EA201270166A1 - Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы - Google Patents
Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазыInfo
- Publication number
- EA201270166A1 EA201270166A1 EA201270166A EA201270166A EA201270166A1 EA 201270166 A1 EA201270166 A1 EA 201270166A1 EA 201270166 A EA201270166 A EA 201270166A EA 201270166 A EA201270166 A EA 201270166A EA 201270166 A1 EA201270166 A1 EA 201270166A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- triazole
- imidazole
- substituted derivatives
- gamma
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Изобретение относится к новым замещенным производным триазола и имидазола формулы (I) , где R, R, А, А, А, А, Х и Hetимеют значения, определенные в формуле изобретения. Соединения согласно настоящему изобретению пригодны в качестве модуляторов гамма-секретазы. Кроме того, изобретение относится к способам получения таких новых соединений, к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного средства.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09165585 | 2009-07-15 | ||
EP10164625 | 2010-06-01 | ||
PCT/EP2010/060083 WO2011006903A1 (en) | 2009-07-15 | 2010-07-13 | Substituted triazole and imidazole derivatives as gamma secretase modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201270166A1 true EA201270166A1 (ru) | 2012-06-29 |
EA021047B1 EA021047B1 (ru) | 2015-03-31 |
Family
ID=42542935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270166A EA021047B1 (ru) | 2009-07-15 | 2010-07-13 | Замещенные производные триазола и имидазола в качестве модуляторов гамма-секретазы |
Country Status (18)
Country | Link |
---|---|
US (1) | US8946266B2 (ru) |
EP (1) | EP2454239B1 (ru) |
JP (2) | JP2012532912A (ru) |
KR (1) | KR20120050450A (ru) |
CN (1) | CN102482227A (ru) |
AP (1) | AP2011006034A0 (ru) |
AU (1) | AU2010272578B2 (ru) |
BR (1) | BR112012000915A2 (ru) |
CA (1) | CA2778517A1 (ru) |
EA (1) | EA021047B1 (ru) |
ES (1) | ES2519565T3 (ru) |
IL (1) | IL217491A (ru) |
MX (1) | MX2012000763A (ru) |
NZ (1) | NZ597505A (ru) |
SG (1) | SG177644A1 (ru) |
TW (1) | TW201109316A (ru) |
WO (1) | WO2011006903A1 (ru) |
ZA (1) | ZA201200285B (ru) |
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NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
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KR20140047032A (ko) | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
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IN2014MN00258A (ru) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc |
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AP2011006034A0 (en) | 2011-12-31 |
BR112012000915A2 (pt) | 2019-09-24 |
US20120135981A1 (en) | 2012-05-31 |
AU2010272578B2 (en) | 2015-03-05 |
ZA201200285B (en) | 2014-06-25 |
IL217491A0 (en) | 2012-02-29 |
CN102482227A (zh) | 2012-05-30 |
WO2011006903A1 (en) | 2011-01-20 |
SG177644A1 (en) | 2012-03-29 |
IL217491A (en) | 2015-08-31 |
EP2454239B1 (en) | 2014-08-13 |
MX2012000763A (es) | 2012-02-08 |
EP2454239A1 (en) | 2012-05-23 |
ES2519565T3 (es) | 2014-11-07 |
JP2015129147A (ja) | 2015-07-16 |
AU2010272578A1 (en) | 2012-01-19 |
TW201109316A (en) | 2011-03-16 |
CA2778517A1 (en) | 2011-01-20 |
KR20120050450A (ko) | 2012-05-18 |
JP2012532912A (ja) | 2012-12-20 |
EA021047B1 (ru) | 2015-03-31 |
NZ597505A (en) | 2013-05-31 |
US8946266B2 (en) | 2015-02-03 |
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