AR042586A1 - 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa - Google Patents

3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa

Info

Publication number
AR042586A1
AR042586A1 ARP020100509A ARP020100509A AR042586A1 AR 042586 A1 AR042586 A1 AR 042586A1 AR P020100509 A ARP020100509 A AR P020100509A AR P020100509 A ARP020100509 A AR P020100509A AR 042586 A1 AR042586 A1 AR 042586A1
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AR
Argentina
Prior art keywords
alkyl
group
hydrogen
aryl
heteroaryl
Prior art date
Application number
ARP020100509A
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English (en)
Original Assignee
Sugen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc filed Critical Sugen Inc
Publication of AR042586A1 publication Critical patent/AR042586A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Derivados de 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona y sales farmacéuticamente aceptables de ellos que modulan la actividad de proteína de quinasas. Las composiciones son útiles en la prevención y tratamiento de afecciones celulares relacionadas tales como el cáncer. Los compuestos tiene la fórmula (1), donde: R1 se selecciona del grupo que consiste en hidrógeno, halo, alquilo, haloalcoxilo, cicloalquilo, heteroalicíclico, hidroxilo, alcoxilo, -C(O)R9, -NR9R10 y -C(O)NR12R13; R2 se selecciona del grupo que consiste en hidrógeno, halo, alquilo, trihalometilo, hidroxilo, alcoxilo, ciano, -NR9R19, -NR9C(O)R10, -C(O)R8, -S(O)2NR9R10 y -SO2R14 (donde R14 es alquilo, arilo, aralquilo, heteroarilo y heteroaralquilo); R3, R4 y R5 son independientemente hidrógeno o alquilo; Z es arilo, heteroarilo, heterociclo, o -NR15R16 donde R15 y R16 son independientemente hidrógeno o alquilo; o R15 y R16 junto con el átomo de nitrógeno al que están unidos forman un grupo heterocicloamino; R6 se selecciona del grupo que consiste en hidrógeno o alquilo; R7 se selecciona del grupo que consiste en hidrógeno, alquilo, arilo, heteroarilo, y -C(O)R17; R8 se selecciona del grupo que consiste en hidroxilo, alcoxilo, y ariloxilo; R9 y R10 son independientemente seleccionados del grupo que consiste en hidrógeno, alquilo, cianoalquilo, cicloalquilo, arilo y heteroarilo; o R9 y R10 se combinan para formar un grupo heterocicloamino; R12 y R13 son independientemente seleccionados del grupo que consiste en hidrógeno, alquilo hidroxialquilo y arilo; o R12 y R13 junto con el átomo de nitrógeno al que están unidos forman un heterocicloamino; se seleccionan del grupo que consiste en hidroxilo, alquilo, cicloalquilo, arilo y heteroarilo; R17 se selecciona del grupo que consiste en hidroxilo, alquilo, cicloalquilo, arilo y heteroarilo; o una sal del mismo aceptable para el uso farmacéutico. Un método para la modulación de la actividad catalítica de una proteína quinasa y método para tratar o prevenir una afección relacionada con la proteína quinasa también se proveen y composiciones farmacéuticas que comprenden al compuesto.
ARP020100509A 2001-02-15 2002-02-14 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa AR042586A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26868301P 2001-02-15 2001-02-15
US31236101P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
AR042586A1 true AR042586A1 (es) 2005-06-29

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ARP020100509A AR042586A1 (es) 2001-02-15 2002-02-14 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa

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