ES2131463B1 - Derivados de ciclopropilglicina con propiedades farmaceuticas. - Google Patents
Derivados de ciclopropilglicina con propiedades farmaceuticas.Info
- Publication number
- ES2131463B1 ES2131463B1 ES009700736A ES9700736A ES2131463B1 ES 2131463 B1 ES2131463 B1 ES 2131463B1 ES 009700736 A ES009700736 A ES 009700736A ES 9700736 A ES9700736 A ES 9700736A ES 2131463 B1 ES2131463 B1 ES 2131463B1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- alkyl
- cycloalkyl
- substituted phenyl
- cyclopropylglycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Derivados de ciclopropilglicina con propiedades farmacéuticas. Un compuesto farmacéutico de la fórmula (I), en la que R{sup,1 es alquilo C{sub,1-10 , alquenilo C{sub,2-10 , alquinilo C{sub,2-10 , cicloalquilo C{sub,3-10 , cicloalquilo C{sub,3-10 -alquiloC{sub,1-10 , cicloalquilo C{sub,3-10 -alquenilo C{sub,2-10 , cicloalquilo C{sub,3-10 -alquinilo C{sub,2-10 , fenilo opcionalmente sustituido-alquilo C{sub,1-10 , fenilo opcionalmente sustituido-alquenilo C{sub,2-10 , fenilo opcionalmente sustituido-alquinilo C{sub,2-10 , naftilo opcionalmente sustituido, naftilo opcionalmente sustituido-alquilo C{sub,1-10 , alcoxi C{sub,1-10 -alquilo C{sub,1-10 , cicloalcoxi C{sub,3-10 -alquilo C{sub,1-10 , radical heterocíclico opcionalmente sustituido, radical heterocíclico opcionalmente sustituido-alquilo C{sub,1-10 , fenilo opcionalmente sustituido condensado con cicloalquilo C{sub,5-10 , grupo tricíclico opcionalmente sustituido, grupo tricíclico opcionalmente sustituido-alquilo C{sub,1-10 o [fenilo opcionalmente sustituido(CH{sub,2 ){sub,n ]{sub,2 -alquilo C{sub,1-10 , donde n es 0 ó 1 a 4, y R{sup,2 es hidrógeno o uno de los valores de R{sup,1 ; o una sal o éster del mismo.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009700736A ES2131463B1 (es) | 1997-04-08 | 1997-04-08 | Derivados de ciclopropilglicina con propiedades farmaceuticas. |
US09/054,874 US6172058B1 (en) | 1997-04-08 | 1998-04-03 | Compounds with pharmaceutical properties |
ES98302693T ES2209063T3 (es) | 1997-04-08 | 1998-04-06 | Derivados de la ciclopropil glicina con propiedades farmaceuticas. |
CA002234025A CA2234025A1 (en) | 1997-04-08 | 1998-04-06 | Novel compounds with pharmaceutical properties |
AT98302693T ATE251119T1 (de) | 1997-04-08 | 1998-04-06 | Cyclopropyl-derivate mit pharmazeutischen eigenschaften |
EP98302693A EP0870760B1 (en) | 1997-04-08 | 1998-04-06 | Cyclopropyl glycine derivatives with pharmaceutical properties |
DE69818538T DE69818538T2 (de) | 1997-04-08 | 1998-04-06 | Cyclopropyl-Derivate mit pharmazeutischen Eigenschaften |
JP10094423A JPH10287633A (ja) | 1997-04-08 | 1998-04-07 | 中枢神経系疾患治療用のシクロプロピルグリシン化合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009700736A ES2131463B1 (es) | 1997-04-08 | 1997-04-08 | Derivados de ciclopropilglicina con propiedades farmaceuticas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2131463A1 ES2131463A1 (es) | 1999-07-16 |
ES2131463B1 true ES2131463B1 (es) | 2000-03-01 |
Family
ID=8298874
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009700736A Expired - Fee Related ES2131463B1 (es) | 1997-04-08 | 1997-04-08 | Derivados de ciclopropilglicina con propiedades farmaceuticas. |
ES98302693T Expired - Lifetime ES2209063T3 (es) | 1997-04-08 | 1998-04-06 | Derivados de la ciclopropil glicina con propiedades farmaceuticas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98302693T Expired - Lifetime ES2209063T3 (es) | 1997-04-08 | 1998-04-06 | Derivados de la ciclopropil glicina con propiedades farmaceuticas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US6172058B1 (es) |
EP (1) | EP0870760B1 (es) |
JP (1) | JPH10287633A (es) |
AT (1) | ATE251119T1 (es) |
CA (1) | CA2234025A1 (es) |
DE (1) | DE69818538T2 (es) |
ES (2) | ES2131463B1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1189874B1 (en) | 1999-06-03 | 2005-01-26 | Lilly, S.A. | Excitatory amino acid receptor modulators |
AU5073600A (en) | 1999-06-03 | 2000-12-28 | Lilly, S.A. | Excitatory amino acid receptor modulators |
US7125871B2 (en) * | 2000-05-31 | 2006-10-24 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
US7081481B2 (en) * | 2000-05-31 | 2006-07-25 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
AU6455501A (en) * | 2000-05-31 | 2001-12-11 | Lilly Co Eli | Excitatory amino acid receptor modulators |
AU2001264554A1 (en) * | 2000-05-31 | 2001-12-11 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
SI1448205T1 (sl) * | 2001-10-05 | 2011-07-29 | Zalicus Inc | Kombinacije za zdravljenje imunoinflamatornih motenj |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5ht受容体介在性の神経新生 |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
JP5433579B2 (ja) * | 2007-09-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換−4−フェニル−1h−ピリジン−2−オン |
TW200922566A (en) | 2007-09-14 | 2009-06-01 | Ortho Mcneil Janssen Pharm | 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
TWI445532B (zh) | 2007-09-14 | 2014-07-21 | Janssen Pharmaceuticals Inc | 1’,3’-二取代-4-苯基-3,4,5,6-四氫-2h,1’h-〔1,4’〕聯吡啶基-2’-酮化物 |
ES2637794T3 (es) * | 2007-11-14 | 2017-10-17 | Janssen Pharmaceuticals, Inc. | Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2 |
CA2735764C (en) | 2008-09-02 | 2016-06-14 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
ES2466341T3 (es) | 2008-10-16 | 2014-06-10 | Janssen Pharmaceuticals, Inc. | Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
WO2010060589A1 (en) | 2008-11-28 | 2010-06-03 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
SG176018A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MX2011011964A (es) | 2009-05-12 | 2012-02-23 | Janssen Pharmaceuticals Inc | Derivados de 1,2,3-triazolo[4,3-a]piridina y su uso para el tratamiento o prevencion de trastornos neurologicos y psiquiatricos. |
ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
PL2649069T3 (pl) | 2010-11-08 | 2016-01-29 | Janssen Pharmaceuticals Inc | Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
US9187439B2 (en) | 2011-09-21 | 2015-11-17 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
US9499586B2 (en) * | 2012-10-16 | 2016-11-22 | Hong Kong Baptist University | Anticancer and anti-obesity cyclic peptide agents |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
DK3096790T3 (da) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
UA127921C2 (uk) | 2014-01-21 | 2024-02-14 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
AR108326A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959463A (en) | 1985-10-15 | 1990-09-25 | Genentech, Inc. | Intermediates |
CA1305177C (en) * | 1987-06-30 | 1992-07-14 | Yasufumi Ohfune | Carboxycyclopropylglycine and process for producing the same |
JP3481975B2 (ja) | 1992-09-08 | 2003-12-22 | サントリー株式会社 | (2s,1’s,2’r)−2−(2−カルボキシ−3−置換オキシメチルシクロプロピル)グリシン及びその製造法 |
GB9325368D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Bristol | Organic compounds |
ES2139928T3 (es) | 1994-09-08 | 2000-02-16 | Lilly Co Eli | Antagonistas de receptores de aminoacidos de excitacion. |
JPH08301825A (ja) * | 1995-03-07 | 1996-11-19 | Suntory Ltd | 3’−置換−(2−カルボキシシクロプロピル)グリシン |
IT1276153B1 (it) * | 1995-11-17 | 1997-10-27 | Roberto Pellicciari | Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato |
EP0913389A4 (en) | 1996-06-28 | 2000-02-02 | Nippon Chemiphar Co | CYCLOPROPYLGLYCINE DERIVATIVES AND AGONISTS OF THE L-GLUTAMATE RECEPTOR TYPE OF METABOLITE REGULATION |
-
1997
- 1997-04-08 ES ES009700736A patent/ES2131463B1/es not_active Expired - Fee Related
-
1998
- 1998-04-03 US US09/054,874 patent/US6172058B1/en not_active Expired - Fee Related
- 1998-04-06 CA CA002234025A patent/CA2234025A1/en not_active Abandoned
- 1998-04-06 EP EP98302693A patent/EP0870760B1/en not_active Expired - Lifetime
- 1998-04-06 ES ES98302693T patent/ES2209063T3/es not_active Expired - Lifetime
- 1998-04-06 DE DE69818538T patent/DE69818538T2/de not_active Expired - Fee Related
- 1998-04-06 AT AT98302693T patent/ATE251119T1/de not_active IP Right Cessation
- 1998-04-07 JP JP10094423A patent/JPH10287633A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2234025A1 (en) | 1998-10-08 |
ES2131463A1 (es) | 1999-07-16 |
ATE251119T1 (de) | 2003-10-15 |
EP0870760A1 (en) | 1998-10-14 |
DE69818538D1 (de) | 2003-11-06 |
US6172058B1 (en) | 2001-01-09 |
DE69818538T2 (de) | 2004-08-05 |
EP0870760B1 (en) | 2003-10-01 |
ES2209063T3 (es) | 2004-06-16 |
JPH10287633A (ja) | 1998-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990716 Kind code of ref document: A1 Effective date: 19990716 |
|
FD1A | Patent lapsed |
Effective date: 20050409 |