UA118010C2 - Інгібітори реплікації вірусів грипу - Google Patents
Інгібітори реплікації вірусів грипуInfo
- Publication number
- UA118010C2 UA118010C2 UAA201402082A UAA201402082A UA118010C2 UA 118010 C2 UA118010 C2 UA 118010C2 UA A201402082 A UAA201402082 A UA A201402082A UA A201402082 A UAA201402082 A UA A201402082A UA 118010 C2 UA118010 C2 UA 118010C2
- Authority
- UA
- Ukraine
- Prior art keywords
- patient
- pharmaceutically acceptable
- structural formula
- biological sample
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Способи інгібування реплікації вірусу грипу в біологічному зразку або у пацієнта, зменшення кількості вірусу грипу в біологічному зразку або в пацієнта і лікування грипу у пацієнта включають введення у вказаний біологічний зразок або пацієнту ефективної кількості сполуки, що відповідає структурній формулі (І): EMBED ISISServer , (I) або її фармацевтично прийнятної солі, де змінні структурної формули (І) є такими, як розкрито в даному описі. Сполука відповідає структурній формулі (І) або структурній формулі її фармацевтично прийнятної солі, де змінні структурної формули (І) є такими, як розкрито в даному описі. Фармацевтична композиція містить ефективну кількість такої сполуки або її фармацевтично прийнятної солі і фармацевтично прийнятний носій, ад'ювант або наповнювач.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161513793P | 2011-08-01 | 2011-08-01 | |
PCT/US2012/049097 WO2013019828A1 (en) | 2011-08-01 | 2012-08-01 | Inhibitors of influenza viruses replication |
Publications (1)
Publication Number | Publication Date |
---|---|
UA118010C2 true UA118010C2 (uk) | 2018-11-12 |
Family
ID=46650922
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201402082A UA118010C2 (uk) | 2011-08-01 | 2012-01-08 | Інгібітори реплікації вірусів грипу |
UAA201807026A UA122808C2 (uk) | 2011-08-01 | 2012-08-01 | Інгібітори реплікації вірусів грипу |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201807026A UA122808C2 (uk) | 2011-08-01 | 2012-08-01 | Інгібітори реплікації вірусів грипу |
Country Status (36)
Country | Link |
---|---|
US (5) | US9051319B2 (uk) |
EP (2) | EP3147284B1 (uk) |
JP (3) | JP5917692B2 (uk) |
KR (1) | KR101967172B1 (uk) |
CN (3) | CN105503862B (uk) |
AP (1) | AP3867A (uk) |
AR (1) | AR087418A1 (uk) |
AU (2) | AU2012290127B2 (uk) |
CA (1) | CA2844054C (uk) |
CL (1) | CL2014000245A1 (uk) |
CO (1) | CO6940412A2 (uk) |
CY (1) | CY1118726T1 (uk) |
DK (1) | DK2739623T3 (uk) |
EA (3) | EA037372B1 (uk) |
EC (1) | ECSP14013189A (uk) |
ES (2) | ES2618919T3 (uk) |
GE (2) | GEP201606531B (uk) |
HK (3) | HK1223914A1 (uk) |
HR (1) | HRP20170421T1 (uk) |
HU (1) | HUE033752T2 (uk) |
IL (2) | IL230618A (uk) |
IN (1) | IN2014CN00562A (uk) |
LT (1) | LT2739623T (uk) |
ME (1) | ME02638B (uk) |
MX (1) | MX339149B (uk) |
PE (1) | PE20141209A1 (uk) |
PL (1) | PL2739623T3 (uk) |
PT (1) | PT2739623T (uk) |
RS (1) | RS55858B1 (uk) |
SG (2) | SG10201503833SA (uk) |
SI (1) | SI2739623T1 (uk) |
TW (3) | TWI594997B (uk) |
UA (2) | UA118010C2 (uk) |
UY (1) | UY34234A (uk) |
WO (1) | WO2013019828A1 (uk) |
ZA (2) | ZA201400604B (uk) |
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ZA200710379B (en) * | 2005-05-20 | 2009-05-27 | Vertex Pharma | Pyrrolopyridines useful as inhibitors of protein kinase |
EP2262498A2 (en) * | 2008-03-10 | 2010-12-22 | Vertex Pharmceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
AU2010262905B2 (en) | 2009-06-17 | 2015-04-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
NZ619699A (en) | 2011-07-05 | 2016-03-31 | Vertex Pharma | Processes and intermediates for producing azaindoles |
UA118010C2 (uk) * | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
EP3068776B1 (en) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
DK3068782T3 (en) | 2013-11-13 | 2018-08-13 | Vertex Pharma | Methods for the preparation of inhibitors of influenza virus replication |
CN103922966B (zh) * | 2014-04-14 | 2015-10-21 | 武汉大学 | 作为甲型流感病毒抑制剂的甲酰胺和异腈类化合物及其制备与应用 |
BR112017002370B1 (pt) * | 2014-08-08 | 2022-11-22 | Janssen Sciences Ireland Uc | Compostos indóis, composição farmacêutica que os compreende e seu uso na inibição da replicação do vírus da gripe |
LT3191489T (lt) * | 2014-09-08 | 2021-01-25 | Janssen Sciences Ireland Unlimited Company | Pirolopirimidinai, skirti naudoti gripo viruso infekcijos atveju |
MA40772A (fr) * | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
CN108290869B (zh) | 2015-11-27 | 2021-05-18 | 爱尔兰詹森科学公司 | 用于在流感病毒感染中使用的杂环吲哚 |
WO2017097234A1 (en) * | 2015-12-09 | 2017-06-15 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
JP7001601B2 (ja) * | 2016-01-07 | 2022-01-19 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | インフルエンザウイルス感染に使用するための官能化ペンタン酸 |
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JP6978097B2 (ja) * | 2016-07-26 | 2021-12-08 | スーヂョウ ロングバイオテック ファーマシューティカルズ カンパニー リミテッドSuzhou Longbiotech Pharmaceuticals Co., Ltd. | Jak阻害剤としての複素環化合物、該化合物の塩類および治療への使用 |
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WO2018041091A1 (en) * | 2016-08-30 | 2018-03-08 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
CN106478460B (zh) * | 2016-09-28 | 2018-06-12 | 衢州学院 | 一种手性N-Boc-3-氨基-4-芳基-丁酸的合成方法 |
AU2017376541B2 (en) | 2016-12-15 | 2021-08-05 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication and uses thereof |
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