BR112015014833A2 - anticorpo isolado ou fragmento de ligação de antígeno deste, ácido nucléico isolado, célula hospedeira, método de ensaiar uma amostra de tecido removido de um humano para expressão de pd-l1, estojo, e, composição de anticorpo que compreende uma mistura de moléculas do anticorpo - Google Patents

anticorpo isolado ou fragmento de ligação de antígeno deste, ácido nucléico isolado, célula hospedeira, método de ensaiar uma amostra de tecido removido de um humano para expressão de pd-l1, estojo, e, composição de anticorpo que compreende uma mistura de moléculas do anticorpo

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Publication number
BR112015014833A2
BR112015014833A2 BR112015014833A BR112015014833A BR112015014833A2 BR 112015014833 A2 BR112015014833 A2 BR 112015014833A2 BR 112015014833 A BR112015014833 A BR 112015014833A BR 112015014833 A BR112015014833 A BR 112015014833A BR 112015014833 A2 BR112015014833 A2 BR 112015014833A2
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BR
Brazil
Prior art keywords
antibody
human
expression
isolated
nucleic acid
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BR112015014833A
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English (en)
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BR112015014833B1 (pt
BR112015014833B8 (pt
Inventor
Linda Liang
Michael Bigler
Patrícia Bourne
Robert H Pierce
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Merck Sharp & Dohme
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49885509&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015014833(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BR112015014833A2 publication Critical patent/BR112015014833A2/pt
Publication of BR112015014833B1 publication Critical patent/BR112015014833B1/pt
Publication of BR112015014833B8 publication Critical patent/BR112015014833B8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Abstract

1 / 1 resumo “anticorpo isolado ou fragmento de ligaã‡ãƒo de antãgeno deste, ãcido nuclã‰ico isolado, cã‰lula hospedeira, mã‰todo de ensaiar uma amostra de tecido removido de um humano para expressãƒo de pd-l1, estojo, e, composiã‡ãƒo de anticorpo que compreende uma mistura de molã‰culas do anticorpo” a presente revelaã§ã£o fornece anticorpos isolados que ligam especificamente em pd-l1 de humano, bem como fragmentos de ligaã§ã£o de antã­geno de tais anticorpos, e estojos compreendendo os anticorpos anti-pd- l1 ou fragmentos de ligaã§ã£o e um conjunto de reagentes para detectar um complexo do anticorpo, ou fragmento de ligaã§ã£o de antã­geno deste, ligado em pd-l1 de humano. os anticorpos e fragmentos de ligaã§ã£o de antã­geno desta revelaã§ã£o sã£o usados para detecã§ã£o imuno-histoquã­mica de expressã£o de pd- l1 de humano em amostras de tecido. sã£o tambã©m fornecidas molã©culas de ã¡cido nuclã©ico que codificam os anticorpos e fragmentos de ligaã§ã£o de antã­geno desta revelaã§ã£o, bem como vetores de expressã£o e cã©lulas hospedeiras para expressã£o destas.
BR112015014833A 2012-12-21 2013-12-18 Anticorpo isolado ou fragmento de ligação, ácido nucleico, método in vitro, kit e composição de anticorpo BR112015014833B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261745386P 2012-12-21 2012-12-21
US61/745,386 2012-12-21
PCT/US2013/075932 WO2014100079A1 (en) 2012-12-21 2013-12-18 Antibodies that bind to human programmed death ligand 1 (pd-l1)

Publications (3)

Publication Number Publication Date
BR112015014833A2 true BR112015014833A2 (pt) 2016-01-12
BR112015014833B1 BR112015014833B1 (pt) 2020-06-16
BR112015014833B8 BR112015014833B8 (pt) 2023-12-05

Family

ID=49885509

Family Applications (1)

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BR112015014833A BR112015014833B8 (pt) 2012-12-21 2013-12-18 Anticorpo isolado ou fragmento de ligação, ácido nucleico, método in vitro, kit e composição de anticorpo

Country Status (25)

Country Link
US (1) US9709568B2 (pt)
EP (2) EP3783030A1 (pt)
JP (4) JP6586014B2 (pt)
KR (1) KR101780877B1 (pt)
CN (2) CN113321731A (pt)
AR (1) AR093984A1 (pt)
AU (1) AU2013361617B2 (pt)
BR (1) BR112015014833B8 (pt)
CA (1) CA2895191C (pt)
CY (1) CY1123708T1 (pt)
DK (1) DK2935329T3 (pt)
ES (1) ES2833046T3 (pt)
HK (1) HK1210785A1 (pt)
HR (1) HRP20201856T1 (pt)
HU (1) HUE052134T2 (pt)
JO (1) JO3812B1 (pt)
LT (1) LT2935329T (pt)
MX (1) MX361502B (pt)
PL (1) PL2935329T3 (pt)
PT (1) PT2935329T (pt)
RS (1) RS61083B1 (pt)
RU (1) RU2689953C2 (pt)
SI (1) SI2935329T1 (pt)
TW (1) TWI655209B (pt)
WO (1) WO2014100079A1 (pt)

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