NO310473B1 - Fremgangsmåte for fremstilling av humanisert immunoglobulin, polynukleotid som koder for nevnte immunoglobulin og cellelinjesom er transfektert med nevnte polynukleotid - Google Patents
Fremgangsmåte for fremstilling av humanisert immunoglobulin, polynukleotid som koder for nevnte immunoglobulin og cellelinjesom er transfektert med nevnte polynukleotid Download PDFInfo
- Publication number
- NO310473B1 NO310473B1 NO19912385A NO912385A NO310473B1 NO 310473 B1 NO310473 B1 NO 310473B1 NO 19912385 A NO19912385 A NO 19912385A NO 912385 A NO912385 A NO 912385A NO 310473 B1 NO310473 B1 NO 310473B1
- Authority
- NO
- Norway
- Prior art keywords
- immunoglobulin
- human
- amino acid
- cdr
- humanized
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title claims abstract description 133
- 102000018358 immunoglobulin Human genes 0.000 title claims abstract description 133
- 238000000034 method Methods 0.000 title claims description 40
- 108091033319 polynucleotide Proteins 0.000 title claims description 14
- 102000040430 polynucleotide Human genes 0.000 title claims description 14
- 239000002157 polynucleotide Substances 0.000 title claims description 14
- 238000002360 preparation method Methods 0.000 title description 3
- 150000001413 amino acids Chemical class 0.000 claims abstract description 93
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 61
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims abstract description 36
- 230000027455 binding Effects 0.000 claims abstract description 32
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 31
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims abstract description 22
- 108010002350 Interleukin-2 Proteins 0.000 claims abstract description 13
- 102000000588 Interleukin-2 Human genes 0.000 claims abstract description 13
- 102000055277 human IL2 Human genes 0.000 claims abstract description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 62
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 239000000427 antigen Substances 0.000 claims description 19
- 108091007433 antigens Proteins 0.000 claims description 19
- 102000036639 antigens Human genes 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 238000006467 substitution reaction Methods 0.000 claims description 10
- 230000003993 interaction Effects 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 3
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 3
- 238000002955 isolation Methods 0.000 claims description 3
- 239000006143 cell culture medium Substances 0.000 claims description 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 abstract description 18
- 102000005962 receptors Human genes 0.000 abstract description 5
- 108020003175 receptors Proteins 0.000 abstract description 5
- 150000007523 nucleic acids Chemical class 0.000 abstract description 3
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 241001529936 Murinae Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 68
- 229940072221 immunoglobulins Drugs 0.000 description 29
- 210000001744 T-lymphocyte Anatomy 0.000 description 26
- 108091034117 Oligonucleotide Proteins 0.000 description 23
- 239000000203 mixture Substances 0.000 description 22
- 241000699666 Mus <mouse, genus> Species 0.000 description 20
- 239000000370 acceptor Substances 0.000 description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 19
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 18
- 239000013612 plasmid Substances 0.000 description 16
- 201000010099 disease Diseases 0.000 description 14
- 239000012634 fragment Substances 0.000 description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 12
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 238000011282 treatment Methods 0.000 description 12
- 238000010561 standard procedure Methods 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 239000013598 vector Substances 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- 229940127089 cytotoxic agent Drugs 0.000 description 8
- 239000002596 immunotoxin Substances 0.000 description 8
- 230000001404 mediated effect Effects 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 230000002637 immunotoxin Effects 0.000 description 7
- 229940051026 immunotoxin Drugs 0.000 description 7
- 231100000608 immunotoxin Toxicity 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000002254 cytotoxic agent Substances 0.000 description 6
- 231100000599 cytotoxic agent Toxicity 0.000 description 6
- 239000012636 effector Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 108700005091 Immunoglobulin Genes Proteins 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 108090001008 Avidin Proteins 0.000 description 4
- 241000283707 Capra Species 0.000 description 4
- 108010004729 Phycoerythrin Proteins 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000013604 expression vector Substances 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 108010039491 Ricin Proteins 0.000 description 3
- 238000000137 annealing Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000011651 chromium Substances 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 230000010076 replication Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 241000557626 Corvus corax Species 0.000 description 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 2
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 208000000389 T-cell leukemia Diseases 0.000 description 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 239000008365 aqueous carrier Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 108010058966 bacteriophage T7 induced DNA polymerase Proteins 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000010367 cloning Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000004540 complement-dependent cytotoxicity Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 231100000433 cytotoxic Toxicity 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 239000000539 dimer Substances 0.000 description 2
- 210000003527 eukaryotic cell Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
- 229960000485 methotrexate Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 1
- WUAPFZMCVAUBPE-NJFSPNSNSA-N 188Re Chemical compound [188Re] WUAPFZMCVAUBPE-NJFSPNSNSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 241000701822 Bovine papillomavirus Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 description 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- GRRNUXAQVGOGFE-UHFFFAOYSA-N Hygromycin-B Natural products OC1C(NC)CC(N)C(O)C1OC1C2OC3(C(C(O)C(O)C(C(N)CO)O3)O)OC2C(O)C(CO)O1 GRRNUXAQVGOGFE-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 101100370002 Mus musculus Tnfsf14 gene Proteins 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241000157426 Pernis Species 0.000 description 1
- 241000577979 Peromyscus spicilegus Species 0.000 description 1
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
- 102000015439 Phospholipases Human genes 0.000 description 1
- 108010064785 Phospholipases Proteins 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000235070 Saccharomyces Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001474728 Satyrodes eurydice Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 102000014384 Type C Phospholipases Human genes 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical compound [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 229940009456 adriamycin Drugs 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000012870 ammonium sulfate precipitation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- JCXGWMGPZLAOME-AKLPVKDBSA-N bismuth-212 Chemical compound [212Bi] JCXGWMGPZLAOME-AKLPVKDBSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 235000019000 fluorine Nutrition 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 230000002414 glycolytic effect Effects 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
- 229940097277 hygromycin b Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000003125 immunofluorescent labeling Methods 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000001865 kupffer cell Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 description 1
- 239000011654 magnesium acetate Substances 0.000 description 1
- 235000011285 magnesium acetate Nutrition 0.000 description 1
- 229940069446 magnesium acetate Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
- 229960000951 mycophenolic acid Drugs 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940002004 the magic bullet Drugs 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/087—Herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/088—Varicella-zoster virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29097588A | 1988-12-28 | 1988-12-28 | |
US31025289A | 1989-02-13 | 1989-02-13 | |
PCT/US1989/005857 WO1990007861A1 (fr) | 1988-12-28 | 1989-12-28 | IMMUNOGLOBULINES CHIMERIQUES SPECIFIQUES CONTRE LA PROTEINE TAC p55 DU RECEPTEUR D'IL-2 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO912385D0 NO912385D0 (no) | 1991-06-19 |
NO912385L NO912385L (no) | 1991-06-19 |
NO310473B1 true NO310473B1 (no) | 2001-07-09 |
Family
ID=26966505
Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19912385A NO310473B1 (no) | 1988-12-28 | 1991-06-19 | Fremgangsmåte for fremstilling av humanisert immunoglobulin, polynukleotid som koder for nevnte immunoglobulin og cellelinjesom er transfektert med nevnte polynukleotid |
NO2001025C NO2001025I2 (no) | 1988-12-28 | 2001-12-17 | Palivizumab |
NO2001026C NO2001026I2 (no) | 1988-12-28 | 2001-12-17 | Daclizumab |
NO2001024C NO2001024I1 (no) | 1988-12-28 | 2001-12-17 | Trastuzumab eller farmasøytiske akseptable salter derav |
NO2005005C NO2005005I2 (no) | 1988-12-28 | 2005-02-18 | Bevacizumab eller farmasoeytisk akseptable salter derav |
NO2005026C NO2005026I2 (no) | 1988-12-28 | 2005-12-07 | Omalizumab eller farmasoeytisk akseptable salter derav |
NO2006009C NO2006009I2 (no) | 1988-12-28 | 2006-08-07 | Natalizumab eller farmasoytisk akseptable salter derav |
NO2007006C NO2007006I2 (no) | 1988-12-28 | 2007-04-18 | Ranibizumab eller farmasoytisk akseptable salter derav |
NO2009026C NO2009026I1 (no) | 1988-12-28 | 2009-11-12 | Certolizumab pegol |
Family Applications After (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2001025C NO2001025I2 (no) | 1988-12-28 | 2001-12-17 | Palivizumab |
NO2001026C NO2001026I2 (no) | 1988-12-28 | 2001-12-17 | Daclizumab |
NO2001024C NO2001024I1 (no) | 1988-12-28 | 2001-12-17 | Trastuzumab eller farmasøytiske akseptable salter derav |
NO2005005C NO2005005I2 (no) | 1988-12-28 | 2005-02-18 | Bevacizumab eller farmasoeytisk akseptable salter derav |
NO2005026C NO2005026I2 (no) | 1988-12-28 | 2005-12-07 | Omalizumab eller farmasoeytisk akseptable salter derav |
NO2006009C NO2006009I2 (no) | 1988-12-28 | 2006-08-07 | Natalizumab eller farmasoytisk akseptable salter derav |
NO2007006C NO2007006I2 (no) | 1988-12-28 | 2007-04-18 | Ranibizumab eller farmasoytisk akseptable salter derav |
NO2009026C NO2009026I1 (no) | 1988-12-28 | 2009-11-12 | Certolizumab pegol |
Country Status (32)
Country | Link |
---|---|
EP (6) | EP1491556B1 (fr) |
JP (6) | JP2828340B2 (fr) |
KR (1) | KR0178385B1 (fr) |
CN (1) | CN1057013C (fr) |
AT (2) | ATE183753T1 (fr) |
AU (1) | AU647383B2 (fr) |
BG (1) | BG61095B2 (fr) |
CA (2) | CA2006865C (fr) |
CZ (1) | CZ418691A3 (fr) |
DD (1) | DD296964A5 (fr) |
DE (14) | DE19975047I2 (fr) |
DK (2) | DK119191A (fr) |
ES (5) | ES2081974T5 (fr) |
FI (1) | FI108797B (fr) |
FR (1) | FR14C0070I1 (fr) |
HK (1) | HK1014718A1 (fr) |
HR (1) | HRP920500B1 (fr) |
HU (1) | HU211174A9 (fr) |
IE (1) | IE20000331A1 (fr) |
IL (2) | IL162181A (fr) |
LU (8) | LU90411I2 (fr) |
MC (1) | MC2146A1 (fr) |
NL (8) | NL990020I2 (fr) |
NO (9) | NO310473B1 (fr) |
NZ (2) | NZ314793A (fr) |
PT (1) | PT92758B (fr) |
RU (1) | RU2126046C1 (fr) |
SG (1) | SG78258A1 (fr) |
SI (1) | SI8912489B (fr) |
WO (1) | WO1990007861A1 (fr) |
YU (1) | YU48700B (fr) |
ZA (1) | ZA899956B (fr) |
Families Citing this family (964)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5800815A (en) * | 1903-05-05 | 1998-09-01 | Cytel Corporation | Antibodies to P-selectin and their uses |
US5851526A (en) * | 1985-04-19 | 1998-12-22 | Ludwig Institute For Cancer Research | Methods of treating colon cancer utilizing tumor-specific antibodies |
US5449760A (en) * | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US7247453B1 (en) * | 1988-12-30 | 2007-07-24 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein C |
DE3900534A1 (de) * | 1989-01-10 | 1990-07-12 | Boehringer Mannheim Gmbh | Diagnostischer nachweis unter verwendung von chimaeren antikoerpern |
US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GR1001050B (el) * | 1990-01-09 | 1993-04-28 | Protein Design Labs Inc | Νεος il-2 υποδοχευς ιδιαζοντων ανθρωπινων ανοσοσφαιρινων. |
HUT60768A (en) | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
GB9020282D0 (en) * | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
US5858725A (en) * | 1990-10-10 | 1999-01-12 | Glaxo Wellcome Inc. | Preparation of chimaeric antibodies using the recombinant PCR strategy |
US5994510A (en) * | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
CZ282603B6 (cs) * | 1991-03-06 | 1997-08-13 | Merck Patent Gesellschaft Mit Beschränkter Haftun G | Humanizované a chimerické monoklonální protilátky |
IE920716A1 (en) * | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
ES2118820T3 (es) * | 1991-04-05 | 1998-10-01 | Univ Washington | Anticuerpos monoclonales para receptores de factores de celulas pluripotentes. |
WO1992019759A1 (fr) * | 1991-04-25 | 1992-11-12 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humains reconstitues diriges contre un recepteur de l'interleukine 6 humaine |
DE69233482T2 (de) * | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
JP4124480B2 (ja) * | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
WO1994004679A1 (fr) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Procede pour fabriquer des anticorps humanises |
GB9115010D0 (en) * | 1991-07-11 | 1991-08-28 | Wellcome Found | Antibody |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
WO1993001831A1 (fr) * | 1991-07-25 | 1993-02-04 | Idec Pharmaceuticals Corporation | Induction de reponses de lymphocytes t cytotoxiques |
US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
US5756096A (en) * | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
US6699472B2 (en) | 1991-08-14 | 2004-03-02 | Genentech, Inc. | Method of treating allergic disorders |
US6329509B1 (en) | 1991-08-14 | 2001-12-11 | Genentech, Inc. | Anti-IgE antibodies |
EP0528767B1 (fr) * | 1991-08-21 | 2000-01-12 | Novartis AG | Dérivés d'anticorps |
GB9120467D0 (en) * | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
JP3024311B2 (ja) * | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
US7070777B1 (en) | 1991-11-15 | 2006-07-04 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting inflammation with an antibody that binds the 5C8 protein |
US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
US5817310A (en) * | 1991-12-02 | 1998-10-06 | Cor Therapeutics, Inc. | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor |
JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
ES2202310T3 (es) * | 1991-12-13 | 2004-04-01 | Xoma Corporation | Metodos y materiales para la preparacion de dominios variables de anticuerpos modificados y sus usos terapeuticos. |
US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
DE69334255D1 (de) * | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
GB9203459D0 (en) * | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5387676A (en) * | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
US7381803B1 (en) | 1992-03-27 | 2008-06-03 | Pdl Biopharma, Inc. | Humanized antibodies against CD3 |
US6129914A (en) * | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
US6033667A (en) * | 1992-05-05 | 2000-03-07 | Cytel Corporation | Method for detecting the presence of P-selectin |
US5874082A (en) * | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US6066718A (en) * | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
GB9223377D0 (en) * | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
EP0752248B1 (fr) | 1992-11-13 | 2000-09-27 | Idec Pharmaceuticals Corporation | Application thérapeutique d'anticorps chimériques et radio-marqués contre l'antigène à differentiation restreinte des lymphocytes B humains pour le traitement du lymphome des cellules B |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
ATE236987T1 (de) * | 1992-11-13 | 2003-04-15 | Idec Pharma Corp | Konsensus-kozak-sequenzen zur säugetier- exprimierung |
US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
US5804187A (en) * | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
SG44845A1 (en) | 1993-01-12 | 1997-12-19 | Biogen Inc | Recombitant anti-vla4 antibody molecules |
US5730979A (en) * | 1993-03-05 | 1998-03-24 | Universite Catholique Delouvain | LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation |
US5951983A (en) * | 1993-03-05 | 1999-09-14 | Universite Catholique De Louvain | Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies |
US5817311A (en) * | 1993-03-05 | 1998-10-06 | Universite Catholique De Louvain | Methods of inhibiting T-cell medicated immune responses with LO-CD2a-specific antibodies |
EP0804235A4 (fr) * | 1993-05-04 | 2001-09-19 | Aeres Biomedical Ltd | Anticorps diriges contre la selectine p et leurs utilisations |
EP0751962B1 (fr) * | 1993-05-28 | 2006-08-02 | The Scripps Research Institute | Procedes d'inhibition de l'activation des cellules induites par cd14 |
WO1994028159A1 (fr) * | 1993-05-31 | 1994-12-08 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstruit contre l'interleukine-6 humaine |
US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
CA2171336C (fr) * | 1993-09-07 | 2011-06-21 | Stephen Dudley Holmes | Anticorps il4 recombinants, utiles pour le traitement des troubles lies a il4 |
US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
EP0729976A1 (fr) | 1993-11-19 | 1996-09-04 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre des cellules medulloblastomateuses humaines |
AU2185195A (en) * | 1993-11-30 | 1995-06-19 | Protein Design Labs, Inc. | Reperfusion therapy using antibodies to L-selectin |
GB9325182D0 (en) * | 1993-12-08 | 1994-02-09 | T Cell Sciences Inc | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
US7435802B2 (en) | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
ES2270425T3 (es) * | 1994-01-25 | 2007-04-01 | Elan Pharmaceuticals, Inc. | Anticuerpos humanizados contra la molecula de adhesion leucocitaria vla-4. |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
AU707440B2 (en) | 1994-03-29 | 1999-07-08 | Celltech Therapeutics Limited | Antibodies against E-selectin |
US5635597A (en) * | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
US5622701A (en) * | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
USRE39548E1 (en) * | 1994-06-17 | 2007-04-03 | Celltech R&D Limited | Interleukin-5 specific recombinant antibodies |
GB9412230D0 (en) * | 1994-06-17 | 1994-08-10 | Celltech Ltd | Interleukin-5 specific recombiant antibodies |
US6048972A (en) * | 1994-07-13 | 2000-04-11 | Chugai Pharmaceutical Co., Ltd. | Recombinant materials for producing humanized anti-IL-8 antibodies |
DE4425115A1 (de) * | 1994-07-15 | 1996-01-18 | Boehringer Mannheim Gmbh | Verfahren zur Modifizierung der Stabilität von Antikörpern |
EP0696455A1 (fr) * | 1994-08-11 | 1996-02-14 | Cellena (Cell Engineering) A.G. | Compositions de transferrine pour l'atténuation des effets secondaires des médicaments cytotoxiques |
US8771694B2 (en) * | 1994-08-12 | 2014-07-08 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells |
US5707621A (en) * | 1994-08-31 | 1998-01-13 | Chugai Pharmaceutical Co., Ltd. | Supression of nephritis-induced protein excretion by anti-IL-8 |
US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
US5693323A (en) * | 1994-12-23 | 1997-12-02 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
US7153508B2 (en) | 1995-06-07 | 2006-12-26 | Biogen Idec Inc. | Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 |
US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
US7175847B1 (en) | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
AU6171196A (en) * | 1995-06-07 | 1996-12-30 | Sloan-Kettering Institute For Cancer Research | Therapeutic uses of ta99 |
US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
US6001358A (en) * | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
GB9600660D0 (en) | 1996-01-12 | 1996-03-13 | Ciba Geigy Ag | Protein |
US6046310A (en) * | 1996-03-13 | 2000-04-04 | Protein Design Labs., Inc. | FAS ligand fusion proteins and their uses |
US5882644A (en) * | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
US6713305B1 (en) | 1996-04-29 | 2004-03-30 | Novartis Ag | Metastasis-associated antigen and antibodies thereto |
EP0909277B2 (fr) | 1996-06-07 | 2008-12-24 | Poniard Pharmaceuticals, Inc. | Anticorps humanises se liant au meme antigene que celui lie par l'anticorps nr-lu-13 et leur utilisation dans des procedes de preciblage |
US6833255B1 (en) | 1996-07-24 | 2004-12-21 | Novartis, Ag | Drosophila melanogaster p70 S6 kinase |
US6534311B2 (en) | 1996-07-24 | 2003-03-18 | Novartis Ag | Drosophila melanogaster p70S6 kinase |
US7147851B1 (en) * | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
US6777540B1 (en) * | 1996-09-02 | 2004-08-17 | Ko Okumura | Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand |
US6013256A (en) * | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
BR9713294A (pt) | 1996-09-26 | 2000-10-17 | Chugai Pharmaceutical Co Ltd | "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano" |
UA76934C2 (en) | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
US20020160005A1 (en) | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
DE69738841D1 (de) | 1996-12-23 | 2008-08-28 | Immunex Corp | Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie |
US6262238B1 (en) * | 1997-01-14 | 2001-07-17 | Roche Diagnostic, Gmbh | Process for modifying the stability of antibodies |
US6590079B2 (en) | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
US6596850B1 (en) | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
AU736287B2 (en) * | 1997-03-21 | 2001-07-26 | Sankyo Company Limited | Humanized anti-human Fas antibody |
US6972323B1 (en) | 1997-04-01 | 2005-12-06 | Sankyo Company, Limited | Anti-Fas antibodies |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
DE69829891T2 (de) | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
US20070059302A1 (en) | 1997-04-07 | 2007-03-15 | Genentech, Inc. | Anti-vegf antibodies |
ATE361099T1 (de) * | 1997-05-15 | 2007-05-15 | Chugai Pharmaceutical Co Ltd | Heilmittel für kachexie |
EP1724282B1 (fr) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Procédé de production de protéines non-immunogènes |
JP4891477B2 (ja) | 1997-10-02 | 2012-03-07 | マックス−プランク−ゲゼルシャフト ツール フォーデルング デル ヴィッセンシャフテン エー.ヴェー. | 血管新生及び/または既存細動脈網から側枝動脈及び/または他の動脈の発達の調節に関する方法 |
CN1277632A (zh) * | 1997-10-03 | 2000-12-20 | 中外制药株式会社 | 天然人源化抗体 |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
EP1745799B1 (fr) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Compositions et méthodes pour le traitement de tumeurs |
ES2364266T3 (es) | 1998-04-03 | 2011-08-30 | Chugai Seiyaku Kabushiki Kaisha | Anticuerpo humanizado hacia el factor tisular humano (tf) y procedimiento para construir el anticuerpo humanizado. |
MY136203A (en) | 1998-08-11 | 2008-08-29 | Idec Pharma Corp | Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody |
JP4689781B2 (ja) * | 1998-09-03 | 2011-05-25 | 独立行政法人科学技術振興機構 | アミノ酸輸送蛋白及びその遺伝子 |
JP2002524529A (ja) | 1998-09-14 | 2002-08-06 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム | インテグリンアンタゴニストを用いて多発性骨髄腫および骨髄腫誘導骨吸収を治療する方法 |
CA2345356C (fr) | 1998-10-06 | 2012-10-02 | Mark Aaron Emalfarb | Systeme de transformation dans le domaine des hotes fongiques filamenteux |
EP1939215A1 (fr) | 1998-10-22 | 2008-07-02 | The University of Montana | Protéines Omp85 de neisseria gonorrhoeae et neisseria meningitidis, compositions contenant ces protéines et procédés d'utilisation correspondants |
EP1616572B1 (fr) | 1998-11-09 | 2010-09-01 | Biogen Idec Inc. | Anticorps chimère anti-CD20, rituxan, pour l'utilisation dans le traitement de la leucémie chronique lymphatique |
GB9825632D0 (en) | 1998-11-23 | 1999-01-13 | Novartis Ag | Organic compounds |
US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
EP1119368A2 (fr) | 1999-03-03 | 2001-08-01 | Biogen, Inc. | Methodes de modulation du metabolisme et du stockage lipidiques |
GB9906380D0 (en) * | 1999-03-19 | 1999-05-12 | Melvin William T | Monoclonal antibodies specific for cypibi |
IL145898A0 (en) | 1999-04-22 | 2002-07-25 | Biogen Inc | Method for the treatment of fibrosis using an antagonist of the integrin alpha-4 subunit |
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
ES2557768T3 (es) | 1999-06-01 | 2016-01-28 | Biogen Ma Inc. | Un anticuerpo monoclonal bloqueante frente a VLA-1 y su uso para el tratamiento de trastornos inflamatorios |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
US7144991B2 (en) | 1999-06-07 | 2006-12-05 | Aletheon Pharmaceuticals, Inc. | Streptavidin expressed gene fusions and methods of use thereof |
US6531580B1 (en) | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
TWI255718B (en) | 1999-07-02 | 2006-06-01 | Chugai Pharmaceutical Co Ltd | Ameliorative agent for low vasopressin concentration |
US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
ES2301491T3 (es) * | 1999-09-30 | 2008-07-01 | Kyowa Hakko Kogyo Co., Ltd. | Anticuerpo humano de trasplante con region de determinacion de la complementariedad contra gangliosido gd3 y derivados del anticuerpo contra gangliosido gd3. |
US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
CA3016482A1 (fr) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | Nouvelle molecule immunoregulatrice b7-h1, |
JP2003517023A (ja) | 1999-12-16 | 2003-05-20 | バイオジェン インコーポレイテッド | 中枢神経系の虚血性損傷または出血性損傷を、抗α4インテグリンアンタゴニストを用いて処置する方法 |
US6656467B2 (en) | 2000-01-27 | 2003-12-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
CA2399080C (fr) * | 2000-02-03 | 2013-05-21 | Millennium Pharmaceuticals, Inc. | Anticorps humanises anti-ccr2 et procedes d'utilisation de ces anticorps |
AU2001234953B2 (en) | 2000-02-11 | 2006-03-16 | Biogen Ma Inc. | Heterologous polypeptide of the tnf family |
CN101670105B (zh) | 2000-02-24 | 2014-08-06 | 华盛顿大学 | 螯合淀粉样蛋白β肽的人源化抗体 |
DK1259547T3 (da) | 2000-03-01 | 2012-10-15 | Medimmune Inc | Højpotente, rekombinante antistoffer og fremgangsmåde til fremstilling heraf |
EP1267926A2 (fr) | 2000-03-17 | 2003-01-02 | Millennium Pharmaceuticals, Inc. | Methode d'inhibition de la stenose et de la restenose |
US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
EP1283057B2 (fr) | 2000-04-28 | 2012-05-30 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs de proliferation cellulaire |
ES2316446T3 (es) | 2000-04-29 | 2009-04-16 | University Of Iowa Research Foundation | Diagnostico y terapeutica para trastornos relacionados con la degeneracion macular. |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
TWI318983B (en) | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
DE60143535D1 (de) | 2000-10-02 | 2011-01-05 | Novartis Vaccines & Diagnostic | Humane antikörper gegen cd40 |
WO2005019269A2 (fr) | 2002-11-27 | 2005-03-03 | Minerva Biotechnologies Corporation | Techniques et compositions pour le diagnostic et le traitement du cancer (muc1) |
US6989247B2 (en) | 2000-11-28 | 2006-01-24 | Celltech R & D, Inc. | Compositions and methods for diagnosing or treating psoriasis |
US7179900B2 (en) | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
PE20020574A1 (es) | 2000-12-06 | 2002-07-02 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido amiloideo beta |
IL158060A0 (en) * | 2001-04-06 | 2004-03-28 | Univ Bristol | Use of cd25 binding molecules in steroid-resistant patients |
IL158376A0 (en) | 2001-04-13 | 2004-05-12 | Biogen Inc | Antibodies to vla-1 |
CZ20033476A3 (cs) * | 2001-05-18 | 2004-05-12 | Boehringeráingelheimáinternationalágmbh | Protilátky specifické pro CD@@v |
US6972324B2 (en) | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
US7541443B2 (en) * | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
WO2002102854A2 (fr) | 2001-06-20 | 2002-12-27 | Morphosys Ag | Anticorps bloquant l'activation d'une tyrosine kinase de type proteine receptrice, procedes permettant l'identification de cet anticorps et utilisations de celui-ci |
US20030013081A1 (en) | 2001-06-26 | 2003-01-16 | Olson William C. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
JP4675512B2 (ja) * | 2001-07-10 | 2011-04-27 | 三井化学株式会社 | 熱殺菌方法 |
EP1578917A4 (fr) | 2001-07-19 | 2008-01-23 | Perlan Therapeutics Inc | Proteines multimeres et methodes de production et d'utilisation de ces proteines |
JP4729717B2 (ja) | 2001-08-03 | 2011-07-20 | 株式会社医学生物学研究所 | GM1ガングリオシド結合型アミロイドβタンパク質を認識する抗体、及び該抗体をコードするDNA |
DK1944040T3 (da) | 2001-08-17 | 2012-10-29 | Univ Washington | Analysefremgangsmåde for Alzheimers sygdom |
PL232477B1 (pl) | 2001-09-20 | 2019-06-28 | Immunex Corp | System ekspresji gospodarza i sposób wytwarzania heteromerycznego kompleksu |
HUP0402049A3 (en) | 2001-09-25 | 2009-04-28 | Astellas Pharma Inc | Recombinant anti-osteopontin antibody and use thereof |
GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
MXPA04004417A (es) * | 2001-11-12 | 2004-08-11 | Merck Patent Gmbh | Anticuerpo anti-tnf alfa modificado. |
EP1944043A1 (fr) | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Séquences d'acides aminés et d'acides nucléiques d'adénovirus simien, vecteurs les contenant, et procédés d'utilisation. |
SG2013034475A (en) | 2001-11-21 | 2016-10-28 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
DK1461300T3 (da) | 2001-11-30 | 2011-10-24 | Biogen Idec Inc | Antistoffer mod kemotaktiske monocytproteiner |
US7393648B2 (en) | 2001-12-03 | 2008-07-01 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
AU2002359568B2 (en) | 2001-12-03 | 2008-02-21 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
GB0129105D0 (en) | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
WO2003068821A2 (fr) * | 2002-02-14 | 2003-08-21 | Immunomedics, Inc. | Anticorps anti-cd20 et proteines hybrides desdits anticorps, et methodes d'utilisation |
NZ561465A (en) * | 2002-02-22 | 2009-04-30 | Pdl Biopharma Inc | Anti-CCR5 antibody |
BR0307975A (pt) | 2002-02-25 | 2005-01-11 | Elan Pharm Inc | Métodos para reduzir cronicamente a inflamação patológica em um paciente e para determinar a eficácia de um regime de administração crÈnica para tratar inflamação patológica em um indivìduo, composição e terapia combinada para tratamento crÈnico de inflamação patológica em um paciente e uso de um inibidor de alfa-4-integrina |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
IL164021A0 (en) | 2002-03-13 | 2005-12-18 | Univ California | Antibodies and anti-pharmaceutical compositions containing the same |
EP1495056B1 (fr) | 2002-03-20 | 2011-03-02 | UCB Pharma, S.A. | Methodes d'analyse d'isomeres de disulfure d'anticorps |
WO2003080675A2 (fr) | 2002-03-22 | 2003-10-02 | Amrad Operations Pty Ltd | Anticorps monoclonal contre le recepteur alpha1 de l'interleukine 13 (il-13ra1) |
GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
US7202067B2 (en) | 2002-05-14 | 2007-04-10 | Martek Biosciences Corporation | Carotene synthase gene and uses therefor |
EP1534753B1 (fr) | 2002-05-28 | 2011-08-03 | UCB Pharma, S.A. | Isomeres de position de peg d'un anticorps contre le tnfalpha (cdp870) |
DE60334453D1 (de) * | 2002-05-30 | 2010-11-18 | Macrogenics Inc | Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten |
GB0213745D0 (en) | 2002-06-14 | 2002-07-24 | Univ Edinburgh | Enzyme |
ATE415416T1 (de) | 2002-06-14 | 2008-12-15 | Monier Tadros | Methode für die herstellung von protamin |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7575742B2 (en) * | 2002-06-28 | 2009-08-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
WO2010011999A2 (fr) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of California | Procédés et compositions pour susciter une réponse immunitaire sélective envers les amyloïdes |
US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
GB0228832D0 (en) | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
WO2008103472A2 (fr) | 2007-02-23 | 2008-08-28 | Elan Pharmaceuticals, Inc. | Prévention et traitement de maladies synucléinopathiques et amyloïdogéniques |
TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
MXPA05005160A (es) | 2002-11-15 | 2005-07-22 | Genmab As | Anticuerpos monoclonales humanos contra la cd25. |
EP1572744B1 (fr) | 2002-12-16 | 2010-06-09 | Genentech, Inc. | Variants d'immunoglobuline et utilisations |
CA2513113A1 (fr) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Procedes de production d'anticoprs humanises et d'amelioration du rendement d'anticorps ou de fragments de liaison d'antigenes en culture cellulaire |
SK50642005A3 (sk) | 2003-01-24 | 2006-02-02 | Elan Pharmaceuticals, Inc. | Kompozícia na liečenie demyelizačných ochorení a paralýzy podávaním remyelizačných látok |
EP1460088A1 (fr) | 2003-03-21 | 2004-09-22 | Biotest AG | Anticorps humanisé contre CD4 avec des caractéristiques immunosuppressives |
US7321065B2 (en) | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
ATE517920T1 (de) | 2003-04-23 | 2011-08-15 | Medarex Inc | Humanisierte antikörper gegen interferon-alpha- rezeptor-1 (ifnar-1) |
EP1631312B1 (fr) | 2003-04-23 | 2008-09-10 | Medarex, Inc. | Compositions et techniques destinees a la therapie d'une maladie intestinale inflammatoire |
US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
ES2640669T3 (es) | 2003-05-19 | 2017-11-03 | Prothena Biosciences Limited | Fragmentos truncados de alfa-sinucleína en enfermedad con cuerpos de lewy |
AU2004253868B2 (en) | 2003-06-13 | 2011-06-16 | Biogen Ma Inc. | Aglycosyl anti-CD154 (CD40 ligand) antibodies and uses thereof |
US8153410B2 (en) | 2003-07-07 | 2012-04-10 | Fox Chase Cancer Center | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules |
US20060162014A1 (en) | 2003-07-07 | 2006-07-20 | Jaffe Eileen K | Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules |
EP1641822B1 (fr) | 2003-07-08 | 2013-05-15 | Genentech, Inc. | Polypeptides heterologues il-17 a/f et utilisation des polypeptides a des fins therapeutiques |
RS53476B (en) | 2003-07-18 | 2014-12-31 | Amgen Fremont Inc. | Hepatocyte Growth Factor Binders |
US7834155B2 (en) | 2003-07-21 | 2010-11-16 | Immunogen Inc. | CA6 antigen-specific cytotoxic conjugate and methods of using the same |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
GB0321997D0 (en) | 2003-09-19 | 2003-10-22 | Novartis Ag | Organic compound |
KR20060121150A (ko) * | 2003-11-11 | 2006-11-28 | 추가이 세이야쿠 가부시키가이샤 | 인간화 항-cd47 항체 |
AU2004290059A1 (en) | 2003-11-12 | 2005-05-26 | Albert Einstein College Of Medicine Of Yeshiva University | Novel sequences encoding hepatitis C virus glycoproteins |
ES2484340T3 (es) | 2003-12-05 | 2014-08-11 | Multimmune Gmbh | Anticuerpos anti hsp70 terapéuticos y diagnósticos |
WO2005056599A2 (fr) | 2003-12-08 | 2005-06-23 | Morphotek, Inc. | Anticorps liant specifiquement pms2 |
WO2005058244A2 (fr) | 2003-12-15 | 2005-06-30 | Alexion Pharmaceuticals, Inc. | Nouveaux anticorps anti-dc-sign |
ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
PT2311873T (pt) | 2004-01-07 | 2018-11-20 | Novartis Vaccines & Diagnostics Inc | Anticorpo monoclonal específico para m-csf e respetivos usos |
US20070280950A1 (en) | 2004-01-19 | 2007-12-06 | Medical And Biological Laboratories Co., Ltd. | Inflammatory Cytokine Inhibitors |
WO2005081783A2 (fr) | 2004-01-30 | 2005-09-09 | Dana Farber Cancer Institute | Procedes pour determiner et quantifier l'exposition a des rayonnements ou a des genotoxines |
AU2005212369B2 (en) | 2004-02-10 | 2011-06-23 | Musc Foundation For Research Development | Inhibition of factor B, the alternative complement pathway and methods related thereto |
JP4805848B2 (ja) | 2004-02-12 | 2011-11-02 | モルフォテック、インク. | 腫瘍抗原の生物活性を特異的に阻止するモノクローナル抗体 |
TWI359026B (en) | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
US7807157B2 (en) | 2004-02-20 | 2010-10-05 | Intellect Neurosciences Inc. | Monoclonal antibodies and use thereof |
EP1730196B1 (fr) | 2004-03-12 | 2010-12-22 | Vasgene Therapeutics, Inc. | Anticorps anti-ephb4 pour inhiber l'angiogenese et la croissance tumorale |
WO2005092926A2 (fr) | 2004-03-19 | 2005-10-06 | Amgen Inc. | Reduction du risque d'anticorps humains et anti-humains par la manipulation du gene v |
US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
MY162179A (en) | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
DK1734996T3 (da) | 2004-04-02 | 2013-06-10 | Univ California | Fremgangsmåder og sammensætninger til behandling og forebyggelse af sygdom, der er associeret med alfa v beta 5-integrin |
WO2005116657A2 (fr) | 2004-05-24 | 2005-12-08 | Universität Zu Köln | Identification d'un transporteur d'ergothioneine et ses utilisations therapeutiques |
EP1602926A1 (fr) | 2004-06-04 | 2005-12-07 | University of Geneva | Nouveaux moyens et méthodes pour le traitement de pertes d'audition ou l'audition fantôme |
DK2662390T3 (da) | 2004-06-21 | 2017-11-06 | Squibb & Sons Llc | Interferon alpha receptor 1-antistoffer og anvendelse heraf |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
WO2006033702A2 (fr) | 2004-07-26 | 2006-03-30 | Biogen Idec Ma Inc. | Anticorps anti-cd154 |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
MX2007001679A (es) | 2004-08-09 | 2007-05-23 | Elan Pharm Inc | Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica. |
CA2478458A1 (fr) | 2004-08-20 | 2006-02-20 | Michael Panzara | Traitement de la sclerose en plaques pediatrique |
FI20041204A0 (fi) | 2004-09-16 | 2004-09-16 | Riikka Lund | Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi |
US7910100B2 (en) | 2004-10-01 | 2011-03-22 | Max-Planck-Gesellschaft zur Forderung der Wissen | Antibodies directed to the mammalian EAG1 ion channel protein |
JP5303146B2 (ja) | 2004-10-06 | 2013-10-02 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | B7−h1ならびに癌の診断、予後診断および処置の方法 |
JP5553963B2 (ja) | 2004-10-22 | 2014-07-23 | アムジエン・インコーポレーテツド | 組換え抗体をリフォールディングする方法 |
CA2584859C (fr) | 2004-10-25 | 2017-11-07 | Merck & Co., Inc. | Anticorps anti-addl et leurs utilisations |
EP1827491A4 (fr) | 2004-11-19 | 2010-07-14 | Biogen Idec Inc | Traitement de la sclerose en plaques |
WO2006066089A1 (fr) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Anticorps du peptide beta-amyloide humanises utilises dans l'amelioration de la cognition |
CN101098891B (zh) | 2005-01-05 | 2014-05-21 | F-星生物技术研究与开发有限公司 | 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域 |
CN101107007B (zh) | 2005-01-27 | 2011-08-17 | 奥克兰儿童医院及研究中心 | 对脑膜炎奈瑟球菌所致疾病具有广谱保护作用的gna1870囊泡疫苗 |
US8088579B2 (en) | 2005-02-14 | 2012-01-03 | University Of Iowa Research Foundation | Complement factor H for diagnosis of age-related macular degeneration |
EP1859277A4 (fr) | 2005-02-17 | 2010-03-17 | Biogen Idec Inc | Traitement de troubles neurologiques |
US8048992B2 (en) | 2005-02-28 | 2011-11-01 | Institute For Antibodies Co., Ltd. | Anti-IgSF4 antibody and utilization of the same |
KR101213894B1 (ko) | 2005-03-02 | 2012-12-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Th2 매개성 병태를 치료하기 위한 kim-1 항체 |
US7592426B2 (en) | 2005-03-10 | 2009-09-22 | Morphotek, Inc. | Anti-mesothelin antibodies |
CA2601400A1 (fr) | 2005-03-19 | 2006-09-28 | Medical Research Council | Ameliorations dans ou concernant le traitement et la prevention d'infections virales |
ES2432091T5 (es) | 2005-03-25 | 2022-03-18 | Gitr Inc | Moléculas de unión GITR y usos de las mismas |
ES2720288T3 (es) | 2005-03-30 | 2019-07-19 | Minerva Biotechnologies Corp | Proliferación de células que expresan MUC1 |
WO2006105448A2 (fr) | 2005-03-30 | 2006-10-05 | Minerva Biotechnologies Corporation | Proliferation de cellules exprimant la muc1 |
ES2440953T3 (es) | 2005-03-31 | 2014-01-31 | The General Hospital Corporation | Modulación de la actividad de HGF/HGFR para tratar un linfedema |
PL2645106T3 (pl) | 2005-04-04 | 2017-11-30 | Biogen Ma Inc. | Sposoby oceniania odpowiedzi immunologicznej na środek leczniczy |
EP1879922A2 (fr) | 2005-04-22 | 2008-01-23 | Morphotek, Inc. | Anticorps presentant une activite d'effecteur immunitaire et s'internalisant dans des cellules alpha positives de recepteur de folate |
CA2607455A1 (fr) | 2005-04-22 | 2006-11-02 | Morphotek, Inc. | Anticorps a activite d'effecteur immunitaire et internalises dans des cellules positives vis-a-vis de l'endosialine |
WO2006117910A1 (fr) | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | Anticorps monoclonal contre la glycoproteine vi de la membrane de la plaquette |
EP1885396A2 (fr) | 2005-05-04 | 2008-02-13 | Quark Pharmaceuticals, Inc. | Anticorps recombinants diriges contre cd55 et cd59 et leur utilisation |
KR101386494B1 (ko) | 2005-05-10 | 2014-04-24 | 인사이트 코포레이션 | 인돌아민 2,3-디옥시게나제의 조절제 및 이의 사용방법 |
US7964200B2 (en) | 2005-05-18 | 2011-06-21 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against Chlamydia infection |
MX2007014148A (es) | 2005-05-19 | 2008-01-11 | Amgen Inc | Composiciones y metodos para incrementar la estabilidad de anticuerpos. |
CN101227924A (zh) | 2005-05-26 | 2008-07-23 | 科罗拉多大学评议会 | 用于治疗外伤性脑损伤、脊髓损伤及相关病症的补体旁路抑制 |
EA018255B1 (ru) | 2005-05-27 | 2013-06-28 | Байоджен Айдек Ма Инк. | Белки, связывающие tweak, и их применение |
WO2006138429A2 (fr) | 2005-06-16 | 2006-12-28 | The Feinstein Institute For Medical Research | Anticorps diriges contre hmgb1 et fragments de ceux-ci |
ES2547463T3 (es) | 2005-06-17 | 2015-10-06 | Merck Sharp & Dohme Corp. | Moléculas de unión a ILT3 y usos de las mismas |
PL1899378T3 (pl) * | 2005-06-21 | 2011-03-31 | Xoma Us Llc | Przeciwciała wiążące IL-1 beta i ich fragmenty |
CN104072614B (zh) | 2005-07-08 | 2017-04-26 | 生物基因Ma公司 | 抗-αvβ6 抗体及其用途 |
AU2006272750B2 (en) | 2005-07-22 | 2011-09-29 | Cytodyn, Inc. | Methods for reducing viral load in HIV-1-infected patients |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
US8652469B2 (en) | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
WO2007030560A2 (fr) | 2005-09-08 | 2007-03-15 | Philadelphia Health & Education Corporation, D/B/A Drexel University College Of Medicine | Identification de modulateurs d'un inhibiteur de serine protease de type kazal et leur utilisation comme agents anticancereux et antiviraux |
US8202523B2 (en) | 2005-09-22 | 2012-06-19 | ProSci, Inc. | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
WO2007051077A2 (fr) | 2005-10-28 | 2007-05-03 | The Regents Of The University Of California | Methodes et composes de detection et d'isolement de cellules lymphomatiques |
US20090155279A1 (en) | 2005-10-28 | 2009-06-18 | Jiro Tanaka | Pseudomonas Aeruginosa Outer Membrane Protein PA5158 |
TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
JP2009516513A (ja) | 2005-11-21 | 2009-04-23 | ラボラトワール セローノ ソシエテ アノニム | ハイブリッド抗原結合分子の組成物及び製造方法並びにその使用 |
CN101506236B (zh) † | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
ES2396440T3 (es) | 2006-01-18 | 2013-02-21 | The General Hospital Corporation | Métodos de aumentar la función linfática |
JP2009531295A (ja) | 2006-02-22 | 2009-09-03 | ユニバーシティ オブ チューリッヒ | 自己免疫疾患又は脱髄疾患を処置するための方法 |
CA2646478A1 (fr) | 2006-03-10 | 2007-09-20 | Zymogenetics, Inc. | Anticorps se liant a la fois avec il-17a et il-17f et procedes d'utilisation |
JP5082104B2 (ja) | 2006-03-23 | 2012-11-28 | 国立大学法人東北大学 | 高機能性二重特異性抗体 |
AU2007232894B2 (en) | 2006-03-30 | 2013-01-31 | Meiji Seika Kaisha, Ltd. | Pseudomonas aeruginosa outer membrane protein PA0427 |
SG170837A1 (en) | 2006-04-05 | 2011-05-30 | Abbott Biotech Ltd | Antibody purification |
EP2666478A3 (fr) | 2006-04-10 | 2014-10-22 | AbbVie Biotechnology Ltd | Utilisations et compositions pour le traitement du psoriasis |
CA2564435A1 (fr) | 2006-04-10 | 2007-10-10 | Abbott Biotechnology Ltd. | Methodes de controle et de traitement des troubles intestinaux |
US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
PL2034830T3 (pl) | 2006-05-25 | 2015-04-30 | Biogen Ma Inc | Przeciwciało anty-VLA-1 do leczenia udaru |
AU2007268591A1 (en) | 2006-05-31 | 2007-12-06 | Astellas Pharma Inc. | Humanized anti-human osteopontin antibody |
EP2035448A4 (fr) | 2006-06-01 | 2010-11-03 | Elan Pharm Inc | Fragments neuroactifs de app |
EP2046384A4 (fr) | 2006-06-15 | 2009-12-02 | Fibron Ltd | Anticorps bloquant l'activation du récepteur du facteur de croissance des fibroblastes et leurs procédés d'utilisation |
US7777008B2 (en) | 2006-06-19 | 2010-08-17 | Tolerx, Inc. | ILT3 binding molecules and uses therefor |
TWI527603B (zh) | 2006-06-30 | 2016-04-01 | 艾伯維生物技術有限責任公司 | 自動注射裝置 |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
JP2009542196A (ja) | 2006-07-07 | 2009-12-03 | インターセル アーゲー | 小型の化膿連鎖球菌抗原およびそれらの使用 |
EP2975057A1 (fr) | 2006-07-10 | 2016-01-20 | Fujita Health University | Nouvel anticorps anti-cd73 |
CN101563105B (zh) | 2006-07-10 | 2013-01-23 | 拜奥根Idec马萨诸塞公司 | 用于抑制smad4-缺陷癌症的组合物和方法 |
KR101437188B1 (ko) | 2006-08-04 | 2014-10-02 | 노바르티스 아게 | Ephb3-특이적 항체 및 이의 용도 |
WO2008019403A1 (fr) | 2006-08-11 | 2008-02-14 | University Of Medicine And Dentistry Of New Jersey | Composés luminescents contenant deux sensibilisateurs, conjugués, et leurs utilisations |
ME00588A (en) | 2006-08-18 | 2011-12-20 | Prlr-specific antibody and uses thereof | |
EP2500415A1 (fr) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Améliorations de culture cellulaire |
AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
EP2083017A4 (fr) | 2006-09-14 | 2011-01-12 | Med & Biological Lab Co Ltd | Anticorps présentant une activité adcc accrue et son procédé de production |
FR2906533B1 (fr) | 2006-09-28 | 2013-02-22 | Pf Medicament | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
JP5570218B2 (ja) | 2006-11-03 | 2014-08-13 | ユースリー ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Fgfr4抗体 |
CN101631802B (zh) | 2006-11-10 | 2014-03-05 | 株式会社立富泰克 | 在体内具有抗肿瘤活性的抗人Dlk-1抗体 |
ES2363622T3 (es) | 2006-11-17 | 2011-08-10 | Novartis Ag | Moléculas de enlace de lingo y el uso farmacéutico de estas. |
EP1923069A1 (fr) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protecteurs contre S. pneumoniae et compositions, méthodes et utilisations associés |
US8288110B2 (en) | 2006-12-04 | 2012-10-16 | Perkinelmer Health Sciences, Inc. | Biomarkers for detecting cancer |
WO2008070780A1 (fr) | 2006-12-07 | 2008-06-12 | Novartis Ag | Anticorps antagonistes contre ephb3 |
EP2505651A3 (fr) | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Isolat de champignon avec activité protéase réduite |
WO2008083169A2 (fr) | 2006-12-26 | 2008-07-10 | The Johns Hopkins University | Compositions et procédés pour le traitement de troubles immunologiques |
CA2673659A1 (fr) | 2006-12-27 | 2008-07-10 | The Johns Hopkins University | Methodes de detection et de diagnostic des reactions et affections inflammatoires par determination du niveau de b7-h4 soluble |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
CN101646781B (zh) | 2006-12-29 | 2016-06-22 | 科罗拉多大学董事会 | 自身免疫病的诊断和治疗靶标及其用途 |
CN103408661B (zh) | 2007-01-05 | 2016-04-06 | 苏黎世大学 | 提供疾患特异性结合分子和靶的方法 |
EP2120984A2 (fr) | 2007-01-12 | 2009-11-25 | Intercell AG | Protéines protectrices de s. agalactia, leurs combinaisons et leurs procédés d'utilisation |
US8168415B2 (en) | 2007-02-07 | 2012-05-01 | The Regents Of The University Of Colorado | Axl fusion proteins as Axl tyrosine kinase inhibitors |
EP2538217A1 (fr) | 2007-02-16 | 2012-12-26 | Genzyme Corporation | Procédé d'identification du risque pour développer un trouble thyroïdien |
CA2678493A1 (fr) | 2007-02-23 | 2008-08-28 | The Trustees Of Columbia University In The City Of New York | Methodes d'activation ou de blocage de la voie de regulation des lymphocytes t cd8+ restreints par hla-e/qa-1 pour le traitement d'une maladie immunologique |
PT3067066T (pt) | 2007-02-23 | 2019-06-17 | Univ California | Prevenção e tratamento da doença sinucleinopática e amiloidogénica |
US8519106B2 (en) | 2007-03-13 | 2013-08-27 | University Of Zurich | Monoclonal human tumor-specific antibody |
SI2125894T1 (sl) | 2007-03-22 | 2019-05-31 | Biogen Ma Inc. | Vezavne beljakovine, vključno s protitelesi, derivati protiteles in fragmenti protiteles, ki specifično vežejo CD154, ter njihove uporabe |
SI2137217T1 (sl) | 2007-04-05 | 2014-07-31 | Morphotek, Inc. | Postopki za inhibiranje vezave endosialina na ligande |
EP2150564A2 (fr) | 2007-04-27 | 2010-02-10 | ZymoGenetics, Inc. | Antagonistes à il-17a, il-17f et il-23p19, et procédés d'utilisation de ceux-ci |
EP2497779A1 (fr) | 2007-05-02 | 2012-09-12 | Intercell AG | Antigènes de Klebsiella |
EP2160403B1 (fr) | 2007-05-11 | 2018-08-08 | Genzyme Corporation | Procédés de production de protéine sécrétée |
EP1997830A1 (fr) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | Molécules à liaison spécifiques RSV et leur moyen de fabrication |
US7709215B2 (en) | 2007-06-01 | 2010-05-04 | Cytonics Corporation | Method for diagnosing and treating acute joint injury |
EP2171451A4 (fr) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | Procédés de traitement de l'arthrite idiopathique juvénile |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
WO2008157356A2 (fr) | 2007-06-14 | 2008-12-24 | Biogen Idec Ma Inc. | Formulations d'anticorps |
EP2511291A3 (fr) | 2007-06-18 | 2012-11-07 | Intercell AG | Antigènes de Chlamydia |
US8921279B2 (en) | 2007-06-26 | 2014-12-30 | F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H | Display of binding agents |
WO2009001940A1 (fr) | 2007-06-27 | 2008-12-31 | Asubio Pharma Co., Ltd. | Remède anticancéreux contenant un anticorps dirigé contre un peptide codé par l'exon-17 de la périostine |
ES2591281T3 (es) | 2007-07-12 | 2016-11-25 | Gitr, Inc. | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
EP2014681A1 (fr) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Nouveaux anticorps à inhibition de dimérisation c-met, et utilisations correspondantes |
AU2008293885A1 (en) | 2007-07-13 | 2009-03-05 | The John Hopkins University | B7-DC variants |
EP2537529B1 (fr) | 2007-08-02 | 2018-10-17 | Gilead Biologics, Inc. | Anticorps inhibiteurs dirigés contre loxl2, et procédés d'utilisation associés |
US8551751B2 (en) | 2007-09-07 | 2013-10-08 | Dyadic International, Inc. | BX11 enzymes having xylosidase activity |
EP2199390B1 (fr) | 2007-08-30 | 2016-12-21 | Daiichi Sankyo Company, Limited | Anticorps anti-epha2 |
WO2009031230A1 (fr) * | 2007-09-06 | 2009-03-12 | Osaka University | Anticorps monoclonaux anti-cd20 |
EP2527369A3 (fr) | 2007-09-13 | 2012-12-19 | University Of Zurich Prorektorat Forschung | Anticorps monoclonal anti-bêta-amyloide (abêta) et ses utilisations |
MX2010002683A (es) | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
CN101883790B (zh) | 2007-10-05 | 2015-09-09 | 基因技术公司 | 抗淀粉样蛋白β抗体在眼病中的用途 |
WO2009048072A1 (fr) | 2007-10-11 | 2009-04-16 | Daiichi Sankyo Company, Limited | ANTICORPS CIBLANT LA PROTÉINE Siglec-15 LIÉE AUX OSTÉOCLASTES |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
CN101965365A (zh) | 2007-10-19 | 2011-02-02 | 伊缪纳斯制药株式会社 | 能够特异性结合Aβ寡聚体的抗体及其应用 |
US20120142608A1 (en) | 2007-11-01 | 2012-06-07 | University of Iowa Research Foundation Corporation | Rca locus analysis to assess susceptibility to amd and mpgnii |
BRPI0818928B1 (pt) | 2007-11-02 | 2021-12-07 | Novartis Ag | Moléculas de ligação a nogo-a isoladas, seu método de produção e seu uso, polinucleotídeo isolado, vetor e sistema de expressão, célula hospedeira isolada, e composição farmacêutica |
WO2009062112A2 (fr) | 2007-11-09 | 2009-05-14 | The Salk Institute For Biological Studies | Utilisation d'inhibiteurs de récepteurs tam en tant qu'antimicrobiens |
EP2918605A1 (fr) | 2007-11-12 | 2015-09-16 | U3 Pharma GmbH | Anticorps axl |
MX347246B (es) | 2007-11-28 | 2017-04-19 | Univ Pennsylvania | Adenovirus e simianos sadv-39, sadv-25.2, sadv-26, sadv-30, sadv-37 y sadv-38. |
WO2009105084A2 (fr) | 2007-11-28 | 2009-08-27 | The Trustees Of The University Of Pennsylvania | Adénovirus c de la sous-famille simiesque sadv-40, -31, et -34 et leurs utilisations |
WO2009079242A2 (fr) | 2007-12-05 | 2009-06-25 | Massachusetts Institute Of Technology | Mutants d'immunoglobuline aglycosylée |
US8779088B2 (en) | 2007-12-17 | 2014-07-15 | Marfl Ab | Vaccine for the treatment of Mycobacterium related disorders |
KR20100100941A (ko) | 2007-12-25 | 2010-09-15 | 메이지 세이카 가부시키가이샤 | 녹농균의 ⅲ형 분비 장치 구성 단백질 pa1698 |
NZ586875A (en) | 2007-12-28 | 2012-10-26 | Elan Pharm Inc | Treatment and prophylaxis of amyloidosis with an antibody that binds a specific epitope of human amyloid A peptide |
KR101634636B1 (ko) | 2008-01-11 | 2016-06-29 | 아스텔라스세이야쿠 가부시키가이샤 | 개량형 인간화 항-인간 α9 인테그린 항체 |
JP2011509650A (ja) * | 2008-01-11 | 2011-03-31 | 株式会社ジーンテクノサイエンス | ヒト化抗−α9インテグリン抗体及びその使用 |
HUE031207T2 (hu) | 2008-01-11 | 2017-07-28 | Adheron Therapeutics Inc | Cadherin-11 EC1 domén elleni antitestek gyulladásos ízületi rendellenességek kezeléséhez |
CA2714413C (fr) | 2008-02-08 | 2017-01-24 | Immunas Pharma, Inc. | Anticorps capable de se fixer specifiquement a un oligomere b et utilisation dudit anticorps |
US8470310B2 (en) | 2008-03-04 | 2013-06-25 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof |
RU2540018C2 (ru) | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
WO2009121690A1 (fr) | 2008-03-13 | 2009-10-08 | Biotest Ag | Agent pour traiter une maladie |
CN102027016A (zh) | 2008-03-13 | 2011-04-20 | 生物测试股份公司 | 一种治疗疾病的试剂 |
CN101977927A (zh) | 2008-03-17 | 2011-02-16 | 英特塞尔股份公司 | 针对肺炎链球菌保护的肽以及与其有关的组合物、方法和用途 |
US8017118B2 (en) | 2008-03-17 | 2011-09-13 | LivTech Inc. — Teikyo University Biotechnology Research Center | Anti-hDlk-1 antibody having an antitumor activity in vivo |
JP5670875B2 (ja) | 2008-03-17 | 2015-02-18 | ウニベルジテーツクリニクム ミュンスター | カーゴ分子の送達ビヒクルおよび炎症反応を免疫調節するための生物学的治療剤としてのYopM |
EP2260863A1 (fr) | 2008-03-27 | 2010-12-15 | Takara Bio, Inc. | Agent prophylactique/thérapeutique pour maladie infectieuse |
EP2276509B1 (fr) | 2008-04-11 | 2016-06-15 | Seattle Genetics, Inc. | Détection et traitement du cancer du pancréas, des ovaires et d'autres cancers |
EP2113255A1 (fr) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Immunoglobuline cytotoxique |
EP2282773B1 (fr) | 2008-05-02 | 2014-01-15 | Seattle Genetics, Inc. | Procédé et compositions pour préparer des anticorps et des dérivés d'anticorps avec une fucosylation centrale réduite |
US9096681B2 (en) | 2008-06-02 | 2015-08-04 | Dana-Farber Cancer Institute, Inc. | XBP1, CD138, and CS1 peptides |
US8575314B2 (en) | 2008-06-20 | 2013-11-05 | National University Corporation Okayama University | Antibody against oxidized LDL/β2GPI complex and use of the same |
KR20190133077A (ko) | 2008-06-25 | 2019-11-29 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | TNFα를 저해하는 안정한 가용성 항체 |
MX2011000052A (es) | 2008-06-25 | 2011-07-29 | Esbatech Alcon Biomed Res Unit | Humanizacion de anticuerpos de conejos usando una estructura de anticuerpos universal. |
KR101882352B1 (ko) | 2008-06-25 | 2018-07-26 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화 |
KR101649548B1 (ko) | 2008-07-08 | 2016-08-19 | 인사이트 홀딩스 코포레이션 | 인돌아민 2,3-디옥시게나아제의 억제제로서의 1,2,5-옥사디아졸 |
WO2010104747A2 (fr) | 2009-03-10 | 2010-09-16 | Baylor Research Institute | Vaccins ciblés vers des cellules présentant des antigènes |
JP5773650B2 (ja) | 2008-07-16 | 2015-09-02 | 株式会社医学生物学研究所 | 抗ヒトclcp1抗体とその用途 |
AU2010222928B2 (en) | 2008-07-16 | 2012-11-29 | Baylor Research Institute | Antigen presenting cell targeted vaccines |
WO2010013498A1 (fr) | 2008-08-01 | 2010-02-04 | 学校法人聖マリアンナ医科大学 | Agent thérapeutique ou agent préventif pour l'arthrose |
US8795981B2 (en) | 2008-08-08 | 2014-08-05 | Molecular Devices, Llc | Cell detection |
US8417011B2 (en) | 2008-09-18 | 2013-04-09 | Molecular Devices (New Milton) Ltd. | Colony detection |
EP2172485A1 (fr) | 2008-10-01 | 2010-04-07 | Pierre Fabre Medicament | Nouveaux anticorps anti CXCR4 et leur utilisation dans le traitement contre le cancer |
JP2012504650A (ja) | 2008-10-02 | 2012-02-23 | セルタクシス,インコーポレイテッド | 免疫細胞の負の走化性の調節方法 |
KR20140101876A (ko) | 2008-10-09 | 2014-08-20 | 미네르바 바이오테크놀로지 코포레이션 | 세포내에서 다능성을 유도하기 위한 방법 |
EP2346904B1 (fr) | 2008-10-29 | 2017-04-12 | China Synthetic Rubber Corporation | Méthodes et agents pour diagnostiquer et traiter un carcinome hépatocellulaire |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US8940290B2 (en) | 2008-10-31 | 2015-01-27 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof |
AR074439A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
US8545839B2 (en) | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
US9469691B2 (en) | 2008-12-02 | 2016-10-18 | Pierre Fabre Medicament | Anti-cMET antibody |
PL2949666T3 (pl) | 2008-12-19 | 2019-07-31 | Biogen International Neuroscience Gmbh | Ludzkie przeciwciała przeciwko alfa-synukleinie |
US8313915B2 (en) | 2009-01-21 | 2012-11-20 | Gundersen Lutheran Medical Foundation, Inc. | Early detection of canine lyme disease by specific peptides and antibodies |
US20100260752A1 (en) | 2009-01-23 | 2010-10-14 | Biosynexus Incorporated | Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria |
US20130243779A1 (en) | 2009-02-05 | 2013-09-19 | Intercell Ag | Peptides protective against e. faecalis, methods and uses relating thereto |
WO2010092176A2 (fr) | 2009-02-13 | 2010-08-19 | Intercell Ag | Antigènes haemophilus influenzae non typables |
WO2010096658A1 (fr) | 2009-02-19 | 2010-08-26 | The Cleveland Clinic Foundation | Corine en tant que marqueur pour une insuffisance cardiaque |
DK2406286T3 (en) | 2009-03-10 | 2016-08-22 | Baylor Res Inst | Anti-cd40 antibodies and uses thereof |
US9315584B2 (en) | 2009-03-25 | 2016-04-19 | Tohoku University | LH-type bispecific antibody |
KR101690340B1 (ko) | 2009-04-09 | 2016-12-27 | 다이이찌 산쿄 가부시키가이샤 | 항 Siglec-15 항체 |
CA2758322C (fr) | 2009-04-10 | 2019-04-02 | Tufts Medical Center, Inc. | Activation de par-1 par la metalloproteinase-1 (mmp-1) |
EP2419447B1 (fr) | 2009-04-17 | 2017-08-23 | Immunas Pharma, Inc. | Anticorps qui se lient spécifiquement aux oligomères a bêta et leur utilisation |
TWI583418B (zh) | 2009-04-29 | 2017-05-21 | 艾伯維生物技術有限責任公司 | 針筒柱塞及自動注射裝置 |
EP2246364A1 (fr) | 2009-04-29 | 2010-11-03 | Pierre Fabre Médicament | Anticorps anti CXCR4 pour le traitement du VIH |
EP2270053A1 (fr) | 2009-05-11 | 2011-01-05 | U3 Pharma GmbH | Anticorps AXL humanisés |
CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
EP2260864A1 (fr) | 2009-06-10 | 2010-12-15 | University of Melbourne | Applications thérapeutiques |
TWI513465B (zh) | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以dll4拮抗劑與化學治療劑治療癌症之方法 |
KR101752515B1 (ko) | 2009-07-24 | 2017-06-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Avb5 인테그린과 결부된 질환의 치료 및 예방을 위한 방법 및 조성물 |
CN102548466A (zh) | 2009-07-28 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 非侵入性体内光学成像方法 |
EP2462451B1 (fr) | 2009-08-05 | 2016-02-17 | Nexigen GmbH | Protéines humaines interagissant avec vhc et procédés d'utilisation |
WO2011024114A1 (fr) | 2009-08-25 | 2011-03-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Molécules de matrice extracellulaire de ciblage pour le traitement du cancer |
TWI412375B (zh) | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗cdcp1抗體 |
CN102666581A (zh) | 2009-08-31 | 2012-09-12 | 艾普利穆恩公司 | 用于抑制移植物排斥的方法和组合物 |
JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
EP2305285A1 (fr) | 2009-09-29 | 2011-04-06 | Julius-Maximilians-Universität Würzburg | Supports et procédés pour traiter les conditions ischémiques |
US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
EP2308897A1 (fr) | 2009-10-09 | 2011-04-13 | Pierre Fabre Medicament | Anticorps chimères spécifiques de CD151 et leurs utilisations pour le traitement du cancer |
WO2011044553A1 (fr) | 2009-10-11 | 2011-04-14 | Biogen Idec Ma Inc. | Tests associés à un anti-vla-4 |
EP2502936B1 (fr) | 2009-11-18 | 2016-01-06 | Tohoku University | Mutant hautement fonctionnel de région variable d'anticorps anti-egfr humanisée |
EP2332929A1 (fr) | 2009-11-25 | 2011-06-15 | ArisGen SA | Dérivés d'orthoester d'éthers couronne comme vehicules pour compositions diagnostiques et pharmaceutiques |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
WO2011068870A2 (fr) | 2009-12-01 | 2011-06-09 | President And Fellows Of Harvard College | Modulation de l'activité d'effecteur spécifique de l'antigène de cellules nk par la modulation de cxcr6 (cd186) |
AU2010330907A1 (en) | 2009-12-16 | 2012-06-14 | Bosch, Phillip | Methods of treating interstitial cystitis |
WO2011088193A2 (fr) | 2010-01-13 | 2011-07-21 | University Of Medicine And Dentistry Of New Jersey | Sondes luminescentes à base de lanthanides chélatés à des fluorophores présentant un rendement quantique amélioré |
EP2525813B1 (fr) | 2010-01-20 | 2017-01-04 | Merck Sharp & Dohme Corp. | Anticorps anti-ilt5 et fragments d'anticorps se liant à ilt5 |
JP5947727B2 (ja) | 2010-01-20 | 2016-07-06 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗ilt5抗体およびilt5結合抗体断片による免疫調節 |
CN102811737A (zh) | 2010-01-29 | 2012-12-05 | 阿克西斯股份有限公司 | 骨关节炎治疗及预防药物组合物和上述组合物的制造方法 |
JP5792636B2 (ja) | 2010-01-29 | 2015-10-14 | Axis株式会社 | 変形性関節症治療剤を含有する注射剤 |
JP2012246222A (ja) | 2010-01-29 | 2012-12-13 | Axis Inc | 変形性関節症治療剤または予防剤を製造するための使用 |
JP2013518590A (ja) | 2010-02-02 | 2013-05-23 | アボツト・バイオテクノロジー・リミテツド | TNF−α阻害剤を用いる処置に対する応答性を予測するための方法および組成物 |
CN106975082A (zh) | 2010-02-08 | 2017-07-25 | 艾更斯司股份有限公司 | 结合于161p2f10b蛋白的抗体药物偶联物(adc) |
SG183356A1 (en) | 2010-02-18 | 2012-09-27 | Univ California | INTEGRIN aVß8 NEUTRALIZING ANTIBODY |
WO2011109398A2 (fr) | 2010-03-02 | 2011-09-09 | President And Fellows Of Harvard College | Procédés et compositions pour le traitement du syndrome d'angelman et des troubles du spectre autistique |
AU2011223456A1 (en) | 2010-03-03 | 2012-10-18 | The University Of British Columbia | Oligomer-specific amyloid beta epitope and antibodies |
CA2794551A1 (fr) | 2010-03-26 | 2011-09-29 | Westfaelische Wilhelms-Universitaet Muenster | Therapie de substitution pour glucocorticoides |
EP2371863A1 (fr) | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Anticorps humanisé anti CXCR4 pour le traitement du cancer |
SI2556090T1 (sl) | 2010-04-09 | 2016-07-29 | Critical Care Diagnostics, Inc. | Protitelesa in testi topnega človeškega ST-2 |
PT3202789T (pt) | 2010-04-16 | 2020-06-16 | Biogen Ma Inc | Anticorpos anti-vla-4 |
JP5809242B2 (ja) | 2010-04-21 | 2015-11-10 | アッヴィ バイオテクノロジー リミテッド | 治療薬の制御送達のための装着型自動注入装置 |
MX2012012736A (es) | 2010-05-07 | 2013-02-26 | Hoffmann La Roche | Metodo de diagnostico para la deteccion de celulas ex vivo. |
SG185583A1 (en) | 2010-05-17 | 2012-12-28 | Livtech Inc | Anti-human trop-2 antibody having antitumor activity in vivo |
WO2011146727A1 (fr) | 2010-05-19 | 2011-11-24 | Philip Bosch | Méthodes de traitement de la cystite interstitielle |
JP5619162B2 (ja) | 2010-07-08 | 2014-11-05 | 本田技研工業株式会社 | 高周波加熱用コイル |
MX338640B (es) | 2010-07-14 | 2016-04-25 | Merck Sharp & Dohme | Anticuerpo monoclonal anti-ligando difundible derivado de amiloide beta y usos de los mismos. |
CN103153331B (zh) | 2010-07-15 | 2017-03-22 | 亚德赫伦医疗公司 | 靶向于钙粘着蛋白‑11的ec1结构域的人源化抗体及相关组合物和方法 |
AU2011283669A1 (en) | 2010-07-29 | 2013-02-07 | Eleven Biotherapeutics, Inc. | Chimeric IL-1 receptor type I agonists and antagonists |
RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
JP2012034668A (ja) | 2010-08-12 | 2012-02-23 | Tohoku Univ | ヒト型化抗egfr抗体リジン置換可変領域断片及びその利用 |
WO2012027494A1 (fr) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Réactifs bispécifiques de ciblage |
AU2011295030B2 (en) | 2010-08-27 | 2016-01-28 | University Of Zurich | A novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases |
WO2012025636A1 (fr) | 2010-08-27 | 2012-03-01 | University Of Zurich | Procédé de validation de cibles et de médicaments pour des affections inflammatoires et/ou cardiovasculaires |
WO2012028697A1 (fr) | 2010-09-01 | 2012-03-08 | Eth Zürich, Institute Of Molecular Biology And Biophysics | Système de purification par affinité sur la base d'une complémentation de brin de donneur |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
US8497138B2 (en) | 2010-09-30 | 2013-07-30 | Genetix Limited | Method for cell selection |
JP5843170B2 (ja) | 2010-09-30 | 2016-01-13 | 国立研究開発法人理化学研究所 | グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤 |
SI2627672T1 (sl) | 2010-10-11 | 2018-10-30 | Biogen International Neuroscience Gmbh | Človeška protitelesa anti-tau |
UA118646C2 (uk) | 2010-10-13 | 2019-02-25 | Янссен Байотек, Інк. | Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини |
US9346889B2 (en) | 2010-10-18 | 2016-05-24 | Mediapharma S.R.L. | ErbB3 binding antibody |
ES2730941T7 (es) | 2010-10-22 | 2020-05-27 | Seattle Genetics Inc | Efectos sinérgicos entre los conjugados de conjugados anticuerpo-fármaco a base de auristatina e inhibidores de la ruta PI3K-AKT-mTOR |
UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
US20130337470A1 (en) | 2010-10-25 | 2013-12-19 | Biogen Idec Ma Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMadCAM LEVELS |
CN103180342A (zh) | 2010-10-27 | 2013-06-26 | 皮埃尔法布雷医药公司 | 用于治疗hiv的抗体 |
BR112013010574A2 (pt) | 2010-10-29 | 2016-08-09 | Daiichi Sankyo Co Ltd | anticorpo, fragmento funcional do anticorpo, composição farmacêutica, usos de um anticorpo ou um fragmento funcional do mesmo e de pelo menos um membro selecionado do grupo que consiste de paclitaxel, carvoplatina, cpt-11, vinblastina, e 5-fu, polinucleotídeo, vetor, célula hospedeira transformada, e, método de produzir o anticorpo |
WO2012068463A2 (fr) | 2010-11-18 | 2012-05-24 | Beth Israel Deaconess Medicall Center, Inc. | Méthodes de traitement de l'obésité par inhibition de la nicotinamide n-méthyltransférase (nnmt) |
MX361929B (es) | 2010-11-19 | 2018-12-19 | Eisai R&D Man Co Ltd Star | Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes. |
AU2011332025B2 (en) | 2010-11-23 | 2015-06-25 | The Trustees Of The University Of Pennsylvania | Subfamily E simian adenoviruses A1321, A1325, A1295, A1309 and A1322 and uses thereof |
CN103380145B (zh) | 2010-12-17 | 2016-10-12 | 生物控股有限公司 | 人类抗-sod1抗体 |
US9085772B2 (en) | 2010-12-27 | 2015-07-21 | National University Corporation Nagoya University | Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell |
CN103347898B (zh) | 2011-01-10 | 2017-12-05 | Ct大西洋有限公司 | 包括与肿瘤相关抗原结合抗体的联合治疗 |
ES2865068T3 (es) | 2011-01-14 | 2021-10-14 | Univ California | Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos |
PE20141436A1 (es) | 2011-01-24 | 2014-11-15 | Abbvie Biotechnology Ltd | Dispositivos de inyeccion automatica con superficies de agarre sobremoldeadas |
WO2012104824A1 (fr) | 2011-02-04 | 2012-08-09 | Ecole polytechnique fédérale de Lausanne (EPFL) | Anticorps thérapeutiques ciblant app-c99 |
WO2012107589A1 (fr) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement et la prévention des infections à vhc |
WO2012110843A1 (fr) | 2011-02-18 | 2012-08-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour promouvoir la fibrinolyse et la thrombolyse |
US20140044644A1 (en) | 2011-02-21 | 2014-02-13 | University Of Zurich | Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders |
JP6385060B2 (ja) | 2011-03-07 | 2018-09-05 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 治療的に活性な抗体のインビボにおける選択 |
EP2683290B1 (fr) | 2011-03-07 | 2018-11-07 | F.Hoffmann-La Roche Ag | Procédés destinés aux tests in vivo d'anticorps thérapeutiques |
WO2012120130A1 (fr) | 2011-03-09 | 2012-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes pour caractériser des patients souffant d'hémolyse |
WO2012125680A1 (fr) | 2011-03-16 | 2012-09-20 | Novartis Ag | Méthodes de traitement de vascularite à l'aide d'un molécule de liaison à l'il-17 |
ES2588730T3 (es) | 2011-03-17 | 2016-11-04 | Miltenyi Biotec Gmbh | Preparados celulares agotados en lo que respecta a TCRalfa/beta |
WO2012135132A1 (fr) | 2011-03-25 | 2012-10-04 | Baylor Research Institute | Compositions et procédés d'immunisation contre le virus de l'hépatite c |
TW201249867A (en) | 2011-04-01 | 2012-12-16 | Astellas Pharma Inc | Novel anti-human il-23 receptor antibody |
ES2605817T3 (es) | 2011-04-21 | 2017-03-16 | Abbvie Inc. | Dispositivo de inyección automático portátil |
RS57279B1 (sr) | 2011-04-25 | 2018-08-31 | Daiichi Sankyo Co Ltd | Anti-b7-h3 antitelo |
CN107998388B (zh) | 2011-05-02 | 2023-07-14 | 千禧制药公司 | 抗α4β7抗体的制剂 |
UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
EP2707711A1 (fr) | 2011-05-09 | 2014-03-19 | The Cleveland Clinic Foundation | Sérum s 100b et ses utilisations |
WO2012163848A1 (fr) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques destinés au traitement de la maladie de crohn |
EP2530088A1 (fr) | 2011-05-30 | 2012-12-05 | Klinikum rechts der Isar der Technischen Universität München | Supports et procédés de diagnostic et de traitement de la sclérose en plaques |
EP2714743A1 (fr) | 2011-06-03 | 2014-04-09 | CT Atlantic Ltd. | Anticorps se liant à mage a3 |
EP2714742A1 (fr) | 2011-06-03 | 2014-04-09 | CT Atlantic Ltd. | Anticorps se liant à mage a3 |
EP2718327A1 (fr) | 2011-06-06 | 2014-04-16 | Neotope Biosciences Limited | Antagonistes de mcam et méthodes de traitement |
WO2012172449A1 (fr) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactames convenant comme inhibiteurs des bêta-sécrétases |
US20140120555A1 (en) | 2011-06-20 | 2014-05-01 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer |
SI2723379T1 (sl) | 2011-06-23 | 2019-03-29 | Biogen International Neuroscience Gmbh | Molekule, ki se vežejo ma anti alfa-sinuklein |
DE202011103324U1 (de) | 2011-07-12 | 2012-01-02 | Nekonal S.A.R.L. | Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
WO2013014262A1 (fr) | 2011-07-27 | 2013-01-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de diagnostic et de traitement du syndrome de myhre |
US8986952B2 (en) | 2011-08-11 | 2015-03-24 | Astellas Pharma Inc. | Anti-human NGF antibody |
EP2741777B1 (fr) | 2011-08-12 | 2017-01-18 | INSERM - Institut National de la Santé et de la Recherche Médicale | Procédés et compositions pharmaceutiques pour le traitement de l'hypertension pulmonaire |
US20140242085A1 (en) | 2011-08-12 | 2014-08-28 | Medical & Biological Laboratories Co., Ltd. | Methods and composition for testing, preventing, and treating aspergillus fumigatus infection |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
AU2012311234B2 (en) | 2011-09-19 | 2017-09-28 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease |
GB2495115A (en) * | 2011-09-29 | 2013-04-03 | Oxford Plastic Sys Ltd | Base for supporting temporary fence panels or posts. |
AR088048A1 (es) | 2011-10-04 | 2014-05-07 | Univ Columbia | Señuelos notch1 humanos |
WO2013050441A1 (fr) | 2011-10-05 | 2013-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et composition pharmaceutique pour l'inhibition ou la prévention de l'agrégation des plaquettes |
WO2013050540A1 (fr) | 2011-10-05 | 2013-04-11 | University Of Bremen | Wnt4 et med12 pour l'utilisation dans le diagnostic et le traitement de maladies tumorales |
WO2013054320A1 (fr) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Anticorps dirigés contre la molécule d'adhésion cellulaire associée à l'antigène carcino-embryonnaire (ceacam) |
WO2013055911A1 (fr) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Biomarqueur znf365/zfp365 pouvant prévoir une réponse anticancéreuse |
JP6466170B2 (ja) | 2011-10-17 | 2019-02-06 | ミネルバ バイオテクノロジーズ コーポレーション | 幹細胞の増殖及び誘導用の培地 |
EP2768971A1 (fr) | 2011-10-20 | 2014-08-27 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Méthodes de dépistage et de traitement du remodelage cardiaque |
EP2589609A1 (fr) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Protéine se liant à un antigène et son utilisation pour l'adressage d'un produit pour le traitement du cancer |
CA2854244A1 (fr) | 2011-11-22 | 2013-05-30 | Cnrs (Centre National De La Recherche Scientifique) | Procedes et compositions pharmaceutiques pour la reduction de l'hyperreactivite dans les voies aeriennes |
US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
ES2638649T3 (es) | 2011-11-28 | 2017-10-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Composición farmacéutica para su uso en el tratamiento de disfunciones asociadas al envejecimiento |
EP2602621A1 (fr) | 2011-12-08 | 2013-06-12 | Julius-Maximilians-Universität Würzburg | LASP-1, nouveau marqueur urinaire pour la détection du carcinome cellulaire transitionnel |
RU2658438C2 (ru) * | 2011-12-13 | 2018-06-21 | Нордик Нановектор Аса | Химерное терапевтическое антитело нн1 против cd-37 |
US20150030602A1 (en) | 2011-12-23 | 2015-01-29 | Phenoquest Ag | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
FR2984750B1 (fr) | 2011-12-23 | 2014-01-10 | Lfb Biotechnologies | Nouvelles compositions pharmaceutiques comprenant un anticorps liant le recepteur humain de l'hormone anti-mullerienne de type ii |
WO2013098419A1 (fr) | 2011-12-28 | 2013-07-04 | Immunoqure Ag | Méthode pour fournir des auto-anticorps monoclonaux à spécificité désirée |
JP2015509085A (ja) | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドQbi Enterprises Ltd. | 治療剤および診断剤の選択的送達のためのendo180を標的とする粒子 |
CN108324943B (zh) | 2012-02-10 | 2024-03-08 | 思进股份有限公司 | Cd30+癌症的检测和治疗 |
US10316095B2 (en) | 2012-02-16 | 2019-06-11 | Santarus, Inc. | Antibody formulations |
JP6207531B2 (ja) | 2012-02-23 | 2017-10-04 | ダイイチサンキョウヨーロッパ ゲーエムベーハー | 放射線感受性を調節するためのher3阻害剤 |
PT2821416T (pt) | 2012-02-28 | 2018-12-14 | Astellas Pharma Inc | Anticorpo de recetor il-23 anti- humano inovador |
EP2825200A4 (fr) | 2012-03-15 | 2015-08-26 | Janssen Biotech Inc | Anticorps anti-cd27 humains, leurs procédés et leurs utilisations |
WO2013142299A1 (fr) | 2012-03-20 | 2013-09-26 | Biogen Idec Ma Inc. | Anticorps neutralisant le virus jcv |
CA2868965A1 (fr) | 2012-03-30 | 2013-10-03 | Daiichi Sankyo Company, Limited | Anticorps anti-siglec-15 |
CA2868959A1 (fr) | 2012-03-30 | 2013-10-03 | Daiichi Sankyo Company, Limited | Anticorps anti-siglec15 ayant une cdr modifiee |
CN103382223B (zh) | 2012-04-01 | 2015-06-10 | 上海益杰生物技术有限公司 | 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽 |
EP3492095A1 (fr) | 2012-04-01 | 2019-06-05 | Technion Research & Development Foundation Limited | Peptides d'inducteur de métalloprotéinase de matrice extracellulaire (emmprin) et anticorps de liaison |
WO2013152010A1 (fr) | 2012-04-02 | 2013-10-10 | Gundersen Lutheran Health System, Inc. | Réactifs, procédés, et kits pour la classification du cancer |
US9714298B2 (en) | 2012-04-09 | 2017-07-25 | Daiichi Sankyo Company, Limited | Anti-FGFR2 antibodies and methods of use thereof for treating cancer |
PL2841457T3 (pl) | 2012-04-27 | 2019-09-30 | Daiichi Sankyo Company, Limited | Przeciwciało anty-ROBO4 |
US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
JP6263117B2 (ja) | 2012-05-11 | 2018-01-17 | 公益財団法人微生物化学研究会 | 抗cxadr抗体 |
ES2766836T3 (es) | 2012-05-15 | 2020-06-15 | Eisai Inc | Métodos para el tratamiento de cáncer gástrico |
KR20150014505A (ko) | 2012-05-18 | 2015-02-06 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용 |
EP2852679A1 (fr) | 2012-05-22 | 2015-04-01 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Procédés pour diagnostiquer et traiter la glomérulosclérose segmentaire focale |
JP5868549B2 (ja) | 2012-05-24 | 2016-02-24 | マウントゲイト グループ リミテッド | 狂犬病感染の予防および治療に関する組成物および方法 |
HUE061555T2 (hu) | 2012-07-13 | 2023-07-28 | Univ Pennsylvania | CAR-ok tumorellenes hatásának toxicitáskezelése |
EP2875049B1 (fr) | 2012-07-18 | 2018-12-26 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Procédés de prévention et de traitement de maladie rénale chronique (mrc) |
JP6578206B2 (ja) | 2012-07-19 | 2019-09-18 | レッドウッド バイオサイエンス, インコーポレイテッド | Cd22に特異的な抗体およびその使用方法 |
EP2881467B1 (fr) | 2012-07-30 | 2018-10-31 | National University Corporation Nagoya University | Anticorps monoclonal dirigé contre la protéine midkine d'origine humaine |
MY181648A (en) | 2012-08-24 | 2020-12-30 | Univ California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
TWI595007B (zh) | 2012-09-10 | 2017-08-11 | Neotope Biosciences Ltd | 抗mcam抗體及相關使用方法 |
US10822420B2 (en) | 2012-09-13 | 2020-11-03 | Chugai Seiyaku Kabushiki Kaisha | Gene knock-in non-human animal |
EP2711016A1 (fr) | 2012-09-21 | 2014-03-26 | Covagen AG | Nouvelles molécules de liaison IL-17A et leurs utilisations médicales |
WO2014054820A1 (fr) | 2012-10-03 | 2014-04-10 | 株式会社リブテック | Anticorps humain anti-dlk-1 ayant une activité anti-tumorale in vivo |
EP2903692B1 (fr) | 2012-10-08 | 2019-12-25 | St. Jude Children's Research Hospital | Thérapies fondées sur la régulation de la stabilité et de la fonction des lymphocytes t régulateurs par l'intermédiaire d'un axe neuropiline-1:sémaphorine |
EP3632471A1 (fr) | 2012-10-11 | 2020-04-08 | Daiichi Sankyo Company, Limited | Conjugués anticorps-médicament |
DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
EP2910573B1 (fr) | 2012-10-19 | 2020-02-19 | Daiichi Sankyo Company, Limited | Conjugué anticorps-médicament produit par liaison par l'intermédiaire d'un lieur ayant une structure hydrophile |
WO2014064203A1 (fr) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonistes lyve-1 utiles dans la prévention ou le traitement d'un état pathologique associé à la lymphangiogenèse |
ES2937015T3 (es) | 2012-11-01 | 2023-03-23 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Anticuerpo contra CD269 (BCMA) |
AR093357A1 (es) | 2012-11-05 | 2015-06-03 | Pf Medicament | Proteinas de union al antigeno y su utilizacion como producto de direccionamiento para el tratamiento del cancer |
WO2014072416A1 (fr) | 2012-11-08 | 2014-05-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement de métastases osseuses |
TW201438736A (zh) | 2012-11-14 | 2014-10-16 | Regeneron Pharma | 以dll4拮抗劑治療卵巢癌之方法 |
MX363407B (es) | 2012-12-10 | 2019-03-22 | Biogen Ma Inc | Anticuerpos del antigeno 2 de celulas dendriticas anti-sangre y usos de los mismos. |
WO2014096672A1 (fr) | 2012-12-17 | 2014-06-26 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes |
US10024844B2 (en) | 2012-12-20 | 2018-07-17 | Hospital For Special Surgery | Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2 |
PT2935326T (pt) | 2012-12-21 | 2020-09-14 | Biogen Ma Inc | Anticorpos anti-tau humanos |
US9771413B2 (en) | 2012-12-31 | 2017-09-26 | Neurimmune Holding Ag | Recombinant human antibodies for therapy and prevention of polyomavirus-related diseases |
EP2752426A1 (fr) | 2013-01-03 | 2014-07-09 | Covagen AG | Composés de liaison d'albumine de sérum humain et leurs protéines de fusion |
AU2013375015A1 (en) | 2013-01-28 | 2015-08-13 | Evec Inc. | Humanized anti-HMGB1 antibody or antigen-binding fragment thereof |
US20150377888A1 (en) | 2013-02-01 | 2015-12-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers |
WO2014123227A1 (fr) | 2013-02-08 | 2014-08-14 | 株式会社医学生物学研究所 | Anticorps dirigés contre la protéine nrg1 humaine |
RU2015139095A (ru) | 2013-02-15 | 2017-03-21 | ИЭсБиЭйТЕК - Э НОВАРТИС КОМПАНИ ЭлЭлСи | Акцепторный каркасный участок для пересадки cdr |
RU2015139890A (ru) | 2013-02-20 | 2017-03-27 | ИЭсБиЭйТЕК - Э НОВАРТИС КОМПАНИ ЭлЭлСи | Акцепторный каркасный участок для пересадки cdr |
FR3004184B1 (fr) | 2013-02-26 | 2016-03-18 | Agronomique Inst Nat Rech | Anticorps anti-gluten desamide et utilisations. |
US9429584B2 (en) | 2013-02-28 | 2016-08-30 | National Cancer Center | Antibody against insoluble fibrin |
JP6218088B2 (ja) | 2013-03-08 | 2017-11-01 | 国立大学法人大阪大学 | ペリオスチンのExon−21部位によりコードされるペプチドに対する抗体及び該抗体を含む炎症関連疾患の予防又は治療用医薬組成物 |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
PL2968468T3 (pl) | 2013-03-13 | 2021-12-20 | Buzzard Pharmaceuticals AB | Preparaty chimerycznej cytokiny do dostarczania do oka |
US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
WO2014151917A1 (fr) | 2013-03-14 | 2014-09-25 | Ffe Therapeutics Llc | Compositions et procédés pour le traitement de troubles liés à l'angiogenèse |
WO2014144466A1 (fr) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anticorps anti-alpha ν bêta 6 et leurs utilisations |
MX2015011670A (es) | 2013-03-15 | 2016-03-31 | Biogen Ma Inc | Tratamiento y prevencion de lesion renal aguda usando anticuerpos anti-alfa v beta 5. |
US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
SG11201507781VA (en) | 2013-03-18 | 2015-10-29 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
EP3747907A3 (fr) | 2013-04-01 | 2021-02-24 | The Regents of the University of California | Méthodes et compositions pour traiter et prévenir la maladie associée à l'intégrine av 8 |
WO2014174596A1 (fr) | 2013-04-23 | 2014-10-30 | 株式会社医学生物学研究所 | Anticorps monoclonal fonctionnel dirigé contre le facteur de croissance de type facteur de croissance épidermique se liant à l'héparine |
US9717648B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
CN107460201A (zh) | 2013-05-08 | 2017-12-12 | 科济生物医药(上海)有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
EP3011334A1 (fr) | 2013-06-20 | 2016-04-27 | The Trustees Of The University Of Pennsylvania | Méthodes permettant de diagnostiquer un cancer du pancréas |
CN105518025B (zh) | 2013-07-03 | 2020-12-08 | 因美诺克股份公司 | 人抗IFN-α抗体 |
JP6450381B2 (ja) | 2013-07-05 | 2019-01-09 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | がんを処置するための可溶性mic中和モノクローナル抗体 |
EP3016973A1 (fr) | 2013-07-05 | 2016-05-11 | INSERM - Institut National de la Santé et de la Recherche Médicale | Nouveaux transcrits d'épissage alternatif pour la chaîne alpha associée au cmh de classe i (mica) et leurs utilisations |
MY177098A (en) | 2013-08-09 | 2020-09-05 | Astellas Pharma Inc | Novel anti-human tslp receptor antibody |
US20160216262A1 (en) | 2013-09-12 | 2016-07-28 | Institut National De La Sante Et De La Recherche Medicale | Method for In Vitro Quantifying Allo-Antibodies, Auto-Antibodies and/or Therapeutic Antibodies |
WO2015040215A1 (fr) | 2013-09-20 | 2015-03-26 | Westfaelische Wilhelms-Universitaet Muenster | Ubiquitine ligases e3 bactériennes pénétrant dans les cellules destinées à être utilisées en immunothérapie |
WO2015048083A1 (fr) | 2013-09-24 | 2015-04-02 | The Feinstein Institute For Medical Research | Peptides inhibant l'activité de protéines de liaison à l'arn inductibles par le froid |
ES2894333T3 (es) | 2013-09-26 | 2022-02-14 | Beth Israel Deaconess Medical Ct Inc | Inhibidores de SGK1 en el tratamiento del síndrome de QT Largo |
JP6494519B6 (ja) | 2013-09-30 | 2019-07-31 | 第一三共株式会社 | 抗lps o11抗体 |
ES2714708T3 (es) | 2013-10-01 | 2019-05-29 | Mayo Found Medical Education & Res | Procedimientos para el tratamiento de cáncer en pacientes con niveles elevados de Bim |
JP6509735B2 (ja) | 2013-10-08 | 2019-05-08 | 第一三共株式会社 | 抗fgfr2抗体と他剤の組合せ |
EP3070167A4 (fr) | 2013-11-06 | 2017-06-07 | Osaka University | Anticorps présentant une large activité neutralisante contre le virus de la grippe a de groupe 1 |
SG11201603231XA (en) | 2013-11-06 | 2016-05-30 | Janssen Biotech Inc | Anti-ccl17 antibodies |
WO2015071701A1 (fr) | 2013-11-15 | 2015-05-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement de cancers du pancréas |
WO2015082446A1 (fr) | 2013-12-02 | 2015-06-11 | F. Hoffmann-La Roche Ag | Traitement du cancer à l'aide d'un anticorps anti-cdcp1 et d'un taxane |
BR112016014920A2 (pt) | 2013-12-24 | 2017-12-12 | Astellas Pharma Inc | novo anticorpo anti-bdca-2 humano |
KR102535900B1 (ko) | 2013-12-25 | 2023-05-26 | 다이이찌 산쿄 가부시키가이샤 | 항 trop2 항체-약물 컨쥬게이트 |
WO2015104711A1 (fr) | 2014-01-09 | 2015-07-16 | Hadasit Medical Research Services And Development Ltd. | Compositions cellulaires améliorées et procédés pour la thérapie du cancer |
JP7037884B2 (ja) | 2014-01-13 | 2022-03-17 | ベイラー リサーチ インスティテュート | Hpv及びhpv関連疾患に対する新規のワクチン |
CN104774264B (zh) | 2014-01-15 | 2018-09-14 | 上海易乐生物技术有限公司 | 抗人proBDNF单克隆抗体及其在疼痛中的作用 |
SG10201800210TA (en) | 2014-01-31 | 2018-02-27 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugate |
JP6666848B2 (ja) | 2014-02-18 | 2020-03-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Nrp−1/obr複合体シグナル伝達経路により媒介される疾患の処置のための方法及び医薬組成物 |
WO2015124570A1 (fr) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et composition pharmaceutique pour le traitement de l'infection par le virus de la grippe a |
EP2915543B1 (fr) | 2014-03-04 | 2018-05-09 | Albert-Ludwigs-Universität Freiburg | Polypeptides dérivés de enterococcus et leur utilisation pour la vaccination et la génération d'anticorps thérapeutiques |
WO2015140351A1 (fr) | 2014-03-21 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour renforcer la myélinisation |
US20170174764A1 (en) | 2014-03-27 | 2017-06-22 | Yeda Research And Development Co. Ltd. | T-cell receptor cdr3 peptides and antibodies |
KR102127623B1 (ko) | 2014-04-10 | 2020-06-29 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
CA2944903A1 (fr) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Suppresseur de tumeur et biomarqueurs oncogenes predictifs de reponse a un inhibiteur de point de controle anti-immunitaire |
RU2685259C2 (ru) | 2014-04-25 | 2019-04-17 | Пьер Фабр Медикамент | Конъюгат антитела и лекарственного средства и его применение для лечения рака |
MA47811A (fr) | 2014-04-25 | 2019-06-19 | Pf Medicament | Kit comprenant un conjugué anticorps-médicament igf-1r et son utilisation pour le traitement du cancer |
CN112851808A (zh) | 2014-04-25 | 2021-05-28 | 皮埃尔法布雷医药公司 | Igf-1r抗体及其作为定位载体用于治疗癌症的用途 |
US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
MX366359B (es) | 2014-04-27 | 2019-07-05 | Ccam Biotherapeutics Ltd | Anticuerpos humanizados contra la molecula de adhesion celular relacionada al antigeno carcinoembrionico 1 (ceacam1). |
WO2015179654A1 (fr) | 2014-05-22 | 2015-11-26 | Mayo Foundation For Medical Education And Research | Distinction d'anticorps anti-b7-h1 agonistes et antagonistes |
TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
CA2953807A1 (fr) | 2014-06-26 | 2015-12-30 | Yale University | Compositions et procedes pour reguler la renalase dans le traitement de certaines maladies et de certains troubles |
CN105315375B (zh) | 2014-07-17 | 2021-04-23 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
EP3169691B1 (fr) | 2014-07-17 | 2020-09-02 | The Trustees Of The University Of Pennsylvania | Procédés permettant d'utiliser des exosomes pour surveiller l'état d'un organe transplanté |
US10517875B2 (en) | 2014-07-23 | 2019-12-31 | Mayo Foundation for Medical Engineering and Research | Targeting DNA-PKcs and B7-H1 to treat cancer |
AU2015326911B2 (en) | 2014-09-30 | 2021-07-08 | Neurimmune Holding Ag | Human-derived anti-dipeptide repeats (DPRs) antibody |
CN106999566B (zh) | 2014-10-03 | 2022-01-28 | 麻省理工学院 | 结合埃博拉病毒糖蛋白的抗体及其用途 |
WO2016057367A1 (fr) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs à base d'angiopoïétine -2 utilisés pour la prédiction de la réponse de point de contrôle anti-immunitaire |
US10806773B2 (en) | 2014-10-09 | 2020-10-20 | Dana-Farber Cancer Institute, Inc. | Multiple-variable IL-2 dose regimen for treating immune disorders |
WO2016081835A2 (fr) | 2014-11-21 | 2016-05-26 | University Of Maryland, Baltimore | Systèmes d'administration particulaires spécifiques d'une structure ciblée |
US20170319661A1 (en) | 2014-12-03 | 2017-11-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and Pharmaceutical Compositions Using Orexins (OXA, OXB) for the Treatment of Prostate Cancers |
EP3256148A1 (fr) | 2015-02-12 | 2017-12-20 | INSERM - Institut National de la Santé et de la Recherche Médicale | Procédés pour prédire la réactivité d'un patient atteint d'une maladie hématologique maligne à un traitement par chimiothérapie et procédés de traitement de ces maladies |
WO2016144673A1 (fr) | 2015-03-06 | 2016-09-15 | Dana-Farber Cancer Institute, Inc. | Biomarqueurs pd-l2 prédictifs de réponses d'inhibiteurs de la voie pd-1 dans les cancers oesophagogastriques |
EP3067062A1 (fr) | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combinaison de tasquinimod ou d'un sel pharmaceutiquement acceptable de celui-ci et d'un inhibiteur de pd1 et/ou de pdl1, destinée à être utilisée comme médicament |
CN108368169A (zh) | 2015-03-18 | 2018-08-03 | 约翰霍普金斯大学 | 靶向钾通道kcnk9的新的单克隆抗体抑制剂 |
US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
US10214591B1 (en) | 2015-04-03 | 2019-02-26 | Alienor Farma | Monoclonal antibody to human line-1 ORF2 protein and method for early detection of transforming cells in pre-neoplastic tissues of a human subject |
US10851176B2 (en) | 2015-04-13 | 2020-12-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods of administering neutralizing anti-protease nexin-1 antibodies to treat hemophilia A |
US20180298104A1 (en) | 2015-04-22 | 2018-10-18 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of th17 mediated diseases |
AU2016273213B2 (en) | 2015-06-01 | 2019-03-14 | Medigene Immunotherapies Gmbh | T cell receptor library |
CA2987871A1 (fr) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | Procede de production d'anticorps diriges contre un recepteur de lymphocytes t |
CA2987877A1 (fr) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | Anticorps specifiques a des recepteurs de lymphocytes t |
ES2909486T3 (es) | 2015-06-19 | 2022-05-06 | Centurion Biopharma Corp | Sistemas de administración para liberación controlada de fármaco |
EP3314250A4 (fr) | 2015-06-26 | 2018-12-05 | Beth Israel Deaconess Medical Center, Inc. | Cancérothérapie ciblant la tétraspanine 33 (tspan33) dans des cellules myéloïdes suppressives |
EP4180455A1 (fr) | 2015-06-29 | 2023-05-17 | Daiichi Sankyo Company, Limited | Procédé de fabrication sélective d'un conjugué anticorps-médicament |
MY188405A (en) | 2015-08-05 | 2021-12-08 | Janssen Biotech Inc | Anti-cd154 antibodies and methods of using them |
EP3350212A1 (fr) | 2015-09-18 | 2018-07-25 | INSERM - Institut National de la Santé et de la Recherche Médicale | Récepteurs de lymphocytes t (tcr) et leurs utilisations pour le diagnostic et le traitement du diabète |
ES2940360T3 (es) | 2015-09-22 | 2023-05-05 | Inst Nat Sante Rech Med | Polipéptidos capaces de inhibir la unión entre leptina y neuropilina-1 |
FI3354729T3 (fi) | 2015-09-24 | 2024-04-23 | Daiichi Sankyo Co Ltd | Anti-garp-vasta-aine |
EP3355921A4 (fr) | 2015-09-30 | 2019-05-22 | Janssen Biotech, Inc. | Anticorps antagonistes se liant spécifiquement au cd40 humain et procédés d'utilisation |
WO2017061615A1 (fr) | 2015-10-08 | 2017-04-13 | 国立大学法人名古屋大学 | Procédé de préparation de lymphocytes t génétiquement modifiés exprimant un récepteur antigénique chimérique |
EP3362093A4 (fr) | 2015-10-13 | 2019-05-08 | Technion Research & Development Foundation Limited | Anticorps monoclonaux neutralisant l'héparanase |
EP3362082A1 (fr) | 2015-10-16 | 2018-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement de maladies inflammatoires auto-immunes |
JP6968790B2 (ja) | 2015-10-26 | 2021-11-17 | ピエール、ファーブル、メディカマン | Igf−1r発現癌の処置のための組成物 |
WO2017075045A2 (fr) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Anticorps anti-b7-h1 |
ITUB20155272A1 (it) | 2015-11-02 | 2017-05-02 | Scuola Normale Superiore | Intracellular antibody |
US20180320136A1 (en) | 2015-11-03 | 2018-11-08 | GlycoMimitics, Inc. | Methods and compositions for the production of monoclonal antibodies, hematopoietic stem cells, and methods of using the same |
BR112018008891A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos |
ITUB20155097A1 (it) | 2015-11-05 | 2017-05-05 | Biouniversa Srl | Anticorpi umanizzati anti-BAG3 |
WO2017097889A1 (fr) | 2015-12-10 | 2017-06-15 | Katholieke Universiteit Leuven | Anticorps anti-adamts13 et leur utilisation pour le traitement ou la prévention de troubles hémorragiques provoqués par un dispositif d'assistance ventriculaire |
AU2016371034A1 (en) | 2015-12-17 | 2018-05-31 | Janssen Biotech, Inc. | Antibodies specifically binding HLA-DR and their uses |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
KR20180089446A (ko) | 2015-12-23 | 2018-08-08 | 메디진 이뮤노테라피스 게엠바하 | 수지상 세포 조성물 |
CA3193481A1 (fr) | 2015-12-31 | 2017-07-06 | Progastrine Et Cancers S.A R.L. | Compositions et methodes pour depister et traiter le cancer |
EP3397964B1 (fr) | 2015-12-31 | 2021-09-29 | Progastrine et Cancers S.à r.l. | Compositions et procédés pour détecter et traiter un cancer ovarien |
EA037027B1 (ru) | 2015-12-31 | 2021-01-27 | Прогастрин Э Кансер С.А Р.Л. | Применение и способ для профилактики или лечения рака желудка с использованием композиции, содержащей моноклональное прогастринсвязывающее антитело |
EP3202788A1 (fr) | 2016-02-05 | 2017-08-09 | MediaPharma S.r.l. | Anticorps à liaison d'endosialin |
EP3205663A1 (fr) | 2016-02-15 | 2017-08-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Moyens et procédés permettant d'inhiber l'expression génique |
WO2017140684A2 (fr) | 2016-02-15 | 2017-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement d'un dysfonctionnement cognitif postopératoire |
BR112018067522A2 (pt) | 2016-03-01 | 2019-02-05 | Univ Of Rijeka Faculty Of Medicine | anticorpos específicos para receptor de poliovírus humano (pvr) |
EP3427055A1 (fr) | 2016-03-07 | 2019-01-16 | Pierre Fabre Medicament | Nouveau procédé universel pour capturer et analyser des adc pour la caractérisation de la distribution de médicament et du rapport médicament-anticorps dans des échantillons biologiques |
US11921116B2 (en) | 2016-03-09 | 2024-03-05 | Memorial Sloan Kettering Cancer Center | Enigma and CDH18 as companion diagnostics for CDK4 inhibitors |
KR102402444B1 (ko) | 2016-03-15 | 2022-05-27 | 엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) | 대상체가 췌관 선암을 앓을 위험을 평가하기 위한 초기 및 비 침습적 방법 및 이러한 질환의 치료 방법 |
WO2017158396A1 (fr) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibiteurs de cytidine désaminase pour le traitement du cancer du pancréas |
EP3433615A1 (fr) | 2016-03-21 | 2019-01-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Procédés de diagnostic et de traitement de lentigos séniles |
WO2017161976A1 (fr) | 2016-03-23 | 2017-09-28 | Mabspace Biosciences (Suzhou) Co., Ltd | Nouveaux anticorps contre pd-l1 |
KR102558066B1 (ko) | 2016-03-28 | 2023-07-25 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
ITUA20162242A1 (it) | 2016-04-01 | 2017-10-01 | St Biochimico Italiano Giovanni Lorenzini Spa | Un nuovo anticorpo anti-erbb2 |
BR112018070302A2 (pt) | 2016-04-18 | 2019-01-29 | Faron Pharmaceuticals Oy | agentes que reconhecem o epítopo de clever-1 e usos dos mesmos |
WO2017191100A1 (fr) | 2016-05-03 | 2017-11-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement de lésions tissulaires |
KR102439719B1 (ko) | 2016-05-11 | 2022-09-02 | 암젠 인크 | 글루타민 합성효소 유전자내 상보성 벡터를 사용한 높은 수준의 헤테로머 단백질을 발현하는 세포의 직접적인 선택 |
WO2017198811A1 (fr) | 2016-05-20 | 2017-11-23 | Christoph Karl | Compositions pharmaceutiques contenant des anticorps anti-rankl, du calcium et de la vitamine d, adaptées au traitement et/ou à la prophylaxie de maladies du métabolisme osseux et d'effets secondaires liés à la thérapie, tels que l'hypocalcémie |
WO2017202813A1 (fr) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques destinés au traitement d'infections pulmonaires bactériennes |
WO2017202814A1 (fr) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement de troubles neuropathologiques caractérisés par une perte de neurones corticaux |
WO2017211900A1 (fr) | 2016-06-07 | 2017-12-14 | Max-Delbrück-Centrum für Molekulare Medizin | Récepteur d'antigène chimère et cellules t-car se liant à bcma |
GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
KR20190025689A (ko) | 2016-07-06 | 2019-03-11 | 프로테나 바이오사이언시즈 리미티드 | 전체 및 s129 인산화된 알파-시누클레인을 검출하기 위한 검정 |
JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用 |
WO2018022479A1 (fr) | 2016-07-25 | 2018-02-01 | Biogen Ma Inc. | Anticorps anti-hspa5 (grp78) et leurs utilisations |
US20190271702A1 (en) | 2016-07-28 | 2019-09-05 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods of treatement of cancer disease by targetting tumor associated macrophage |
AU2017308734A1 (en) | 2016-08-12 | 2019-02-14 | Janssen Biotech, Inc. | Fc engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them |
SG11201900746RA (en) | 2016-08-12 | 2019-02-27 | Janssen Biotech Inc | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
WO2018057618A1 (fr) | 2016-09-20 | 2018-03-29 | Dana-Farber Cancer Institute, Inc. | Compositions et méthodes pour l'identification, l'évaluation, la prévention et le traitement de la lma au moyen de biomarqueurs usp10 et de modulateurs |
AU2017341000A1 (en) | 2016-10-07 | 2019-04-11 | Daiichi Sankyo Company, Limited | Therapy for drug-resistant cancer by administration of anti-HER2 antibody/drug conjugate |
EP3527225A4 (fr) | 2016-10-12 | 2020-06-10 | Daiichi Sankyo Company, Limited | Composition contenant un anticorps anti-robo4 et un autre agent |
MY191894A (en) | 2016-10-13 | 2022-07-18 | Nat Univ Singapore | Antibodies that bind zika virus envelope protein and uses thereof |
IT201600111877A1 (it) | 2016-11-07 | 2018-05-07 | Biouniversa Srl | Anti-BAG3 antibodies in combination with inhibitors of immune check-point for therapeutic use |
UA126388C2 (uk) | 2016-11-18 | 2022-09-28 | Астеллас Фарма Інк. | Fab-фрагмент антитіла до muc1 людини |
AU2017377233A1 (en) | 2016-12-12 | 2019-06-13 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
MX2019006897A (es) | 2016-12-13 | 2019-08-22 | Astellas Pharma Inc | Anticuerpo anti cd73 humana. |
IL267340B2 (en) | 2016-12-15 | 2023-12-01 | Nat Inst Biotechnology Negev Ltd | Monoclonal antibodies against PCNA and their use |
IL267567B1 (en) | 2016-12-22 | 2024-04-01 | Daiichi Sankyo Co Ltd | Anti-CD3 antibody - for use in treating or preventing cancer and molecules containing the antibody |
US20180179490A1 (en) | 2016-12-27 | 2018-06-28 | Miltenyi Biotec Gmbh | CELL COMPOSITION DEPLETED FROM TCRab and CD45RA POSITIVE CELLS |
US11773182B2 (en) | 2017-01-05 | 2023-10-03 | The Johns Hopkins University | Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA) |
AU2018210081A1 (en) | 2017-01-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Anti-GPR20 antibody and anti-GPR20 antibody-drug conjugate |
WO2018140510A1 (fr) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Composition et méthodes de traitement d'un accident vasculaire cérébral et d'autres troubles du snc |
KR20190133160A (ko) | 2017-02-07 | 2019-12-02 | 다이이찌 산쿄 가부시키가이샤 | 항-gprc5d 항체 및 항-gprc5d 항체를 포함하는 분자 |
EP3363459A1 (fr) | 2017-02-17 | 2018-08-22 | Alexander Klimka | Polypeptides épitopes de s. aureus et anticorps anticorps monoclonaux respectifs pour le traitement d'infections et le diagnostic immunitaire |
JP7325045B2 (ja) | 2017-02-27 | 2023-08-14 | カイロス セラピューティクス, インコーポレイテッド | 癌を処置する抗体コンストラクトおよび方法 |
CN117982673A (zh) | 2017-02-28 | 2024-05-07 | 第一三共株式会社 | 抗her3抗体-药物偶联物的应用 |
EP4095161A1 (fr) | 2017-03-15 | 2022-11-30 | Tsinghua University | Nouveaux anticorps anti-trkb |
JOP20180021A1 (ar) | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
WO2018167283A1 (fr) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés pour le diagnostic et le traitement d'un remodelage neuronal associé à un adénocarcinome canalaire pancréatique |
US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
KR102616819B1 (ko) | 2017-03-30 | 2023-12-21 | 프로가스트린 에 캔서스 에스.에이 알.엘. | 폐암을 치료하기 위한 조성물 및 방법 |
SG11201908997UA (en) | 2017-03-30 | 2019-10-30 | Ecs Progastrin Sa | Compositions and methods for detecting prostate cancer |
TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗gpr20抗體、其製造方法及其應用 |
US10722589B2 (en) | 2017-04-03 | 2020-07-28 | Covagen Ag | FGFR3 binding molecules |
WO2018185516A1 (fr) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques destinées à traiter une toxicité cardiovasculaire induite par une thérapie anticancéreuse |
WO2018189335A1 (fr) | 2017-04-13 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de diagnostic et de traitement d'un adénocarcinome canalaire pancréatique |
WO2018189403A1 (fr) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques destinées au traitement du cancer |
WO2018209301A1 (fr) | 2017-05-11 | 2018-11-15 | Cytodyn Inc. | Procédés de traitement ou de prévention d'une maladie du greffon contre l'hôte impliquant l'administration d'agents du récepteur anti-ccr5 |
TW202330036A (zh) | 2017-05-15 | 2023-08-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物之製造方法 |
AU2018282094A1 (en) | 2017-06-05 | 2019-12-12 | Janssen Biotech, Inc. | Antibodies that specifically bind PD-1 and methods of use |
EP3634496A4 (fr) | 2017-06-06 | 2021-09-08 | Dana-Farber Cancer Institute, Inc. | Procédés de sensibilisation de cellules cancéreuses à une destruction médiée par des lymphocytes t par modulation de voies moléculaires |
WO2019005503A1 (fr) | 2017-06-29 | 2019-01-03 | Rutgers, The State University Of New Jersey | Compositions et procédés ciblant la signalisation g12 en vue d'une thérapie bronchodilatatrice |
CN110913905A (zh) | 2017-06-30 | 2020-03-24 | 国立大学法人北海道大学 | 不产生生长障碍的小儿骨质疏松症治疗药 |
TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
BR112020001255A2 (pt) | 2017-07-21 | 2020-07-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | composições imunogênicas de neisseria meningitidis |
TW202402805A (zh) | 2017-07-27 | 2024-01-16 | 日商第一三共股份有限公司 | 抗cd147抗體、醫藥組成物、該等之用途及抗cd147抗體之製造方法 |
EP3658582A1 (fr) | 2017-07-28 | 2020-06-03 | Intrepida Bio, Inc. | Anticorps anti-bag3 utilisés en tant que réactif thérapeutique dans des maladies cardiovasculaires |
US11680110B2 (en) | 2017-07-31 | 2023-06-20 | Hoffmann-La Roche Inc. | Three-dimensional structure-based humanization method |
EP3444272A1 (fr) | 2017-08-17 | 2019-02-20 | International-Drug-Development-Biotech | Traitement de cancers positifs ck8 en relation avec le statut du gène kras |
CA3072859A1 (fr) | 2017-08-23 | 2019-02-28 | Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinscht | Recepteur d'antigene chimere et lymphocytes t a car se liant a cxcr5 |
BR112020003474A2 (pt) | 2017-08-23 | 2020-10-20 | Daiichi Sankyo Company, Limited | composição farmacêutica, e, método para produzir uma composição farmacêutica |
SG11202000997YA (en) | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Improved method for producing antibody-drug conjugate |
CN117838880A (zh) | 2017-08-31 | 2024-04-09 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
CN116999573A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体-药物偶联物及其制造方法、药物组合物及其在制备***的药物中的应用 |
EP3692997A4 (fr) | 2017-10-03 | 2021-09-29 | Tokyo Metropolitan Institute of Medical Science | Médicament contre la grippe |
JP7384668B2 (ja) | 2017-10-05 | 2023-11-21 | 第一三共株式会社 | 細胞傷害性t細胞枯渇用組成物 |
KR101966362B1 (ko) | 2017-10-20 | 2019-04-05 | 주식회사 녹십자 | 항-msln 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
CA3082365A1 (fr) | 2017-11-09 | 2019-05-16 | Pinteon Therapeutics Inc. | Methodes et compositions pour la generation et l'utilisation d'anticorps tau phosphoryles specifiques a une conformation humanisee |
CA3083985A1 (fr) | 2017-11-30 | 2019-06-06 | Centurion Biopharma Corporation | Systemes d'administration de medicaments a base de maytansinoides |
US11377473B2 (en) | 2017-11-30 | 2022-07-05 | Centurion Biopharma Corporation | Albumin-binding prodrugs of auristatin E derivatives |
WO2019106126A1 (fr) | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Modulateurs mdm2 pour le diagnostic et le traitement du liposarcome |
DK3720879T3 (da) | 2017-12-05 | 2022-06-20 | Progastrine Et Cancers S A R L | Kombinationsterapi mellem anti-progastrin-antistof og immunterapi til behandling af cancer |
WO2019121872A1 (fr) | 2017-12-20 | 2019-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de diagnostic et de traitement du cancer du foie |
US20190225689A1 (en) | 2018-01-22 | 2019-07-25 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-pd-1 antibodies |
TW201940881A (zh) | 2018-01-26 | 2019-10-16 | 瑞士商Ecs前胃泌激素公司 | 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術 |
US11834487B2 (en) | 2018-02-12 | 2023-12-05 | Hadasit Medical Research Services & Development Ltd. | Modulation of SLAMF6 splice variants for cancer therapy |
WO2019158512A1 (fr) | 2018-02-13 | 2019-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes pour le pronostic et le traitement du glioblastome |
CN112384515A (zh) | 2018-02-27 | 2021-02-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶 |
EP3759492A1 (fr) | 2018-02-27 | 2021-01-06 | ECS-Progastrin SA | Progastrine en tant que biomarqueur pour l'immunothérapie |
KR20200128017A (ko) | 2018-03-05 | 2020-11-11 | 각코우호우징 사이타마이카다이가쿠 | 이소성 골화의 치료 또는 예방을 위한 의약 조성물 |
WO2019185683A1 (fr) | 2018-03-28 | 2019-10-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement du cancer |
JP2021521445A (ja) | 2018-04-13 | 2021-08-26 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前立腺癌又は乳癌を患っている患者の転帰を予測するための及び処置のための方法 |
EP3781590A1 (fr) | 2018-04-20 | 2021-02-24 | Medizinische Hochschule Hannover | Récepteur antigénique chimérique et lymphocytes t-car se liant à l'antigène du virus de l'herpès |
WO2019207066A1 (fr) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions destinés au traitement du syndrome de sjögren |
WO2019211369A1 (fr) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement du cancer |
WO2019211370A1 (fr) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pharmaceutiques pour le traitement du cancer |
JP2021522801A (ja) | 2018-05-09 | 2021-09-02 | イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | ヒトネクチン4に特異的な抗体 |
MX2020012055A (es) | 2018-05-11 | 2021-01-29 | Astellas Pharma Inc | Acido nucleico para el tratamiento de alergia por crustaceos. |
JPWO2019216394A1 (ja) | 2018-05-11 | 2021-05-27 | アステラス製薬株式会社 | ダニアレルギー治療のための核酸 |
CA3100317A1 (fr) | 2018-05-17 | 2019-11-21 | Astellas Pharma Inc. | Complexe ayant un fragment fab d'anticorps anti-muc1 humaine, un lieur peptidique et/ou un ligand |
MX2020012376A (es) | 2018-05-18 | 2021-03-09 | Incyte Corp | Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b. |
EP3802607A2 (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech, Inc. | Anticorps anti-tmeff2 monospécifiques et multispécifiques et leurs utilisations |
AU2019274657A1 (en) | 2018-05-24 | 2020-12-10 | Janssen Biotech, Inc. | PSMA binding agents and uses thereof |
KR20210012007A (ko) | 2018-05-24 | 2021-02-02 | 얀센 바이오테크 인코포레이티드 | 항-cd3 항체 및 이의 용도 |
WO2019230645A1 (fr) | 2018-05-28 | 2019-12-05 | 第一三共株式会社 | Traitement du cancer à her2 muté par administration d'un conjugué anticorps anti-her2-médicament |
AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
KR20210018192A (ko) | 2018-05-31 | 2021-02-17 | 다이이찌 산쿄 가부시키가이샤 | 항인간 tlr7 항체 |
CA3098420A1 (fr) | 2018-06-01 | 2019-12-05 | Novartis Ag | Molecules de liaison dirigees contre bcma et leurs utilisations |
WO2019234099A1 (fr) | 2018-06-06 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de diagnostic, de prédiction du résultat et de traitement d'un patient souffrant d'insuffisance cardiaque à fraction d'éjection préservée |
WO2019234221A1 (fr) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de stratification et de traitement d'un patient souffrant de leucémie lymphoïde chronique |
EP3810651A1 (fr) | 2018-06-20 | 2021-04-28 | Incyte Corporation | Anticorps anti-pd-1 et leurs utilisations |
WO2019244107A1 (fr) | 2018-06-21 | 2019-12-26 | Daiichi Sankyo Company, Limited | Compositions comprenant des fragments de liaison à l'antigène cd3 et leurs utilisations |
MA53010A (fr) | 2018-06-29 | 2021-05-05 | Incyte Corp | Formulations d'un inhibiteur de axl/mer |
WO2020007898A1 (fr) | 2018-07-04 | 2020-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes et compositions pour le traitement d'une lésion cérébrale ou d'une maladie neurodégénérative |
CN112566942A (zh) | 2018-07-25 | 2021-03-26 | 第一三共株式会社 | 用于制造抗体-药物缀合物的有效方法 |
WO2020022499A1 (fr) | 2018-07-27 | 2020-01-30 | 国立大学法人大阪大学 | Composition pour l'inhibition du vieillissement, la prévention, l'atténuation ou le traitement de maladies liées à l'âge, ou le prolongement de la durée de vie |
JP7406488B2 (ja) | 2018-07-27 | 2023-12-27 | 第一三共株式会社 | 抗体-薬物コンジュゲートの薬物部位を認識する蛋白質 |
EA202190403A1 (ru) | 2018-07-31 | 2021-05-24 | Дайити Санкио Компани, Лимитед | Лечение метастатической опухоли головного мозга путем введения конъюгата антитело-лекарственное средство |
AU2019320336A1 (en) | 2018-08-06 | 2021-03-04 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and tubulin inhibitor |
AU2019337051B2 (en) | 2018-09-06 | 2023-11-23 | Daiichi Sankyo Company, Limited | Novel cyclic dinucleotide derivative and antibody-drug conjugate thereof |
CA3113207A1 (fr) | 2018-09-20 | 2020-03-26 | Daiichi Sankyo Company, Limited | Traitement d'un cancer a her3 mutant par l'administration d'un conjugue anticorps anti-her3-medicament |
EP3854875A4 (fr) | 2018-09-21 | 2022-07-06 | National University Corporation Tokyo Medical and Dental University | Anticorps monoclonal humain se fixant spécifiquement a hmgb1 humain, et composition pharmaceutique pour le traitement ou la prévention de la maladie d'alzheimer contenant ledit anticorps monoclonal humain |
CN113453724A (zh) | 2018-09-27 | 2021-09-28 | 皮埃尔法布雷医药公司 | 基于磺酰基马来酰亚胺的连接子和相应的偶联物 |
BR112021005665A2 (pt) | 2018-09-28 | 2021-06-22 | Pierre Fabre Medicament | novas imunocitocinas para o tratamento de câncer |
EP3865154A4 (fr) | 2018-10-10 | 2022-11-09 | Astellas Pharma Inc. | Composition pharmaceutique contenant un complexe de fragment fab d'anticorps au site anti-humain marqué |
UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
EP3867269A1 (fr) | 2018-10-18 | 2021-08-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinaison d'un antagoniste big-h3 et d'un inhibiteur de point de contrôle immunitaire pour le traitement d'une tumeur solide |
SG11202104463YA (en) | 2018-10-31 | 2021-05-28 | Astellas Pharma Inc | Anti-human fn14 antibody |
WO2020099235A1 (fr) | 2018-11-12 | 2020-05-22 | Mediapharma S.R.L. | Anticorps bispécifiques dirigés contre 90k humain, et soit l'endosialine, soit her3 |
AU2019379418A1 (en) | 2018-11-14 | 2021-06-03 | Daiichi Sankyo Company, Limited | Anti-CDH6 antibody-pyrrolobenzodiazepine derivative conjugate |
TW202034959A (zh) | 2018-12-11 | 2020-10-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與parp抑制劑之組合 |
WO2020132560A2 (fr) | 2018-12-21 | 2020-06-25 | Aim Immunotech Inc. | Compositions et méthodes pour cancérothérapie |
CN113195000A (zh) | 2018-12-21 | 2021-07-30 | 第一三共株式会社 | 抗体-药物缀合物和激酶抑制剂的组合 |
KR20210113201A (ko) | 2019-01-07 | 2021-09-15 | 아스텔라스세이야쿠 가부시키가이샤 | 배위자 및 CEACAM5 항체 Fab 프래그먼트를 포함하는 복합체 |
TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | ***新抗原及其用途 |
WO2020144697A1 (fr) | 2019-01-13 | 2020-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anticorps spécifiques à la nectine-2 humaine |
EP3917515A1 (fr) | 2019-01-29 | 2021-12-08 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Traitement de l'agent causal de l'angiogenèse |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
CN113795513A (zh) | 2019-02-13 | 2021-12-14 | 布里格姆妇女医院 | 抗外周***地址素抗体及其用途 |
WO2020178193A1 (fr) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthode de traitement de la sarcoïdose |
US20220154153A1 (en) | 2019-03-22 | 2022-05-19 | Université de Paris | New inhibitors of lrrk2/pp1 interaction |
US20220154191A1 (en) | 2019-03-25 | 2022-05-19 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Enhancement of cytolytic t-cell activity by inhibiting ebag9 |
US20220177601A1 (en) | 2019-03-25 | 2022-06-09 | Daiichi Sankyo Company, Limited | Anti-her2 antibody-pyrrolobenzodiazepine derivative conjugate |
KR20210143237A (ko) | 2019-03-25 | 2021-11-26 | 다이이찌 산쿄 가부시키가이샤 | 항체-피롤로벤조디아제핀 유도체 컨쥬게이트 |
CA3139180A1 (fr) | 2019-03-27 | 2020-10-01 | Daiichi Sankyo Company, Limited | Combinaison d'un conjugue anticorps-derive de pyrrolobenzodiazepine et d'un inhibiteur de parp |
AU2020255907A1 (en) | 2019-04-01 | 2021-10-28 | Chiome Bioscience Inc. | Medicament for treating cancer |
CA3131895A1 (fr) | 2019-04-02 | 2020-10-08 | Kenjockety Biotechnology, Inc. | Anticorps multi-specifiques d'un antigene associe a un cancer et d'une pompe d'efflux, ainsi que compositions, reactifs, kits et methodes associes a ceux-ci |
AU2020259404A1 (en) | 2019-04-19 | 2021-09-23 | Janssen Biotech, Inc. | Methods of treating prostate cancer with an anti- PSMA/CD3 antibody |
WO2020229546A1 (fr) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lymphocytes t régulateurs ciblés par un agent de blocage alpha de la lymphotoxine et leurs utilisations |
BR112021023901A2 (pt) | 2019-05-29 | 2022-01-18 | Daiichi Sankyo Co Ltd | Conjugado anticorpo-fármaco anti-trop2, composição farmacêutica, método para tratar ou prevenir câncer, e, uso de um conjugado anticorpo-fármaco anti-trop2 na fabricação de um fármaco para o tratamento ou prevenção do câncer |
WO2020261093A1 (fr) | 2019-06-24 | 2020-12-30 | Novartis Ag | Schéma posologique et polythérapies pour des anticorps multispécifiques ciblant un antigène de maturation des lymphocytes b |
JPWO2021020282A1 (fr) | 2019-07-26 | 2021-02-04 | ||
CR20220025A (es) | 2019-07-26 | 2022-05-04 | Janssen Biotech Inc | Proteínas que comprenden dominios de unión al antígeno de la peptidasa 2 relacionada con la calicreína y sus usos |
WO2021019706A1 (fr) | 2019-07-31 | 2021-02-04 | 国立大学法人信州大学 | Procédé de fabrication de population cellulaire contenant des cellules immunitaires d'expression de récepteur antigénique chimérique |
CA3148776A1 (fr) | 2019-08-01 | 2021-02-04 | Incyte Corporation | Schema posologique pour un inhibiteur d'ido |
CA3146474A1 (fr) | 2019-08-02 | 2021-02-11 | Denis BURGER | Methodes de traitement ou de prevention de cancers comprenant l'administration d'agents anti-recepteur ccr5 |
MX2022001841A (es) | 2019-08-12 | 2022-08-17 | Biond Biologics Ltd | Anticuerpos contra ilt2 y uso de los mismos. |
EP3792632A1 (fr) | 2019-09-16 | 2021-03-17 | Vito NV | Marqueurs d'immunothérapie |
EP4031578A1 (fr) | 2019-09-18 | 2022-07-27 | Novartis AG | Anticorps d'entpd2, polythérapies, et procédés d'utilisation des anticorps et des polythérapies |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
WO2021058744A1 (fr) | 2019-09-27 | 2021-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Utilisation d'inhibiteurs d'hormone antimüllerienne pour le traitement du cancer |
WO2021059075A1 (fr) | 2019-09-27 | 2021-04-01 | Janssen Biotech, Inc. | Anticorps anti-ceacam et leurs utilisations |
BR112022007632A2 (pt) | 2019-10-25 | 2022-07-12 | Daiichi Sankyo Co Ltd | Composição farmacêutica e preparação de kit para tratamento de câncer, e, métodos para tratamento de câncer e de um paciente com câncer |
CN115151566A (zh) | 2019-11-15 | 2022-10-04 | 普利安特治疗公司 | 用于活化整合素的组合物和方法 |
AU2020385683A1 (en) | 2019-11-18 | 2022-06-30 | Janssen Biotech, Inc. | Vaccines based on mutant CALR and JAK2 and their uses |
JP2023506772A (ja) * | 2019-12-10 | 2023-02-20 | シーシーオーエイ セラピューティクス (ハンヂョウ) カンパニー リミテッド | ヒト化抗糖タンパク質ibアルファ(gpibalpha)抗体 |
KR20220143005A (ko) | 2019-12-20 | 2022-10-24 | 노바록 바이오테라퓨틱스 리미티드 | 항-인터루킨-23 p19 항체 및 이의 사용 방법 |
KR20220150281A (ko) | 2020-01-03 | 2022-11-10 | 인사이트 코포레이션 | A2a/a2b 및 pd-1/pd-l1 억제제를 포함하는 조합 요법 |
WO2021140173A1 (fr) | 2020-01-10 | 2021-07-15 | Biouniversa S.R.L. | Méthodes et utilisations pour le traitement de tumeurs fibreuses solides avec des inhibiteurs de bags |
US20230070181A1 (en) | 2020-02-05 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment of cancer disease by targeting an epigenetic factor |
TW202140012A (zh) | 2020-02-12 | 2021-11-01 | 比利時商健生藥品公司 | 用於治療尿路上皮癌的fgfr酪胺酸激酶抑制劑和抗pd1藥劑 |
TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
CN115209881A (zh) | 2020-03-03 | 2022-10-18 | 活跃生物技术有限公司 | 用于组合疗法的他喹莫德或其药学上可接受的盐 |
JP2023516441A (ja) | 2020-03-06 | 2023-04-19 | インサイト・コーポレイション | Axl/mer阻害剤及びpd-1/pd-l1阻害剤を含む併用療法 |
IL296124A (en) | 2020-03-06 | 2022-11-01 | Daiichi Sankyo Co Ltd | Conjugation of an antibody with a drug including a novel cyclic dinucleotide derivative |
US11896619B2 (en) | 2020-03-10 | 2024-02-13 | Massachusetts Institute Of Technology | Compositions and methods for immunotherapy of NPM1c-positive cancer |
MX2022011320A (es) | 2020-03-13 | 2022-12-08 | Janssen Biotech Inc | Materiales y métodos para la unión de lectina tipo ig de unión a ácido siálico. |
EP4130036A4 (fr) | 2020-03-30 | 2024-05-15 | Nat Cancer Ct | Conjugué anticorps-médicament |
US11045546B1 (en) | 2020-03-30 | 2021-06-29 | Cytodyn Inc. | Methods of treating coronavirus infection |
EP3889183A1 (fr) | 2020-04-01 | 2021-10-06 | Pierre Fabre Medicament | Complexe de protéine comprenant une immunocytokine |
CA3179348A1 (fr) | 2020-04-06 | 2021-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anticorps diriges contre nkp46 et leurs constructions pour le traitement de cancers et d'infections |
US20230174670A1 (en) | 2020-05-14 | 2023-06-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-cd25 antibodies, antigen-binding fragments thereof, and medical uses thereof |
JP2023526529A (ja) | 2020-05-19 | 2023-06-21 | アンスティテュ・クリー | サイトカイン放出症候群の診断及び処置の方法 |
PE20230389A1 (es) | 2020-05-27 | 2023-03-06 | Janssen Biotech Inc | Proteinas que comprenden dominios de union al antigeno de cd3 y usos de estas |
AU2021281828A1 (en) | 2020-05-27 | 2023-02-02 | Arialys Therapeutics, Inc. | Anti-human NR1 antibody derivative |
US20230192902A1 (en) | 2020-06-04 | 2023-06-22 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
WO2021260583A1 (fr) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur de la dna-pk |
WO2021260580A1 (fr) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de l'atm |
AU2021298251A1 (en) | 2020-06-24 | 2023-02-02 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and ATR inhibitor |
WO2021260582A1 (fr) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur d'aurora b |
TW202216207A (zh) | 2020-06-24 | 2022-05-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及cdk9抑制劑之組合 |
WO2021260139A1 (fr) | 2020-06-25 | 2021-12-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de traitement et de diagnostic d'états pathologiques associés à un stress intense |
JPWO2022014698A1 (fr) | 2020-07-17 | 2022-01-20 | ||
CA3186675A1 (fr) | 2020-07-20 | 2022-01-27 | Yasuki KAMAI | Combinaison d'un conjugue anticorps-medicament anti-her2 avec son inhibiteur de dimerisation |
JP2023536818A (ja) | 2020-07-29 | 2023-08-30 | ヤンセン バイオテツク,インコーポレーテツド | Hla-g抗原結合ドメインを含むタンパク質及びそれらの使用 |
RU2764216C1 (ru) * | 2020-08-10 | 2022-01-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Чувашский государственный университет имени И.Н. Ульянова" | Способ лечения гломерулонефритов с нефротическим синдромом рецидивирующего течения |
IL300588A (en) | 2020-08-12 | 2023-04-01 | Biond Biologics Ltd | Antibodies against ILT-2 and their use |
EP4199959A1 (fr) | 2020-08-24 | 2023-06-28 | Charité - Universitätsmedizin Berlin | Construction de récepteur antigénique chimérique codant pour une molécule inhibitrice de point de contrôle et une cytokine immunostimulante et cellules exprimant car reconnaissant cd44v6 |
EP4199958A1 (fr) | 2020-08-24 | 2023-06-28 | Charité - Universitätsmedizin Berlin | Cellules exprimant le récepteur antigénique chimérique (car) reconnaissant l'ace |
WO2022051591A2 (fr) | 2020-09-04 | 2022-03-10 | Novarock Biotherapeutics, Ltd. | Anticorps anti-nectine-4 et leurs utilisations |
EP4210722A1 (fr) | 2020-09-07 | 2023-07-19 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Méthodes de traitement de maladies inflammatoires de l'intestin |
EP4211598A2 (fr) | 2020-09-12 | 2023-07-19 | AstraZeneca UK Limited | Procédé de notation de thérapie par conjugué anticorps anti-her2-médicament |
TW202228692A (zh) | 2020-10-05 | 2022-08-01 | 日商凱依歐姆 生物科學股份有限公司 | 癌症治療用醫藥 |
US20230372527A1 (en) | 2020-10-09 | 2023-11-23 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and parp1 selective inhibitor |
KR20230086765A (ko) | 2020-10-13 | 2023-06-15 | 얀센 바이오테크 인코포레이티드 | 분화 클러스터 iv 및/또는 viii을 조절하기 위한 바이오-조작된 t 세포 매개 면역, 물질 및 기타 방법 |
WO2022084399A1 (fr) | 2020-10-21 | 2022-04-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fragments de sparc à terminaison c pour le traitement du cancer |
CA3199319A1 (fr) | 2020-10-22 | 2022-04-28 | Janssen Biotech, Inc. | Proteines comprenant des domaines de liaison a l'antigene du ligand 3 de type delta et leurs utilisations |
WO2022097090A1 (fr) | 2020-11-05 | 2022-05-12 | Novartis Ag | Schéma posologique et polythérapies avec des anticorps multispécifiques ciblant un antigène de maturation des lymphocytes b et des inhibiteurs de gamma secrétase |
US20240011094A1 (en) | 2020-11-06 | 2024-01-11 | Institut National de la Santé et de la Recherche Médicale | Methods for diagnosis and treating polycystic ovary syndrome (pcos) |
US20230414778A1 (en) | 2020-11-11 | 2023-12-28 | Daiichi Sankyo Company, Limited | COMBINATION OF ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPalpha ANTIBODY |
WO2022102695A1 (fr) | 2020-11-12 | 2022-05-19 | 第一三共株式会社 | Traitement du mésothéliome par l'administration d'un conjugué anticorps-médicament anti-b7-h3 |
CA3200860A1 (fr) | 2020-11-16 | 2022-05-19 | Astellas Pharma Inc. | Anticorps bispecifique anti-tspan8-anti-cd3 et anticorps anti-tspan8 |
EP4251282A1 (fr) | 2020-11-27 | 2023-10-04 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Procédés de diagnostic et de surveillance de la nécrolyse épidermique toxique |
TW202241436A (zh) | 2020-11-30 | 2022-11-01 | 美商英塞特公司 | 抗cd19抗體及帕薩昔布(parsaclisib)之組合療法 |
WO2022115120A1 (fr) | 2020-11-30 | 2022-06-02 | Incyte Corporation | Polythérapie comprenant un anticorps anti-cd19 et le parsaclisib |
JPWO2022124247A1 (fr) | 2020-12-09 | 2022-06-16 | ||
EP4271384A1 (fr) | 2020-12-29 | 2023-11-08 | Incyte Corporation | Polythérapie comprenant des inhibiteurs a2a/a2b, des inhibiteurs pd-1/pd-l1 et des anticorps anti-cd73 |
JP2024503658A (ja) | 2021-01-13 | 2024-01-26 | メモリアル スローン-ケタリング キャンサー センター | 抗dll3抗体-薬物コンジュゲート |
WO2022153194A1 (fr) | 2021-01-13 | 2022-07-21 | Memorial Sloan Kettering Cancer Center | Conjugué anticorps-dérivé de pyrrolobenzodiazépine |
WO2022153212A1 (fr) | 2021-01-13 | 2022-07-21 | Axon Neuroscience Se | Anticorps neutralisant le sars-cov-2 |
AU2022214491A1 (en) | 2021-01-28 | 2023-09-14 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
WO2022162569A1 (fr) | 2021-01-29 | 2022-08-04 | Novartis Ag | Régimes posologiques d'anticorps anti-cd73 et anti-entpd2 et leurs utilisations |
TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體-免疫賦活化劑共軛物之新穎製造方法 |
CA3206413A1 (fr) | 2021-02-11 | 2022-08-18 | Pinchas TSUKERMAN | Anticorps diriges contre cd112r et leurs utilisations |
WO2022171771A1 (fr) | 2021-02-12 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Protéines de liaison à l'antigène c3 du complément |
US20220378929A1 (en) | 2021-02-25 | 2022-12-01 | MediBoston Limted | Anti-her2 antibody-drug conjugates and uses thereof |
EP4301777A1 (fr) | 2021-03-02 | 2024-01-10 | Dana-Farber Cancer Institute, Inc. | Procédés de traitement de troubles des globules rouges |
WO2022191313A1 (fr) | 2021-03-12 | 2022-09-15 | 第一三共株式会社 | Glycane et procédé de production d'un médicament contenant un glycane |
EP4305064A1 (fr) | 2021-03-12 | 2024-01-17 | Fibrosys S.r.l. | Anticorps monoclonaux pour le traitement d'infections virales |
AR125210A1 (es) | 2021-03-24 | 2023-06-21 | Janssen Biotech Inc | Anticuerpos dirigidos a cd22 y cd79b |
BR112023019205A2 (pt) | 2021-03-26 | 2023-10-24 | Janssen Biotech Inc | Anticorpos humanizados contra tau de filamento helicoidal pareado e usos dos mesmos |
WO2022218998A1 (fr) | 2021-04-13 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de traitement d'une infection par le virus de l'hépatite b et d |
CR20230523A (es) | 2021-04-14 | 2024-01-23 | Villaris Therapeutics Inc | Anticuerpos anti-cd122 y usos de estos |
KR20230171465A (ko) | 2021-04-22 | 2023-12-20 | 아스텔라스세이야쿠 가부시키가이샤 | 항cldn4-항cd137 이중특이성 항체 |
WO2022261183A2 (fr) | 2021-06-08 | 2022-12-15 | Dana-Farber Cancer Institute, Inc. | Compositions et procédés de traitement et/ou d'identification d'un agent pour le traitement de cancers intestinaux |
CN113361141B (zh) * | 2021-07-11 | 2022-02-18 | 西南石油大学 | 一种dna图谱算法的改进试验方法 |
CA3231632A1 (fr) | 2021-09-15 | 2023-03-23 | Daiichi Sankyo Company, Limited | Conjugue anticorps-medicament destine a etre utilise dans des methodes de traitement de cancer resistant a la chimiotherapie |
WO2023041744A1 (fr) | 2021-09-17 | 2023-03-23 | Institut Curie | Inhibiteurs de bet pour le traitement du cancer à déficit en bap1 |
WO2023046322A1 (fr) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceutica Nv | Protéines comprenant des domaines de liaison à cd20, et leurs utilisations |
WO2023052541A1 (fr) | 2021-09-30 | 2023-04-06 | Imcheck Therapeutics | Combinaison d'un anticorps d'activation anti-btn3a et d'un agoniste il-2 en vue d'une utilisation en thérapie |
CA3234598A1 (fr) | 2021-10-27 | 2023-05-04 | Daniel Olive | Anticorps d'activation de butyrophiline (btn) 3a a utiliser dans des methodes de traitement de troubles infectieux |
EP4177266A1 (fr) | 2021-11-05 | 2023-05-10 | Katholieke Universiteit Leuven | Neutralisation d'anticorps humains anti-sars-cov-2 |
TW202329936A (zh) | 2021-11-18 | 2023-08-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物與parp1選擇性抑制劑之組合 |
WO2023089032A1 (fr) | 2021-11-19 | 2023-05-25 | Institut Curie | Méthodes de traitement du cancer hrd et du cancer associé au brca |
WO2023097119A2 (fr) | 2021-11-29 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Méthodes et compositions pour moduler riok2 |
WO2023099763A1 (fr) | 2021-12-03 | 2023-06-08 | Institut Curie | Inhibiteurs de sirt6 destinés à être utilisés dans le traitement du cancer hrd résistant |
WO2023105528A1 (fr) | 2021-12-12 | 2023-06-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Anticorps spécifiques de ceacam1 |
WO2023118395A1 (fr) | 2021-12-22 | 2023-06-29 | Morphosys Ag | Paradigme de traitement pour une thérapie par anticorps anti-cd19 |
WO2023126823A1 (fr) | 2021-12-28 | 2023-07-06 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur d'atr |
WO2023126822A1 (fr) | 2021-12-28 | 2023-07-06 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur de rasg12c |
WO2023152581A1 (fr) | 2022-02-09 | 2023-08-17 | Janssen Biotech, Inc. | Méthode de traitement du cancer à l'aide d'un anticorps anti-psmaxcd3 |
WO2023166081A1 (fr) | 2022-03-02 | 2023-09-07 | Heidelberg Immunotherapeutics Gmbh | Vaccin comprenant un anticorps ou une protéine de fusion contenant fc comprenant une partie fc d'un anticorps |
WO2023175614A1 (fr) | 2022-03-15 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Anticorps anti-protéine liée au tnfr induite par glucocorticoïdes (gitr) et leurs utilisations |
WO2023175483A1 (fr) | 2022-03-16 | 2023-09-21 | Astrazeneca Uk Limited | Procédé de notation pour une thérapie par conjugué anticorps-médicament anti-trop2 |
TW202400140A (zh) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合 |
TW202400650A (zh) | 2022-05-11 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體與cd47抑制劑之組合 |
WO2023228095A1 (fr) | 2022-05-24 | 2023-11-30 | Daiichi Sankyo Company, Limited | Schéma posologique d'un conjugué anticorps anti-cdh6-médicament |
WO2024013723A1 (fr) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Conjugués anticorps-médicament qui se lient à cdcp1 et leurs utilisations |
WO2024023750A1 (fr) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | Association d'un conjugué anticorps-médicament et d'un inhibiteur de point de contrôle bispécifique |
US20240101718A1 (en) | 2022-09-28 | 2024-03-28 | Incyte Corporation | Anti-pd-1/lag-3 bispecific antibodies and uses thereof |
WO2024074498A1 (fr) | 2022-10-04 | 2024-04-11 | Imcheck Therapeutics | Combinaison d'un anticorps d'activation de btn3a, d'un inhibiteur de bcl2 et d'un agent d'hypométhylation destinée à être utilisée dans le traitement du cancer |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
JPS6033453B2 (ja) * | 1978-08-17 | 1985-08-02 | 富士電機株式会社 | 魚切断加工自動化装置 |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6014678A (ja) * | 1983-07-04 | 1985-01-25 | Taiheiyo Kogyo Kk | 電磁弁 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB2188941B (en) * | 1986-04-14 | 1990-06-06 | Bayer Ag | Monoclonal antibodies recognizing human interleukin-2-receptor |
DK554986A (da) * | 1986-11-19 | 1988-07-18 | Novo Industri As | Human-human hybride cellelinier samt dermed producerede monoklonale cancerantistoffer |
GB8720833D0 (en) * | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
WO1989007452A1 (fr) * | 1988-02-12 | 1989-08-24 | Medical Research Council | Ameliorations relatives a des anticorps |
WO1989009622A1 (fr) * | 1988-04-15 | 1989-10-19 | Protein Design Labs, Inc. | Anticorps chimeriques specifiques au recepteur il-2 |
JP5598363B2 (ja) | 2011-02-15 | 2014-10-01 | ソニー株式会社 | 記憶装置およびその動作方法 |
-
1989
- 1989-11-27 IL IL162181A patent/IL162181A/en not_active IP Right Cessation
- 1989-12-27 IL IL92904A patent/IL92904A0/xx not_active IP Right Cessation
- 1989-12-28 EP EP04076438.3A patent/EP1491556B1/fr not_active Expired - Lifetime
- 1989-12-28 ES ES90903576T patent/ES2081974T5/es not_active Expired - Lifetime
- 1989-12-28 DE DE19975047C patent/DE19975047I2/de active Active
- 1989-12-28 EP EP04076439.1A patent/EP1477497B1/fr not_active Expired - Lifetime
- 1989-12-28 DE DE200712000037 patent/DE122007000037I1/de active Pending
- 1989-12-28 JP JP2503677A patent/JP2828340B2/ja not_active Ceased
- 1989-12-28 WO PCT/US1989/005857 patent/WO1990007861A1/fr active IP Right Grant
- 1989-12-28 DE DE122005000057C patent/DE122005000057I2/de active Active
- 1989-12-28 MC MC@@@@D patent/MC2146A1/fr unknown
- 1989-12-28 DE DE98204240.0T patent/DE98204240T1/de active Pending
- 1989-12-28 CN CN89109618A patent/CN1057013C/zh not_active Expired - Lifetime
- 1989-12-28 DE DE122009000071C patent/DE122009000071I1/de active Pending
- 1989-12-28 KR KR1019900701939A patent/KR0178385B1/ko not_active IP Right Cessation
- 1989-12-28 ES ES04076439.1T patent/ES2523810T3/es not_active Expired - Lifetime
- 1989-12-28 DE DE68925536T patent/DE68925536T3/de not_active Expired - Lifetime
- 1989-12-28 DE DE68929061T patent/DE68929061T2/de not_active Expired - Lifetime
- 1989-12-28 DE DE04076439.1T patent/DE04076439T1/de active Pending
- 1989-12-28 ES ES95105609T patent/ES2136760T3/es not_active Expired - Lifetime
- 1989-12-28 AU AU51532/90A patent/AU647383B2/en not_active Expired
- 1989-12-28 YU YU248989A patent/YU48700B/sh unknown
- 1989-12-28 AT AT95105609T patent/ATE183753T1/de not_active IP Right Cessation
- 1989-12-28 PT PT92758A patent/PT92758B/pt active IP Right Grant
- 1989-12-28 DE DE2000175038 patent/DE10075038I2/de active Active
- 1989-12-28 DE DE1989625536 patent/DE122006000036I1/de active Pending
- 1989-12-28 EP EP90903576A patent/EP0451216B9/fr not_active Expired - Lifetime
- 1989-12-28 EP EP95105609A patent/EP0682040B1/fr not_active Revoked
- 1989-12-28 SI SI8912489A patent/SI8912489B/sl unknown
- 1989-12-28 ES ES04076438.3T patent/ES2440825T3/es not_active Expired - Lifetime
- 1989-12-28 ES ES98204240.0T patent/ES2492815T3/es not_active Expired - Lifetime
- 1989-12-28 AT AT90903576T patent/ATE133452T1/de active
- 1989-12-28 ZA ZA899956A patent/ZA899956B/xx unknown
- 1989-12-28 IE IE20000331A patent/IE20000331A1/en unknown
- 1989-12-28 EP EP10185689A patent/EP2341080A1/fr not_active Withdrawn
- 1989-12-28 CA CA002006865A patent/CA2006865C/fr not_active Expired - Lifetime
- 1989-12-28 DE DE68925536A patent/DE68925536D1/de not_active Expired - Lifetime
- 1989-12-28 DE DE04076438.3T patent/DE04076438T1/de active Pending
- 1989-12-28 RU SU4895847/13A patent/RU2126046C1/ru active
- 1989-12-28 EP EP98204240.0A patent/EP0939127B1/fr not_active Expired - Lifetime
- 1989-12-28 CA CA002328851A patent/CA2328851C/fr not_active Expired - Lifetime
- 1989-12-28 DE DE122005000007C patent/DE122005000007I2/de active Active
- 1989-12-28 DE DE2000175005 patent/DE10075005I2/de active Active
-
1990
- 1990-01-04 NZ NZ314793A patent/NZ314793A/xx unknown
- 1990-01-04 NZ NZ231984A patent/NZ231984A/en unknown
- 1990-01-17 DD DD90337159A patent/DD296964A5/de unknown
-
1991
- 1991-05-20 FI FI912436A patent/FI108797B/fi active Protection Beyond IP Right Term
- 1991-06-19 NO NO19912385A patent/NO310473B1/no not_active IP Right Cessation
- 1991-06-19 DK DK119191A patent/DK119191A/da not_active Application Discontinuation
- 1991-12-31 CZ CS914186A patent/CZ418691A3/cs unknown
-
1992
- 1992-01-20 BG BG95784A patent/BG61095B2/xx unknown
- 1992-09-26 HR HRP-2489/89A patent/HRP920500B1/xx not_active IP Right Cessation
-
1995
- 1995-06-16 HU HU95P/P00236P patent/HU211174A9/hu active Protection Beyond IP Right Term
-
1996
- 1996-04-13 SG SG1996007855A patent/SG78258A1/en unknown
-
1998
- 1998-01-12 JP JP00433498A patent/JP3604058B2/ja not_active Expired - Lifetime
- 1998-07-16 DK DK199800941A patent/DK174317B1/da not_active IP Right Cessation
- 1998-12-28 HK HK98115967A patent/HK1014718A1/xx not_active IP Right Cessation
-
1999
- 1999-07-02 LU LU90411C patent/LU90411I2/fr unknown
- 1999-07-14 NL NL990020C patent/NL990020I2/nl unknown
-
2000
- 2000-02-11 NL NL300005C patent/NL300005I2/nl unknown
- 2000-02-11 LU LU90528C patent/LU90528I2/fr unknown
- 2000-11-03 NL NL300023C patent/NL300023I2/nl unknown
- 2000-11-09 LU LU90676C patent/LU90676I2/fr unknown
-
2001
- 2001-12-17 NO NO2001025C patent/NO2001025I2/no unknown
- 2001-12-17 NO NO2001026C patent/NO2001026I2/no unknown
- 2001-12-17 NO NO2001024C patent/NO2001024I1/no unknown
-
2003
- 2003-01-20 JP JP2003011705A patent/JP2003245090A/ja not_active Withdrawn
- 2003-01-20 JP JP2003011706A patent/JP2003245091A/ja not_active Withdrawn
-
2005
- 2005-02-04 LU LU91139C patent/LU91139I2/fr unknown
- 2005-02-10 NL NL300173C patent/NL300173I2/nl unknown
- 2005-02-18 NO NO2005005C patent/NO2005005I2/no unknown
- 2005-12-02 LU LU91208C patent/LU91208I2/fr unknown
- 2005-12-07 NO NO2005026C patent/NO2005026I2/no unknown
- 2005-12-12 NL NL300213C patent/NL300213I2/nl unknown
-
2006
- 2006-08-07 LU LU91272C patent/LU91272I2/fr unknown
- 2006-08-07 NL NL300239C patent/NL300239I2/nl unknown
- 2006-08-07 NO NO2006009C patent/NO2006009I2/no unknown
-
2007
- 2007-03-02 JP JP2007053539A patent/JP2007145863A/ja not_active Withdrawn
- 2007-04-11 LU LU91333C patent/LU91333I2/fr unknown
- 2007-04-18 NO NO2007006C patent/NO2007006I2/no unknown
- 2007-04-18 NL NL300279C patent/NL300279I2/nl unknown
-
2009
- 2009-04-21 JP JP2009103471A patent/JP2009165488A/ja not_active Withdrawn
- 2009-11-12 NO NO2009026C patent/NO2009026I1/no unknown
- 2009-11-19 NL NL300426C patent/NL300426I1/nl unknown
- 2009-12-09 LU LU91627C patent/LU91627I2/fr unknown
-
2014
- 2014-09-17 FR FR14C0070C patent/FR14C0070I1/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO310473B1 (no) | Fremgangsmåte for fremstilling av humanisert immunoglobulin, polynukleotid som koder for nevnte immunoglobulin og cellelinjesom er transfektert med nevnte polynukleotid | |
US5585089A (en) | Humanized immunoglobulins | |
US20080160018A1 (en) | Humanized immunoglobulins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: TRASTUZUMAB ELLER FARMASOEYTISKE AKSEPTABLE SALTER DERAV; NAT. REG. NO/DATE: NO , EU/1/00/14 20000928; FIRST REG. NO/DATE: EP , EU/1/00/14 20000828 Spc suppl protection certif: 2001024 Filing date: 20011217 Extension date: 20141228 Effective date: 20031229 |
|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: XOLAIR, 75 MG OG 150 MG, PULVER OG VAESKE TIL INJEKSJONSVAESKE, OPPLOESNING; NAT. REG. NO/DATE: EU/1/05/319/00-002/NO 20051025; FIRST REG. NO/DATE: EU , EU/1/05/319/00-002 20051025 Spc suppl protection certif: 2005026 Filing date: 20051207 Extension date: 20141228 |
|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: TYSABRI; NAT. REG. NO/DATE: EU106346NO 20060627; FIRST REG. NO/DATE: EU , EU106346 20060627 Spc suppl protection certif: 2006009 Filing date: 20060807 Extension date: 20141228 |
|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: DACLIZUMAB; NAT. REG. NO/DATE: NO , 97-3585 19991126; FIRST REG. NO/DATE: EP , EU/1/99/09 19990226 Spc suppl protection certif: 2001026 Filing date: 20011217 Extension date: 20130303 |
|
SPCF | Filing of supplementary protection certificate |
Free format text: PRODUCT NAME: LUCENTIS 10 MG/ML INJEKSJONSVAESKE, OPPLOSNING "NOVARTIS EUROPHARM" - 1 HETTEGLASS; NAT. REG. NO/DATE: EU106374001NO 20070207; FIRST REG. NO/DATE: LI , 57664 20060825 Spc suppl protection certif: 2007006 Filing date: 20070418 Extension date: 20141228 |
|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: AVASTIN, 25 MG/ML, KONSENTRAT TIL OPPLOSNING FOR INFUSJON, INTRAVENOS ANVENDELSE; NAT. REG. NO/DATE: EU/1/04/300/001/NO-002/NO 20050118; FIRST REG. NO/DATE: EU , EU/1/04/300/001-002 20050112 Spc suppl protection certif: 2005005 Filing date: 20050218 Extension date: 20141228 Free format text: PRODUCT NAME: XOLAIR, 75 MG OG 150 MG, PULVER OG VAESKE TIL INJEKSJONSVAESKE, OPPLOESNING; NAT. REG. NO/DATE: EU/1/05/319/00-002/NO 20051025; FIRST REG. NO/DATE: EU , EU/1/05/319/00-002 20051025 Spc suppl protection certif: 2005026 Filing date: 20051207 Extension date: 20141228 |
|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: LUCENTIS 10 MG/ML INJEKSJONSVAESKE, OPPLOSNING "NOVARTIS EUROPHARM" - 1 HETTEGLASS; NAT. REG. NO/DATE: EU106374001NO 20070207; FIRST REG. NO/DATE: LI , 57664 20060825 Spc suppl protection certif: 2007006 Filing date: 20070418 Extension date: 20141228 Free format text: PRODUCT NAME: TYSABRI; NAT. REG. NO/DATE: EU106346NO 20060627; FIRST REG. NO/DATE: EU , EU106346 20060627 Spc suppl protection certif: 2006009 Filing date: 20060807 Extension date: 20141228 |
|
MK1K | Patent expired | ||
SPCX | Expiry of an spc |
Spc suppl protection certif: 2005005 Effective date: 20141228 Spc suppl protection certif: 2001024 Effective date: 20141228 Spc suppl protection certif: 2006009 Effective date: 20141228 Spc suppl protection certif: 2007006 Effective date: 20141228 Spc suppl protection certif: 2005026 Effective date: 20141228 |