AR092530A1 - Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento - Google Patents
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamentoInfo
- Publication number
- AR092530A1 AR092530A1 ARP130103248A ARP130103248A AR092530A1 AR 092530 A1 AR092530 A1 AR 092530A1 AR P130103248 A ARP130103248 A AR P130103248A AR P130103248 A ARP130103248 A AR P130103248A AR 092530 A1 AR092530 A1 AR 092530A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- pyrazol
- dimethyl
- amine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Reivindicación 1: Un compuesto de amino-quinolina caracterizado porque es de la fórmula (1), en la que: R¹ es alquilo C₁₋₆, halo-alquilo C₁₋₆, cicloalquilo C₃₋₆ o heterocicloalquilo de 4 - 6 miembros, en donde: dicho alquilo C₁₋₆ está opcionalmente sustituido con un grupo seleccionado del grupo que consiste en ciano, hidroxilo, alcoxi C₁₋₆, alcoxi C₁₋₆alcoxi C₂₋₆, -CO₂H, -CO₂-alquilo C₁₋₄, -SO₂-alquilo C₁₋₄, cicloalquilo C₃₋₆ y heterocicloalquilo de 4 - 6 miembros, en donde dicho cicloalquilo C₃₋₆ o heterocicloalquilo de 4 - 6 miembros está opcionalmente sustituido con 1 ó 2 grupos cada uno seleccionado independientemente del grupo que consiste en halógeno, -CF₃, hidroxilo, amino, alquil C₁₋₄-amino-, alquil C₁₋₄-alquil C₁₋₄-amino-, alquilo C₁₋₄, hidroxi-alquilo C₁₋₄ y alcoxi C₁₋₄, dicho cicloalquilo C₃₋₆ o heterocicloalquilo de 4 - 6 miembros está opcionalmente sustituido con 1 - 3 grupos seleccionados cada uno independientemente del grupo que consiste en halógeno, -CF₃, hidroxilo, ciano, amino, alquil C₁₋₄-amino-, alquil C₁₋₄-alquil C₁₋₄amino-, alquilo C₁₋₄, hidroxi-alquilo C₁₋₄-, oxo y alcoxi C₁₋₄ y R² es fluoro, hidroxi, alcoxi C₁₋₆-, halo-alcoxi C₁₋₆-, alcoxi C₁₋₄alcoxi C₂₋₆, halo-alcoxi C₁₋₄alcoxi C₂₋₆-, hidroxi-alcoxi C₂₋₆-, cicloalquil C₃₋₆-alcoxi C₁₋₄-, cicloalquil C₃₋₆-oxi-, heterocicloalquil (de 4 - 6 miembros)-alcoxi C₁₋₄ o heterocicloalquil (de 4 - 6 miembros)-oxi-, en donde el resto halo-alquilo C₁₋₆ del halo-alcoxi C₁₋₆- y el resto haloalquilo C₁₋₄ de los grupos halo-alcoxi C₁₋₄alcoxi C₂₋₆- contienen 1, 2 ó 3 átomos de fluoro, en donde el resto cicloalquilo C₃₋₆ del cicloalquil C₃₋₆-alcoxi C₁₋₄- o el cicloalcoxi C₃₋₆- está opcionalmente sustituido con un grupo seleccionado del grupo que consiste en ciano, halo, hidroxilo, alcoxi C₁₋₆ y alcoxi C₁₋₄alcoxi C₂₋₆, y en donde el resto heterocicloalquilo de 4 - 6 miembros del heterocicloalquil (de 4 - 6 miembros)-alcoxi C₁₋₄- o heterocicloalquil (de 4 - 6 miembros)-oxi- está opcionalmente sustituido con un grupo seleccionado del grupo que consiste en ciano, halo, hidroxilo, alcoxi C₁₋₆ y alcoxi C₁₋₄alcoxi C₂₋₆; R³ es H, metilo; R⁴ es H, metilo o trifluorometilo; y R⁵ es H o alquilo C₁₋₃; o una de sus sales; con la condición de que el compuesto no sea: 6-(terc-butilsulfonil)-N-(4,5-dimetil-1H-pirazol-3-il)-7-metoxiquinolin-4-amina, 2-((4-((4,5-dimetil-1H-pirazol-3-il)amino)-7-metoxiquinolin-6-il)sulfonil)-2-metilpropan-1-ol, N-(4,5-dimetil-1H-pirazol-3-il)-7-metoxi-6-((tetrahidro-2H-piran-4-il)sulfonil)quinolin-4-amina, N-(4,5-dimetil-1H-pirazol-3-il)-6-((2,2-dimetiltetrahidro-2H-piran-4-il)sulfonil)-7-metoxiquinolin-4-amina, N-(4,5-dimetil-1H-pirazol-3-il)-7-metoxi-6-((4-metiltetrahidro-2H-piran-4-il)sulfonil)quinolin-4-amina, N-(4,5-dimetil-1H-pirazol-3-il)-7-metoxi-6-((2-metoxietil)sulfonil)quinolin-4-amina, N-(4,5-dimetil-1H-pirazol-3-il)-7-metoxi-6-(((3R,4R)-3-metiltetrahidro-2H-piran-4-il)sulfonil)quinolin-4-amina, N-(4,5-dimetil-1H-pirazol-3-il)-6-(((2R,6S)-2,6-dimetiltetrahidro-2H-piran-4-il)sulfonil)-7-metoxiquinolin-4-amina, 6-(terc-butilsulfonil)-4-((4,5-dimetil-1H-pirazol-3-il)amino)quinolin-7-ol, 2-{[4-[(4,5-dimetil-1H-pirazol-3-il)amino]-7-(metiloxi)-6-quinolinil]sulfonil}etanol, N-(4,5-dimetil-1H-pirazol-3-il)-6-[(1-metiletil)sulfonil]-7-(metiloxi)-4-quinolinamina, 6-(isopropil-sulfonil)-7-metoxi-N-(4-metil-5-(trifluorometil)-1H-pirazol-3-il)quinolin-4-amina, 6-(terc-butilsulfonil)-7-metoxi-N-(4-metil-5-(trifluorometil)-1H-pirazol-3-il)quinolin-4-amina, 6-(terc-butilsulfonil)-N-(4,5-dimetil-1H-pirazol-3-il)-7-etoxiquinolin-4-amina, 7-metoxi-N-(4-metil-5-(trifluorometil)-1H-pirazol-3-il)-6-((tetrahidro-2H-piran-4-il)sulfonil)quinolin-4-amina, 2-((6-(terc-butilsulfonil)-4-((4,5-dimetil-1H-pirazol-3-il)amino)quinolin-7-il)oxi)etanol, 6-(terc-butilsulfonil)-7-(difluorometoxi)-N-(4,5-dimetil-1H-pirazol-3-il)quinolin-4-amina, o 7-(difluorometoxi)-N-(4,5-dimetil-1H-pirazol-3-il)-6-((tetrahidro-2H-piran-4-il)sulfonil)quinolin-4-amina, o una de sus sales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261700536P | 2012-09-13 | 2012-09-13 | |
US201361767378P | 2013-02-21 | 2013-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR092530A1 true AR092530A1 (es) | 2015-04-22 |
Family
ID=50278701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130103248A AR092530A1 (es) | 2012-09-13 | 2013-09-11 | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
Country Status (21)
Country | Link |
---|---|
US (1) | US9216965B2 (es) |
EP (1) | EP2895167B1 (es) |
JP (1) | JP6258331B2 (es) |
KR (1) | KR20150053920A (es) |
CN (1) | CN104602692B (es) |
AR (1) | AR092530A1 (es) |
AU (1) | AU2013315387B2 (es) |
BR (1) | BR112015004967A2 (es) |
CA (1) | CA2883155A1 (es) |
CL (1) | CL2015000615A1 (es) |
CR (1) | CR20150133A (es) |
DO (1) | DOP2015000059A (es) |
EA (1) | EA027984B1 (es) |
ES (1) | ES2713172T3 (es) |
IL (1) | IL237158A0 (es) |
MX (1) | MX2015003275A (es) |
PE (1) | PE20150774A1 (es) |
PH (1) | PH12015500345A1 (es) |
SG (1) | SG11201500973WA (es) |
TW (1) | TW201425307A (es) |
WO (1) | WO2014043437A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
JP6026441B2 (ja) | 2011-03-04 | 2016-11-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | キナーゼ阻害剤としてのアミノキノリン |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
RU2662810C2 (ru) | 2013-02-21 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Хиназолины в качестве ингибиторов киназы |
GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
GB201516243D0 (en) | 2015-09-14 | 2015-10-28 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
US20190112317A1 (en) | 2015-10-05 | 2019-04-18 | The Trustees Of Columbia University In The City Of New York | Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies |
CN107158385B (zh) * | 2016-03-14 | 2020-07-14 | 苏州大学 | Rip3抑制剂在制备抗血小板血栓药物中的用途 |
EP3445759A1 (en) | 2016-04-20 | 2019-02-27 | GlaxoSmithKline Intellectual Property Development Ltd | Conjugates comprising ripk2 inhibitors |
WO2020094613A1 (en) | 2018-11-06 | 2020-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nod2 inhibitors for the treatment of hereditary periodic fevers |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4916135A (en) | 1989-05-08 | 1990-04-10 | Hoechst Roussel Pharmaceuticals Inc. | N-heteroaryl-4-quinolinamines |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
US6046206A (en) | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
US6391874B1 (en) | 1996-07-13 | 2002-05-21 | Smithkline Beecham Corporation | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
AU3969697A (en) | 1996-08-01 | 1998-02-25 | Dow Agrosciences Llc | Quinolinium derivatives having fungicidal activity |
AU733551B2 (en) | 1996-09-25 | 2001-05-17 | Astrazeneca Ab | Qinoline derivatives inhibiting the effect of growth factors such as VEGF |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
US6593333B1 (en) | 1998-10-01 | 2003-07-15 | Astrazeneca Ab | Substituted anilino-quinazoline (or quinoline) compounds and use thereof |
GB2345486A (en) | 1999-01-11 | 2000-07-12 | Glaxo Group Ltd | Heteroaromatic protein tyrosine kinase inhibitors |
JP4870304B2 (ja) | 1999-09-21 | 2012-02-08 | アストラゼネカ アクチボラグ | キナゾリン誘導体およびそれらの医薬品としての使用 |
AU2001228638A1 (en) | 2000-01-28 | 2001-08-07 | Astrazeneca Ab | Chemical compounds |
CA2400447C (en) | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
US6521618B2 (en) | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
US6589758B1 (en) | 2000-05-19 | 2003-07-08 | Amgen Inc. | Crystal of a kinase-ligand complex and methods of use |
BR0113056A (pt) | 2000-08-09 | 2003-07-08 | Astrazeneca Ab | Composto, processo papa a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, e, uso de um composto |
GB0104422D0 (en) | 2001-02-22 | 2001-04-11 | Glaxo Group Ltd | Quinoline derivative |
SE0101675D0 (sv) | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
CN100491372C (zh) | 2001-12-24 | 2009-05-27 | 阿斯特拉曾尼卡有限公司 | 作为欧若拉激酶抑制剂的取代喹唑啉衍生物 |
TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
US7262200B2 (en) | 2002-10-25 | 2007-08-28 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
US20040122161A1 (en) | 2002-12-21 | 2004-06-24 | Paul Charles W. | Hot melt adhesive based on acrylic block copolymers |
WO2004058781A1 (en) | 2002-12-24 | 2004-07-15 | Astrazeneca Ab | Phosphonooxy quinazoline derivatives and their pharmaceutical use |
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
BRPI0410720A (pt) | 2003-05-27 | 2006-06-20 | Pfizer Prod Inc | quinazolinas e pirido[3,4-d]pirimidinas como inibidores do receptor de tirosina cinase |
AU2004253967B2 (en) | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
UA84167C2 (ru) | 2003-09-16 | 2008-09-25 | Астразенека Аб | Производные хиназолина как ингибиторы тирозинкиназы, способ их получения (варианты), фармацевтическая композиция на их основе |
PL2210607T3 (pl) | 2003-09-26 | 2012-01-31 | Exelixis Inc | N-[3-fluoro-4-({6-(metyloksy)-7-[(3-morfolin-4-ylopropylo)oksy]chinolin-4-ylo} oxy)fenylo]-N'-(4-fluorofenylo)cyklopropano-1,1-dikarboksamid do leczenia raka |
NZ547009A (en) | 2003-12-23 | 2009-09-25 | Pfizer | Novel quinoline derivatives |
EP1734040A4 (en) | 2004-03-23 | 2007-11-28 | Banyu Pharma Co Ltd | SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE |
WO2005115145A2 (en) | 2004-05-20 | 2005-12-08 | Wyeth | Quinone substituted quinazoline and quinoline kinase inhibitors |
JP2008500374A (ja) | 2004-05-27 | 2008-01-10 | バーテックス ファーマシューティカルズ インコーポレイテッド | 自己炎症性疾患の処置のためのiceインヒビター |
EP1781293A1 (en) | 2004-06-04 | 2007-05-09 | Amphora Discovery Corporation | Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
FR2873695A1 (fr) | 2004-07-30 | 2006-02-03 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien |
EP1833830B1 (de) | 2004-12-22 | 2009-10-14 | Bayer Schering Pharma Aktiengesellschaft | Chinolinderivat, dessen verwendung, herstellung und dieses enthaltendes arzneimittel |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
AU2006231646A1 (en) | 2005-04-06 | 2006-10-12 | Exelixis, Inc. | C-Met modulators and methods of use |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
EP1746096A1 (en) | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazole analogues and uses thereof in the treatment of cancer |
ITMI20052008A1 (it) | 2005-10-21 | 2007-04-22 | Ctg Pharma S R L | Nuovi antimalarici derivati della 4-aminochinolina |
FR2902100A1 (fr) | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
US7511063B2 (en) | 2006-08-16 | 2009-03-31 | Schering Corporation | High affinity quinoline-based kinase ligands |
JP2008063278A (ja) | 2006-09-07 | 2008-03-21 | Fujifilm Finechemicals Co Ltd | 1−ピリジン−4−イル−インドール類の製造方法 |
AU2007296744A1 (en) | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
TW200829555A (en) | 2006-11-10 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
US8148532B2 (en) | 2007-03-14 | 2012-04-03 | Guoqing Paul Chen | Spiro substituted compounds as angiogenesis inhibitors |
US20080234267A1 (en) | 2007-03-20 | 2008-09-25 | Karen Elizabeth Lackey | Compounds and Methods of Treatment |
WO2008119771A2 (en) | 2007-03-30 | 2008-10-09 | Clanotech Ab | Quinoline-s-carboxylic acid derivatives as tyrosine kinase inhibitors |
MX2009011089A (es) | 2007-04-23 | 2009-10-30 | Sanofi Aventis | Derivados de quinolina-carboxamida en calidad de antagonistas de p2y12. |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
EP2152267A2 (en) | 2007-06-01 | 2010-02-17 | Wyeth LLC | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles |
CN101362719B (zh) | 2007-08-06 | 2012-04-18 | 北京师范大学 | 喹啉类衍生物以及包含其的组合物 |
US7790746B2 (en) | 2007-10-12 | 2010-09-07 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
US7939546B2 (en) | 2007-10-12 | 2011-05-10 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
GB0801416D0 (en) | 2008-01-25 | 2008-03-05 | Piramed Ltd | Pharmaceutical compounds |
DE102008062566A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Aminosäureester-Prodrugs und ihre Verwendung |
US20130005726A1 (en) | 2010-03-08 | 2013-01-03 | Derek Abbott | Compositions and methods for treating inflammatory disorders |
US20130023532A1 (en) | 2010-03-26 | 2013-01-24 | Casillas Linda N | Indazolyl-pyrimidines as kinase inhibitors |
US20130023534A1 (en) | 2010-03-26 | 2013-01-24 | Casillas Linda N | Pyrazolyl-pyrimidines as kinase inhibitors |
WO2011123609A1 (en) | 2010-03-31 | 2011-10-06 | Glaxo Group Limited | Imidazolyl-imidazoles as kinase inhibitors |
EP2566477B1 (en) | 2010-05-07 | 2015-09-02 | GlaxoSmithKline Intellectual Property Development Limited | Amino-quinolines as kinase inhibitors |
UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
US9133162B2 (en) * | 2011-02-28 | 2015-09-15 | Sunshine Lake Pharma Co., Ltd. | Substituted quinoline compounds and methods of use |
JP6026441B2 (ja) * | 2011-03-04 | 2016-11-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | キナーゼ阻害剤としてのアミノキノリン |
TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
AR092530A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
RU2662810C2 (ru) | 2013-02-21 | 2018-07-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Хиназолины в качестве ингибиторов киназы |
-
2013
- 2013-09-11 AR ARP130103248A patent/AR092530A1/es unknown
- 2013-09-11 TW TW102132714A patent/TW201425307A/zh unknown
- 2013-09-13 EP EP13836616.6A patent/EP2895167B1/en active Active
- 2013-09-13 MX MX2015003275A patent/MX2015003275A/es unknown
- 2013-09-13 PE PE2015000276A patent/PE20150774A1/es not_active Application Discontinuation
- 2013-09-13 SG SG11201500973WA patent/SG11201500973WA/en unknown
- 2013-09-13 BR BR112015004967A patent/BR112015004967A2/pt active Search and Examination
- 2013-09-13 WO PCT/US2013/059600 patent/WO2014043437A1/en active Application Filing
- 2013-09-13 AU AU2013315387A patent/AU2013315387B2/en not_active Ceased
- 2013-09-13 CN CN201380045559.XA patent/CN104602692B/zh not_active Expired - Fee Related
- 2013-09-13 US US14/396,559 patent/US9216965B2/en not_active Expired - Fee Related
- 2013-09-13 ES ES13836616T patent/ES2713172T3/es active Active
- 2013-09-13 CA CA2883155A patent/CA2883155A1/en not_active Abandoned
- 2013-09-13 JP JP2015532064A patent/JP6258331B2/ja not_active Expired - Fee Related
- 2013-09-13 KR KR1020157006177A patent/KR20150053920A/ko not_active Application Discontinuation
- 2013-09-13 EA EA201590552A patent/EA027984B1/ru not_active IP Right Cessation
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2015
- 2015-02-09 IL IL237158A patent/IL237158A0/en unknown
- 2015-02-17 PH PH12015500345A patent/PH12015500345A1/en unknown
- 2015-03-12 CL CL2015000615A patent/CL2015000615A1/es unknown
- 2015-03-13 DO DO2015000059A patent/DOP2015000059A/es unknown
- 2015-03-13 CR CR20150133A patent/CR20150133A/es unknown
Also Published As
Publication number | Publication date |
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EA201590552A1 (ru) | 2015-06-30 |
EP2895167A4 (en) | 2016-03-16 |
CL2015000615A1 (es) | 2015-08-28 |
JP6258331B2 (ja) | 2018-01-10 |
IL237158A0 (en) | 2015-04-30 |
TW201425307A (zh) | 2014-07-01 |
AU2013315387B2 (en) | 2016-09-08 |
PE20150774A1 (es) | 2015-05-28 |
DOP2015000059A (es) | 2015-05-15 |
JP2015528508A (ja) | 2015-09-28 |
KR20150053920A (ko) | 2015-05-19 |
EP2895167A1 (en) | 2015-07-22 |
EA027984B1 (ru) | 2017-09-29 |
CN104602692B (zh) | 2017-06-23 |
CA2883155A1 (en) | 2014-03-20 |
AU2013315387A1 (en) | 2015-02-26 |
US9216965B2 (en) | 2015-12-22 |
MX2015003275A (es) | 2015-07-06 |
SG11201500973WA (en) | 2015-04-29 |
BR112015004967A2 (pt) | 2020-04-22 |
WO2014043437A1 (en) | 2014-03-20 |
EP2895167B1 (en) | 2018-12-05 |
CR20150133A (es) | 2015-05-04 |
ES2713172T3 (es) | 2019-05-20 |
CN104602692A (zh) | 2015-05-06 |
US20150094333A1 (en) | 2015-04-02 |
PH12015500345A1 (en) | 2015-04-20 |
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