AR061083A1 - Derivados de cicloalquilaminoacidos y composiciones farmaceuticas que los contienen - Google Patents
Derivados de cicloalquilaminoacidos y composiciones farmaceuticas que los contienenInfo
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- AR061083A1 AR061083A1 ARP070102020A ARP070102020A AR061083A1 AR 061083 A1 AR061083 A1 AR 061083A1 AR P070102020 A ARP070102020 A AR P070102020A AR P070102020 A ARP070102020 A AR P070102020A AR 061083 A1 AR061083 A1 AR 061083A1
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- alkyl
- group
- heteroaryl
- cycloalkyl
- heterocyclyl
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Abstract
Se refiere a compuestos de Formula 1 y a sales farmacéuticamente aceptables, profármacos, solvatos o hidratos de los mismos. También se refiere a un método de uso de tales compuestos en el tratamiento de enfermedades hiperproliferativas y enfermedades autoinmunes de mamíferos, especialmente en seres humanos, y a composiciones farmacéuticas que contienen tales compuestos. Reivindicacion 1: Un compuesto de formula (1) o una sal farmacéuticamente aceptable del mismo, en la que B se selecciona entre el grupo que consiste en fenilo y un anillo heteroarilo (de 5 a 6 miembros); D se selecciona entre el grupo que consiste en fenilo y un anillo heteroarilo (de 5 a 6 miembros); E se selecciona entre el grupo que consiste en fenilo y un anillo heteroarilo (de 5 a 6 miembros); R1 es un radical seleccionado entre el grupo que consiste en hidrogeno, alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)-, heteroaril (C1-12)-, R7- SO2-, , R7-C(O)-, R7O-C(O)- y (R7)2N-C(O)-; donde cada uno de dichos radicales alquil (C1-6)-, alquenil C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)-, heteroaril (C1-12)-, R7-SO2-, R7-C(O)-, R7O-C(O)- y (R7)2N- C(O)-R1 puede estar opcionalmente sustituido con uno a tres restos seleccionados independientemente entre el grupo que consiste en hidrogeno, hidroxi, halogeno, -CN, alquil (C1-6)-, alcoxi (C1-6)-, perhaloalquil (C1-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)- y heteroaril (C1-12)-; cada R2 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, hidroxi, halogeno, -CN, alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3- 7)-, heterociclil (C2-9)-, aril (C6-10)- y heteroaril (C1-12)-; donde cada uno de dichos radicales alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)- y heteroaril (C1-12)- R2 puede estar opcionalmente sustituido con uno a tres restos seleccionados independientemente entre el grupo que consiste en hidrogeno, hidroxi, halogeno, -CN, alquil (C1-6)-, perhaloalquil (C1-4)-, perhaloalcoxi (C1-4)-, cicloalquil (C3-7)-, heterociclil (C2-9)- , aril (C6-10)- y heteroaril (C1-12)-; cada r3 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, halogeno, hidroxi, -CN, alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, alcoxi (C1-6)-, perhaloalquil (C1-6)- y perhaloalcoxi (C1-6)-; cada R4 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, halogeno, hidroxi, -CN, -N(R6)2, alquil (C1-6)-, alquenil (C2-6)-, alquinil (C3-6)-, alcoxi (C1-6)-, perhaloalquil (C1-6)-, alquil (C1-6)-S(O)k-, R10C(O)N(R10)-, (R10)2NC(O)-, R10C(O)-, R10OC(O)-, (R10)2NC(O)N(R10)-, (R10)2NS(O)-, (R10)2NS(O)2-, cicloalquil (C3-7)-, aril (C6-10)-, heterociclil (C2-9)- y heteroaril (C1-12)-; donde cada uno de dichos radicales alquil (C1-6)-, alquenil (C2-6)-, alquinil (C3-6)-, alcoxi (C1-6)-, alquil (C1-6)-S(O)k-, R10C(O)N(R10)-, (R10)2NC(O)-, R10C(O)-, R10OC(O)-, (R10)2NC(O)N(R10)-, (R10)2NS(O)-, (R10)2NS(O)2-, cicloalquil(C3-7)-, aril (C6-10)-, heterociclil (C2-9)- y heteroaril (C1-12)-R4 puede estar opcionalmente sustituido con uno a cinco restos seleccionados independientemente entre el grupo que consiste en halogeno, hidroxi, -CN, alquil (C1-6)-, cicloalquil (C3-7)-, alcoxi (C1-6)- y perhaloalcoxi (C1-6)-; R5 es un radical seleccionado entre el grupo que consiste en hidrogeno, halogeno, -CN, alquil (C1-10)-, alcoxi (C1-6)-, alquenil (C2-10)-, alquinil (C2-10)-, cicloalquil (C3-7)-, aril (C6-10)-, heterociclil (C2-9)-, heteroaril (C1-12)-, cicloalquil (C3-7)-O-, aril (C6-10)-O-, heterociclil (C2-9)-O-, heteroaril (C1-12)-O-, R7-S-, R7-SO-, R7-SO2-, R7-C(O)-, R7-C(O)-O-, R7O-C(O)- y (R7)2N-C(O)-; donde cada uno de dichos radicales alquil (C1-10)-, alcoxi (C1-6)- y alquinil (C2-10)-R5 puede estar opcionalmente sustituido con uno a cinco restos seleccionados independientemente entre el grupo que consiste en halogeno, hidroxi, -CN, alquil (C1-6), cicloalquil (C3-7)-, aril (C6-10)-, alcoxi (C1-6)-, heterociclil (C2-9)- y heteroaril (C1-12)-; donde cada uno de dichos radicales cicloalquil (C3-7)- y cicloalquil (C3-7)-O-R5 puede estar opcionalmente sustituido con uno a cinco restos seleccionados independientemente entre el grupo que consiste en halogeno, hidroxi, -CN, alquil (C1- 6)-, aril (C6-10)-, alcoxi (C1-6)-, heterociclil (C2-9)- y heteroaril (C1-12)-; donde cada uno de dichos radicales aril (C6-10)-, heterociclil (C2-9)-, heteroaril (C1-12)-, aril (C6-10)-O-, heterociclil (C2-9)-O- y heteroaril (C1-12)-O-R5 puede estar opcionalmente sustituido con uno a cinco restos seleccionados independientemente entre el grupo que consiste en halogeno, hidroxi, -CN, alquil (C1-6)- y alcoxi (C1-6)-; donde cada uno de dichos radicales R7-S-, R7-SO-, R7-SO2-, R7-C(O)-, R7- C(O)-O-, R7O-C(O)- y (R7)2N-C(O)-R5 puede estar opcionalmente sustituido con uno a cinco restos seleccionados independientemente entre el grupo que consiste en halogeno, hidroxi, -CN, alquil (C1-6)-, cicloalquil (C3-7)- y alcoxi (C1-6)-; donde cada uno de los restos alquil (C1-6)-, alcoxi (C1-6)-, aril (C6-10)-, alcoxi (C1-6)-, heterociclil (C2-9)- y heteroaril (C1-12)- mencionados anteriormente para cada uno de los radicales R5 mencionados anteriormente puede estar opcionalmente sustituido con uno a cinco grupos halogeno; opcionalmente dicho radical R5 y un radical R4 o dos radicales R4 pueden tomarse junto con E para formar un anillo bicíclico condensado (de 8 a 10 miembros) que contiene opcionalmente de 1 a 4 heteroátomos seleccionados entre el grupo que consiste en O, S o N(R6); donde dicho anillo bicíclico condensado (de 8 a 10 miembros) está opcionalmente sustituido adicionalmente con uno a dos grupos oxo (=O); cada R6 en un enlace o un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, alquil (C1-6)-, -CN y perhaloalquil (C1-6)-; cada R7 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, -CN, alquil (C1-6)-, perhaloalquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)- y heteroaril (C1-12)-; cada R8 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, hidroxi, halogeno, -CN, -NH(R)), alquil (C1-6)-, perhaloalquil (C1-6)- y alcoxi (C1-6)-; donde cada uno de dichos radicales alquil (c1-6)- y alcoxi (c1-6)-R8 está opcionalmente sustituido con uno a cinco restos seleccionados entre el grupo que consiste en perhaloalquil (C1-6)-, - O(R9) y -N(R9)2; cada R9 es un radical seleccionado independientemente entre el grupo que consiste en hidrogeno, alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)-, heteroaril (C1-12)-, R7-S- , R7-SO-, R7-SO2-, R7-C(O)-, R7-C(O)-O-, R7O-C(O)- y (R7)2N-C(O)-; donde cada uno de dichos radicales alquil (C1-6)-, alquenil (C2-6)-, alquinil (C2-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)-, heteroaril (C1-12)-R9 está opcionalmente sustituido con uno a tres restos seleccionados independientementes entre el grupo que consiste en hidrogeno, hidroxi, halogeno, -CN, alquil (C1-6)-, alcoxi (C1-6)-, perhaloalquil (C1-6)-, cicloalquil (C3-7)-, heterociclil (C2-9)-, aril (C6-10)- y heteroaril (C1-12)-; cada R10 es un radical seleccionado entre el grupo que consiste en hidrogeno y alquil (C1-6)-; k es un numero entero de 0 a 2; cada uno de m y n es independientemente un numero entero de 0 a 3; p es un numero entero de 1 a 2; q es un numero entero de 0 a 2; y cada uno de r, s, t y u es independientemente un numero entero de 0 a 4.
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-
2007
- 2007-04-26 EA EA200802058A patent/EA200802058A1/ru unknown
- 2007-04-26 MX MX2008013990A patent/MX2008013990A/es not_active Application Discontinuation
- 2007-04-26 RS RSP-2008/0525A patent/RS20080525A/sr unknown
- 2007-04-26 AU AU2007251282A patent/AU2007251282A1/en not_active Abandoned
- 2007-04-26 ME MEP-433/08A patent/MEP43308A/xx unknown
- 2007-04-26 UA UAA200812272A patent/UA91129C2/ru unknown
- 2007-04-26 WO PCT/IB2007/001125 patent/WO2007132307A1/en active Application Filing
- 2007-04-26 CA CA002651629A patent/CA2651629A1/en not_active Abandoned
- 2007-04-26 EP EP07734443A patent/EP2021338A1/en not_active Withdrawn
- 2007-04-26 CN CNA2007800260187A patent/CN101490046A/zh active Pending
- 2007-04-26 EP EP10173690A patent/EP2258700A1/en not_active Withdrawn
- 2007-04-26 KR KR1020087029960A patent/KR20090007792A/ko active IP Right Grant
- 2007-04-26 BR BRPI0711358-7A patent/BRPI0711358A2/pt not_active IP Right Cessation
- 2007-04-26 JP JP2009508526A patent/JP4383525B2/ja active Active
- 2007-05-04 NL NL2000627A patent/NL2000627C2/nl not_active IP Right Cessation
- 2007-05-07 UY UY30326A patent/UY30326A1/es not_active Application Discontinuation
- 2007-05-08 PE PE2007000558A patent/PE20080091A1/es not_active Application Discontinuation
- 2007-05-08 DO DO2007000092A patent/DOP2007000092A/es unknown
- 2007-05-08 TW TW096116240A patent/TW200808783A/zh unknown
- 2007-05-09 AR ARP070102020A patent/AR061083A1/es not_active Application Discontinuation
- 2007-05-09 US US11/746,314 patent/US7671043B2/en not_active Expired - Fee Related
-
2008
- 2008-10-17 NO NO20084382A patent/NO20084382L/no not_active Application Discontinuation
- 2008-10-21 ZA ZA200809002A patent/ZA200809002B/xx unknown
- 2008-10-27 IL IL194954A patent/IL194954A0/en unknown
- 2008-10-30 CR CR10412A patent/CR10412A/es not_active Application Discontinuation
- 2008-11-06 TN TNP2008000446A patent/TNSN08446A1/en unknown
- 2008-11-07 EC EC2008008870A patent/ECSP088870A/es unknown
- 2008-11-07 MA MA31363A patent/MA30403B1/fr unknown
-
2010
- 2010-01-04 US US12/651,885 patent/US20100120794A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2007132307A1 (en) | 2007-11-22 |
KR20090007792A (ko) | 2009-01-20 |
US7671043B2 (en) | 2010-03-02 |
JP4383525B2 (ja) | 2009-12-16 |
BRPI0711358A2 (pt) | 2011-09-27 |
MX2008013990A (es) | 2009-01-29 |
NL2000627A1 (nl) | 2007-11-12 |
NL2000627C2 (nl) | 2009-03-17 |
DOP2007000092A (es) | 2007-12-31 |
ZA200809002B (en) | 2009-12-30 |
IL194954A0 (en) | 2009-08-03 |
TNSN08446A1 (en) | 2010-04-14 |
UA91129C2 (ru) | 2010-06-25 |
EP2258700A1 (en) | 2010-12-08 |
RS20080525A (en) | 2009-09-08 |
TW200808783A (en) | 2008-02-16 |
UY30326A1 (es) | 2008-01-02 |
ECSP088870A (es) | 2008-12-30 |
EA200802058A1 (ru) | 2009-06-30 |
CN101490046A (zh) | 2009-07-22 |
MEP43308A (en) | 2011-02-10 |
US20100120794A1 (en) | 2010-05-13 |
MA30403B1 (fr) | 2009-05-04 |
US20070270438A1 (en) | 2007-11-22 |
CR10412A (es) | 2008-11-28 |
AU2007251282A1 (en) | 2007-11-22 |
EP2021338A1 (en) | 2009-02-11 |
NO20084382L (no) | 2008-11-19 |
JP2009536190A (ja) | 2009-10-08 |
PE20080091A1 (es) | 2008-02-14 |
CA2651629A1 (en) | 2007-11-22 |
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