HUP0105231A2 - Heteroaril-szubsztituált kinolin-2-on-származék rákellenes szerek és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Heteroaril-szubsztituált kinolin-2-on-származék rákellenes szerek és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0105231A2 HUP0105231A2 HU0105231A HUP0105231A HUP0105231A2 HU P0105231 A2 HUP0105231 A2 HU P0105231A2 HU 0105231 A HU0105231 A HU 0105231A HU P0105231 A HUP0105231 A HU P0105231A HU P0105231 A2 HUP0105231 A2 HU P0105231A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- alkyl group
- substituted
- oxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002837 carbocyclic group Chemical group 0.000 abstract 3
- -1 carbonyloxy, oxy Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000004149 thio group Chemical class *S* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
A tal lm ny (1) ltal nos képletű vegyületekre és farmakológiailagelfogadható sóikra és szolv tjaikra, valamint hatóanyagként ilyenvegyületeket tartalmazó gyógyszerkészítményekre vonatkozik, amelyekemlős"k esetén abnorm lis sejtn"vekedés g tl s ra, t"bbek k"z"tt r kkezelésére alkalmazhatók. A képletben R1 jelentése hidrogénatom, adottesetben karbonil-, karboniloxi-, oxi-, szulfocsoporton keresztülkapcsolódó alkilcsoporttal vagy egy vagy t"bbgyűrűs karbociklusos vagyheterociklusos csoporttal helyettesített alkilcsoport, R2 jelentésehalogénatom, cianocsoport, helyettesített karboxilcsoport, R3, R4, R5,R6 és R7 jelentése hidrogén- vagy halogénatom, alkil-, alkenil-,alkinil-, ciano-, nitro-, trifluormetil-, azidocsoport vagy karbonil-,karboniloxi-, oxi-, szulfo- vagy aminocsoporton keresztül kapcsolódóalkilcsoport vagy egy vagy t"bbgyűrűs karbociklusos vagyheterociklusos csoport, Z jelentése adott esetben helyettesítettheteroarom s csoport, R8 jelentése hidrogénatom, oxi- vagykarboniloxicsoporton keresztül kapcsolódó alkilcsoport vagy egy- vagyt"bbgyűrűs karbociklusos vagy heterociklusos csoport, cianocsoport,helyettesített amino-, imino-, karboxil-, tio- vagy alkilcsoport, R9jelentése imidazolilalkil- vagy piridinilalkil- csoport. A tal lm ny trgya tov bb elj r s az (1) ltal nos képletű vegyületek elő llít s ra,tov bb a tal lm ny t rgyk"rébe tartoznak az elj r s sor n képződőintermedierek is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11970299P | 1999-02-11 | 1999-02-11 | |
PCT/IB2000/000121 WO2000047574A1 (en) | 1999-02-11 | 2000-02-04 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0105231A2 true HUP0105231A2 (hu) | 2002-04-29 |
HUP0105231A3 HUP0105231A3 (en) | 2003-01-28 |
Family
ID=22385869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0105231A HUP0105231A3 (en) | 1999-02-11 | 2000-02-04 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents and medicaments containing the compounds |
Country Status (39)
Country | Link |
---|---|
US (3) | US6258824B1 (hu) |
EP (1) | EP1150973B1 (hu) |
JP (3) | JP4090200B2 (hu) |
KR (1) | KR20010102073A (hu) |
CN (1) | CN1340051A (hu) |
AP (1) | AP2001002241A0 (hu) |
AR (1) | AR028985A1 (hu) |
AT (1) | ATE297916T1 (hu) |
AU (1) | AU2124800A (hu) |
BG (1) | BG105860A (hu) |
BR (1) | BR0008202A (hu) |
CA (1) | CA2362394C (hu) |
CO (1) | CO5140097A1 (hu) |
CZ (1) | CZ20012910A3 (hu) |
DE (1) | DE60020812T2 (hu) |
DZ (1) | DZ3009A1 (hu) |
EA (1) | EA200100766A1 (hu) |
EE (1) | EE200100425A (hu) |
ES (1) | ES2243228T3 (hu) |
GT (1) | GT200000014A (hu) |
HK (1) | HK1042096A1 (hu) |
HN (1) | HN2000000019A (hu) |
HR (1) | HRP20010574A2 (hu) |
HU (1) | HUP0105231A3 (hu) |
ID (1) | ID29584A (hu) |
IL (1) | IL144307A0 (hu) |
IS (1) | IS5997A (hu) |
MA (1) | MA26718A1 (hu) |
NO (1) | NO20013909L (hu) |
OA (1) | OA11833A (hu) |
PA (1) | PA8490601A1 (hu) |
PE (1) | PE20001464A1 (hu) |
PL (1) | PL349839A1 (hu) |
SK (1) | SK11002001A3 (hu) |
SV (1) | SV2001000020A (hu) |
TN (1) | TNSN00028A1 (hu) |
TR (2) | TR200201296T2 (hu) |
WO (1) | WO2000047574A1 (hu) |
ZA (1) | ZA200106520B (hu) |
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BR112016008215A2 (pt) | 2013-10-15 | 2017-09-26 | Janssen Pharmaceutica Nv | moduladores de quinolinila ligados por alquila de roryt |
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CN108003150A (zh) * | 2016-10-31 | 2018-05-08 | 河南工业大学 | 4-杂芳基喹啉酮衍生物的制备方法及其应用 |
KR20210038906A (ko) | 2018-07-26 | 2021-04-08 | 스미토모 다이니폰 파마 온콜로지, 인크. | 비정상적 acvr1 발현과 연관된 질환을 치료하는 방법 및 그에 사용하기 위한 acvr1 억제제 |
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DE2732531A1 (de) * | 1977-07-19 | 1979-02-01 | Hoechst Ag | Imidazolcarbonsaeuren und deren derivate |
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US5053543A (en) * | 1990-11-28 | 1991-10-01 | Glaxo Inc. | Synthesis of 2-aminobenzophenones |
US5136085A (en) * | 1990-11-28 | 1992-08-04 | Glaxo Inc. | Synthesis of 2-aminobenzophenones |
TW349948B (en) | 1995-10-31 | 1999-01-11 | Janssen Pharmaceutica Nv | Farnesyl transferase inhibiting 2-quinolone derivatives |
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EP0988038B1 (en) * | 1997-06-02 | 2002-08-14 | Janssen Pharmaceutica N.V. | (imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation |
GEP20033001B (en) | 1998-08-27 | 2003-06-25 | Pfizer Prod Inc | Alkynyl-Substituted Quinolin-2-One Derivatives Useful As Anticancer Agents |
HUP0105231A3 (en) * | 1999-02-11 | 2003-01-28 | Pfizer Prod Inc | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents and medicaments containing the compounds |
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