DE69801764T2 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number
DE69801764T2
DE69801764T2 DE69801764T DE69801764T DE69801764T2 DE 69801764 T2 DE69801764 T2 DE 69801764T2 DE 69801764 T DE69801764 T DE 69801764T DE 69801764 T DE69801764 T DE 69801764T DE 69801764 T2 DE69801764 T2 DE 69801764T2
Authority
DE
Germany
Prior art keywords
citalopram
compound
halogen
formula
grignard reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69801764T
Other languages
English (en)
Other versions
DE69801764D1 (de
Inventor
Hans Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE69801764D1 publication Critical patent/DE69801764D1/de
Application granted granted Critical
Publication of DE69801764T2 publication Critical patent/DE69801764T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
DE69801764T 1997-07-08 1998-03-03 Verfahren zur herstellung von citalopram Expired - Lifetime DE69801764T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5278897P 1997-07-08 1997-07-08
DK82697 1997-07-08
PCT/DK1998/000081 WO1998019513A2 (en) 1997-07-08 1998-03-03 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
DE69801764D1 DE69801764D1 (de) 2001-10-25
DE69801764T2 true DE69801764T2 (de) 2002-07-04

Family

ID=26064729

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69801764T Expired - Lifetime DE69801764T2 (de) 1997-07-08 1998-03-03 Verfahren zur herstellung von citalopram
DE1015416T Pending DE1015416T1 (de) 1997-07-08 1998-03-03 Verfahren zur herstellung von citalopram

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1015416T Pending DE1015416T1 (de) 1997-07-08 1998-03-03 Verfahren zur herstellung von citalopram

Country Status (23)

Country Link
US (1) US6229026B1 (de)
EP (1) EP1015416B1 (de)
JP (1) JP3526581B2 (de)
KR (1) KR100357975B1 (de)
CN (1) CN1206207C (de)
AT (1) ATE205824T1 (de)
AU (1) AU737610B2 (de)
BG (1) BG64823B1 (de)
CA (1) CA2291067C (de)
CZ (1) CZ291440B6 (de)
DE (2) DE69801764T2 (de)
DK (1) DK1015416T3 (de)
EA (1) EA001728B1 (de)
ES (1) ES2148120T3 (de)
HU (1) HU228744B1 (de)
IL (2) IL133511A (de)
IS (1) IS2023B (de)
NO (1) NO322146B1 (de)
NZ (1) NZ501737A (de)
PT (1) PT1015416E (de)
SK (1) SK283309B6 (de)
TR (1) TR200000066T2 (de)
WO (1) WO1998019513A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
JP2002533450A (ja) * 1998-12-23 2002-10-08 ハー・ルンドベック・アクチエゼルスカベット ５−シアノフタリドの製造方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) * 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
US6245782B1 (en) 1999-05-17 2001-06-12 Heartdrug Research L.L.C. Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
ATE355268T1 (de) 1999-10-25 2006-03-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ES2229774T3 (es) 1999-10-25 2005-04-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
ES2219095T3 (es) 1999-12-28 2004-11-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
UA73336C2 (en) 1999-12-30 2005-07-15 Lundbeck & Co As H A method for the preparation of 5-cyano-phtalid
ES2206177T3 (es) 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
IT1317729B1 (it) * 2000-01-18 2003-07-15 Norpharma S P A Procedimento per la preparazione della 5-carbossiftalide.
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
EP1265883A1 (de) 2000-03-13 2002-12-18 H. Lundbeck A/S Verfahren zur herstellung von citalopram
CZ20023100A3 (cs) * 2000-03-13 2003-02-12 H. Lundbeck A/S Způsob výroby citalopramu
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
DE60101786T2 (de) 2000-03-14 2004-07-15 H. Lundbeck A/S, Valby Verfahren zur herstellung von citalopram
AU2001244086A1 (en) * 2000-03-16 2001-09-24 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622A (fi) * 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
TR200201166T1 (tr) 2000-12-22 2002-10-21 H.Lundbecks A/S Saf sitalopram hazırlanması için yöntem
TR200200018T1 (tr) * 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
CA2435925A1 (en) 2001-01-30 2002-08-08 Orion Corporation Fermion Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
IN192057B (de) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
TR200400189T2 (tr) 2001-07-31 2004-12-21 H.Lundbeck A/S Esitalopram içeren kristal yapılı bileşim.
PT1281707E (pt) * 2001-08-02 2005-04-29 Infosint Sa Processo para a preparacao de isobenzofuranos 5-substituidos
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1288211A1 (de) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Verbessertes Verfahren zur Herstellung von Citalopram-Hydrobromid aus 5-Bromphthalid
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
GB2387596B (en) * 2002-02-27 2004-02-11 Matrix Lab Ltd Process
HU0200980D0 (de) * 2002-03-14 2002-05-29 Gabor S Pal Dr
BG65515B1 (bg) * 2002-07-26 2008-10-31 H. Lundbeck A/S Метод за получаване на 5-цианофталид
WO2004016602A1 (en) * 2002-08-14 2004-02-26 Natco Pharma Limited Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
CN1761659A (zh) 2003-03-21 2006-04-19 H·隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
EP1486492A3 (de) 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. Ein Verfahren zur Hydrogenolyse von [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran
ATE293106T1 (de) * 2003-10-28 2005-04-15 Adorkem Technology Spa Verfahren zur herstellung von citalopram
WO2006021971A2 (en) 2004-08-23 2006-03-02 Sun Pharmaceutical Industries Limited 'process for preparation of citalopram and enantiomers'
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (de) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide

Also Published As

Publication number Publication date
CA2291067A1 (en) 1998-05-14
DK1015416T3 (da) 2001-11-05
AU737610B2 (en) 2001-08-23
AU6609898A (en) 1998-05-29
IS5300A (is) 1999-12-14
JP3526581B2 (ja) 2004-05-17
US6229026B1 (en) 2001-05-08
DE69801764D1 (de) 2001-10-25
NO20000008D0 (no) 2000-01-03
PT1015416E (pt) 2002-03-28
SK283309B6 (sk) 2003-05-02
KR20010021516A (ko) 2001-03-15
SK32000A3 (en) 2000-07-11
IL133511A (en) 2004-05-12
CN1495157A (zh) 2004-05-12
JP2002509526A (ja) 2002-03-26
WO1998019513A3 (en) 2000-05-04
HUP0003177A2 (hu) 2001-04-28
IL153125A (en) 2008-11-03
CZ200062A3 (cs) 2000-07-12
HUP0003177A3 (en) 2002-12-28
CA2291067C (en) 2002-07-30
EP1015416A2 (de) 2000-07-05
NO20000008L (no) 2000-01-03
EA200000102A1 (ru) 2000-06-26
DE1015416T1 (de) 2000-10-05
KR100357975B1 (ko) 2002-10-25
WO1998019513A2 (en) 1998-05-14
ATE205824T1 (de) 2001-10-15
BG64823B1 (bg) 2006-05-31
CZ291440B6 (cs) 2003-03-12
NZ501737A (en) 2001-10-26
TR200000066T2 (tr) 2000-11-21
EP1015416B1 (de) 2001-09-19
IL133511A0 (en) 2001-04-30
HU228744B1 (en) 2013-05-28
NO322146B1 (no) 2006-08-21
EA001728B1 (ru) 2001-08-27
ES2148120T1 (es) 2000-10-16
ES2148120T3 (es) 2002-01-16
CN1206207C (zh) 2005-06-15
BG104116A (en) 2000-12-29
IS2023B (is) 2005-08-15

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Legal Events

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