AR052887A1 - Derivados de tiazol, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para tratar enfermedades mediadas por la inhibicion de la protein quinasa - Google Patents
Derivados de tiazol, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para tratar enfermedades mediadas por la inhibicion de la protein quinasaInfo
- Publication number
- AR052887A1 AR052887A1 ARP060100240A ARP060100240A AR052887A1 AR 052887 A1 AR052887 A1 AR 052887A1 AR P060100240 A ARP060100240 A AR P060100240A AR P060100240 A ARP060100240 A AR P060100240A AR 052887 A1 AR052887 A1 AR 052887A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halo
- substituted
- alkoxy
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Composiciones farmacéuticas que comprenden a dichos compuestos y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con la actividad anormal o desregulada de la quinasa, particularmente enfermedades o trastornos que comprenden la activacion anormal de las quinasa Ab1, Bcr-Ab1, FGFR3, PDGFRbeta y b-Raf. Reivindicacion 1: Un compuesto de formula (1), en la que: n se selecciona del 0, 1, 2, 3 y 4; Y se selecciona de C, S, S(O) P y P(O); R1 se selecciona de alquilo C1-6, ariloC6-10-alquiloC0-4, heteroariloC5-10-alquiloC0-4, cicloalquiloC3-12-alquiloC0-4, heterocicloalquiloC3-8- alquiloC0-4 y -XNR7R8; en donde cualquier arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R1 se encuentra sustituido con 1-3 radicales independientemente seleccionados de halo, alquilo C1-6, alquiloC1-6 sustituido con halo, alcoxi C1-6, alcoxi C1-6 sustituido con halo, alquiltio C1-6, alquiltio C1-6 sustituido con halo, -XNR7R8, -XNR7XNR7R8, - XNR7R9, arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12 y heterocicloalquilo C3-8; en donde cualquier sustituyente arilo, heteroarilo, cicloalquilo o heterocicloalquilo en R1 puede estar opcionalmente sustituido con 1 a 3 radicales independientemente seleccionados de halo, alquilo C1-6, alquilo C1-6 sustituido con halo, alquilo C1-6 sustituido con hidroxi, alcoxi C1-6 y alcoxi C1-6 sustituido con halo; y en donde cualquier alquilo de R1 puede tener un metileno reemplazado con O; en donde X se selecciona independientemente de un enlace y alquileno C1-6; R7 y R8 seleccionan independientemente de hidrogeno y alquilo C1-6; en donde cualquier metileno de R7 y R8 se puede reemplazar con O; en donde R9 se selecciona de ariloC6- 10-alquiloC0-4, heteroariloC5-10-alquiloC0-4, cicloalquiloC3-12-alquiloC0-4 y heterocicloalquiloC3-8-alquiloC0-4; R2 se selecciona de hidrogeno y alquilo C1-6; R3 se selecciona de hidrogeno y alquilo C1-6; R4 se selecciona de halo, alquilo C1-6, alquilo C1-6 sustituido con halo, alcoxi C1-6, alcoxi c1-6 sustituido con halo, alquiltio C1-6 y alquiltio C1-6 con halo; R5 se selecciona del hidrogeno y alquilo C1-6; y R6 se selecciona de arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12 y heterocicloalquilo C3-8; en donde dicho arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R6 se encuentra opcionalmente sustituido con 1 a 3 sustituyentes seleccionados independientemente de halo, alquilo C1-6, alquilo C1-6 sustituido con halo, alcoxi C1-6, alcoxi C1-6 sustituido con halo, alquiltio C1-6, alquiltio C1-6 sustituido con halo, arilo C6-10, heteroarilo C5-10, cicloalquilo C3-12, y heterocicloalquilo C3-8; en donde los sustituyentes arilo, heteroarilo, cicloalquilo o heterocicloalquilo en R6 pueden estar opcionalmente sustituidos con 1 a 3 radicales independientemente seleccionados de hidroxi, halo, alquilo C1-6, alquilo C1-6 sustituido con halo, alquilo C1-6 sustituido con hidroxi, alcoxi C1-6 y alcoxi C1-6 sustituido con halo; y las sales, hidratos, solvatos, isomeros y profármacos farmacéuticamente aceptables de dichos compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64760605P | 2005-01-26 | 2005-01-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052887A1 true AR052887A1 (es) | 2007-04-11 |
Family
ID=36740973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060100240A AR052887A1 (es) | 2005-01-26 | 2006-01-23 | Derivados de tiazol, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para tratar enfermedades mediadas por la inhibicion de la protein quinasa |
Country Status (15)
Country | Link |
---|---|
US (1) | US20090105250A1 (es) |
EP (1) | EP1841431A4 (es) |
JP (1) | JP2008528585A (es) |
KR (1) | KR100919905B1 (es) |
CN (1) | CN101106990B (es) |
AR (1) | AR052887A1 (es) |
AU (1) | AU2006209183B2 (es) |
BR (1) | BRPI0607307A2 (es) |
CA (1) | CA2593803A1 (es) |
GT (1) | GT200600028A (es) |
MX (1) | MX2007008973A (es) |
PE (1) | PE20060877A1 (es) |
RU (1) | RU2368602C2 (es) |
TW (1) | TW200637547A (es) |
WO (1) | WO2006081172A2 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1809614B1 (en) | 2004-04-08 | 2014-05-07 | TargeGen, Inc. | Benzotriazine inhibitors of kinases |
PL382308A1 (pl) | 2004-08-25 | 2007-08-20 | Targegen, Inc. | Związki heterocykliczne i sposoby stosowania |
PE20061394A1 (es) * | 2005-03-15 | 2006-12-15 | Bristol Myers Squibb Co | Metabolitos de n-(2-cloro-6-metilfenil)-2-[[6-[4-(2-hidroxietil)-1-piperazinil]-2-metil-4-pirimidinil]amino]-5-tiazolcarboxamidas |
EP1904065A2 (en) * | 2005-07-14 | 2008-04-02 | AB Science | Use of dual c-kit/fgfr3 inhibitors for treating multiple myeloma |
CA2637172A1 (en) * | 2006-01-27 | 2007-08-09 | Array Biopharma Inc. | Pyridin-2-amine derivatives and their use as glucokinase activators |
AU2007296743B2 (en) * | 2006-09-11 | 2012-02-16 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
EP2078004B1 (en) | 2006-10-31 | 2015-02-25 | Merck Sharp & Dohme Corp. | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors |
MX2009004786A (es) | 2006-10-31 | 2009-06-05 | Schering Corp | Derivados de anilinopiperazina y sus metodos de uso. |
JP2011513330A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | Raf阻害化合物およびその使用方法 |
AR072657A1 (es) * | 2008-02-29 | 2010-09-15 | Genentech Inc | Compuestos inhibidores de raf y metodos para su uso |
CA2716947A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
CA2716949A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
DK2300013T3 (en) | 2008-05-21 | 2017-12-04 | Ariad Pharma Inc | PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
JO3101B1 (ar) * | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
US8765747B2 (en) | 2009-06-12 | 2014-07-01 | Dana-Farber Cancer Institute, Inc. | Fused 2-aminothiazole compounds |
US9180127B2 (en) * | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
WO2011147764A1 (en) | 2010-05-28 | 2011-12-01 | N.V. Organon | Thieno (2, 3b) pyrazine compounds as b - raf inhibitors |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
RU2011122942A (ru) * | 2011-06-08 | 2012-12-20 | Общество С Ограниченной Ответственностью "Асинэкс Медхим" | Новые ингибиторы киназ |
MX2014002471A (es) * | 2011-08-31 | 2014-03-27 | Novartis Ag | Combinaciones sinergicas de los inhibidores de p13k y mek. |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
EP3569598A1 (en) | 2011-11-17 | 2019-11-20 | Dana Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
RU2495430C1 (ru) * | 2012-03-29 | 2013-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Астраханская государственная академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО АГМА Минздравсоцразвития России) | Способ оценки эффективности терапии хронического миелолейкоза |
ES2605388T3 (es) * | 2012-04-26 | 2017-03-14 | Ono Pharmaceutical Co., Ltd. | Compuesto inhibidor de Trk |
US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
RU2495427C1 (ru) * | 2012-07-04 | 2013-10-10 | Федеральное бюджетное учреждение науки "Уфимский научно-исследовательский институт медицины труда и экологии человека" | Способ прогнозирования ответа на химиотерапию при хроническом лимфолейкозе |
EP2909194A1 (en) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
WO2014069434A1 (ja) * | 2012-10-30 | 2014-05-08 | カルナバイオサイエンス株式会社 | 新規チアゾリジノン誘導体 |
SG10201700808UA (en) | 2013-02-19 | 2017-02-27 | Ono Pharmaceutical Co | Trk-INHIBITING COMPOUND |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
JP6879740B2 (ja) | 2013-12-13 | 2021-06-02 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | リンパ形質細胞性リンパ腫を処置する方法 |
AU2014361800B2 (en) | 2013-12-13 | 2020-05-07 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
WO2015164604A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
WO2016065138A1 (en) | 2014-10-22 | 2016-04-28 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
JP6854762B2 (ja) | 2014-12-23 | 2021-04-07 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の阻害剤 |
JP6861166B2 (ja) | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2996978A1 (en) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
TWI620748B (zh) * | 2016-02-05 | 2018-04-11 | National Health Research Institutes | 氨基噻唑化合物及其用途 |
WO2017147701A1 (en) | 2016-03-01 | 2017-09-08 | Ontario Institute For Cancer Research (Oicr) | Inhibitors of wdr5 protein-protein binding |
CN109195965B (zh) | 2016-03-01 | 2022-07-26 | 普罗佩纶治疗公司 | Wdr5蛋白质-蛋白质结合的抑制剂 |
WO2018183122A1 (en) * | 2017-03-27 | 2018-10-04 | Sidecar Therapeutics, Inc. | Apoptosis signal-regulating kinase 1 (ask 1) inhibitor compounds |
WO2019202160A2 (en) | 2018-04-20 | 2019-10-24 | Iomx Therapeutics Ag | A 5-thiazolecarboxamide kinase inhibitor and uses thereof |
RU2768755C1 (ru) * | 2018-05-09 | 2022-03-24 | ЭлДжи КЕМ, ЛТД. | Новое соединение, проявляющее ингибирующую активность в отношении энтеропептидазы |
EP3643713A1 (en) | 2018-10-23 | 2020-04-29 | iOmx Therapeutics AG | Heterocyclic kinase inhibitors and uses thereof |
EP3901151A1 (en) | 2020-04-21 | 2021-10-27 | iOmx Therapeutics AG | Halogenated-heteroaryl and other heterocyclic kinase inhibitors, and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602004028907D1 (de) * | 2003-02-06 | 2010-10-14 | Bristol Myers Squibb Co | Als kinaseinhibitoren geeignete verbindungen auf thiazolylbasis |
-
2006
- 2006-01-19 JP JP2007553154A patent/JP2008528585A/ja active Pending
- 2006-01-19 EP EP06733803A patent/EP1841431A4/en not_active Withdrawn
- 2006-01-19 CA CA002593803A patent/CA2593803A1/en not_active Abandoned
- 2006-01-19 CN CN2006800032754A patent/CN101106990B/zh not_active Expired - Fee Related
- 2006-01-19 AU AU2006209183A patent/AU2006209183B2/en not_active Ceased
- 2006-01-19 MX MX2007008973A patent/MX2007008973A/es not_active Application Discontinuation
- 2006-01-19 WO PCT/US2006/002266 patent/WO2006081172A2/en active Application Filing
- 2006-01-19 BR BRPI0607307-7A patent/BRPI0607307A2/pt not_active IP Right Cessation
- 2006-01-19 RU RU2007132262/04A patent/RU2368602C2/ru not_active IP Right Cessation
- 2006-01-19 KR KR1020077017155A patent/KR100919905B1/ko not_active IP Right Cessation
- 2006-01-19 US US11/814,912 patent/US20090105250A1/en not_active Abandoned
- 2006-01-23 AR ARP060100240A patent/AR052887A1/es not_active Application Discontinuation
- 2006-01-23 PE PE2006000097A patent/PE20060877A1/es not_active Application Discontinuation
- 2006-01-24 GT GT200600028A patent/GT200600028A/es unknown
- 2006-01-24 TW TW095102616A patent/TW200637547A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP1841431A4 (en) | 2009-12-09 |
CA2593803A1 (en) | 2006-08-03 |
EP1841431A2 (en) | 2007-10-10 |
PE20060877A1 (es) | 2006-10-16 |
GT200600028A (es) | 2006-10-18 |
WO2006081172A3 (en) | 2006-09-14 |
KR20070095978A (ko) | 2007-10-01 |
TW200637547A (en) | 2006-11-01 |
US20090105250A1 (en) | 2009-04-23 |
KR100919905B1 (ko) | 2009-10-06 |
BRPI0607307A2 (pt) | 2009-08-25 |
AU2006209183B2 (en) | 2009-11-19 |
AU2006209183A1 (en) | 2006-08-03 |
RU2007132262A (ru) | 2009-03-10 |
JP2008528585A (ja) | 2008-07-31 |
WO2006081172A2 (en) | 2006-08-03 |
CN101106990B (zh) | 2010-12-08 |
RU2368602C2 (ru) | 2009-09-27 |
CN101106990A (zh) | 2008-01-16 |
MX2007008973A (es) | 2007-09-18 |
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