EA202090659A1 - СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ - Google Patents

СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ

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Publication number
EA202090659A1
EA202090659A1 EA202090659A EA202090659A EA202090659A1 EA 202090659 A1 EA202090659 A1 EA 202090659A1 EA 202090659 A EA202090659 A EA 202090659A EA 202090659 A EA202090659 A EA 202090659A EA 202090659 A1 EA202090659 A1 EA 202090659A1
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EA
Eurasian Patent Office
Prior art keywords
methylpropoxy
heptan
pyrazolo
carbonitrile
diazabicyclo
Prior art date
Application number
EA202090659A
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English (en)
Inventor
Марк Рейнолдс
Чарльз Тодд Иэри
Original Assignee
Локсо Онколоджи, Инк.
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Application filed by Локсо Онколоджи, Инк. filed Critical Локсо Онколоджи, Инк.
Publication of EA202090659A1 publication Critical patent/EA202090659A1/ru

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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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Abstract

Раскрыты 6-(2-гидрокси-2-метилпропокси)-4-(6-(6-((6-метоксипиридин-3-ил)метил)-3,6-диазабицикло[3.1.1]гептан-3-ил)пиридин-3-ил)пиразоло[1,5-a]пиридин-3-карбонитрил или его фармацевтически приемлемая соль, аморфная форма, полиморфная форма или фармацевтическая композиция (включая твердые составы или жидкие составы) и их применение для лечения заболеваний и расстройств, которые можно лечить ингибитором киназы RET, таких как заболевания и расстройства, связанные с RET, например пролиферативные расстройства, такие как раковые заболевания, в том числе гематологические раковые заболевания и солидные опухоли, и желудочно-кишечные расстройства, такие как СРК.
EA202090659A 2017-10-10 2018-10-10 СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ EA202090659A1 (ru)

Applications Claiming Priority (2)

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US201762570601P 2017-10-10 2017-10-10
PCT/US2018/055285 WO2019075114A1 (en) 2017-10-10 2018-10-10 FORMULATIONS COMPRISING 6- (2-HYDROXY-2-METHYLPROPOXY) -4- (6- (6 - ((6-METHOXYPYRIDIN-3-YL) METHYL) -3,6-DIAZABICYCLO [3.1.1] HEPTAN-3- YL) PYRIDIN-3-YL) PYRAZOLO [1,5-A] pYRIDINE-3-carbonitrile

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EA202090659A1 true EA202090659A1 (ru) 2020-08-05

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US (4) US10786489B2 (ru)
EP (1) EP3694556A1 (ru)
JP (2) JP7153719B2 (ru)
KR (2) KR102396864B1 (ru)
CN (1) CN111465413A (ru)
AR (1) AR113759A1 (ru)
AU (1) AU2018347375B2 (ru)
BR (1) BR112020005368A2 (ru)
CA (1) CA3079010C (ru)
EA (1) EA202090659A1 (ru)
IL (1) IL273729B1 (ru)
MX (1) MX2020003585A (ru)
TW (1) TWI812649B (ru)
UY (1) UY37926A (ru)
WO (1) WO2019075114A1 (ru)

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