CY1112392T1 - Κρυσταλλικη βαση εσκιταλοπραμης και δισκια διασπειρομενα στο στομα που αποτελουνται απο βαση εσκιταλοπραμης - Google Patents
Κρυσταλλικη βαση εσκιταλοπραμης και δισκια διασπειρομενα στο στομα που αποτελουνται απο βαση εσκιταλοπραμηςInfo
- Publication number
- CY1112392T1 CY1112392T1 CY20111100116T CY111100116T CY1112392T1 CY 1112392 T1 CY1112392 T1 CY 1112392T1 CY 20111100116 T CY20111100116 T CY 20111100116T CY 111100116 T CY111100116 T CY 111100116T CY 1112392 T1 CY1112392 T1 CY 1112392T1
- Authority
- CY
- Cyprus
- Prior art keywords
- salts
- excitalopram
- escitalopram
- base
- oral
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 5
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002585 base Substances 0.000 abstract 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 239000007919 dispersible tablet Substances 0.000 abstract 2
- 229960004341 escitalopram Drugs 0.000 abstract 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- -1 oxalate Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται στην κρυσταλλική βάση του ευρέως γνωστού αντικαταθλιπτικού φαρμάκου εσκιταλοπράμη, S-1-[3-(διμεθυλαμινο)προπυλ]-1-(4-φθορο-φαινυλ)-1,3-διυδρο-5-ισοβενζοφουρανκαρβονιτρίλιο, σε συστάσεις της εν λόγω βάσεως, σε μία διαδικασία για την παρασκευή καθαρών αλάτων εσκιταλοπράμης, όπως το οξαλικό, με τη χρήση της βάσεως, στα άλατα που λαμβάνονται μέσω της εν λόγω διαδικασίας και σε συστάσεις που περιέχουν αυτά τα άλατα, και σε μία διαδικασία για την παρασκευή ελεύθερης βάσεως καθαρής εσκιταλοπράμης ή αλάτων εσκιταλοπράμης, όπως το οξαλικό, με τη χρήση της υδροβρωμικής, στα άλατα που λαμβάνονται μέσω της εν λόγω διαδικασίας και σε συστάσεις που περιέχουν αυτά τα άλατα. Τέλος η παρούσα εφεύρεση αναφέρεται σε ένα δισκίο διασπειρόμενο στο στόμα που έχει σκληρότητα τουλάχιστον 22 Ν και χρόνο αποσυνθέσεως στο στόμα μικρότερο από 120 s και περιλαμβάνει ένα δραστικό φαρμακευτικό συστατικό που προσροφάται σε έναν υδατοδιαλυτό παράγοντα πληρώσεως όπου το δραστικό φαρμακευτικό συστατικό έχει σημείο τήξεως στο εύρος των 40-100°C, καθώς επίσης και σε μία μέθοδο για τη δημιουργία αυτού του δισκίου του διασπειρόμενου στο στόμα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200500912 | 2005-06-22 | ||
EP06742481.2A EP1896439B2 (en) | 2005-06-22 | 2006-06-22 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112392T1 true CY1112392T1 (el) | 2015-12-09 |
Family
ID=37546630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100116T CY1112392T1 (el) | 2005-06-22 | 2011-02-03 | Κρυσταλλικη βαση εσκιταλοπραμης και δισκια διασπειρομενα στο στομα που αποτελουνται απο βαση εσκιταλοπραμης |
Country Status (39)
Country | Link |
---|---|
EP (3) | EP2325177A1 (el) |
JP (5) | JP4906852B2 (el) |
KR (5) | KR20110084341A (el) |
CN (2) | CN101189220A (el) |
AR (2) | AR055062A1 (el) |
AT (3) | AT10983U1 (el) |
AU (2) | AU2006261452B2 (el) |
BG (1) | BG66086B1 (el) |
BR (1) | BRPI0612295A2 (el) |
CA (2) | CA2646780A1 (el) |
CY (1) | CY1112392T1 (el) |
CZ (3) | CZ299906B6 (el) |
DE (2) | DE112006001619T5 (el) |
DK (3) | DK1896439T4 (el) |
EA (2) | EA201001108A1 (el) |
EE (1) | EE00773U1 (el) |
ES (2) | ES2356838T5 (el) |
FI (2) | FI20077133A (el) |
GB (2) | GB2442160B (el) |
HR (1) | HRP20110093T4 (el) |
HU (1) | HUP0800135A3 (el) |
IL (1) | IL187454A0 (el) |
IS (1) | IS8705A (el) |
LT (1) | LT5550B (el) |
LV (1) | LV13677B (el) |
MX (1) | MX2007015328A (el) |
MY (2) | MY143239A (el) |
NO (2) | NO20080359L (el) |
PL (2) | PL1896439T5 (el) |
PT (1) | PT1896439E (el) |
RS (1) | RS51575B2 (el) |
SG (1) | SG169358A1 (el) |
SI (1) | SI1896439T2 (el) |
SK (1) | SK500402007A3 (el) |
TR (2) | TR200708792T1 (el) |
TW (2) | TWI347942B (el) |
UA (1) | UA86536C2 (el) |
WO (1) | WO2006136169A2 (el) |
ZA (2) | ZA200711066B (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
EP2134325A2 (en) * | 2007-03-01 | 2009-12-23 | Aurobindo Pharma Limited | Stable solid dosage forms of an antidepressant |
ME02391B (me) | 2010-07-23 | 2016-09-20 | H Lundbeck As | Postupak za prečišćavanje farmaceutski prihvatljivih soli escitaloprama |
CN103360353A (zh) * | 2013-08-07 | 2013-10-23 | 中国药科大学 | 草酸艾司西酞普兰杂质的制备方法 |
JP2018016569A (ja) * | 2016-07-26 | 2018-02-01 | 株式会社トクヤマ | (1s)−1−[3−(ジメチルアミノ)プロピル]−1−(4−フルオロフェニル)−1,3−ジヒドロイソベンゾフラン−5−カルボニトリル蓚酸塩の製造方法 |
WO2018190294A1 (ja) * | 2017-04-10 | 2018-10-18 | 東和薬品株式会社 | エスシタロプラム医薬組成物 |
CN110711198B (zh) * | 2018-07-12 | 2022-03-15 | 山东大学 | D-甘露糖在制备抗抑郁药物中的应用 |
KR102331187B1 (ko) | 2019-04-09 | 2021-11-26 | 주식회사 라이트팜텍 | 에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법 |
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GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
JPH05222041A (ja) * | 1992-02-13 | 1993-08-31 | Mitsubishi Gas Chem Co Inc | アデニン誘導体の精製法 |
RU2161954C2 (ru) * | 1994-01-27 | 2001-01-20 | Дзе Борд оф Регентс оф Дзе Юниверсити оф Оклахома | Быстрорастворяющиеся во рту лекарственные формы |
US5607697A (en) * | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
AU4655597A (en) | 1997-06-30 | 1999-01-19 | Beloit Technologies, Inc. | Method and apparatus for the high speed application of coating to a traveling paper web |
DE69801764T2 (de) | 1997-07-08 | 2002-07-04 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
DE69714480T2 (de) | 1997-11-11 | 2003-03-06 | Lundbeck & Co As H | Verfahren zur Herstellung von Citalopram |
FR2785538B1 (fr) * | 1998-11-06 | 2004-04-09 | Prographarm Laboratoires | Comprime a delitement rapide perfectionne |
US20020071864A1 (en) * | 1999-03-25 | 2002-06-13 | Yuhan Corporation | Rapidly disintegrable tablet for oral administration |
ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
JP2001226372A (ja) * | 1999-12-06 | 2001-08-21 | Sumika Fine Chemicals Co Ltd | ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法 |
GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
US7510728B2 (en) * | 2000-10-06 | 2009-03-31 | Takeda Pharmaceutical Company Limited | Solid preparations |
JP4446463B2 (ja) * | 2000-10-16 | 2010-04-07 | 第一三共株式会社 | 口腔内速崩壊性医薬組成物およびその製造方法 |
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CA2445843A1 (en) * | 2001-05-01 | 2002-11-07 | H. Lundbeck A/S | The use of enantiomeric pure escitalopram |
US6872405B2 (en) * | 2001-05-10 | 2005-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Quick-disintegrating tablet in buccal cavity and manufacturing method thereof |
GB0113842D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
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IS7239A (is) | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
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HU227491B1 (en) * | 2003-11-25 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Tablet containing citalopram hydrogen bromide |
EA200601641A1 (ru) * | 2004-03-05 | 2006-12-29 | Х. Лундбекк А/С | Кристаллическая композиция, содержащая оксалат эсциталопрама |
WO2006106531A1 (en) * | 2005-04-04 | 2006-10-12 | Jubilant Organosys Ltd | Process for the preparation of escitalopram or its acid addition salts |
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2006
- 2006-06-15 TW TW095121358A patent/TWI347942B/zh not_active IP Right Cessation
- 2006-06-15 TW TW100102601A patent/TWI358407B/zh not_active IP Right Cessation
- 2006-06-21 MY MYPI2010000618A patent/MY143239A/en unknown
- 2006-06-21 AR ARP060102654A patent/AR055062A1/es not_active Application Discontinuation
- 2006-06-21 MY MYPI20062933A patent/MY143252A/en unknown
- 2006-06-22 SI SI200630923T patent/SI1896439T2/sl unknown
- 2006-06-22 CA CA002646780A patent/CA2646780A1/en not_active Abandoned
- 2006-06-22 EP EP10179395A patent/EP2325177A1/en not_active Withdrawn
- 2006-06-22 EA EA201001108A patent/EA201001108A1/ru unknown
- 2006-06-22 SK SK50040-2007A patent/SK500402007A3/sk unknown
- 2006-06-22 KR KR1020117015711A patent/KR20110084341A/ko not_active Application Discontinuation
- 2006-06-22 ES ES06742481.2T patent/ES2356838T5/es active Active
- 2006-06-22 GB GB0724557A patent/GB2442160B/en not_active Expired - Fee Related
- 2006-06-22 CZ CZ20070898A patent/CZ299906B6/cs not_active IP Right Cessation
- 2006-06-22 ES ES200750085A patent/ES2319073B1/es not_active Expired - Fee Related
- 2006-06-22 CN CNA2006800200393A patent/CN101189220A/zh active Pending
- 2006-06-22 CZ CZ20080429A patent/CZ301286B6/cs not_active IP Right Cessation
- 2006-06-22 WO PCT/DK2006/000366 patent/WO2006136169A2/en active Application Filing
- 2006-06-22 HU HU0800135A patent/HUP0800135A3/hu unknown
- 2006-06-22 RS RS20110057A patent/RS51575B2/sr unknown
- 2006-06-22 DK DK06742481.2T patent/DK1896439T4/en active
- 2006-06-22 EP EP06742481.2A patent/EP1896439B2/en active Active
- 2006-06-22 KR KR1020077028918A patent/KR20080018191A/ko not_active Application Discontinuation
- 2006-06-22 AT AT0900506U patent/AT10983U1/de not_active IP Right Cessation
- 2006-06-22 KR KR1020127014205A patent/KR20120064140A/ko not_active Application Discontinuation
- 2006-06-22 BR BRPI0612295-7A patent/BRPI0612295A2/pt not_active IP Right Cessation
- 2006-06-22 TR TR2007/08792T patent/TR200708792T1/xx unknown
- 2006-06-22 SG SG201100648-3A patent/SG169358A1/en unknown
- 2006-06-22 PL PL06742481T patent/PL1896439T5/pl unknown
- 2006-06-22 CN CN201010286088XA patent/CN101928269A/zh active Pending
- 2006-06-22 PL PL384185A patent/PL384185A1/pl unknown
- 2006-06-22 CZ CZ20080430A patent/CZ300686B6/cs not_active IP Right Cessation
- 2006-06-22 KR KR1020117005777A patent/KR101340815B1/ko active IP Right Grant
- 2006-06-22 KR KR1020107026804A patent/KR20100133023A/ko not_active Application Discontinuation
- 2006-06-22 AU AU2006261452A patent/AU2006261452B2/en not_active Withdrawn - After Issue
- 2006-06-22 DE DE112006001619T patent/DE112006001619T5/de not_active Withdrawn
- 2006-06-22 PT PT06742481T patent/PT1896439E/pt unknown
- 2006-06-22 DE DE602006019961T patent/DE602006019961D1/de active Active
- 2006-06-22 AT AT06742481T patent/ATE497500T1/de active
- 2006-06-22 TR TR2010/00625T patent/TR201000625T1/xx unknown
- 2006-06-22 GB GB0811164A patent/GB2448834B/en not_active Expired - Fee Related
- 2006-06-22 ZA ZA200711066A patent/ZA200711066B/xx unknown
- 2006-06-22 EP EP10179318A patent/EP2385044A1/en not_active Withdrawn
- 2006-06-22 EA EA200800102A patent/EA019239B1/ru not_active IP Right Cessation
- 2006-06-22 UA UAA200800362A patent/UA86536C2/ru unknown
- 2006-06-22 CA CA2612827A patent/CA2612827C/en not_active Expired - Fee Related
- 2006-06-22 EE EEU200800003U patent/EE00773U1/xx not_active IP Right Cessation
- 2006-06-22 MX MX2007015328A patent/MX2007015328A/es active IP Right Grant
- 2006-06-22 JP JP2008517323A patent/JP4906852B2/ja active Active
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2007
- 2007-11-18 IL IL187454A patent/IL187454A0/en unknown
- 2007-12-19 BG BG10110024A patent/BG66086B1/bg unknown
- 2007-12-20 FI FI20077133A patent/FI20077133A/fi unknown
- 2007-12-21 LV LVP-07-157A patent/LV13677B/lv unknown
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2008
- 2008-01-14 IS IS8705A patent/IS8705A/is unknown
- 2008-01-18 NO NO20080359A patent/NO20080359L/no unknown
- 2008-01-21 DK DK200800075A patent/DK200800075A/da not_active Application Discontinuation
- 2008-01-21 LT LT2008005A patent/LT5550B/lt not_active IP Right Cessation
- 2008-10-07 JP JP2008260742A patent/JP4415056B2/ja active Active
- 2008-10-07 FI FI20080548A patent/FI20080548A/fi unknown
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2009
- 2009-02-27 DK DKPA200900284A patent/DK200900284A/da not_active Application Discontinuation
- 2009-03-10 ZA ZA200901698A patent/ZA200901698B/en unknown
- 2009-05-12 JP JP2009115279A patent/JP2009179634A/ja active Pending
- 2009-05-12 JP JP2009115280A patent/JP2009179635A/ja active Pending
- 2009-07-07 AT AT0041709U patent/AT11883U1/de not_active IP Right Cessation
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2010
- 2010-03-05 AU AU2010200844A patent/AU2010200844A1/en not_active Withdrawn
- 2010-12-20 NO NO20101777A patent/NO20101777L/no not_active Application Discontinuation
- 2010-12-27 AR ARP100104958A patent/AR079750A2/es not_active Application Discontinuation
-
2011
- 2011-02-03 CY CY20111100116T patent/CY1112392T1/el unknown
- 2011-02-04 HR HRP20110093TT patent/HRP20110093T4/hr unknown
- 2011-11-24 JP JP2011255804A patent/JP5731957B2/ja active Active
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