PE20080070A1 - Derivados de indolobenzazepina fusionados a ciclopropilo como inhibidores de la polimerasa ns5b del virus de la hepatitis c - Google Patents
Derivados de indolobenzazepina fusionados a ciclopropilo como inhibidores de la polimerasa ns5b del virus de la hepatitis cInfo
- Publication number
- PE20080070A1 PE20080070A1 PE2007000585A PE2007000585A PE20080070A1 PE 20080070 A1 PE20080070 A1 PE 20080070A1 PE 2007000585 A PE2007000585 A PE 2007000585A PE 2007000585 A PE2007000585 A PE 2007000585A PE 20080070 A1 PE20080070 A1 PE 20080070A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- hepatitis
- cyclopropyl
- virus
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A COMPUESTOS DE DERIVADOS DE INDOLOBENZAZEPINA FUSIONADOS A CICLOPROPILO DE FORMULA (I) DONDE R1 ES CO2R5 O CONR6R7, DONDE R5 ES H O ALQUILO(C1-C6); R6 ES H, ALQUILO(C1-C6), ALQUIL(C1-C6)SO2, CICLOALQUIL(C3-C7)SO2, ENTRE OTROS; R7 ES H O ALQUILO(C1-C6); R2 ES UN COMPUESTO DE FORMULA (i) O (ii), DONDE R8 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), AMINOCARBONILO, ENTRE OTROS; R3 ES H, HALO, ALQUILO(C1-C6), OH, ENTRE OTROS; R4 ES CICLOALQUILO(C3-C7). SON COMPUESTOS PREFERIDOS: (+/-)-8-CICLOHEXIL-N-(METILSULFONIL)-1,1a,2,12b-TETRAHIDRO-11-METOXI-1a-(3-METIL-3,8-DIAZABICICLO[3.2.1]OCTANO-8-CARBONIL)CICLOPROP[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA, (+/-)-8-CICLOHEXIL-N-(ETILSULFONIL)-1,1a,2,12b-TETRAHIDRO-11-METOXI-1a-(3-METIL-3,8-DIAZABICICLO[3.2.1]OCTANO-8-CARBONIL)CICLOPROP[d]INDOLO[2,1-a][2]BENZAZEPINA-5-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA POLIMERASA NS5B DEL VIRUS DE LA HEPATITIS C SIENDO UTILES EN EL TRATAMIENTO DE LA INFECCION DE LA HEPATITIS C
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80112506P | 2006-05-17 | 2006-05-17 | |
US80200506P | 2006-05-19 | 2006-05-19 | |
US85208406P | 2006-10-16 | 2006-10-16 | |
US89475707P | 2007-03-14 | 2007-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080070A1 true PE20080070A1 (es) | 2008-03-10 |
Family
ID=38512732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000585A PE20080070A1 (es) | 2006-05-17 | 2007-05-15 | Derivados de indolobenzazepina fusionados a ciclopropilo como inhibidores de la polimerasa ns5b del virus de la hepatitis c |
Country Status (25)
Country | Link |
---|---|
US (1) | US7456166B2 (es) |
EP (1) | EP2024375B1 (es) |
JP (1) | JP5284952B2 (es) |
KR (1) | KR101417145B1 (es) |
AR (1) | AR061008A1 (es) |
AT (1) | ATE501156T1 (es) |
AU (1) | AU2007253998B2 (es) |
BR (1) | BRPI0711821A2 (es) |
CA (1) | CA2651690C (es) |
CY (1) | CY1111526T1 (es) |
DE (1) | DE602007013036D1 (es) |
DK (1) | DK2024375T3 (es) |
EA (1) | EA015286B1 (es) |
HK (1) | HK1122814A1 (es) |
HR (1) | HRP20110194T1 (es) |
IL (1) | IL195025A (es) |
MX (1) | MX2008014435A (es) |
NO (1) | NO341663B1 (es) |
NZ (1) | NZ572555A (es) |
PE (1) | PE20080070A1 (es) |
PL (1) | PL2024375T3 (es) |
SI (1) | SI2024375T1 (es) |
TW (1) | TWI401244B (es) |
WO (1) | WO2007136982A1 (es) |
ZA (1) | ZA200809548B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1688420A4 (en) * | 2003-11-19 | 2008-10-22 | Japan Tobacco Inc | 5-5 LOW-CONDENSED HETEROCYCLIC COMPOUND AND THEIR USE AS HCV POLYMERASE INHIBITOR |
US20070049593A1 (en) * | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
US7521443B2 (en) * | 2006-05-17 | 2009-04-21 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7456167B2 (en) * | 2006-05-25 | 2008-11-25 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7541351B2 (en) * | 2007-01-11 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7541352B2 (en) * | 2007-02-02 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7517872B2 (en) * | 2007-02-22 | 2009-04-14 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7998951B2 (en) * | 2007-03-05 | 2011-08-16 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
CN101679437B (zh) | 2007-03-13 | 2013-04-17 | 百时美施贵宝公司 | 环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂 |
US7521444B2 (en) * | 2007-03-14 | 2009-04-21 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7547690B2 (en) * | 2007-03-14 | 2009-06-16 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US7541353B2 (en) * | 2007-03-14 | 2009-06-02 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7538102B2 (en) * | 2007-03-14 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US7538103B2 (en) * | 2007-03-15 | 2009-05-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
NZ580917A (en) | 2007-05-04 | 2012-06-29 | Vertex Pharma | Combinations of protease inhibitors such as VX-950 and polymerase inhibitors for the treatment of HCV infection |
US7652004B2 (en) * | 2007-08-09 | 2010-01-26 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US8143243B2 (en) * | 2007-08-09 | 2012-03-27 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
US7642251B2 (en) * | 2007-08-09 | 2010-01-05 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
SI2209789T1 (sl) * | 2007-11-20 | 2012-06-29 | Bristol Myers Squibb Co | Ciklopropil zliti indolobenzazepin hcv ns5b inhibitorji |
US8129367B2 (en) * | 2007-11-21 | 2012-03-06 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
US8124601B2 (en) | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
CN101903351B (zh) | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
DK2238142T3 (da) * | 2007-12-24 | 2012-10-08 | Janssen R & D Ireland | Makrocykliske indoler som hepatitis C-virusinhibitorer |
JP2011515486A (ja) * | 2008-03-27 | 2011-05-19 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎の治療用化合物 |
CN101981038B (zh) * | 2008-03-27 | 2013-07-10 | 百时美施贵宝公司 | 二氧戊环和二氧戊环酮稠合的吲哚并苯并二氮杂*hcv ns5b抑制剂 |
ES2416062T3 (es) * | 2008-03-27 | 2013-07-30 | Bristol-Myers Squibb Company | Inhibidores de NS5B del VHC de indolobenzadiazepina condensados con pirrolidina |
US8133884B2 (en) * | 2008-05-06 | 2012-03-13 | Bristol-Myers Squibb Company | Compounds for the treatment of hepatitis C |
TWI454476B (zh) * | 2008-07-08 | 2014-10-01 | Tibotec Pharm Ltd | 用作c型肝炎病毒抑制劑之巨環吲哚衍生物 |
UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
MX2011007195A (es) | 2009-01-07 | 2013-07-12 | Scynexis Inc | Derivado de ciclosporina para el uso en el tratamiento de infección de virus de hepatitis c (vhc) y virus de inmunodeficiencia humana (vih). |
US8143244B2 (en) * | 2009-02-26 | 2012-03-27 | Bristol-Myers Squibb Company | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
AU2011268922B2 (en) | 2010-06-24 | 2014-06-12 | Janssen Sciences Ireland Uc | Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid |
US20120196794A1 (en) * | 2010-08-06 | 2012-08-02 | Bristol-Myers Squibb Company | Combinations of Hepatitis C Virus Inhibitors |
US9173887B2 (en) | 2010-12-22 | 2015-11-03 | Abbvie Inc. | Hepatitis C inhibitors and uses thereof |
US8937041B2 (en) | 2010-12-30 | 2015-01-20 | Abbvie, Inc. | Macrocyclic hepatitis C serine protease inhibitors |
BR112013016480A2 (pt) | 2010-12-30 | 2016-09-20 | Abbvie Inc | macrocíclo da fenantridina inibadores da protease da serina da hepatite c |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
US8716275B2 (en) * | 2011-10-20 | 2014-05-06 | Bristol-Myers Squibb Company | Compound for the treatment of hepatitis C |
EA025391B1 (ru) * | 2012-07-18 | 2016-12-30 | Бристол-Майерс Сквибб Холдингс Айеленд | НОВЫЕ СПОСОБЫ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ (4bS,5aR)-12-ЦИКЛОГЕКСИЛ-N-(N,N-ДИМЕТИЛСУЛЬФАМОИЛ)-3-МЕТОКСИ-5a-((1R,5S)-3-МЕТИЛ-3,8-ДИАЗАБИЦИКЛО[3.2.1]ОКТАН-8-КАРБОНИЛ)-4b,5,5a,6-ТЕТРАГИДРОБЕНЗО[3,4]ЦИКЛОПРОПА[5,6]АЗЕПИНО[1,2-a]ИНДОЛ-9-КАРБОКСАМИДА |
EP3089757A1 (en) | 2014-01-03 | 2016-11-09 | AbbVie Inc. | Solid antiviral dosage forms |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US753137A (en) * | 1904-02-23 | Dust-pan | ||
US752354A (en) * | 1904-02-16 | Composition post | ||
US756203A (en) * | 1903-11-14 | 1904-04-05 | Oliver E Barthel | Muffler. |
RS50815B (sr) | 2004-02-24 | 2010-08-31 | Japan Tobacco Inc. | Kondenzovana heterotetraciklična jedinjenja i njihova upotreba kao inhibitora hcv polimeraza |
US7153848B2 (en) * | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7348425B2 (en) * | 2004-08-09 | 2008-03-25 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
ATE384723T1 (de) | 2004-10-13 | 2008-02-15 | Merck Patent Gmbh | Als kinaseinhibitoren geeignete derivate des n,n'-diphenylharnstoffs |
AU2005298412B2 (en) * | 2004-10-26 | 2011-06-09 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7399758B2 (en) * | 2005-09-12 | 2008-07-15 | Meanwell Nicholas A | Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors |
US7473688B2 (en) * | 2005-09-13 | 2009-01-06 | Bristol-Myers Squibb Company | Indolobenzazepine HCV NS5B inhibitors |
US7456165B2 (en) * | 2006-02-08 | 2008-11-25 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
GB0608928D0 (en) * | 2006-05-08 | 2006-06-14 | Angeletti P Ist Richerche Bio | Therapeutic agents |
-
2007
- 2007-05-03 US US11/743,921 patent/US7456166B2/en not_active Expired - Fee Related
- 2007-05-04 DE DE602007013036T patent/DE602007013036D1/de active Active
- 2007-05-04 EP EP07761873A patent/EP2024375B1/en active Active
- 2007-05-04 JP JP2009511151A patent/JP5284952B2/ja active Active
- 2007-05-04 NZ NZ572555A patent/NZ572555A/en unknown
- 2007-05-04 WO PCT/US2007/068209 patent/WO2007136982A1/en active Application Filing
- 2007-05-04 AT AT07761873T patent/ATE501156T1/de active
- 2007-05-04 SI SI200730612T patent/SI2024375T1/sl unknown
- 2007-05-04 MX MX2008014435A patent/MX2008014435A/es active IP Right Grant
- 2007-05-04 CA CA2651690A patent/CA2651690C/en not_active Expired - Fee Related
- 2007-05-04 PL PL07761873T patent/PL2024375T3/pl unknown
- 2007-05-04 DK DK07761873.4T patent/DK2024375T3/da active
- 2007-05-04 AU AU2007253998A patent/AU2007253998B2/en not_active Ceased
- 2007-05-04 EA EA200802346A patent/EA015286B1/ru not_active IP Right Cessation
- 2007-05-04 BR BRPI0711821-0A patent/BRPI0711821A2/pt not_active IP Right Cessation
- 2007-05-04 KR KR1020087027866A patent/KR101417145B1/ko active IP Right Grant
- 2007-05-15 PE PE2007000585A patent/PE20080070A1/es active IP Right Grant
- 2007-05-17 AR ARP070102138A patent/AR061008A1/es active IP Right Grant
- 2007-05-17 TW TW096117512A patent/TWI401244B/zh not_active IP Right Cessation
-
2008
- 2008-10-30 IL IL195025A patent/IL195025A/en not_active IP Right Cessation
- 2008-11-04 NO NO20084637A patent/NO341663B1/no not_active IP Right Cessation
- 2008-11-07 ZA ZA2008/09548A patent/ZA200809548B/en unknown
-
2009
- 2009-03-31 HK HK09103021.8A patent/HK1122814A1/xx not_active IP Right Cessation
-
2011
- 2011-03-16 HR HR20110194T patent/HRP20110194T1/hr unknown
- 2011-06-03 CY CY20111100539T patent/CY1111526T1/el unknown
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