EA201291282A1 - Азотсодержащие гетероарильные соединения - Google Patents
Азотсодержащие гетероарильные соединенияInfo
- Publication number
- EA201291282A1 EA201291282A1 EA201291282A EA201291282A EA201291282A1 EA 201291282 A1 EA201291282 A1 EA 201291282A1 EA 201291282 A EA201291282 A EA 201291282A EA 201291282 A EA201291282 A EA 201291282A EA 201291282 A1 EA201291282 A1 EA 201291282A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- nitrogen
- heteroarryl
- drugs
- esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Настоящее изобретение относится к новым азотсодержащим гетероарильным соединениям формулы (I)где А, А,, R, R, R, R, Rи Rтакие, как определено в описании и формуле изобретения, а также к их фармацевтически приемлемым солям и эфирам. Эти соединения ингибируют PDE10A и могут применяться в качестве лекарственных средств.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10165427 | 2010-06-09 | ||
PCT/EP2011/059234 WO2011154327A1 (en) | 2010-06-09 | 2011-06-06 | Nitrogen containing heteroaryl compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201291282A1 true EA201291282A1 (ru) | 2013-06-28 |
EA022075B1 EA022075B1 (ru) | 2015-10-30 |
Family
ID=44483879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201291282A EA022075B1 (ru) | 2010-06-09 | 2011-06-06 | Азотсодержащие гетероарильные соединения |
Country Status (24)
Country | Link |
---|---|
US (1) | US8703768B2 (ru) |
EP (1) | EP2580207B1 (ru) |
JP (1) | JP5940523B2 (ru) |
KR (1) | KR101757959B1 (ru) |
CN (1) | CN102947292B (ru) |
AR (1) | AR081649A1 (ru) |
BR (1) | BR112012031343A2 (ru) |
CA (1) | CA2799022A1 (ru) |
CL (1) | CL2012003421A1 (ru) |
CO (1) | CO6620065A2 (ru) |
CR (1) | CR20120594A (ru) |
EA (1) | EA022075B1 (ru) |
EC (1) | ECSP12012330A (ru) |
HK (1) | HK1178900A1 (ru) |
IL (1) | IL223069A0 (ru) |
MA (1) | MA34340B1 (ru) |
MX (1) | MX2012013907A (ru) |
NZ (1) | NZ603230A (ru) |
PE (1) | PE20130279A1 (ru) |
SG (1) | SG185655A1 (ru) |
TW (1) | TW201202221A (ru) |
UA (1) | UA108105C2 (ru) |
WO (1) | WO2011154327A1 (ru) |
ZA (1) | ZA201209119B (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2011119217A (ru) * | 2008-10-14 | 2012-11-27 | Актелион Фармасьютикалз Лтд | Производные фенетиламида и их гетероциклические аналоги |
MA34234B1 (fr) | 2010-04-07 | 2013-05-02 | Hoffmann La Roche | Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation |
US8772316B2 (en) | 2011-02-18 | 2014-07-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A) |
KR20140074964A (ko) | 2011-09-27 | 2014-06-18 | 에프. 호프만-라 로슈 아게 | 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 사용 방법 |
EP2712862A1 (en) * | 2012-09-28 | 2014-04-02 | Splicos | New anti-invasive compounds |
US9586948B2 (en) | 2012-10-08 | 2017-03-07 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
AU2014221799B2 (en) | 2013-02-27 | 2017-09-28 | Mochida Pharmaceutical Co., Ltd. | Novel pyrazole derivative |
ES2624453T3 (es) * | 2013-04-29 | 2017-07-14 | F. Hoffmann-La Roche Ag | Derivados de 2-fenil o 2-hetaril-imidazol[1,2-a]piridina |
GB201316600D0 (en) * | 2013-09-18 | 2013-10-30 | Redx Pharma Ltd | Agricultural chemicals |
EP3061754A4 (en) * | 2013-10-23 | 2017-03-22 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
KR20170107536A (ko) * | 2015-01-30 | 2017-09-25 | 바스프 에스이 | 제초 페닐피리미딘 |
JP6920202B2 (ja) * | 2015-02-06 | 2021-08-18 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Irak阻害剤としてのピリダジノン大環状化合物及びその使用 |
CN104610189A (zh) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途 |
CN104974075A (zh) * | 2015-08-07 | 2015-10-14 | 新秀化学(烟台)有限公司 | 一种n, n-二(2,2,6,6-四甲基-4-哌啶基) -1,3-苯二甲酰胺的制备方法 |
CN116478132A (zh) | 2016-07-12 | 2023-07-25 | 锐新医药公司 | 作为变构shp2抑制剂的2,5-双取代型及2,5,6-三取代型3-甲基吡嗪 |
WO2018019555A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
WO2018019767A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
WO2018019765A1 (en) | 2016-07-27 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
WO2018019574A1 (en) | 2016-07-28 | 2018-02-01 | Basf Se | Herbicidal pyrimidine compounds |
MX2019008696A (es) | 2017-01-23 | 2019-09-13 | Revolution Medicines Inc | Compuestos de piridina como inhibidores de shp2 alostericos. |
MX2019008695A (es) | 2017-01-23 | 2019-09-11 | Revolution Medicines Inc | Compuestos biciclicos como inhibidores alostericos de shp2. |
EP3694848A1 (en) | 2017-10-12 | 2020-08-19 | Revolution Medicines, Inc. | Pyridine, pyrazine, and triazine compounds as allosteric shp2 inhibitors |
EP3724189B1 (en) | 2017-12-15 | 2023-10-04 | Revolution Medicines, Inc. | Polycyclic compounds as allosteric shp2 inhibitors |
WO2019121352A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
WO2019123195A1 (en) * | 2017-12-20 | 2019-06-27 | Pi Industries Ltd. | Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same. |
WO2019121374A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Herbicidal pyrimidine compounds |
DK3853219T3 (da) | 2018-09-19 | 2023-10-09 | Bayer Ag | Herbicidt virksomme substituerede phenylpyrimidinhydrazider |
CA3117927A1 (en) * | 2018-11-02 | 2020-05-07 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
JP7288074B2 (ja) | 2019-10-31 | 2023-06-06 | 富士フイルム株式会社 | ピラジン誘導体またはその塩およびその利用 |
CN116056766A (zh) | 2020-07-30 | 2023-05-02 | 富士胶片株式会社 | 含氮杂环化合物或其盐、其利用以及其中间体 |
AU2021377248A1 (en) | 2020-11-13 | 2023-06-22 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
EP4319872A1 (en) * | 2021-04-05 | 2024-02-14 | Inipharm, Inc. | Thiazole/isothiazole hsd17b13 inhibitors and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9910079D0 (en) | 1999-05-01 | 1999-06-30 | Smithkline Beecham Plc | Novel compounds |
EP1193261A1 (en) | 2000-10-02 | 2002-04-03 | Warner-Lambert Company | New thiadiazoles and their use as phosphodiesterase-7 inhibitors |
US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
AU2005215379A1 (en) | 2004-02-12 | 2005-09-01 | Merck & Co., Inc. | Bipyridyl amides as modulators of metabotropic glutamate receptor-5 |
US20060199828A1 (en) | 2005-03-04 | 2006-09-07 | Georg Jaeschke | Pyrazine-2-carboxyamide derivatives |
BRPI0607583A2 (pt) * | 2005-03-04 | 2009-09-15 | Hoffmann La Roche | derivados de piridin-2-carboxamida como antagonistas mglur5, método para sua preparação, medicamento contendo os mesmos, bem como uso relacionado aos referidos compostos |
AR057987A1 (es) | 2005-11-24 | 2008-01-09 | Astrazeneca Ab | Compuestos agonistas de cb1 (receptor cannabinoide) |
MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
WO2009026241A1 (en) | 2007-08-23 | 2009-02-26 | Kalypsys, Inc. | Heterocyclic modulators of tgr5 |
US8470820B2 (en) * | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
-
2011
- 2011-06-02 US US13/151,301 patent/US8703768B2/en active Active
- 2011-06-06 CA CA2799022A patent/CA2799022A1/en not_active Abandoned
- 2011-06-06 MX MX2012013907A patent/MX2012013907A/es active IP Right Grant
- 2011-06-06 JP JP2013513638A patent/JP5940523B2/ja not_active Expired - Fee Related
- 2011-06-06 KR KR1020137000568A patent/KR101757959B1/ko active IP Right Grant
- 2011-06-06 NZ NZ603230A patent/NZ603230A/xx not_active IP Right Cessation
- 2011-06-06 SG SG2012085015A patent/SG185655A1/en unknown
- 2011-06-06 UA UAA201214955A patent/UA108105C2/ru unknown
- 2011-06-06 BR BR112012031343A patent/BR112012031343A2/pt not_active Application Discontinuation
- 2011-06-06 WO PCT/EP2011/059234 patent/WO2011154327A1/en active Application Filing
- 2011-06-06 EA EA201291282A patent/EA022075B1/ru not_active IP Right Cessation
- 2011-06-06 EP EP11723077.1A patent/EP2580207B1/en not_active Not-in-force
- 2011-06-06 PE PE2012002298A patent/PE20130279A1/es not_active Application Discontinuation
- 2011-06-06 CN CN201180027950.8A patent/CN102947292B/zh not_active Expired - Fee Related
- 2011-06-06 MA MA35502A patent/MA34340B1/fr unknown
- 2011-06-07 AR ARP110101963A patent/AR081649A1/es unknown
- 2011-06-08 TW TW100120008A patent/TW201202221A/zh unknown
-
2012
- 2012-10-26 CO CO12192367A patent/CO6620065A2/es active IP Right Grant
- 2012-11-15 IL IL223069A patent/IL223069A0/en unknown
- 2012-11-26 CR CR20120594A patent/CR20120594A/es unknown
- 2012-12-03 ZA ZA2012/09119A patent/ZA201209119B/en unknown
- 2012-12-05 CL CL2012003421A patent/CL2012003421A1/es unknown
- 2012-12-07 EC ECSP12012330 patent/ECSP12012330A/es unknown
-
2013
- 2013-05-17 HK HK13105859.4A patent/HK1178900A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1178900A1 (en) | 2013-09-19 |
AR081649A1 (es) | 2012-10-10 |
CN102947292B (zh) | 2015-08-19 |
JP5940523B2 (ja) | 2016-06-29 |
WO2011154327A1 (en) | 2011-12-15 |
KR101757959B1 (ko) | 2017-07-14 |
PE20130279A1 (es) | 2013-03-08 |
UA108105C2 (ru) | 2015-03-25 |
MA34340B1 (fr) | 2013-06-01 |
TW201202221A (en) | 2012-01-16 |
CN102947292A (zh) | 2013-02-27 |
CR20120594A (es) | 2013-01-03 |
US8703768B2 (en) | 2014-04-22 |
SG185655A1 (en) | 2012-12-28 |
EP2580207B1 (en) | 2017-09-27 |
IL223069A0 (en) | 2013-02-03 |
KR20130112858A (ko) | 2013-10-14 |
ECSP12012330A (es) | 2012-12-28 |
BR112012031343A2 (pt) | 2016-11-01 |
NZ603230A (en) | 2013-09-27 |
EP2580207A1 (en) | 2013-04-17 |
EA022075B1 (ru) | 2015-10-30 |
CA2799022A1 (en) | 2011-12-15 |
JP2013528193A (ja) | 2013-07-08 |
CO6620065A2 (es) | 2013-02-15 |
CL2012003421A1 (es) | 2013-07-26 |
ZA201209119B (en) | 2015-05-27 |
MX2012013907A (es) | 2012-12-17 |
US20110306589A1 (en) | 2011-12-15 |
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