FI66428C - Foerfarande foer framstaellning av maenniskospecifikt interferon - Google Patents
Foerfarande foer framstaellning av maenniskospecifikt interferon Download PDFInfo
- Publication number
- FI66428C FI66428C FI790188A FI790188A FI66428C FI 66428 C FI66428 C FI 66428C FI 790188 A FI790188 A FI 790188A FI 790188 A FI790188 A FI 790188A FI 66428 C FI66428 C FI 66428C
- Authority
- FI
- Finland
- Prior art keywords
- interferon
- cells
- human
- animal
- permanent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/91—Cell lines ; Processes using cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (7)
1. Förfarande för framställning av människospecifikt interferon genom att odla en permanent människocellinje, utsätta de erhallna cellerna för inverkan av en interferoninducer för inducering av produktionen av människospecifikt interferon och uppsamla och rena interferonet, kännetecknat av att man i odlings-skedet transplanterar den permanenta människocellinjen tili kroppen av ett varmblodigt djur - exklusive människan - och att inducerskedet utförs in vitro eller in vivo, varvid kvaliteten hos och kvantiteten av interferonet förbättras avsevärt.
2. Förfarande för framställning av människocpecifikt interferon genom att odla en permanent människocellinje, utsätta de erhällna cellerna för inverkan av en interferoninducer för inducering av produktionen av människospecifikt interferon och uppsamla och rena interferonet, kännetecknat av att man i odlings-skedet inokulerar den permanenta människocellinjen i ett närings-medium i en diffusionskammare, som har porer med en diameter av -7 -5 cirka 10 - 10 m, placerar diffusionskammaren i eller pä kroppen av ett varmblodigt djur - exklusive människan - pä sä sätt att djurets näringskroppsvätska har tillträde tili kammaren, och tilläter cellerna att förökas samtidigt som djuret tilläts ge cellerna av sin näringskroppsvätska, och att inducerskedet utförs in vitro eller in vivo, varvid kvaliteten hos och kvantiteten av interferonet förbättras avsevärt.
3. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att den permanenta människocellinjen härrör sig frän människoleukocyter eller -lymfocyter.
4. Förfarande enligt patentkravet 1 eller 2, kännetecknat av att den permanenta människocellinjen är Namalva, BALL-1, NALL-1, TALL-1 eller JBL.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP536878 | 1978-01-22 | ||
JP536878A JPS5498307A (en) | 1978-01-22 | 1978-01-22 | Production of interferon |
JP13402678A JPS5562024A (en) | 1978-10-31 | 1978-10-31 | Preventive and remedy for interferon-sensitive disease |
JP13402678 | 1978-10-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI790188A FI790188A (fi) | 1979-07-23 |
FI66428B FI66428B (fi) | 1984-06-29 |
FI66428C true FI66428C (fi) | 1984-10-10 |
Family
ID=26339293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI790188A FI66428C (fi) | 1978-01-22 | 1979-01-19 | Foerfarande foer framstaellning av maenniskospecifikt interferon |
Country Status (14)
Country | Link |
---|---|
US (1) | US4276282A (sv) |
AU (1) | AU533201B2 (sv) |
CA (1) | CA1135186A (sv) |
CH (1) | CH637831A5 (sv) |
DE (1) | DE2902136C2 (sv) |
DK (1) | DK153848C (sv) |
ES (1) | ES477060A1 (sv) |
FI (1) | FI66428C (sv) |
FR (1) | FR2414920A1 (sv) |
GB (1) | GB2016015B (sv) |
IT (1) | IT1116493B (sv) |
NL (1) | NL192086C (sv) |
NO (1) | NO152976C (sv) |
SE (1) | SE436969B (sv) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5598118A (en) * | 1979-01-18 | 1980-07-25 | Hayashibara Takeshi | Preparation of type-2 interferon and drug containing the same |
JPS55122717A (en) * | 1979-03-15 | 1980-09-20 | Asai Gerumaniumu Kenkyusho:Kk | Interferon inducer |
EP0039325A1 (de) * | 1979-10-19 | 1981-11-11 | ROMANO, Amalia | Mittel zur behandlung von virusinfektionen des auges und anderer organe |
US4328207A (en) * | 1979-12-27 | 1982-05-04 | Ken Hayashibara | Process for preparing mouse interferon |
US4396601A (en) * | 1980-03-26 | 1983-08-02 | The Regents Of The University Of Calif. | Gene transfer in intact mammals |
US4497796A (en) * | 1980-03-26 | 1985-02-05 | The Regents Of The University Of California | Gene transfer in intact mammals |
US4621053A (en) * | 1980-07-30 | 1986-11-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of human peptide hormones |
JPS5739795A (en) * | 1980-08-22 | 1982-03-05 | Hayashibara Biochem Lab Inc | Preparation of human prolactin |
JPS6045848B2 (ja) * | 1980-07-31 | 1985-10-12 | 株式会社林原生物化学研究所 | ヒト成長ホルモンの製造方法 |
JPS5729294A (en) * | 1980-07-30 | 1982-02-17 | Hayashibara Biochem Lab Inc | Preparation of human insulin |
JPS6045850B2 (ja) * | 1980-12-13 | 1985-10-12 | 株式会社林原生物化学研究所 | ヒト副腎皮質刺激ホルモンの製法 |
JPS6045851B2 (ja) * | 1980-12-19 | 1985-10-12 | 株式会社林原生物化学研究所 | ヒト胎盤性ラクトゲンの製造方法 |
JPS5825440B2 (ja) * | 1980-12-30 | 1983-05-27 | 株式会社林原生物化学研究所 | ヒトカルシトニンの製造方法 |
JPS5826317B2 (ja) * | 1980-12-30 | 1983-06-02 | 株式会社 林原生物化学研究所 | ヒト甲状腺刺激ホルモンの製造方法 |
JPS5825439B2 (ja) * | 1980-12-30 | 1983-05-27 | 株式会社林原生物化学研究所 | ヒト副甲状腺ホルモンの製造方法 |
US4462985A (en) * | 1980-08-22 | 1984-07-31 | University Of Illinois Foundation | Delivery of biologically active components of heterologous species interferon isolates |
JPS586475B2 (ja) * | 1980-08-23 | 1983-02-04 | 株式会社 林原生物化学研究所 | ヒト絨毛性性腺刺激ホルモンの製造方法 |
JPS6045849B2 (ja) * | 1980-08-25 | 1985-10-12 | 林原 健 | ヒトエリトロポエチンの製造方法 |
JPS5743696A (en) * | 1980-08-27 | 1982-03-11 | Hayashibara Biochem Lab Inc | Preparation of human luteinizing hormone |
JPS585671B2 (ja) * | 1980-08-27 | 1983-02-01 | 株式会社 林原生物化学研究所 | ヒト卵胞刺激ホルモンの製造方法 |
JPS5852634B2 (ja) * | 1980-12-05 | 1983-11-24 | 株式会社林原生物化学研究所 | ウロキナ−ゼの製造法 |
JPS609795B2 (ja) * | 1980-12-11 | 1985-03-13 | 株式会社林原生物化学研究所 | ヒト上皮細胞成長因子の製造方法 |
US4364863A (en) * | 1980-12-29 | 1982-12-21 | Schering Corporation | Extraction of interferon from bacteria |
JPS6030657B2 (ja) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | ヒト細胞増殖促進因子の製造方法 |
JPS6030654B2 (ja) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | ヒトコロニ−刺激因子の製造方法 |
DE3249946C2 (de) * | 1981-07-21 | 1996-03-21 | Hayashibara Biochem Lab | hTNF-haltiges therapeutisches Mittel gegen maligne Tumoren und dessen Verwendung |
FR2513124B1 (fr) * | 1981-07-21 | 1989-11-17 | Hayashibara Biochem Lab | Production et applications du facteur de lyse des cellules-cibles |
EP0090837A1 (en) * | 1981-10-08 | 1983-10-12 | BERG, Kurt Frimann | Method and composition for treating a patient suffering from interferonsusceptible disorder |
US4675295A (en) * | 1981-10-28 | 1987-06-23 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for producing subculturable lymphokine-producing human T cell hybridomas |
JPS58126786A (ja) * | 1982-01-25 | 1983-07-28 | Hayashibara Biochem Lab Inc | ヒトカリクレインの製造方法 |
JPS58138395A (ja) * | 1982-02-12 | 1983-08-17 | Hayashibara Biochem Lab Inc | ヒト免疫応答抑制因子の製造方法 |
US4624917A (en) * | 1982-02-17 | 1986-11-25 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of human T-cell growth factor |
US4987079A (en) * | 1982-07-06 | 1991-01-22 | Wilbur D. Smith | Composition and method for in vitro cell culture |
JPS59501533A (ja) * | 1982-08-10 | 1984-08-30 | ザ トラステイ− オブ コロンビア ユニバ−シテイ− イン ザ シテイ オブ ニユ− ヨ−ク | 蛋白質様物質の製造における真生核促進体連鎖の使用 |
US5702699A (en) * | 1982-09-23 | 1997-12-30 | Cetus Corporation | Process for the recovery of lipophilic proteins |
US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4820515A (en) * | 1982-12-13 | 1989-04-11 | Texas A&M University System | Method of using interferon in low dosage to regulate appetite and efficiency of food utilization |
US5910304A (en) * | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
US4489163A (en) | 1983-04-14 | 1984-12-18 | The Salk Institute For Biological Studies | rCRF and analogs |
WO1984004887A1 (en) * | 1983-06-13 | 1984-12-20 | Ragnvald Erik Lindblom | A METHOD OF TREATING INTERFERON SENSITIVE DISEASES, AND A METHOD AND A DEVICE FOR PREPARING A gamma-INTERFERON CONTAINING PREPARATION |
US4680174A (en) * | 1984-05-24 | 1987-07-14 | Damon Biotech, Inc. | Induction of immune response by immunization with encapsulated antigen-producing cells |
US5019385A (en) * | 1984-11-09 | 1991-05-28 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Novel lymphopine LK 2 and pharmaceutic compositions containing same |
ZA878295B (en) * | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
CA1320905C (en) * | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
US5175385A (en) * | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
DE3731255A1 (de) * | 1987-09-17 | 1989-04-06 | Boehringer Ingelheim Int | Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen |
US5017371A (en) * | 1988-01-06 | 1991-05-21 | Amarillo Cell Culture Company, Incorporated | Method for reducing side effects of cancer therapy |
JPH0665297A (ja) * | 1992-08-21 | 1994-03-08 | Hayashibara Biochem Lab Inc | メラニン合成抑制蛋白質とその製造方法並びに用途 |
EP0619120B1 (en) * | 1993-04-09 | 2002-09-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Use of human interferon-alpha for the manufacture of a medicament for treatment of respiratory disease in cats |
JP4004088B2 (ja) * | 1995-09-26 | 2007-11-07 | 株式会社林原生物化学研究所 | 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質 |
US7135458B1 (en) | 1995-11-15 | 2006-11-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use |
US5723718A (en) * | 1994-12-20 | 1998-03-03 | St. Joseph's Hospital And Medical Center | Induction of immune tolerance to tumor cells |
US5939286A (en) * | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
US6204022B1 (en) | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
JPH1080270A (ja) * | 1996-07-19 | 1998-03-31 | Hayashibara Biochem Lab Inc | ポリペプチドをプロセッシングする酵素 |
TW515843B (en) * | 1996-07-25 | 2003-01-01 | Hayashibara Biochem Lab | Process for producing an active polypeptide inducing interferon-γ production |
DE69933528T2 (de) * | 1998-11-09 | 2007-08-09 | Nippon Biologicals, Inc. | Verfahren zur Cytokinproduktionn unter Verwendung eines Sendai Virus Expressionssystems |
EP1092773A3 (en) * | 1999-10-15 | 2001-08-08 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Polypeptide and uses thereof |
JP2002201141A (ja) * | 2000-10-27 | 2002-07-16 | Hayashibara Biochem Lab Inc | 蛋白質合成抑制遺伝子の発現増強剤 |
JP2005525784A (ja) * | 2001-08-12 | 2005-09-02 | ペプジェン コーポレイション | ハイブリッドインターフェロン/インターフェロンτタンパク質、組成物、および使用方法 |
EP2978438A1 (en) | 2013-03-29 | 2016-02-03 | Centre National de la Recherche Scientifique (C.N.R.S.) | Cgrp receptor agonist for hiv treatment or prevention |
WO2015140348A2 (en) | 2014-03-21 | 2015-09-24 | Centre National De La Recherche Scientifique (Cnrs) | Use of dj-1 deglycase activity |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR6914761D0 (pt) * | 1969-01-17 | 1973-03-08 | Merck & Co Inc | Processos quimicos |
-
1979
- 1979-01-11 GB GB7901089A patent/GB2016015B/en not_active Expired
- 1979-01-12 AU AU43345/79A patent/AU533201B2/en not_active Expired
- 1979-01-19 DK DK025579A patent/DK153848C/da not_active IP Right Cessation
- 1979-01-19 FI FI790188A patent/FI66428C/fi not_active IP Right Cessation
- 1979-01-19 DE DE2902136A patent/DE2902136C2/de not_active Expired
- 1979-01-19 SE SE7900493A patent/SE436969B/sv not_active IP Right Cessation
- 1979-01-19 IT IT47712/79A patent/IT1116493B/it active
- 1979-01-19 NO NO790195A patent/NO152976C/no unknown
- 1979-01-19 CH CH54179A patent/CH637831A5/fr not_active IP Right Cessation
- 1979-01-19 FR FR7901324A patent/FR2414920A1/fr active Granted
- 1979-01-22 NL NL7900476A patent/NL192086C/nl not_active IP Right Cessation
- 1979-01-22 CA CA000320042A patent/CA1135186A/en not_active Expired
- 1979-01-22 ES ES477060A patent/ES477060A1/es not_active Expired
- 1979-01-22 US US06/005,585 patent/US4276282A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4276282A (en) | 1981-06-30 |
AU4334579A (en) | 1979-08-02 |
DK153848C (da) | 1989-04-03 |
NL192086B (nl) | 1996-10-01 |
SE436969B (sv) | 1985-02-04 |
FR2414920A1 (fr) | 1979-08-17 |
NL192086C (nl) | 1997-02-04 |
FI66428B (fi) | 1984-06-29 |
NO790195L (no) | 1979-07-24 |
DK25579A (da) | 1979-07-23 |
FI790188A (fi) | 1979-07-23 |
CH637831A5 (fr) | 1983-08-31 |
NO152976C (no) | 1985-12-27 |
ES477060A1 (es) | 1979-12-16 |
NL7900476A (nl) | 1979-07-24 |
DK153848B (da) | 1988-09-12 |
DE2902136C2 (de) | 1986-09-04 |
AU533201B2 (en) | 1983-11-10 |
GB2016015B (en) | 1982-05-06 |
NO152976B (no) | 1985-09-16 |
SE7900493L (sv) | 1979-07-23 |
IT1116493B (it) | 1986-02-10 |
FR2414920B1 (sv) | 1982-08-06 |
IT7947712A0 (it) | 1979-01-19 |
DE2902136A1 (de) | 1979-08-09 |
CA1135186A (en) | 1982-11-09 |
GB2016015A (en) | 1979-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired | ||
MA | Patent expired |
Owner name: ASHIDA, SHIN Owner name: HAYASHIBARA, KEN |