HRP20171051T1 - Spojevi 6,7-dihidropirazolo[1,5-a]pirazin-4(5h)-ona i njihova uporaba kao negativnih alosternih modulatora receptora mglur2 - Google Patents
Spojevi 6,7-dihidropirazolo[1,5-a]pirazin-4(5h)-ona i njihova uporaba kao negativnih alosternih modulatora receptora mglur2 Download PDFInfo
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- HRP20171051T1 HRP20171051T1 HRP20171051TT HRP20171051T HRP20171051T1 HR P20171051 T1 HRP20171051 T1 HR P20171051T1 HR P20171051T T HRP20171051T T HR P20171051TT HR P20171051 T HRP20171051 T HR P20171051T HR P20171051 T1 HRP20171051 T1 HR P20171051T1
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- GLQXAHBYDJPCHG-UHFFFAOYSA-N 6,7-dihydro-5h-pyrazolo[1,5-a]pyrazin-4-one Chemical class O=C1NCCN2N=CC=C12 GLQXAHBYDJPCHG-UHFFFAOYSA-N 0.000 title 1
- 101150016175 Grm2 gene Proteins 0.000 title 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 title 1
- 229940126662 negative allosteric modulator Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 31
- 239000001257 hydrogen Substances 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- -1 2-pyridinyl Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 4
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 206010020765 hypersomnia Diseases 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 208000011117 substance-related disease Diseases 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 3
- 208000027626 Neurocognitive disease Diseases 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 208000000044 Amnesia Diseases 0.000 claims 2
- 208000031091 Amnestic disease Diseases 0.000 claims 2
- 206010012218 Delirium Diseases 0.000 claims 2
- 206010012335 Dependence Diseases 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 2
- 208000037490 Medically Unexplained Symptoms Diseases 0.000 claims 2
- 208000019022 Mood disease Diseases 0.000 claims 2
- 208000029726 Neurodevelopmental disease Diseases 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 208000027520 Somatoform disease Diseases 0.000 claims 2
- 230000006986 amnesia Effects 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000020685 sleep-wake disease Diseases 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 201000009032 substance abuse Diseases 0.000 claims 2
- 231100000736 substance abuse Toxicity 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000007822 coupling agent Substances 0.000 claims 1
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical compound CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 claims 1
- 150000002688 maleic acid derivatives Chemical class 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Claims (23)
1. Spoj s formulom (I)
[image]
ili njegov stereoizomerni oblik,
naznačen time da
R1 je fenil ili 2-piridinil, svaki proizvoljno supstituiran s jednim ili više supstituenata koji su svaki neovisno odabrani iz skupine koja sadrži halo, C1-4alkil, mono- ili poli-haloC1-4alkil, -O-C1-4alkil, -C1-4alkil-O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, -C1-4alkil-OH, C1-4alkiltio, mono- ili poli-haloC1-4alkiltio, cijano, C3-7cikloalkil proizvoljno supstituiran s trifluorometilom, te -SF5; ili je
[image]
R 2 je odabran od
[image]
pri čemu R5 i R6 su svaki neovisno odabrani iz skupine koja sadrži vodik, halo, cijano, C1-4alkil, -C1-4alkil-OH, C3-7cikloalkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, -O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, 1-acetilazetidin-3-il, i NR'R";
pri čemu R' je odabran od vodika i C1-4alkila;
R" je odabran od vodika i C1-4alkila; ili
R' i R" zajedno s atomom dušika na koji su oni vezani tvore heterocikličku skupinu odabranu iz skupine koja sadrži 1-azetidinil, 1-pirrolidinil, 1-piperidinil, 1-piperazinil, i 4-morpholinil; pri čemu svaka od heterocikličkih skupina može biti proizvoljno supstituirana sa supstituentom koji se bira od halo, hidroksila, C1-4alkila, mono- ili poli-haloC1-4alkila, i -(CO)C1-4alkila;
R3 je odabran od vodika i C1-4alkila;
R4 je odabran od iz skupine koja sadrži vodik, C1-4alkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, i -C1-4alkil-OH;
ili N-oksid, ili njegova farmaceutski prihvatljiva sol ili solvat.
2. Spoj prema zahtjevu 1, ili njegov stereoizomerni oblik, naznačen time da
R1 je fenil ili 2-piridinil, svaki proizvoljno supstituiran s jednim ili više supstituenata koji je svaki neovisno odabran iz skupine koja sadrži halo, C1-4alkil, mono- ili poli-haloC1-4alkil, -O-C1-4alkil, -C1-4alkil-O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, -C1-4alkil-OH, mono- ili poli-haloC1-4alkiltio, cijano, i -SF5; ili je
[image]
R 2 je odabran od
[image]
pri čemu R5 i R6 su svaki neovisno odabrani iz skupine koja sadrži vodik, halo, cijano, C1-4alkil, -C1-4alkil-OH, C3-7cikloalkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, -O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, i NR'R";
pri čemu R' je odabran od vodika i C1-4alkila;
R" je odabran od vodika i C1-4alkila; ili
R' i R" zajedno s atomom dušika na koji su oni vezani tvore heterocikličku skupinu odabranu iz skupine koja sadrži 1-azetidinil, 1-pirrolidinil, i 1-piperidinil; pri čemu svaka od heterocikličkih skupina može biti proizvoljno supstituirana s halo supstituentom;
R3 je odabran od vodika i C1-4alkila;
R4 je odabran iz skupine koja sadrži vodik, C1-4alkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, i -C1-4alkil-OH;
ili N-oksid, ili njegova farmaceutski prihvatljiva sol ili solvat.
3. Spoj prema zahtjevu 1 ili 2, ili njegov stereoizomerni oblik, naznačen time da R1 je fenil, proizvoljno supstituiran s jednim ili više supstituenata koji su svaki neovisno odabrani iz skupine koja sadrži halo, C1-4alkil, mono- ili poli-haloC1-4alkil, -O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, cijano i -SF5; ili je
[image]
R2 je odabran od
[image]
pri čemu R5 i R6 su svaki neovisno odabrani iz skupine koja sadrži vodik, C1-4alkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, -O-C1-4alkil, i NR'R";
pri čemu R' je odabran od vodika i C1-4alkila;
R" je odabran od vodika i C1-4alkila;
R3 je odabran od vodika i C1-4alkila;
R4 je odabran iz skupine koja sadrži vodik, C1-4alkil, mono- ili poli-haloC1-4alkil, -C1-4alkil-O-C1-4alkil, i -C1-4alkil-OH;
ili njegova farmaceutski prihvatljiva sol ili solvat.
4. Spoj prema bilo kojem od zahtjeva 1 do 3, ili njegov stereoizomerni oblik, naznačen time da
R1 je fenil, proizvoljno supstituiran s jednim ili više supstituenata neovisno odabranih iz skupine koja sadrži halo, C1-4alkil, mono- ili poli-haloC1-4alkil, -O-C1-4alkil, mono- ili poli-haloC1-4alkiloksi, cijano i -SF5; ili je
[image]
R 2 je odabran od
[image]
pri čemu R5 i R6 su svaki neovisno odabrani iz skupine koja sadrži vodik, C1-4alkil, -C1-4alkil-O-C1-4alkil, -O-C1-4alkil, i NR'R";
pri čemu R' je vodik;
R" je vodik;
R3 je odabran od vodika i C1-4alkila;
R4 je odabran iz skupine koja sadrži vodik i C1-4alkil;
ili njegova farmaceutski prihvatljiva sol ili solvat.
5. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomerni oblik, naznačen time da
R1 je fenil, proizvoljno supstituiran s jednim ili više supstituenata koji su svaki neovisno odabrani iz skupine koja sadrži halo, C1-4alkil, poli-haloC1-4alkil i -SF5;
R2 je odabran od
[image]
pri čemu R5 i R6 su svaki neovisno odabrani iz skupine koja sadrži vodik, C1-4alkil i -O-C1-4alkil;
R3 je odabran od vodika i C1-4alkila;
R4 je vodik;
ili njegova farmaceutski prihvatljiva sol ili solvat.
6. Spoj prema bilo kojem od zahtjeva 1 do 4, ili njegov stereoizomerni oblik, naznačen time da
R1 je odabran iz skupine koju čine
[image]
[image]
[image]
i ostatak varijabli su kako je definirano u bilo kojem od zahtjeva 1 do 4.
7. Farmaceutski pripravak naznačen time da sadrži terapijski učinkovitu količinu spoja prema bilo kojem od zahtjeva 1 do 6 i farmaceutski prihvatljiv nosač ili pomoćno sredstvo.
8. Spoj prema bilo kojem od zahtjeva 1 do 6 ili farmaceutski pripravak prema zahtjevu 7 naznačen time da je za uporabu kao lijek.
9. Spoj prema bilo kojem od zahtjeva 1 do 6 ili farmaceutski pripravak prema zahtjevu 7 naznačen time da je za uporabu za liječenje ili za sprječavanje stanja ili bolesti središnjeg živčanog sustava odabranih od poremećaja raspoloženja; delirija, demencije, amnezijskih i drugih kognitivnih poremećaja; poremećaja koji se obično prvo dijagnosticiraju kod novorođenčadi, u djetinjstvu ili adolescenciji; poremećaja povezanih s tvarima; šizofrenije i drugih psihotičkih poremećaja; somatoformnih poremećaja; hipersomnog poremećaja spavanja.
10. Spoj prema bilo kojem od zahtjeva 1 do 6 ili farmaceutski pripravak prema zahtjevu 7 naznačen time da je za uporabu za liječenje ili za sprječavanje stanja ili bolesti središnjeg živčanog sustava odabranih od depresivnih poremećaja; neurokognitivnih poremećaja; neurorazvojnih poremećaja; poremećaja ovisnosti o tvarima i poremećaja ovisnosti; raznih šizofrenija i ostalih psihotičnih poremećaja; somatskih simptoma i srodnih poremećaja; i poremećaja hipersomnije.
11. Spoj ili farmaceutski pripravak za uporabu prema zahtjevu 9 ili 10, naznačen time da se stanja ili bolesti središnjeg živčanog sustava biraju od demencije ili neurokognitivnog poremećaja, velikog depresivnog poremećaja, depresije, depresije otporne na liječenje, deficita pažnje/ hiperaktivnog poremećaja i šizofrenije.
12. Postupak pripreme farmaceutskog pripravka prema zahtjevu 7, naznačen time da se farmaceutski prihvatljiv nosač blisko miješa s terapeutski učinkovitom količinom spoja prema bilo kojem od zahtjeva 1 do 6.
13. Proizvod naznačen time da sadrži spoj prema bilo kojem od zahtjeva 1 do 6 i dodatno farmaceutsko sredstvo, kao kombinirani pripravak za istovremenu, odvojenu ili uzastopnu primjenu u liječenju ili prevenciji stanja ili bolesti središnjeg živčanog sustava odabranih od poremećaja raspoloženja; delirija, demencije, amnezijskih i drugih kognitivnih poremećaja; poremećaja koji se obično prvo dijagnosticiraju kod novorođenčadi, u djetinjstvu ili adolescenciji; poremećaja povezanih s tvarima; šizofrenije i drugih psihotičkih poremećaja; somatoformnih poremećaja; hipersomnog poremećaja spavanja.
14. Proizvod naznačen time da sadrži spoj prema bilo kojem od zahtjeva 1 do 6 i dodatno farmaceutsko sredstvo, kao kombinirani pripravak za istovremenu, odvojenu ili uzastopnu primjenu u liječenju ili prevenciji stanja ili bolesti središnjeg živčanog sustava odabranih od depresivnih poremećaja; neurokognitivnih poremećaja; neurorazvojnih poremećaja; poremećaja ovisnosti o tvarima i poremećaja ovisnosti; raznih šizofrenija i ostalih psihotičnih poremećaja; somatskih simptoma i srodnih poremećaja; i poremećaja hipersomnije.
15. Spoj s formulom (V)
[image]
pri čemu R2a je halo, i R3 i R4 su kako je definirano u bilo kojem od zahtjeva 1 do 6.
16. Spoj prema zahtjevu 15, naznačen time da ima Formulu (V')
[image]
17. Spoj prema zahtjevu 15 ili 16, naznačen time da ima Formulu (I-13) ili (I-13a)
[image]
ili njegova sol.
18. Spoj s formulom (II)
[image]
naznačen time da R2, R3 i R4 su kako je definirano u bilo kojem od zahtjeva 1 do 6.
19. Postupak za pripravu spoja prema formuli (I) kako je definirano u bilo kojem od zahtjeva 1 do 6, naznačen time da sadrži korake a) i b)
a) reakciju spoja s formulom (V), pri čemu R2a je halo, s prikladnim boronskim vrstama, u prisutnosti paladijevog katalizatora i prikladne baze i otapala, da se dobije spoj s formulom (II)
[image]
b) reakciju spoja s formulom (II) dobivenu u koraku a) s spojem s formulom (III) gdje X je halo, u prisutnosti prikladnog sredstva za spajanje ili katalizatora i liganda, u prisutnosti baze u pogodnom otapalu
[image]
20. Spoj prema zahtjevu 1 ili 2, naznačen time da spoj je
[image]
ili N-oksid, ili njegova farmaceutski prihvatljiva sol ili solvat.
21. Spoj prema zahtjevu 20 naznačen time da spoj je slobodna baza, hidrokloridna sol, sulfatna sol, metansulfonatna sol ili maleatna sol.
22. Spoj prema zahtjevu 20, naznačen time da spoj je
[image]
ili njegova farmaceutski prihvatljiva sol ili solvat.
23. Spoj prema zahtjevu 1 ili 2, naznačen time da spoj je
[image]
ili njegova farmaceutski prihvatljiva sol ili solvat.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13170447 | 2013-06-04 | ||
EP13173939 | 2013-06-27 | ||
EP14166450 | 2014-04-29 | ||
PCT/EP2014/061478 WO2014195311A1 (en) | 2013-06-04 | 2014-06-03 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP14727824.6A EP3004107B1 (en) | 2013-06-04 | 2014-06-03 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors |
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Publication Number | Publication Date |
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HRP20171051T1 true HRP20171051T1 (hr) | 2017-10-06 |
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HRP20171051TT HRP20171051T1 (hr) | 2013-06-04 | 2017-07-10 | Spojevi 6,7-dihidropirazolo[1,5-a]pirazin-4(5h)-ona i njihova uporaba kao negativnih alosternih modulatora receptora mglur2 |
Country Status (31)
Country | Link |
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US (2) | US10106542B2 (hr) |
EP (1) | EP3004107B1 (hr) |
JP (1) | JP6357533B2 (hr) |
KR (1) | KR102223050B1 (hr) |
CN (2) | CN105263935B (hr) |
AU (1) | AU2014276963C1 (hr) |
BR (1) | BR112015029982A2 (hr) |
CA (1) | CA2910507C (hr) |
CL (1) | CL2015003499A1 (hr) |
CY (1) | CY1119499T1 (hr) |
DK (1) | DK3004107T3 (hr) |
EA (1) | EA030426B1 (hr) |
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