PA8854101A1 - Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa - Google Patents
Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasaInfo
- Publication number
- PA8854101A1 PA8854101A1 PA20098854101A PA8854101A PA8854101A1 PA 8854101 A1 PA8854101 A1 PA 8854101A1 PA 20098854101 A PA20098854101 A PA 20098854101A PA 8854101 A PA8854101 A PA 8854101A PA 8854101 A1 PA8854101 A1 PA 8854101A1
- Authority
- PA
- Panama
- Prior art keywords
- secretasa
- modulators
- gamma
- imidazol
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS DERIVADOS DE IMIDAZOL BICÍCLICOS SUSTITUIDOS DE FÓRMULA (1) EN DONDE R0, R1, R3, R4, X, A1, A2, A3, A4, Y1, Y2 E Y3 TIENEN EL SIGNIFICADO DEFINIDO EN LAS REIVINDICACIONES. LOS COMPUESTOS DE ACUERDO CON LA PRESENTE INVENCIÓN SON ÚTILES COMO MODULADORES DE GAMMA SECRETASA. LA INVENCIÓN TAMBIÉN SE REFIERE A PROCESOS PARA PREPARAR DICHOS NUEVOS COMPUESTOS, A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS NUEVOS COMPUESTOS COMO INGREDIENTES ACTIVOS, ASÍ COMO AL USO DE DICHOS COMPUESTOS COMO MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08172202 | 2008-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8854101A1 true PA8854101A1 (es) | 2010-07-27 |
Family
ID=40451180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20098854101A PA8854101A1 (es) | 2008-12-18 | 2009-12-15 | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
Country Status (21)
Country | Link |
---|---|
US (1) | US8546440B2 (es) |
EP (1) | EP2379552B1 (es) |
JP (2) | JP2012512831A (es) |
KR (1) | KR20110102455A (es) |
CN (1) | CN102256974B (es) |
AP (1) | AP2011005692A0 (es) |
AR (1) | AR074771A1 (es) |
AU (1) | AU2009327103B2 (es) |
BR (1) | BRPI0922664A2 (es) |
CA (1) | CA2742914A1 (es) |
EA (1) | EA018625B1 (es) |
ES (1) | ES2460642T3 (es) |
IL (1) | IL213563A (es) |
MX (1) | MX2011006543A (es) |
NZ (1) | NZ594036A (es) |
PA (1) | PA8854101A1 (es) |
SG (1) | SG172213A1 (es) |
TW (1) | TWI438203B (es) |
UA (1) | UA104151C2 (es) |
WO (1) | WO2010070008A1 (es) |
ZA (1) | ZA201104504B (es) |
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US7868001B2 (en) * | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
CA2742897A1 (en) | 2008-11-06 | 2010-05-14 | Astrazeneca Ab | Modulators of amyloid beta. |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
CA2806655A1 (en) | 2010-07-28 | 2012-02-02 | Bayer Intellectual Property Gmbh | Substituted imidazo[1,2-b]pyridazines |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
ES2545135T3 (es) | 2011-04-06 | 2015-09-08 | Bayer Pharma Aktiengesellschaft | Imidazopiridinas sustituidas y compuestos intermedios de las mismas |
EA024890B1 (ru) | 2011-04-07 | 2016-10-31 | Байер Интеллектчуал Проперти Гмбх | Имидазопиридазины в качестве ингибиторов akt киназы |
IN2014MN00258A (es) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
AU2012325916A1 (en) * | 2011-10-20 | 2014-05-01 | Glaxosmithkline Llc | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
KR20140077963A (ko) | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
BR112014008126A2 (pt) | 2011-11-01 | 2017-04-18 | Hoffmann La Roche | composto, método para o tratamento, composição farmacêutica, utilização de um composto e invenção |
JP6109192B2 (ja) | 2012-01-10 | 2017-04-05 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピリダジンアミド化合物及びsyk阻害剤としてのそれらの使用 |
JP6106745B2 (ja) * | 2012-05-16 | 2017-04-05 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | (特に)アルツハイマー病の治療に有用な置換3,4−ジヒドロ−2H−ピリド[1,2−a]ピラジン−1,6−ジオン誘導体 |
FR2993564B1 (fr) | 2012-07-20 | 2014-08-22 | Metabrain Res | Derives d'imidazopyridine utiles dans le traitement du diabete |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US10112943B2 (en) | 2012-12-20 | 2018-10-30 | Janssen Pharmaceutica Nv | Substituted imidazoles as gamma secretase modulators |
AU2014206834B2 (en) | 2013-01-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
EA032662B1 (ru) * | 2013-06-12 | 2019-06-28 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE) |
AU2014280124B2 (en) * | 2013-06-12 | 2018-11-01 | Janssen Pharmaceutica Nv | 4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (BACE) |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
US9856263B2 (en) | 2014-04-28 | 2018-01-02 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
CA2967164A1 (en) | 2014-12-18 | 2016-06-23 | Janssen Pharmaceutica Nv | 2,3,4,5-tetrahydropyridin-6-amine and 3,4-dihydro-2h-pyrrol-5-amine compound inhibitors of beta-secretase |
ES2842749T3 (es) * | 2014-12-23 | 2021-07-14 | Gilead Sciences Inc | Procesos para preparar inhibidores de ASK1 |
MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
JP6628805B2 (ja) | 2015-02-03 | 2020-01-15 | ファイザー・インク | 新規シクロプロパベンゾフラニルピリドピラジンジオン |
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US11339138B2 (en) * | 2018-10-05 | 2022-05-24 | E. I. Du Pont De Nemours And Company | Process and intermediates for the preparation of certain nematicidal sulfonamides |
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CA2406383A1 (en) | 2000-04-13 | 2001-10-25 | Mayo Foundation For Medical Education And Research | A.beta.42 lowering agents |
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DE602005023965D1 (de) | 2004-03-08 | 2010-11-18 | Prosidion Ltd | Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase |
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CN101631786A (zh) * | 2006-12-20 | 2010-01-20 | 先灵公司 | 新颖的jnk抑制剂 |
US8183276B2 (en) | 2007-02-08 | 2012-05-22 | Christian Fischer | Therapeutic agents |
EP2155737A1 (en) * | 2007-05-07 | 2010-02-24 | Schering Corporation | Gamma secretase modulators |
KR101138045B1 (ko) | 2007-05-11 | 2012-04-24 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타에 대한 조절제로서의 헤트아릴아닐린 |
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JP2010538068A (ja) | 2007-09-06 | 2010-12-09 | シェーリング コーポレイション | ガンマセクレターゼモジュレーター |
EP2210102A2 (en) | 2007-10-19 | 2010-07-28 | Erac As | Edta resistant s100a12 complexes (erac) |
MX2010006243A (es) | 2007-12-06 | 2010-08-31 | Schering Corp | Moduladores de gamma secretasa. |
MX2010006378A (es) | 2007-12-11 | 2010-09-07 | Schering Corp | Moduladores de gamma secretasa. |
CN101952275B (zh) | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
EP2356115A1 (en) * | 2008-11-06 | 2011-08-17 | Schering Corporation | Gamma secretase modulators |
EP2367817A4 (en) | 2008-12-03 | 2012-05-09 | Via Pharmaceuticals Inc | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE ENZYME |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
CN102325765B (zh) | 2009-02-06 | 2014-12-24 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的双环杂环化合物 |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
WO2010126745A1 (en) | 2009-04-27 | 2010-11-04 | High Point Pharmaceuticals, Llc | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS |
CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
KR20120050450A (ko) | 2009-07-15 | 2012-05-18 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절제로서의 치환된 트리아졸 및 이미다졸 유도체 |
-
2009
- 2009-12-15 PA PA20098854101A patent/PA8854101A1/es unknown
- 2009-12-16 ES ES09797025.5T patent/ES2460642T3/es active Active
- 2009-12-16 EA EA201170829A patent/EA018625B1/ru not_active IP Right Cessation
- 2009-12-16 KR KR1020117016065A patent/KR20110102455A/ko not_active Application Discontinuation
- 2009-12-16 AP AP2011005692A patent/AP2011005692A0/xx unknown
- 2009-12-16 EP EP09797025.5A patent/EP2379552B1/en active Active
- 2009-12-16 US US13/133,027 patent/US8546440B2/en active Active
- 2009-12-16 UA UAA201105485A patent/UA104151C2/ru unknown
- 2009-12-16 AU AU2009327103A patent/AU2009327103B2/en not_active Ceased
- 2009-12-16 BR BRPI0922664A patent/BRPI0922664A2/pt not_active IP Right Cessation
- 2009-12-16 MX MX2011006543A patent/MX2011006543A/es active IP Right Grant
- 2009-12-16 NZ NZ594036A patent/NZ594036A/xx not_active IP Right Cessation
- 2009-12-16 SG SG2011044310A patent/SG172213A1/en unknown
- 2009-12-16 WO PCT/EP2009/067321 patent/WO2010070008A1/en active Application Filing
- 2009-12-16 CA CA2742914A patent/CA2742914A1/en not_active Abandoned
- 2009-12-16 CN CN200980151827.XA patent/CN102256974B/zh active Active
- 2009-12-16 JP JP2011541412A patent/JP2012512831A/ja active Pending
- 2009-12-17 AR ARP090104939A patent/AR074771A1/es not_active Application Discontinuation
- 2009-12-17 TW TW098143263A patent/TWI438203B/zh not_active IP Right Cessation
-
2011
- 2011-06-15 IL IL213563A patent/IL213563A/en not_active IP Right Cessation
- 2011-06-17 ZA ZA2011/04504A patent/ZA201104504B/en unknown
-
2015
- 2015-06-25 JP JP2015127609A patent/JP2015164969A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2742914A1 (en) | 2010-06-24 |
CN102256974A (zh) | 2011-11-23 |
AP2011005692A0 (en) | 2011-06-30 |
ZA201104504B (en) | 2014-01-29 |
JP2012512831A (ja) | 2012-06-07 |
MX2011006543A (es) | 2011-07-20 |
IL213563A0 (en) | 2011-07-31 |
AU2009327103A1 (en) | 2011-07-21 |
NZ594036A (en) | 2012-10-26 |
TWI438203B (zh) | 2014-05-21 |
AR074771A1 (es) | 2011-02-09 |
UA104151C2 (ru) | 2014-01-10 |
SG172213A1 (en) | 2011-07-28 |
CN102256974B (zh) | 2014-07-30 |
JP2015164969A (ja) | 2015-09-17 |
US20110237580A1 (en) | 2011-09-29 |
EA018625B1 (ru) | 2013-09-30 |
EA201170829A1 (ru) | 2011-12-30 |
KR20110102455A (ko) | 2011-09-16 |
BRPI0922664A2 (pt) | 2016-01-05 |
US8546440B2 (en) | 2013-10-01 |
WO2010070008A1 (en) | 2010-06-24 |
IL213563A (en) | 2015-06-30 |
TW201035093A (en) | 2010-10-01 |
ES2460642T3 (es) | 2014-05-14 |
EP2379552A1 (en) | 2011-10-26 |
EP2379552B1 (en) | 2014-02-26 |
AU2009327103B2 (en) | 2014-12-04 |
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