EA201201663A1 - Производные 2-(ариламино)-3н-имидазо[4,5-b]пиридин-6-карбоксамида и их применение в качестве ингибиторов mpges-1 - Google Patents

Производные 2-(ариламино)-3н-имидазо[4,5-b]пиридин-6-карбоксамида и их применение в качестве ингибиторов mpges-1

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Publication number
EA201201663A1
EA201201663A1 EA201201663A EA201201663A EA201201663A1 EA 201201663 A1 EA201201663 A1 EA 201201663A1 EA 201201663 A EA201201663 A EA 201201663A EA 201201663 A EA201201663 A EA 201201663A EA 201201663 A1 EA201201663 A1 EA 201201663A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mpges
inhibitors
arylamino
imidazo
carboxamide
Prior art date
Application number
EA201201663A
Other languages
English (en)
Inventor
Хеннинг Припке
Хенри Додс
Раймунд Кюльцер
Роланд Пфау
Дирк Штенкамп
Беньямин Пелькман
Роберт Рённ
Димитрийс Лубрикс
Эдгарс Суна
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201201663A1 publication Critical patent/EA201201663A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Настоящее изобретение относится к соединениям формулы (I), к их применению в качестве ингибиторов микросомной простагландин-Е-синтазы-1 (mPGES-1), к фармацевтическим композициям, содержащим эти соединения, и к применению таких соединений в качестве лекарственных средств, предназначенных для лечения и/или предупреждения воспалительных заболеваний и ассоциированных патологических состояний. Значения А, М, W, R, R, R, Rприведены в описании.
EA201201663A 2010-08-20 2011-08-19 Производные 2-(ариламино)-3н-имидазо[4,5-b]пиридин-6-карбоксамида и их применение в качестве ингибиторов mpges-1 EA201201663A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10173502 2010-08-20
PCT/EP2011/064257 WO2012022792A1 (en) 2010-08-20 2011-08-19 2-(arylamino)-3h-imidazo[4,5-b]pyridine-6-carboxamide derivatives and their use as mpges-1 inhibitors

Publications (1)

Publication Number Publication Date
EA201201663A1 true EA201201663A1 (ru) 2013-08-30

Family

ID=44474976

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201663A EA201201663A1 (ru) 2010-08-20 2011-08-19 Производные 2-(ариламино)-3н-имидазо[4,5-b]пиридин-6-карбоксамида и их применение в качестве ингибиторов mpges-1

Country Status (15)

Country Link
US (1) US8586604B2 (ru)
EP (1) EP2606046A1 (ru)
JP (1) JP5554450B2 (ru)
KR (1) KR20130098305A (ru)
CN (1) CN103097382A (ru)
AR (1) AR082509A1 (ru)
AU (1) AU2011290724B2 (ru)
BR (1) BR112013003843A2 (ru)
CA (1) CA2807089A1 (ru)
CL (1) CL2013000351A1 (ru)
EA (1) EA201201663A1 (ru)
MX (1) MX2013001805A (ru)
NZ (1) NZ605432A (ru)
TW (1) TW201302741A (ru)
WO (1) WO2012022792A1 (ru)

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Also Published As

Publication number Publication date
MX2013001805A (es) 2013-04-29
CA2807089A1 (en) 2012-02-23
CL2013000351A1 (es) 2013-06-21
CN103097382A (zh) 2013-05-08
BR112013003843A2 (pt) 2016-06-28
US8586604B2 (en) 2013-11-19
WO2012022792A1 (en) 2012-02-23
AU2011290724A1 (en) 2013-01-10
JP5554450B2 (ja) 2014-07-23
TW201302741A (zh) 2013-01-16
US20120208839A1 (en) 2012-08-16
JP2013534235A (ja) 2013-09-02
NZ605432A (en) 2015-04-24
AR082509A1 (es) 2012-12-12
AU2011290724B2 (en) 2015-11-05
KR20130098305A (ko) 2013-09-04
EP2606046A1 (en) 2013-06-26

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