NO307053B1 - 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene - Google Patents
0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivateneInfo
- Publication number
- NO307053B1 NO307053B1 NO951312A NO951312A NO307053B1 NO 307053 B1 NO307053 B1 NO 307053B1 NO 951312 A NO951312 A NO 951312A NO 951312 A NO951312 A NO 951312A NO 307053 B1 NO307053 B1 NO 307053B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- derivatives
- well
- pharmaceutical preparations
- preparations containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Dental Preparations (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929221220A GB9221220D0 (en) | 1992-10-09 | 1992-10-09 | Organic componds |
PCT/EP1993/002604 WO1994009010A1 (fr) | 1992-10-09 | 1993-09-24 | Derives o-alkyles de la rapamycine et leur utilisation, en particulier comme immunosuppresseurs |
Publications (3)
Publication Number | Publication Date |
---|---|
NO951312D0 NO951312D0 (no) | 1995-04-05 |
NO951312L NO951312L (no) | 1995-06-08 |
NO307053B1 true NO307053B1 (no) | 2000-01-31 |
Family
ID=10723188
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO951312A NO307053B1 (no) | 1992-10-09 | 1995-04-05 | 0-alkylerte rapamycinderivater samt farmasøytiske preparater inneholdende derivatene |
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO2004001C NO2004001I2 (no) | 1992-10-09 | 2004-03-24 | 40-0-(2-hydroksy)etyl rapamycin (everolimus) |
NO2017067C NO2017067I2 (no) | 1992-10-09 | 2017-12-07 | Everolimus - forlenget SPC |
Country Status (28)
Country | Link |
---|---|
US (2) | US5665772A (fr) |
EP (3) | EP0867438B1 (fr) |
JP (2) | JP3117462B2 (fr) |
KR (2) | KR100308598B1 (fr) |
AT (2) | ATE272063T1 (fr) |
AU (1) | AU676198B2 (fr) |
BR (1) | BR1100353A (fr) |
CA (2) | CA2145383C (fr) |
CY (2) | CY2125B1 (fr) |
CZ (1) | CZ283333B6 (fr) |
DE (3) | DE122004000033I2 (fr) |
DK (2) | DK0663916T3 (fr) |
ES (2) | ES2124793T3 (fr) |
FI (2) | FI109540B (fr) |
FR (1) | FR04C0012I2 (fr) |
GB (1) | GB9221220D0 (fr) |
GE (1) | GEP20002331B (fr) |
HU (1) | HU224074B1 (fr) |
LU (1) | LU91104I2 (fr) |
NL (1) | NL300154I2 (fr) |
NO (3) | NO307053B1 (fr) |
NZ (1) | NZ256026A (fr) |
PL (1) | PL176174B1 (fr) |
PT (1) | PT867438E (fr) |
RO (1) | RO114451B1 (fr) |
RU (1) | RU2143434C1 (fr) |
SK (2) | SK286054B6 (fr) |
WO (1) | WO1994009010A1 (fr) |
Families Citing this family (420)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
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USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
DE69430060T2 (de) | 1993-04-23 | 2002-11-07 | Abbott Lab | Antikörper von rapamycinen mit offenem ring |
USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
ES2308955T5 (es) * | 1993-09-28 | 2012-04-03 | R.P. Scherer Gmbh | Fabricación de cápsulas de gelatina blanda |
EP0729471A1 (fr) * | 1993-11-19 | 1996-09-04 | Abbott Laboratories | Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
SK78196A3 (en) * | 1993-12-17 | 1997-02-05 | Sandoz Ag | Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them |
GB9405350D0 (en) * | 1994-03-18 | 1994-05-04 | Sandoz Ltd | Organic compounds |
EP0786986B1 (fr) * | 1994-10-26 | 2002-03-20 | Novartis AG | Utilisation d'un alcool gras unsaturé |
US7205279B2 (en) * | 1995-10-25 | 2007-04-17 | Novartis Ag | Pharmaceutical compositions |
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US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
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US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
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BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
GB9606452D0 (en) | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
KR100616020B1 (ko) * | 1996-03-27 | 2007-01-31 | 노파르티스 아게 | 맥관장애및이종이식술에서의라파마이신유도체의용도 |
EP1208847B8 (fr) | 1996-07-30 | 2007-02-14 | Novartis AG | Compositions pharmaceutiques destinees au traitement des etats de rejet de greffe ainsi que des maladies autoimmunes ou inflammatoires |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
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US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
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US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5310903A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
SK78196A3 (en) * | 1993-12-17 | 1997-02-05 | Sandoz Ag | Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them |
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1992
- 1992-10-09 GB GB929221220A patent/GB9221220D0/en active Pending
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1993
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- 1993-09-24 EP EP20030028783 patent/EP1413581A1/fr not_active Ceased
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1995
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1997
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- 1997-05-23 US US08/862,911 patent/US6440990B1/en not_active Expired - Fee Related
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1998
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1999
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2000
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2001
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2004
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