CO2018001405A2 - Receptores de antígenos quiméricos basados en anticuerpos de dominio simple - Google Patents

Receptores de antígenos quiméricos basados en anticuerpos de dominio simple

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Publication number
CO2018001405A2
CO2018001405A2 CONC2018/0001405A CO2018001405A CO2018001405A2 CO 2018001405 A2 CO2018001405 A2 CO 2018001405A2 CO 2018001405 A CO2018001405 A CO 2018001405A CO 2018001405 A2 CO2018001405 A2 CO 2018001405A2
Authority
CO
Colombia
Prior art keywords
single domain
chimeric antigen
domain antibodies
antigen receptor
receptor based
Prior art date
Application number
CONC2018/0001405A
Other languages
English (en)
Inventor
Xiaohu Fan
Chuan-Chu Chou
Qiuchuan Zhuang
Pingyan Wang
Lin Wang
Lei Yang
Jiaying Hao
Original Assignee
Legend Biotech Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Legend Biotech Ireland Ltd filed Critical Legend Biotech Ireland Ltd
Publication of CO2018001405A2 publication Critical patent/CO2018001405A2/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

RESUMEN La presente solicitud proporciona anticuerpos de dominio simple, y receptores de antígenos quiméricos que comprenden uno o más dominios de unión al antígeno, cada uno de los cuales comprende un anticuerpo de dominio simple. También se proporcionan células efectoras inmunitarias modificadas genéticamente (tales como linfocitos T) que comprenden los receptores de antígenos quiméricos. También se proporcionan composiciones farmacéuticas, kits y métodos para tratar el cáncer.
CONC2018/0001405A 2015-08-11 2018-02-13 Receptores de antígenos quiméricos basados en anticuerpos de dominio simple CO2018001405A2 (es)

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