EA201791916A1 - 2'-замещенные карбануклеозидные аналоги для противовирусного лечения - Google Patents

2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Info

Publication number
EA201791916A1
EA201791916A1 EA201791916A EA201791916A EA201791916A1 EA 201791916 A1 EA201791916 A1 EA 201791916A1 EA 201791916 A EA201791916 A EA 201791916A EA 201791916 A EA201791916 A EA 201791916A EA 201791916 A1 EA201791916 A1 EA 201791916A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbaneculose
analogues
substituted
virus treatment
compounds
Prior art date
Application number
EA201791916A
Other languages
English (en)
Inventor
Майкл О'Нил Ханрахан Кларк
Original Assignee
Джилид Сайэнс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201791916A1 publication Critical patent/EA201791916A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/30—Vaccines

Abstract

Предложены соединения формулы Iа также фармацевтические композиции, содержащие соединения формулы I, и способы лечения ортомиксовирусных инфекций путем введения этих соединений. Предложенные соединения, композиции и способы являются особенно подходящими для лечения инфекций, вызванных вирусом гриппа человека.
EA201791916A 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения EA201791916A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261610411P 2012-03-13 2012-03-13

Publications (1)

Publication Number Publication Date
EA201791916A1 true EA201791916A1 (ru) 2018-07-31

Family

ID=47997868

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201491548A EA028928B9 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения
EA201791916A EA201791916A1 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201491548A EA028928B9 (ru) 2012-03-13 2013-03-11 2'-замещенные карбануклеозидные аналоги для противовирусного лечения

Country Status (19)

Country Link
US (4) US9481704B2 (ru)
EP (4) EP2834258B1 (ru)
JP (3) JP6242378B2 (ru)
KR (1) KR102068856B1 (ru)
CN (2) CN104185638A (ru)
AU (2) AU2013232378B2 (ru)
CA (1) CA2866381C (ru)
EA (2) EA028928B9 (ru)
ES (3) ES2621217T3 (ru)
HK (2) HK1207083A1 (ru)
IL (2) IL234586A (ru)
IN (1) IN2014DN08505A (ru)
MD (1) MD4496C1 (ru)
MX (1) MX355267B (ru)
NZ (1) NZ629996A (ru)
PL (1) PL2834258T3 (ru)
PT (1) PT2834258T (ru)
SI (1) SI2834258T1 (ru)
WO (1) WO2013138236A1 (ru)

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Also Published As

Publication number Publication date
KR102068856B1 (ko) 2020-01-21
JP2019069986A (ja) 2019-05-09
AU2013232378A1 (en) 2014-09-25
US20130243725A1 (en) 2013-09-19
US20210253622A1 (en) 2021-08-19
US9481704B2 (en) 2016-11-01
JP2017206528A (ja) 2017-11-24
US10941177B2 (en) 2021-03-09
US20190016749A1 (en) 2019-01-17
CA2866381C (en) 2020-03-24
CN104185638A (zh) 2014-12-03
EP3210993A1 (en) 2017-08-30
IL256397A (en) 2018-02-28
MD20140112A2 (ru) 2015-02-28
JP6525441B2 (ja) 2019-06-05
US11787832B2 (en) 2023-10-17
SI2834258T1 (sl) 2017-04-26
EA201491548A1 (ru) 2015-02-27
JP6242378B2 (ja) 2017-12-06
EP3351552B1 (en) 2021-05-19
ES2878087T3 (es) 2021-11-18
EP2834258A1 (en) 2015-02-11
ES2709071T3 (es) 2019-04-15
AU2017279590A1 (en) 2018-01-18
EA028928B9 (ru) 2018-05-31
NZ629996A (en) 2016-10-28
EP3210993B1 (en) 2018-12-12
CA2866381A1 (en) 2013-09-19
EP3351552A1 (en) 2018-07-25
KR20140135820A (ko) 2014-11-26
AU2013232378B2 (en) 2017-09-28
MX355267B (es) 2018-04-12
WO2013138236A1 (en) 2013-09-19
EA028928B1 (ru) 2018-01-31
CN106749272A (zh) 2017-05-31
MX2014011009A (es) 2014-10-13
MD4496B1 (ru) 2017-07-31
IN2014DN08505A (ru) 2015-05-15
JP2015509983A (ja) 2015-04-02
EP3932931A1 (en) 2022-01-05
PT2834258T (pt) 2017-04-07
MD4496C1 (ru) 2018-02-28
EP2834258B1 (en) 2017-01-04
HK1207083A1 (en) 2016-01-22
PL2834258T3 (pl) 2017-07-31
CN106749272B (zh) 2019-08-30
ES2621217T3 (es) 2017-07-03
US20170114086A1 (en) 2017-04-27
HK1256856A1 (zh) 2019-10-04
IL234586A (en) 2017-12-31

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