PT3004107T - Compostos de 6,7-di-hidropirazolo[1,5-a]pirazin-4(5h)-ona e sua utilização como moduladores alostéricos negativos de recetores mglur2 - Google Patents

Compostos de 6,7-di-hidropirazolo[1,5-a]pirazin-4(5h)-ona e sua utilização como moduladores alostéricos negativos de recetores mglur2

Info

Publication number
PT3004107T
PT3004107T PT147278246T PT14727824T PT3004107T PT 3004107 T PT3004107 T PT 3004107T PT 147278246 T PT147278246 T PT 147278246T PT 14727824 T PT14727824 T PT 14727824T PT 3004107 T PT3004107 T PT 3004107T
Authority
PT
Portugal
Prior art keywords
dihydropyrazolo
pyrazin
compounds
allosteric modulators
negative allosteric
Prior art date
Application number
PT147278246T
Other languages
English (en)
Portuguese (pt)
Inventor
Luc Maria Van Gool Michiel
Alonso-De Diego Sergio-Alvar
Maria Cid-Núñez José
Delgado-González Óscar
Marie Antonius Decorte Annelies
James Macdonald Gregor
Adrianus Hendrikus Petrus Megens Antonius
Avelino Trabanco-Suárez Andrés
García-Molina Aránzazu
Ignacio Andrés-Gil José
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT3004107T publication Critical patent/PT3004107T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials Engineering (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT147278246T 2013-06-04 2014-06-03 Compostos de 6,7-di-hidropirazolo[1,5-a]pirazin-4(5h)-ona e sua utilização como moduladores alostéricos negativos de recetores mglur2 PT3004107T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13170447 2013-06-04
EP13173939 2013-06-27
EP14166450 2014-04-29

Publications (1)

Publication Number Publication Date
PT3004107T true PT3004107T (pt) 2017-08-16

Family

ID=50884400

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147278246T PT3004107T (pt) 2013-06-04 2014-06-03 Compostos de 6,7-di-hidropirazolo[1,5-a]pirazin-4(5h)-ona e sua utilização como moduladores alostéricos negativos de recetores mglur2

Country Status (31)

Country Link
US (2) US10106542B2 (zh)
EP (1) EP3004107B1 (zh)
JP (1) JP6357533B2 (zh)
KR (1) KR102223050B1 (zh)
CN (2) CN107474050B (zh)
AU (1) AU2014276963C1 (zh)
BR (1) BR112015029982A2 (zh)
CA (1) CA2910507C (zh)
CL (1) CL2015003499A1 (zh)
CY (1) CY1119499T1 (zh)
DK (1) DK3004107T3 (zh)
EA (1) EA030426B1 (zh)
ES (1) ES2637295T3 (zh)
HK (2) HK1216527A1 (zh)
HR (1) HRP20171051T1 (zh)
HU (1) HUE033057T2 (zh)
IL (1) IL242868B (zh)
JO (1) JO3368B1 (zh)
LT (1) LT3004107T (zh)
ME (1) ME02949B (zh)
MX (1) MX368861B (zh)
MY (1) MY192029A (zh)
PH (1) PH12015502685B1 (zh)
PL (1) PL3004107T3 (zh)
PT (1) PT3004107T (zh)
RS (1) RS56128B1 (zh)
SG (1) SG11201509938YA (zh)
SI (1) SI3004107T1 (zh)
TW (2) TWI674264B (zh)
UA (1) UA117016C2 (zh)
WO (1) WO2014195311A1 (zh)

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JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
UA121965C2 (uk) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування
KR102502485B1 (ko) 2014-01-21 2023-02-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
JP6513075B2 (ja) * 2014-02-27 2019-05-15 国立大学法人 東京大学 オートタキシン阻害活性を有する縮合ピラゾール誘導体
JOP20150179B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
JOP20150177B1 (ar) 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
ES2727379T3 (es) 2014-12-03 2019-10-15 Janssen Pharmaceutica Nv Compuestos de 6,7-dihidropirazolo[1,5-a]pirazin-4(5H)-ona y su uso como moduladores alostéricos negativos de receptores de mGlu2
WO2016087489A1 (en) * 2014-12-03 2016-06-09 Janssen Pharmaceutica Nv Radiolabelled mglur2 pet ligands
MA41338B1 (fr) 2015-01-16 2019-07-31 Hoffmann La Roche Composés de pyrazine pour le traitement de maladies infectieuses
CN107580598B (zh) 2015-07-15 2020-11-13 豪夫迈·罗氏有限公司 作为代谢型谷氨酸受体调节剂的乙炔基衍生物
JP2018154554A (ja) * 2015-07-29 2018-10-04 大日本住友製薬株式会社 新規リンカー部位を持つ縮合ピラゾール誘導体およびその医薬用途
US11045562B2 (en) 2015-12-18 2021-06-29 Janssen Pharmaceutica Nv Radiolabelled mGluR2/3 PET ligands
HUE050665T2 (hu) 2015-12-18 2020-12-28 Janssen Pharmaceutica Nv Radiojelzett MGLUR2/3 PET ligandumok
JP6936305B2 (ja) 2016-07-18 2021-09-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ エチニル誘導体
KR102296043B1 (ko) 2016-09-27 2021-08-30 머크 샤프 앤드 돔 코포레이션 mGluR2-음성 알로스테릭 조정제로서의 크로만, 이소크로만 및 디히드로이소벤조푸란 유도체, 조성물, 및 그의 용도
EP3719023A4 (en) 2017-11-24 2021-07-07 Sumitomo Dainippon Pharma Co., Ltd. 6,7-DIHYDROPYRAZOLO [1,5-a] DERIVATIVE PYRAZINONE AND ITS MEDICAL APPLICATION
JP7266010B2 (ja) * 2019-05-30 2023-04-27 住友ファーマ株式会社 ６，７－ジヒドロピラゾロ［１，５－ａ］ピラジノン誘導体又はその塩を含有する医薬
TW202317579A (zh) * 2021-07-13 2023-05-01 美商傳達治療有限公司 PI3Kα抑制劑及其使用方法

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