AR065556A1 - Derivados de 3-(( 1,2,4) triazolo (4,3-a) piridin -7-il) benzamida - Google Patents

Derivados de 3-(( 1,2,4) triazolo (4,3-a) piridin -7-il) benzamida

Info

Publication number
AR065556A1
AR065556A1 ARP080100852A ARP080100852A AR065556A1 AR 065556 A1 AR065556 A1 AR 065556A1 AR P080100852 A ARP080100852 A AR P080100852A AR P080100852 A ARP080100852 A AR P080100852A AR 065556 A1 AR065556 A1 AR 065556A1
Authority
AR
Argentina
Prior art keywords
groups
group
crarb
optionally substituted
alkyl
Prior art date
Application number
ARP080100852A
Other languages
English (en)
Inventor
Juan Bernat Vidal
Paul Robert Eastwood
Trias Cristina Esteve
Rodriguez Jacob Gonzalez
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of AR065556A1 publication Critical patent/AR065556A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente se refiere a inhibidores de la proteína quinasa p38 activada por mitogenos, a procedimientos para su preparacion, a composiciones farmacéuticas que los contienen, y a su uso en terapia. utiles para dolor, artritis reumatoidea, Alzheimer,osteoporosis. Reivindicacion 1: Un compuesto de formula (1) en donde R1 se selecciona del grupo que consiste en grupos alquilo C1-4, cicloalquilo C3-7 y -(CH2)(1-3)-cicloalquilo C3-7, R2 se selecciona del grupo que consiste en átomos de hidrogeno yátomos de halogeno, R3 se selecciona del grupo que consiste en grupos metilo y átomos de halogeno, L se selecciona del grupo que consiste en enlace directo, -(CRaRb)(1-2)-, -CO-, -S-, -O-, -(CRaRb)(0-1)-NH-CO, -CO-NH-(CRaRb)(0-1)-, -(CRaRb)(0-1)-NH-SO2-, -CRaRb)(0-1)-N(R5) y -N(R5)-(CRaRb)(0-1)-; en donde Ra, Rb y R5 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno y grupos alquilo C1-4, R4 se selecciona del grupo que consiste en átomos de hidrogeno, gruposhidroxi, grupos alcoxi C1-4, grupos alquilo C1-4 opcionalmente sustituidos con átomos de fluor, grupos cicloalquilo C3-6 opcionalmente sustituidos con átomos de fluor o con alquilo C1-4, grupos arilo C5-14 que están opcionalmente sustituidos conátomos de halogeno o con grupos seleccionados de alquilo C1-4, trifluorometilo y difluorometilo, o grupos heteroarilo de 5 a 14 miembros que contienen al menos un heteroátomo seleccionado de N, O y S, estando dichos grupos heteroarilo opcionalmentesustituidos con átomos de halogeno o con grupos seleccionados de alquilo C1-4, trifluorometilo y difluorometilo; o grupos heterocíclicos de 3 a 7 miembros que contienen al menos un heteroátomo seleccionado de N, O y S, estando dichos gruposheterocíclicos opcionalmente sustituidos con grupos alquilo C1-4, Y1 y Y2 se seleccionan independientemente del grupo que consiste en átomos de hidrogeno, fluor y cloro, y sus sales y N-oxidos farmacéuticamente aceptables.
ARP080100852A 2007-03-02 2008-02-29 Derivados de 3-(( 1,2,4) triazolo (4,3-a) piridin -7-il) benzamida AR065556A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200700565A ES2320955B1 (es) 2007-03-02 2007-03-02 Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.

Publications (1)

Publication Number Publication Date
AR065556A1 true AR065556A1 (es) 2009-06-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100852A AR065556A1 (es) 2007-03-02 2008-02-29 Derivados de 3-(( 1,2,4) triazolo (4,3-a) piridin -7-il) benzamida

Country Status (19)

Country Link
US (1) US8258122B2 (es)
EP (1) EP2118100A1 (es)
JP (1) JP5318785B2 (es)
KR (1) KR20090115978A (es)
CN (1) CN101679413B (es)
AR (1) AR065556A1 (es)
AU (1) AU2008224179A1 (es)
CA (1) CA2682756A1 (es)
CL (1) CL2008000612A1 (es)
CO (1) CO6220952A2 (es)
EC (1) ECSP099662A (es)
ES (1) ES2320955B1 (es)
NZ (1) NZ579917A (es)
PE (1) PE20081800A1 (es)
RU (1) RU2009136299A (es)
TW (1) TW200900062A (es)
UY (1) UY30942A1 (es)
WO (1) WO2008107125A1 (es)
ZA (1) ZA200906736B (es)

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UY30942A1 (es) 2008-07-31
US8258122B2 (en) 2012-09-04
PE20081800A1 (es) 2008-12-18
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CN101679413B (zh) 2013-07-03
CA2682756A1 (en) 2008-09-12
CN101679413A (zh) 2010-03-24
AU2008224179A1 (en) 2008-09-12
TW200900062A (en) 2009-01-01
US20100120731A1 (en) 2010-05-13
ZA200906736B (en) 2010-10-27
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WO2008107125A1 (en) 2008-09-12
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ECSP099662A (es) 2009-10-30
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