461T3 (sl)
HR (1) HRP20231614T1 (sl)
IL (2) IL261957B (sl)
LT (1) LT3436461T (sl)
MX (1) MX2018011792A (sl)
PE (1) PE20190175A1 (sl)
PH (1) PH12018502102A1 (sl)
PL (1) PL3436461T3 (sl)
PT (1) PT3436461T (sl)
RS (1) RS65129B1 (sl)
SG (2) SG10202009423QA (sl)
SI (1) SI3436461T1 (sl)
TW (2) TWI828027B (sl)
UA (1) UA123785C2 (sl)
WO (1) WO2017172596A1 (sl)

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WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
RS65129B1 (sr) 2016-03-28 2024-02-29 Incyte Corp Jedinjenja pirolotriazina kao inhibitori tam
JOP20190156B1 (ar) 2016-12-23 2023-09-17 Bayer Pharma AG أميدات عطرية لحمض الكربوكسيليك بصفتها مضادات لمستقبلة البراديكينين b1
US20200197385A1 (en) 2017-08-23 2020-06-25 Ono Pharmaceutical Co., Ltd. Therapeutic agent for cancer containing axl inhibitor as active ingredient
WO2019067594A1 (en) * 2017-09-27 2019-04-04 Incyte Corporation SALTS OF PYRROLOTRIAZINE DERIVATIVES USEFUL AS TAM INHIBITORS
JP7223998B2 (ja) 2017-10-13 2023-02-17 小野薬品工業株式会社 Ａｘｌ阻害剤を有効成分として含む固形がん治療剤
WO2019141202A1 (zh) * 2018-01-17 2019-07-25 南京药捷安康生物科技有限公司 Tam家族激酶/和csf1r激酶抑制剂及其用途
BR112020014516A2 (pt) 2018-01-26 2020-12-08 Bristol-Myers Squibb Company Aminopirrolotriazinas como inibidores de quinase
CN110627796B (zh) * 2018-06-21 2022-07-12 北京越之康泰生物医药科技有限公司 含氮杂环类衍生物及其在医药上的应用
PE20211805A1 (es) 2018-06-29 2021-09-14 Incyte Corp Formulaciones de un inhibidor de axl/mer
UY38349A (es) 2018-08-30 2020-03-31 Array Biopharma Inc Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met
CN111689991B (zh) * 2019-03-13 2023-06-09 习峰 取代的杂芳基化合物及其组合物和用途
CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
JPWO2021020362A1 (sl) * 2019-07-29 2021-02-04
CN112409361B (zh) * 2019-08-23 2022-08-16 山东轩竹医药科技有限公司 Tam抑制剂及其用途
AU2020342108B2 (en) * 2019-09-06 2024-03-07 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Compound having Axl and c-Met kinase inhibitory activity, preparation thereof and application thereof
CN113336758B (zh) * 2020-03-03 2022-08-19 北京桦冠医药科技有限公司 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法
US20210275666A1 (en) 2020-03-06 2021-09-09 Incyte Corporation Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
CN111233870A (zh) * 2020-03-11 2020-06-05 中国科学技术大学 用于快速制备瑞德西韦药物中间体的方法
CN113683629B (zh) * 2020-05-18 2023-07-04 北京范恩柯尔生物科技有限公司 取代的杂芳基化合物及其组合物和用途
JP2023533771A (ja) * 2020-07-10 2023-08-04 ベイジン ファインドキュア バイオサイエンシーズ リミテッド トリアジン系化合物およびその組成物と用途
CN116583287A (zh) * 2021-02-05 2023-08-11 四川科伦博泰生物医药股份有限公司 一类哒嗪酮杂环化合物及其制备方法和用途
WO2023016296A1 (zh) * 2021-08-12 2023-02-16 四川科伦博泰生物医药股份有限公司 一类杂环化合物及其制备方法和用途
TW202330519A (zh) * 2021-09-29 2023-08-01 香港商德琪研發有限公司 作為ｔａｍ抑制劑的吡唑并吡啶化合物
WO2023155886A1 (en) * 2022-02-17 2023-08-24 Shanghai Antengene Corporation Limited Pyrazolopyridine compounds as tam inhibitors
WO2024054793A1 (en) 2022-09-09 2024-03-14 University Of Rochester Inhibition of efferocytosis as a treatment to prevent bone loss and increase bone density and strength

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