DE69714480T2 - Verfahren zur Herstellung von Citalopram - Google Patents
Verfahren zur Herstellung von CitalopramInfo
- Publication number
- DE69714480T2 DE69714480T2 DE69714480T DE69714480T DE69714480T2 DE 69714480 T2 DE69714480 T2 DE 69714480T2 DE 69714480 T DE69714480 T DE 69714480T DE 69714480 T DE69714480 T DE 69714480T DE 69714480 T2 DE69714480 T2 DE 69714480T2
- Authority
- DE
- Germany
- Prior art keywords
- citalopram
- preparation
- compound
- halogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK1997/000513 WO1998019512A2 (en) | 1997-11-11 | 1997-11-11 | Method for the preparation of citalopram |
CN97182416A CN1286687A (zh) | 1997-11-11 | 1997-11-11 | 制备西酞普兰的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69714480D1 DE69714480D1 (de) | 2002-09-05 |
DE69714480T2 true DE69714480T2 (de) | 2003-03-06 |
Family
ID=37709785
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69714480T Expired - Fee Related DE69714480T2 (de) | 1997-11-11 | 1997-11-11 | Verfahren zur Herstellung von Citalopram |
DE1042310T Pending DE1042310T1 (de) | 1997-11-11 | 1997-11-11 | Verfahren zur herstellung von citaloprame |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1042310T Pending DE1042310T1 (de) | 1997-11-11 | 1997-11-11 | Verfahren zur herstellung von citaloprame |
Country Status (20)
Country | Link |
---|---|
US (1) | US6258842B1 (de) |
EP (1) | EP1042310B1 (de) |
JP (1) | JP3813820B2 (de) |
CN (1) | CN1286687A (de) |
AT (1) | ATE221522T1 (de) |
AU (1) | AU738359B2 (de) |
BR (1) | BR9714925A (de) |
CA (1) | CA2291072C (de) |
CZ (1) | CZ292911B6 (de) |
DE (2) | DE69714480T2 (de) |
DK (1) | DK1042310T3 (de) |
EA (1) | EA002770B1 (de) |
ES (1) | ES2149734T3 (de) |
HU (1) | HUP0002953A3 (de) |
IS (1) | IS2009B (de) |
SK (1) | SK283907B6 (de) |
TR (1) | TR200001341T2 (de) |
UA (1) | UA62984C2 (de) |
WO (1) | WO1998019512A2 (de) |
ZA (1) | ZA9810058B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
JP3892667B2 (ja) * | 1998-10-20 | 2007-03-14 | ハー・ルンドベック・アクチエゼルスカベット | シタロプラムの製造方法 |
WO2000039112A1 (en) | 1998-12-23 | 2000-07-06 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
EP1173431B2 (de) | 1999-04-14 | 2009-08-26 | H. Lundbeck A/S | Verfahren zur herstellung von citalopram |
US6245782B1 (en) | 1999-05-17 | 2001-06-12 | Heartdrug Research L.L.C. | Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors |
ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991486A1 (it) * | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
GB2360281B (en) | 1999-10-25 | 2002-01-16 | Lundbeck & Co As H | Method for the preparation of citalopram |
DE69935355T2 (de) * | 1999-10-25 | 2007-11-08 | H. Lundbeck A/S, Valby | Verfahren zur Herstellung von Citalopram |
AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
DE69915713T2 (de) | 1999-12-28 | 2005-03-03 | H. Lundbeck A/S | Verfahren zur herstellung von citalopram |
MXPA02006504A (es) * | 1999-12-30 | 2002-12-09 | Lundbeck & Co As H | Metodo para la preparacion de citalopram. |
SI1254129T1 (en) | 2000-01-14 | 2004-02-29 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
FR2805812A1 (fr) | 2000-02-24 | 2001-09-07 | Lundbeck & Co As H | Procede de preparation du citalopram |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
TR200202195T2 (tr) * | 2000-03-13 | 2002-12-23 | H. Lundbeck A/S | 5-Yer değiştirmiş 1-(4-florofenil)-1,3- dihidroizobenzofuran'ın adım adım alkillenmesi |
CZ20023384A3 (cs) | 2000-03-13 | 2003-01-15 | H. Lundbeck A/S | Způsob výroby citalopramu a meziprodukt |
CA2402557A1 (en) | 2000-03-14 | 2001-09-20 | Hans Petersen | Method for the preparation of citalopram |
MXPA02008652A (es) * | 2000-03-16 | 2003-02-24 | Lundbeck & Co As H | Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos. |
AR032455A1 (es) * | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
US6879110B2 (en) * | 2000-07-27 | 2005-04-12 | Semiconductor Energy Laboratory Co., Ltd. | Method of driving display device |
IL144817A0 (en) | 2000-08-18 | 2002-06-30 | Lundbeck & Co As H | Method for the preparation of citalopram |
IT1319686B1 (it) * | 2000-12-12 | 2003-10-23 | C D Farmasint S R L | Procedimento di preparazione di citalopram. |
WO2001045483A2 (en) | 2000-12-22 | 2001-06-28 | H. Lundbeck A/S | Method for the preparation of pure citalopram |
DE10112828C1 (de) * | 2000-12-28 | 2002-11-21 | Lundbeck & Co As H | Verfahren zur Herstellung von Citalopram |
EA003459B1 (ru) | 2000-12-28 | 2003-06-26 | Х.Лундбекк А/С | Способ получения чистого циталопрама |
EP1355897A1 (de) | 2001-01-30 | 2003-10-29 | Orion Corporation Fermion | Verfahren zur herstellung von 1-(3-dimethylaminopropyl)-1-(4-fluorphenyl)-1,3-dihydrobenzofuran-5-carbonitrile |
CA2445843A1 (en) * | 2001-05-01 | 2002-11-07 | H. Lundbeck A/S | The use of enantiomeric pure escitalopram |
BG65271B1 (bg) * | 2001-06-18 | 2007-11-30 | H. Lundbeck A/S | Метод за получаване на циталопрам |
PL366995A1 (en) | 2001-07-31 | 2005-02-07 | H.Lundbeck A/S | Crystalline composition containing escitalopram |
IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
US7148364B2 (en) | 2002-01-07 | 2006-12-12 | Sun Pharmaceutical Industries | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile |
HU0200980D0 (de) * | 2002-03-14 | 2002-05-29 | Gabor S Pal Dr | |
BG65515B1 (bg) * | 2002-07-26 | 2008-10-31 | H. Lundbeck A/S | Метод за получаване на 5-цианофталид |
PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
US6812355B2 (en) | 2002-10-22 | 2004-11-02 | Sekhsaria Chemicals Limited | Process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
ITMI20030479A1 (it) * | 2003-03-13 | 2004-09-14 | Adorkem Technology S P A | Procedimento per la preparazione di un ciano-isobenzofurano. |
US6781003B1 (en) * | 2003-06-09 | 2004-08-24 | Aurobindo Pharma Ltd. | Preparation of pure citalopram |
US7019153B2 (en) | 2003-06-10 | 2006-03-28 | Sun Pharmaceutical Industries Limited | Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid |
DE60300502T2 (de) * | 2003-10-28 | 2006-02-23 | Adorkem Technology S.P.A., Costa Volpino | Verfahren zur Herstellung von Citalopram |
CN100569765C (zh) * | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
WO2006021971A2 (en) | 2004-08-23 | 2006-03-02 | Sun Pharmaceutical Industries Limited | 'process for preparation of citalopram and enantiomers' |
WO2006103550A1 (en) * | 2005-03-31 | 2006-10-05 | Ranbaxy Laboratories Limited | Processes for the preparation of citalopram and its intermediate 5-aminophthalide |
US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
TWI358407B (en) | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
CN100391952C (zh) * | 2005-07-12 | 2008-06-04 | 广东西陇化工有限公司 | 西酞普兰盐的制备方法 |
US9339500B2 (en) * | 2008-03-04 | 2016-05-17 | Intra-Cellular Therapies, Inc. | Methods of treating vasomotor symptoms |
CN105801329B (zh) * | 2016-04-29 | 2017-11-28 | 阜阳欣奕华材料科技有限公司 | 一种晕苯的制备方法 |
CN105801333B (zh) * | 2016-04-29 | 2017-12-22 | 江苏佳麦化工有限公司 | 一种晕苯的制备方法 |
CN105801328B (zh) * | 2016-04-29 | 2017-12-08 | 浙江瑞灿科技有限公司 | 一种晕苯的制备方法 |
CN106748627A (zh) * | 2016-11-14 | 2017-05-31 | 苏州市罗森助剂有限公司 | 一种一锅法制备3,5‑二甲基溴苯的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1143703A (de) | 1965-03-18 | |||
GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
-
1997
- 1997-11-11 BR BR9714925-0A patent/BR9714925A/pt not_active Application Discontinuation
- 1997-11-11 JP JP2000583315A patent/JP3813820B2/ja not_active Expired - Fee Related
- 1997-11-11 EA EA200000511A patent/EA002770B1/ru not_active IP Right Cessation
- 1997-11-11 AT AT97945799T patent/ATE221522T1/de not_active IP Right Cessation
- 1997-11-11 TR TR2000/01341T patent/TR200001341T2/xx unknown
- 1997-11-11 WO PCT/DK1997/000513 patent/WO1998019512A2/en active IP Right Grant
- 1997-11-11 DK DK97945799T patent/DK1042310T3/da active
- 1997-11-11 AU AU51168/98A patent/AU738359B2/en not_active Ceased
- 1997-11-11 HU HU0002953A patent/HUP0002953A3/hu unknown
- 1997-11-11 SK SK682-2000A patent/SK283907B6/sk unknown
- 1997-11-11 CA CA002291072A patent/CA2291072C/en not_active Expired - Fee Related
- 1997-11-11 CN CN97182416A patent/CN1286687A/zh active Pending
- 1997-11-11 DE DE69714480T patent/DE69714480T2/de not_active Expired - Fee Related
- 1997-11-11 DE DE1042310T patent/DE1042310T1/de active Pending
- 1997-11-11 ES ES97945799T patent/ES2149734T3/es not_active Expired - Lifetime
- 1997-11-11 EP EP97945799A patent/EP1042310B1/de not_active Expired - Lifetime
- 1997-11-11 UA UA2000052827A patent/UA62984C2/uk unknown
- 1997-11-11 CZ CZ20001736A patent/CZ292911B6/cs not_active IP Right Cessation
-
1998
- 1998-11-03 ZA ZA9810058A patent/ZA9810058B/xx unknown
-
2000
- 2000-04-18 IS IS5461A patent/IS2009B/is unknown
- 2000-04-28 US US09/564,365 patent/US6258842B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK1042310T3 (da) | 2002-12-02 |
DE1042310T1 (de) | 2001-04-19 |
EA200000511A1 (ru) | 2000-10-30 |
SK6822000A3 (en) | 2000-10-09 |
BR9714925A (pt) | 2003-07-22 |
ATE221522T1 (de) | 2002-08-15 |
ZA9810058B (en) | 1999-05-05 |
CA2291072C (en) | 2002-08-20 |
US6258842B1 (en) | 2001-07-10 |
CZ20001736A3 (cs) | 2000-10-11 |
ES2149734T1 (es) | 2000-11-16 |
IS2009B (is) | 2005-05-13 |
AU5116898A (en) | 1998-05-29 |
JP2002530295A (ja) | 2002-09-17 |
ES2149734T3 (es) | 2003-02-16 |
EP1042310B1 (de) | 2002-07-31 |
UA62984C2 (en) | 2004-01-15 |
WO1998019512A3 (en) | 1998-08-13 |
CA2291072A1 (en) | 1998-05-14 |
HUP0002953A2 (hu) | 2001-04-28 |
WO1998019512A2 (en) | 1998-05-14 |
CZ292911B6 (cs) | 2004-01-14 |
TR200001341T2 (tr) | 2000-11-21 |
HUP0002953A3 (en) | 2002-12-28 |
DE69714480D1 (de) | 2002-09-05 |
IS5461A (is) | 2000-04-18 |
JP3813820B2 (ja) | 2006-08-23 |
SK283907B6 (sk) | 2004-04-06 |
EP1042310A2 (de) | 2000-10-11 |
CN1286687A (zh) | 2001-03-07 |
AU738359B2 (en) | 2001-09-13 |
EA002770B1 (ru) | 2002-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |