EA201892734A1 - ПРОИЗВОДНЫЕ АЗАБЕНЗИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ pI3K BETA - Google Patents

ПРОИЗВОДНЫЕ АЗАБЕНЗИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ pI3K BETA

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Publication number
EA201892734A1
EA201892734A1 EA201892734A EA201892734A EA201892734A1 EA 201892734 A1 EA201892734 A1 EA 201892734A1 EA 201892734 A EA201892734 A EA 201892734A EA 201892734 A EA201892734 A EA 201892734A EA 201892734 A1 EA201892734 A1 EA 201892734A1
Authority
EA
Eurasian Patent Office
Prior art keywords
integrator
beta inhibitors
pi3k beta
azabenzimidazole
derivatives
Prior art date
Application number
EA201892734A
Other languages
English (en)
Other versions
EA037871B1 (ru
Inventor
Изабелль Ноэлль Констанс Пилатт
Оливье Алексис Жорж Керолль
Патрик Рене Анжибо
Дидье Жан-Клод Бертело
Софи Купа
Кристоф Габриэль Марсель Деместр
Ливен Мерпул
Гийом Жан Морис Мерсе
Лоранс Анна Мевеллек
Кристоф Мейер
Элизабет Терез Жанн Паскье
Виржини Софи Понселе
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201892734A1 publication Critical patent/EA201892734A1/ru
Publication of EA037871B1 publication Critical patent/EA037871B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Настоящее изобретение относится к производным азабензимидазола формулы (I)где переменные имеют значения, определенные в формуле изобретения. Соединения согласно настоящему изобретению являются пригодными в качестве ингибиторов pI3Kβ. Кроме того, настоящее изобретение относится к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного препарата.
EA201892734A 2016-06-16 2017-06-15 Производные азабензимидазола в качестве ингибиторов pi3k beta EA037871B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16174712 2016-06-16
PCT/EP2017/064672 WO2017216293A1 (en) 2016-06-16 2017-06-15 Azabenzimidazole derivatives as pi3k beta inhibitors

Publications (2)

Publication Number Publication Date
EA201892734A1 true EA201892734A1 (ru) 2019-05-31
EA037871B1 EA037871B1 (ru) 2021-05-28

Family

ID=56132833

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892734A EA037871B1 (ru) 2016-06-16 2017-06-15 Производные азабензимидазола в качестве ингибиторов pi3k beta

Country Status (13)

Country Link
US (1) US20190263804A1 (ru)
EP (1) EP3472147B1 (ru)
JP (1) JP7158286B2 (ru)
KR (1) KR102472198B1 (ru)
CN (1) CN109311843B (ru)
AU (1) AU2017286380B2 (ru)
BR (1) BR112018076169A2 (ru)
CA (1) CA3025746A1 (ru)
EA (1) EA037871B1 (ru)
ES (1) ES2818620T3 (ru)
IL (1) IL263653A (ru)
MX (1) MX2018015709A (ru)
WO (1) WO2017216293A1 (ru)

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CN111989323A (zh) 2018-04-12 2020-11-24 拜耳公司 作为农药的n-(环丙基甲基)-5-(甲基磺酰基)-n-{1-[1-(嘧啶-2-基)-1h-1，2，4-***-5-基]乙基}苯甲酰胺衍生物及相应的吡啶甲酰胺衍生物
US11485741B2 (en) 2018-04-24 2022-11-01 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (TLR7) agonists
CA3098061A1 (en) 2018-04-25 2019-10-31 Bayer Aktiengesellschaft Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
JP2022541807A (ja) 2019-07-23 2022-09-27 バイエル・アクチエンゲゼルシヤフト 殺有害生物剤としての新規なヘテロアリール－トリアゾール化合物
CN110551101B (zh) * 2019-08-28 2020-11-24 沈阳药科大学 1、6-二取代-苯并五元杂环类衍生物及其用途
CN114867529A (zh) 2019-10-09 2022-08-05 拜耳公司 作为农药的新的杂芳基***化合物
WO2021154662A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
EP4097104A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
CN115135654A (zh) 2020-01-27 2022-09-30 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
WO2021154669A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
CN115210236A (zh) 2020-01-27 2022-10-18 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
WO2021154668A1 (en) 2020-01-27 2021-08-05 Bristol-Myers Squibb Company 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
US20230127326A1 (en) 2020-01-27 2023-04-27 Bristol-Myers Squibb Company C3-SUBSTITUTED 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
CN115135655A (zh) 2020-01-27 2022-09-30 百时美施贵宝公司 作为Toll样受体7(TLR7)激动剂的1H-吡唑并[4,3-d]嘧啶化合物
EP4097100A1 (en) 2020-01-27 2022-12-07 Bristol-Myers Squibb Company 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists
TW202342475A (zh) * 2022-02-18 2023-11-01 大陸商四川海思科製藥有限公司 一種吡唑並吡啶衍生物及其在醫藥上的應用

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US5177074A (en) * 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
EP1993537A4 (en) 2006-03-02 2010-05-19 Glaxosmithkline Llc THIAZOLONES AS INHIBITORS OF P13-KINASES
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Also Published As

Publication number Publication date
CN109311843A (zh) 2019-02-05
AU2017286380B2 (en) 2021-02-04
EP3472147B1 (en) 2020-06-17
JP2019518059A (ja) 2019-06-27
EA037871B1 (ru) 2021-05-28
US20190263804A1 (en) 2019-08-29
AU2017286380A1 (en) 2018-12-06
CA3025746A1 (en) 2017-12-21
EP3472147A1 (en) 2019-04-24
IL263653A (en) 2019-01-31
KR102472198B1 (ko) 2022-11-28
MX2018015709A (es) 2019-03-21
JP7158286B2 (ja) 2022-10-21
KR20190016976A (ko) 2019-02-19
ES2818620T3 (es) 2021-04-13
BR112018076169A2 (pt) 2019-03-26
CN109311843B (zh) 2021-10-08
WO2017216293A1 (en) 2017-12-21

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