PE20091811A1 - DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 - Google Patents
DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1Info
- Publication number
- PE20091811A1 PE20091811A1 PE2009000571A PE2009000571A PE20091811A1 PE 20091811 A1 PE20091811 A1 PE 20091811A1 PE 2009000571 A PE2009000571 A PE 2009000571A PE 2009000571 A PE2009000571 A PE 2009000571A PE 20091811 A1 PE20091811 A1 PE 20091811A1
- Authority
- PE
- Peru
- Prior art keywords
- halogen
- ona
- hexahydro
- imidazol
- hsd1
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000008624 imidazolidinones Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOLIDINONA DE FORMULA (I) DONDE R1 ES BORNILO, FENILALQUILO, ADAMANTILO, ENTRE OTROS; R2 Y R3 JUNTO AL ATOMO DE N* Y DE C* FORMAN (E), (F), (G), ENTRE OTROS, DONDE UNO DE R7 Y R8 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; UNO DE R13 Y R14 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; R4 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; A ES CR5R6 O CARBONILO, DONDE R5 Y R6 SON CADA UNO H. SON COMPUESTOS PREFERIDOS: (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-7a-METIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-FENIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA 11BETA-HIDROXIESTEROIDE-DESHIDROGENASA DE TIPO 1 (11BETA-HSD1) SIENDO UTILES PARA EL TRATAMIENTO DE LA DIABETES, OBESIDAD, DISLIPIDEMIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08155430 | 2008-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091811A1 true PE20091811A1 (es) | 2009-11-21 |
Family
ID=40790778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000571A PE20091811A1 (es) | 2008-04-30 | 2009-04-27 | DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 |
Country Status (18)
Country | Link |
---|---|
US (1) | US8124636B2 (es) |
EP (1) | EP2280970B1 (es) |
JP (1) | JP2011520790A (es) |
KR (1) | KR20110008198A (es) |
CN (1) | CN102015706B (es) |
AR (1) | AR071512A1 (es) |
AU (1) | AU2009242248A1 (es) |
BR (1) | BRPI0910549A2 (es) |
CA (1) | CA2722487A1 (es) |
CL (1) | CL2009001019A1 (es) |
ES (1) | ES2445094T3 (es) |
IL (1) | IL208626A0 (es) |
MX (1) | MX2010011642A (es) |
PE (1) | PE20091811A1 (es) |
RU (1) | RU2538986C2 (es) |
TW (1) | TW200946535A (es) |
WO (1) | WO2009132986A1 (es) |
ZA (1) | ZA201007431B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
SG186275A1 (en) | 2010-07-06 | 2013-01-30 | Astrazeneca Ab | Therapeutic agents 976 |
US8497288B2 (en) * | 2011-05-09 | 2013-07-30 | Hoffmann-La Roche Inc. | Hexahydropyrroloimidazolone compounds |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
US20230040182A1 (en) * | 2019-10-07 | 2023-02-09 | D. E. Shaw Research, Llc | ARYL HETEROBICYCLIC COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3809390A1 (de) * | 1988-03-16 | 1989-09-28 | Schering Ag | Perhydro-imidazopyridine und -pyrroloimidazole, verfahren zu ihrer herstellung und ihre verwendung als herbizide mittel |
ES2292262T3 (es) * | 1998-12-24 | 2008-03-01 | Astellas Pharma Inc. | Compuestos de imidazol y su uso medicinal. |
EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
TW200407324A (en) * | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
EP1786774B1 (en) * | 2004-08-30 | 2009-10-14 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
WO2008007664A1 (fr) * | 2006-07-11 | 2008-01-17 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique bicycique et son utilisation |
WO2008044656A1 (fr) * | 2006-10-06 | 2008-04-17 | Taisho Pharmaceutical Co., Ltd. | Dérivé d'imidazolidinone |
MX2009003939A (es) * | 2006-10-19 | 2009-05-11 | Hoffmann La Roche | Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes. |
-
2009
- 2009-04-16 US US12/424,587 patent/US8124636B2/en not_active Expired - Fee Related
- 2009-04-21 KR KR1020107024234A patent/KR20110008198A/ko not_active Application Discontinuation
- 2009-04-21 CA CA2722487A patent/CA2722487A1/en not_active Abandoned
- 2009-04-21 WO PCT/EP2009/054701 patent/WO2009132986A1/en active Application Filing
- 2009-04-21 AU AU2009242248A patent/AU2009242248A1/en not_active Abandoned
- 2009-04-21 MX MX2010011642A patent/MX2010011642A/es active IP Right Grant
- 2009-04-21 BR BRPI0910549A patent/BRPI0910549A2/pt not_active IP Right Cessation
- 2009-04-21 EP EP09738030.7A patent/EP2280970B1/en not_active Not-in-force
- 2009-04-21 ES ES09738030.7T patent/ES2445094T3/es active Active
- 2009-04-21 JP JP2011506654A patent/JP2011520790A/ja active Pending
- 2009-04-21 RU RU2010148534/04A patent/RU2538986C2/ru not_active IP Right Cessation
- 2009-04-21 CN CN200980115164.6A patent/CN102015706B/zh not_active Expired - Fee Related
- 2009-04-27 PE PE2009000571A patent/PE20091811A1/es not_active Application Discontinuation
- 2009-04-28 TW TW098114080A patent/TW200946535A/zh unknown
- 2009-04-28 AR ARP090101500A patent/AR071512A1/es not_active Application Discontinuation
- 2009-04-29 CL CL2009001019A patent/CL2009001019A1/es unknown
-
2010
- 2010-10-11 IL IL208626A patent/IL208626A0/en unknown
- 2010-10-18 ZA ZA2010/07431A patent/ZA201007431B/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2538986C2 (ru) | 2015-01-10 |
CN102015706A (zh) | 2011-04-13 |
US8124636B2 (en) | 2012-02-28 |
RU2010148534A (ru) | 2012-06-10 |
JP2011520790A (ja) | 2011-07-21 |
EP2280970A1 (en) | 2011-02-09 |
IL208626A0 (en) | 2010-12-30 |
AR071512A1 (es) | 2010-06-23 |
ES2445094T3 (es) | 2014-02-28 |
MX2010011642A (es) | 2010-11-25 |
BRPI0910549A2 (pt) | 2016-04-19 |
KR20110008198A (ko) | 2011-01-26 |
CL2009001019A1 (es) | 2011-01-07 |
TW200946535A (en) | 2009-11-16 |
CN102015706B (zh) | 2014-07-16 |
AU2009242248A1 (en) | 2009-11-05 |
ZA201007431B (en) | 2013-03-27 |
WO2009132986A1 (en) | 2009-11-05 |
EP2280970B1 (en) | 2014-01-08 |
CA2722487A1 (en) | 2009-11-05 |
US20090275573A1 (en) | 2009-11-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |