EA201171066A1 - Новые замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы - Google Patents
Новые замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазыInfo
- Publication number
- EA201171066A1 EA201171066A1 EA201171066A EA201171066A EA201171066A1 EA 201171066 A1 EA201171066 A1 EA 201171066A1 EA 201171066 A EA201171066 A EA 201171066A EA 201171066 A EA201171066 A EA 201171066A EA 201171066 A1 EA201171066 A1 EA 201171066A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzimidazole
- substituted derivatives
- modulators
- gamma
- secretis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Изобретение относится к новым замещенным производным бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина формулы (I) , где R, R, R, R, X, А, А, А, А, Y, Y, Yи Z имеют указанные в формуле изобретения значения. Соединения согласно настоящему изобретению пригодны в качестве модуляторов гамма-секретазы. Изобретение, далее, относится к способам получения таких новых соединений, фармацевтическим композициям, включающим вышеуказанные соединения в качестве активного ингредиента, а также к применению вышеуказанных соединений в качестве лекарственного средства.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09153188 | 2009-02-19 | ||
EP09163409 | 2009-06-22 | ||
PCT/EP2010/051843 WO2010094647A1 (en) | 2009-02-19 | 2010-02-15 | Novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives as gamma secretase modulators |
Publications (2)
Publication Number | Publication Date |
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EA201171066A1 true EA201171066A1 (ru) | 2012-04-30 |
EA020141B1 EA020141B1 (ru) | 2014-08-29 |
Family
ID=42136263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171066A EA020141B1 (ru) | 2009-02-19 | 2010-02-15 | Замещенные производные бензоксазола, бензимидазола, оксазолопиридина и имидазопиридина в качестве модуляторов гамма-секретазы |
Country Status (18)
Country | Link |
---|---|
US (1) | US8772504B2 (ru) |
EP (1) | EP2398793B1 (ru) |
JP (1) | JP5512705B2 (ru) |
KR (1) | KR20110124772A (ru) |
CN (1) | CN102341388B (ru) |
AR (1) | AR075520A1 (ru) |
AU (1) | AU2010215579B2 (ru) |
BR (1) | BRPI1016120A2 (ru) |
CA (1) | CA2749495A1 (ru) |
EA (1) | EA020141B1 (ru) |
ES (1) | ES2452881T3 (ru) |
IL (1) | IL214687A (ru) |
MX (1) | MX2011008754A (ru) |
MY (1) | MY151983A (ru) |
SG (1) | SG173668A1 (ru) |
TW (1) | TWI461425B (ru) |
WO (1) | WO2010094647A1 (ru) |
ZA (1) | ZA201106086B (ru) |
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2010
- 2010-02-12 TW TW099104538A patent/TWI461425B/zh not_active IP Right Cessation
- 2010-02-15 CN CN201080008839.XA patent/CN102341388B/zh not_active Expired - Fee Related
- 2010-02-15 SG SG2011058245A patent/SG173668A1/en unknown
- 2010-02-15 ES ES10706973.4T patent/ES2452881T3/es active Active
- 2010-02-15 EA EA201171066A patent/EA020141B1/ru not_active IP Right Cessation
- 2010-02-15 WO PCT/EP2010/051843 patent/WO2010094647A1/en active Application Filing
- 2010-02-15 BR BRPI1016120A patent/BRPI1016120A2/pt not_active IP Right Cessation
- 2010-02-15 EP EP10706973.4A patent/EP2398793B1/en active Active
- 2010-02-15 JP JP2011550537A patent/JP5512705B2/ja not_active Expired - Fee Related
- 2010-02-15 US US13/144,557 patent/US8772504B2/en active Active
- 2010-02-15 MY MYPI2011003788 patent/MY151983A/en unknown
- 2010-02-15 CA CA2749495A patent/CA2749495A1/en not_active Abandoned
- 2010-02-15 AU AU2010215579A patent/AU2010215579B2/en not_active Ceased
- 2010-02-15 KR KR1020117021607A patent/KR20110124772A/ko not_active Application Discontinuation
- 2010-02-15 MX MX2011008754A patent/MX2011008754A/es not_active Application Discontinuation
- 2010-02-18 AR ARP100100483A patent/AR075520A1/es unknown
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2011
- 2011-08-16 IL IL214687A patent/IL214687A/en not_active IP Right Cessation
- 2011-08-18 ZA ZA2011/06086A patent/ZA201106086B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2011008754A (es) | 2011-09-09 |
BRPI1016120A2 (pt) | 2016-04-12 |
CA2749495A1 (en) | 2010-08-26 |
SG173668A1 (en) | 2011-09-29 |
ZA201106086B (en) | 2015-04-29 |
KR20110124772A (ko) | 2011-11-17 |
US8772504B2 (en) | 2014-07-08 |
WO2010094647A1 (en) | 2010-08-26 |
CN102341388B (zh) | 2014-05-07 |
TW201040177A (en) | 2010-11-16 |
AU2010215579A1 (en) | 2011-08-04 |
TWI461425B (zh) | 2014-11-21 |
AR075520A1 (es) | 2011-04-06 |
CN102341388A (zh) | 2012-02-01 |
US20120022090A1 (en) | 2012-01-26 |
JP5512705B2 (ja) | 2014-06-04 |
EP2398793B1 (en) | 2013-12-18 |
EP2398793A1 (en) | 2011-12-28 |
IL214687A (en) | 2015-01-29 |
AU2010215579B2 (en) | 2014-04-10 |
ES2452881T3 (es) | 2014-04-03 |
JP2012518024A (ja) | 2012-08-09 |
IL214687A0 (en) | 2011-11-30 |
EA020141B1 (ru) | 2014-08-29 |
MY151983A (en) | 2014-07-31 |
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