PT2457908T - Processo para a preparação de compostos úteis como inibidores de sglt - Google Patents

Processo para a preparação de compostos úteis como inibidores de sglt

Info

Publication number
PT2457908T
PT2457908T PT121560395T PT12156039T PT2457908T PT 2457908 T PT2457908 T PT 2457908T PT 121560395 T PT121560395 T PT 121560395T PT 12156039 T PT12156039 T PT 12156039T PT 2457908 T PT2457908 T PT 2457908T
Authority
PT
Portugal
Prior art keywords
sglt
inhibitors
preparation
compounds useful
compounds
Prior art date
Application number
PT121560395T
Other languages
English (en)
Inventor
Ferdinand Maria Filliers Walter
Hubert J Nieste Patrick
Hatsuda Masanori
Yoshinaga Masahiko
Yada Mitsuhiro
Teleha Christopher
Laurent Maria Broeckx Rudy
Original Assignee
Janssen Pharmaceutica Nv
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42106967&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2457908(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv, Mitsubishi Tanabe Pharma Corp filed Critical Janssen Pharmaceutica Nv
Publication of PT2457908T publication Critical patent/PT2457908T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12—Radicals substituted by halogen atoms or nitro or nitroso radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT121560395T 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt PT2457908T (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10623108P 2008-10-17 2008-10-17
US10626008P 2008-10-17 2008-10-17
US12/578,934 US9056850B2 (en) 2008-10-17 2009-10-14 Process for the preparation of compounds useful as inhibitors of SGLT

Publications (1)

Publication Number Publication Date
PT2457908T true PT2457908T (pt) 2017-03-02

Family

ID=42106967

Family Applications (3)

Application Number Title Priority Date Filing Date
PT121560395T PT2457908T (pt) 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt
PT121560353T PT2455374T (pt) 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt
PT97369284T PT2346888E (pt) 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt

Family Applications After (2)

Application Number Title Priority Date Filing Date
PT121560353T PT2455374T (pt) 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt
PT97369284T PT2346888E (pt) 2008-10-17 2009-10-15 Processo para a preparação de compostos úteis como inibidores de sglt

Country Status (30)

Country Link
US (1) US9056850B2 (pt)
EP (3) EP2455374B1 (pt)
JP (3) JP6123111B2 (pt)
KR (2) KR101724598B1 (pt)
CN (3) CN103467439B (pt)
AR (1) AR073892A1 (pt)
AU (1) AU2009305413B2 (pt)
BR (1) BRPI0920356B1 (pt)
CA (2) CA2946212C (pt)
CL (1) CL2011000849A1 (pt)
CY (3) CY1113867T1 (pt)
DK (3) DK2455374T3 (pt)
EA (1) EA021373B1 (pt)
ES (3) ES2611881T3 (pt)
HK (1) HK1224289A1 (pt)
HR (3) HRP20130254T1 (pt)
HU (2) HUE052432T2 (pt)
IL (2) IL212270A0 (pt)
LT (2) LT2455374T (pt)
MX (1) MX2011004054A (pt)
NZ (1) NZ592204A (pt)
PL (3) PL2455374T3 (pt)
PT (3) PT2457908T (pt)
RS (3) RS61484B1 (pt)
SI (3) SI2346888T1 (pt)
SM (2) SMT201300058B (pt)
TW (3) TWI588143B (pt)
UA (1) UA107450C2 (pt)
WO (1) WO2010043682A2 (pt)
ZA (1) ZA201103587B (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE035130T2 (en) * 2007-09-10 2018-05-02 Janssen Pharmaceutica Nv A method for preparing compounds useful as SGLT inhibitors
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
SI2451797T1 (sl) 2009-07-10 2013-07-31 Janssen Pharmaceutica, N.V. Postopek kristalizacije 1-(beta-d-glukopiranosil)-4-metil-3-(5-(4-fluorofenil)-2-tienilmetil) benzena
SI2488515T1 (sl) * 2009-10-14 2017-04-26 Janssen Pharmaceutica Nv Postopek za pripravo spojin, ki so uporabne kot inhibitorji SGLT2
US8163704B2 (en) 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
JP6227406B2 (ja) 2010-05-11 2017-11-08 ヤンセン ファーマシューティカ エヌ．ベー． ＳＧＬＴの阻害剤としての１−（β−Ｄ−グルコピラノシル）−２−チエニル−メチルベンゼン誘導体を含有する医薬製剤
AU2011276332A1 (en) * 2010-07-06 2013-01-17 Janssen Pharmaceutica Nv Formulation for co-therapy treatment of diabetes
AU2012241897C1 (en) 2011-04-13 2017-05-11 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US9193751B2 (en) 2012-04-10 2015-11-24 Theracos, Inc. Process for the preparation of benzylbenzene SGLT2 inhibitors
WO2013152476A1 (en) * 2012-04-10 2013-10-17 Theracos, Inc. Process for the preparation of benzylbenzene sglt2 inhibitors
US10323056B2 (en) 2013-05-08 2019-06-18 Lek Pharmaceuticals D.D. Crystalline hydrates of 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
CN104418834B (zh) * 2013-08-23 2017-09-15 重庆博腾制药科技股份有限公司 一种抗糖尿病药物中间体的合成方法
CN104418847A (zh) * 2013-09-10 2015-03-18 天津药物研究院 4-(6-脱氧-β-D-吡喃葡萄糖基)-2-[5-(4-氟苯基)噻吩-2-甲基]-1-甲基苯的制备工艺
CN103601715B (zh) * 2013-11-22 2015-08-19 沈阳化工大学 一种2-(4-氟苯基)噻吩的分离提纯方法
EP2918579A1 (en) 2014-03-14 2015-09-16 LEK Pharmaceuticals d.d. Synthesis of 2-arylmethyl-5-aryl-thiophene
EP2933255A1 (en) 2014-04-17 2015-10-21 LEK Pharmaceuticals d.d. Novel crystalline form of 1-(beta-D-glucopyranosyl)-4- methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene
WO2015181692A1 (en) * 2014-05-27 2015-12-03 Glenmark Pharmaceuticals Limited Process for preparation of canagliflozin
CN105330706B (zh) * 2014-06-05 2019-04-16 江苏豪森药业集团有限公司 卡格列净中间体的制备方法
CN104119324B (zh) * 2014-07-23 2016-03-30 齐鲁天和惠世制药有限公司 一种卡格列净的制备方法
CN104292209A (zh) * 2014-09-11 2015-01-21 浙江丽晶化学有限公司 一种制备2-(4-氟苯基)噻吩(化合物v)的新方法
CN104402946B (zh) * 2014-11-17 2018-01-02 连云港恒运药业有限公司 卡格列净中间体及其无定形的制备方法
WO2016083790A1 (en) * 2014-11-25 2016-06-02 Cipla Limited Process for the preparation of canagliflozin
CN105753910A (zh) * 2014-12-16 2016-07-13 康普药业股份有限公司 一种卡格列净中间体的制备方法
CN105753827A (zh) * 2014-12-17 2016-07-13 中美华世通生物医药科技（武汉）有限公司 制备化合物的方法
WO2016128995A1 (en) 2015-02-09 2016-08-18 Indoco Remedies Limited Process for the preparation of sglt inhibitor compounds
EP3259249A4 (en) * 2015-02-16 2019-02-13 B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University INTRODUCTION OF ALKYL SUBSTITUENTS IN AROMATIC COMPOUNDS
US10633372B2 (en) * 2015-02-27 2020-04-28 Msn Laboratories Private Limited Process for the preparation of amorphous (1S)-1,5-anhydro-1-[3-[[5-(4 fluorophenyl)-2-thienyl]-4-methylphenyl]-D-glucitol and its polymorphs thereof
EP3298007B1 (en) 2015-05-22 2020-07-22 Janssen Pharmaceutica NV Anhydrous crystalline form of (1s)-1,5-anhydro-1-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-d-glucitol
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CZ2015729A3 (cs) 2015-10-13 2017-04-26 Zentiva, K.S. Příprava intermediátů pro syntézu Canagliflozinu a Dapagliflozinu
CN106938998B (zh) * 2017-04-07 2018-07-03 四川智强医药科技开发有限公司 卡格列净有关物质的合成方法
US11198703B2 (en) 2017-05-09 2021-12-14 Piramal Enterprises Limited Process for the preparation of SGLT2 inhibitors and intermediates thereof
CN109553609B (zh) * 2017-09-26 2020-09-04 北大方正集团有限公司 一种卡格列净的制备方法
WO2019230864A1 (ja) 2018-05-31 2019-12-05 株式会社トクヤマ ジアリールメタン化合物の製造方法
JP7046868B2 (ja) * 2018-05-31 2022-04-04 株式会社トクヤマ ジアリールメタン化合物の製造方法
JPWO2020050361A1 (ja) * 2018-09-06 2021-08-30 株式会社トクヤマ β−Ｃ−アリールグリコシド誘導体の製造方法
CN109180662A (zh) * 2018-10-17 2019-01-11 北大医药股份有限公司 一种卡格列净的制备方法
JP2022028986A (ja) * 2018-12-17 2022-02-17 株式会社トクヤマ Ｃ－アリールヒドロキシグリコキシド誘導体の製造方法
WO2020129899A1 (ja) * 2018-12-17 2020-06-25 株式会社トクヤマ Ｃ－アリールヒドロキシグリコキシド誘導体の製造方法
CN110698468B (zh) * 2019-09-24 2020-11-03 杭州华东医药集团新药研究院有限公司 一种坎格列净的制备方法
CN111057049B (zh) * 2019-11-18 2021-06-01 杭州华东医药集团新药研究院有限公司 一种卡格列净半水化合物的制备方法
CN113943329A (zh) * 2020-07-16 2022-01-18 尚科生物医药（上海）有限公司 一种坎格列净中间体的非对映异构体的制备方法
US20240025873A1 (en) 2020-11-18 2024-01-25 Tokuyama Corporation Method for producing ketone derivative
CN112608299A (zh) * 2020-12-24 2021-04-06 山东铂源药业有限公司 一种4-(6-氨基吡啶-3-基)哌啶-1-甲酸叔丁酯的合成方法
CN113372326A (zh) * 2021-06-23 2021-09-10 江苏法安德医药科技有限公司 一种2-(4-氟苯基)噻吩的分离提纯方法
CN113429379A (zh) * 2021-06-28 2021-09-24 江苏法安德医药科技有限公司 一种lh-1801中间体及其制备方法和应用
WO2023080243A1 (ja) * 2021-11-08 2023-05-11 株式会社トクヤマ Ｃ－アリールグリコサイド誘導体の製造方法
CN115557940B (zh) * 2022-12-06 2023-06-20 恒升德康(南京)医药科技有限公司 一种利用微通道反应器连续化生产卡格列净的方法

Family Cites Families (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2799241A (en) 1949-01-21 1957-07-16 Wisconsin Alumni Res Found Means for applying coatings to tablets or the like
US4160861A (en) 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4584369A (en) 1981-07-31 1986-04-22 Sloan-Kettering Institute For Cancer Research Anti-leukemic beta-glycosyl C-nucleosides
JPS5939889A (ja) 1982-08-30 1984-03-05 Noguchi Kenkyusho ２，４，６↓−トリ↓−０↓−アセチル↓−３↓−デオキシ↓−ヘキソノ↓−１，５↓−ラクトンの製造方法
JP2544609B2 (ja) 1986-10-07 1996-10-16 和光純薬工業株式会社 Ｔｃｎｑ錯体
US4863957A (en) 1987-12-21 1989-09-05 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
CA1327013C (en) 1988-06-23 1994-02-15 Peter Rex Brawn Cosmetic composition
CA1334969C (en) 1988-08-19 1995-03-28 Mark James Suto Substituted dihydroisoquinoline and phthalazine derivatives as potentiators of the lethal effects of radiation and certain chemotherapeutic agents, selected compounds, analogs andprocess
ATE123237T1 (de) 1990-08-24 1995-06-15 Spirig Ag Verfahren zur herstellung von pellets.
JPH04253974A (ja) 1991-02-05 1992-09-09 Ishihara Sangyo Kaisha Ltd スルホニル尿素系化合物、それらの製造方法及びそれらを含有する除草剤
EP0517969A1 (en) 1991-06-10 1992-12-16 AUSIMONT S.p.A. Process for increasing the bleaching efficiency of an inorganic persalt or of hydrogen peroxide
US5149838A (en) 1991-09-20 1992-09-22 Merck & Co., Inc. Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents
US5610294A (en) 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
ZA927272B (en) 1991-10-29 1994-03-23 Du Pont Herbicidal triazolecarboxamides
GB9208161D0 (en) 1992-04-14 1992-05-27 Pfizer Ltd Indoles
US5334225A (en) 1992-07-15 1994-08-02 Kao Corporation Keratinous fiber dye composition containing a 2-substituted amino-5-alkylphenol derivative coupler
US5731292A (en) 1992-11-12 1998-03-24 Tanabe Seiyaku Co., Ltd. Dihydrochalcone derivatives which are hypoglycemic agents
CA2102591C (en) 1992-11-12 2000-12-26 Kenji Tsujihara Hypoglycemic agent
DE4243279A1 (de) 1992-12-21 1994-06-23 Bayer Ag Substituierte Triole
US6297363B1 (en) 1993-02-12 2001-10-02 Nomura Co., Ltd. Glycoside indoles
JPH06256354A (ja) 1993-03-01 1994-09-13 Nippon Nohyaku Co Ltd 新規テトラゾール化合物及びその製法
JP3187611B2 (ja) 1993-05-17 2001-07-11 キヤノン株式会社 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
JPH07242526A (ja) 1994-03-03 1995-09-19 Sogo Yatsukou Kk 化粧料
US5830873A (en) 1994-05-11 1998-11-03 Tanabe Seiyaku Co., Ltd. Propiophenone derivative and a process for preparing the same
EP0732921A4 (en) 1994-09-30 1998-09-02 Ohio State Res Found C-GLYCOSIDANOLOGIST OF N- (4-HYDROXYPHENYL) RETINAMIDE-O-GLUCURONIDE
US5780483A (en) 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
WO1997025033A1 (en) 1995-10-31 1997-07-17 Eli Lilly And Company Antithrombotic diamines
JP3059088B2 (ja) 1995-11-07 2000-07-04 田辺製薬株式会社 プロピオフェノン誘導体およびその製法
US5723495A (en) 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
JPH09263549A (ja) 1996-01-25 1997-10-07 Fujisawa Pharmaceut Co Ltd ベンゼン誘導体の製造法
IL121525A0 (en) 1996-08-26 1998-02-08 Tanabe Seiyaku Co Process for preparing optically active benzothiazepine compound and intermediate therefor
DE69712172T2 (de) 1996-12-26 2002-10-31 Tanabe Seiyaku Co Propiophenonderivate und Verfahren zu ihrer Herstellung
US6153632A (en) 1997-02-24 2000-11-28 Rieveley; Robert B. Method and composition for the treatment of diabetes
WO1998042347A1 (en) 1997-03-25 1998-10-01 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing a phosphorylamide and an ayntibiotic
BR9908911A (pt) 1998-03-19 2001-10-02 Bristol Myers Squibb Co Sistema bifásico e processo de distribuição por liberação controlada de substâncias farmacêuticas de alta solubilidade
JP2002518364A (ja) * 1998-06-18 2002-06-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 有機チタネートおよびグリニャール試薬を用いてカルボキサミドを対称および非対称二置換する方法
FR2780403B3 (fr) 1998-06-24 2000-07-21 Sanofi Sa Nouvelle forme de l'irbesartan, procedes pour obtenir ladite forme et compositions pharmaceutiques en contenant
JP2000034239A (ja) 1998-07-16 2000-02-02 Asahi Glass Co Ltd トリフルオロメチル化芳香族化合物の製造方法
JP3857429B2 (ja) 1998-07-17 2006-12-13 ポーラ化成工業株式会社 含硫黄抗真菌剤
US6069238A (en) 1998-09-30 2000-05-30 Eli Lilly And Company Spirocyclic C-glycosides
ATE299499T1 (de) 1998-11-09 2005-07-15 Black James Foundation Gastrin und cholecystokinin rezeptor ligande
NZ511614A (en) 1998-11-12 2003-12-19 Smithkline Beecham P Modified release pharmaceutical composition containing the insulin sensitiser 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione and the antidiabetic agent metaformin
US20020032164A1 (en) 1998-12-30 2002-03-14 Dale Roderic M. K. Antimicrobial compounds and methods for their use
GB9912961D0 (en) 1999-06-03 1999-08-04 Pfizer Ltd Metalloprotease inhibitors
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
MXPA02004282A (es) 1999-11-03 2003-02-17 Squibb Bristol Myers Co Metodo para tratar la diabetes.
JP3450810B2 (ja) 2000-01-31 2003-09-29 キヤノン株式会社 脂肪族ポリエステル、脂肪族ポリエステルの製造方法およびセルロースの再資源化方法
US6627611B2 (en) 2000-02-02 2003-09-30 Kotobuki Pharmaceutical Co Ltd C-glycosides and preparation of thereof as antidiabetic agents
JP4456768B2 (ja) 2000-02-02 2010-04-28 壽製薬株式会社 Ｃ−配糖体を含有する薬剤
JP2003525288A (ja) 2000-03-03 2003-08-26 ファイザー・プロダクツ・インク 抗炎症剤／鎮痛剤としてのピラゾールエーテル誘導体
PL205605B1 (pl) 2000-03-17 2010-05-31 Kissei Pharmaceutical Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna, zastosowanie tej pochodnej do wytwarzania kompozycji oraz pochodna benzylofenolu
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
GB0011098D0 (en) 2000-05-08 2000-06-28 Black James Foundation Pharmaceutical compositions comprising protpn pump inhibitors and gastrin/cholecystokinin receptor ligands
EP1172362A1 (de) 2000-07-11 2002-01-16 Basf Aktiengesellschaft Azadioxacycloalkene und ihre Verwendung zur Bekämpfung von Schadpilzen und tierischen Schädlingen
KR100426030B1 (ko) 2000-07-22 2004-04-03 (주) 한켐 락톤계 당화합물에서의 키랄성 전환방법
EP1326829A2 (en) 2000-09-29 2003-07-16 Bayer Pharmaceuticals Corporation 17-beta-hydroxysteroid dehydrogenase-ii inhibitors
AU2002210990A1 (en) 2000-11-02 2002-05-15 Ajinomoto Co. Inc. Novel pyrazole derivatives and diabetes remedies containing the same
JP2002167430A (ja) 2000-12-01 2002-06-11 Canon Inc 脂肪族ポリエステル、脂肪族ポリエステルの製造方法およびデンプンの資源化方法
US6476352B2 (en) 2000-12-18 2002-11-05 General Electric Company Laser beam stop sensor and method for automatically detecting the presence of laser beam stop material using a laser beam stop sensor
DK1354888T3 (da) 2000-12-28 2009-09-21 Kissei Pharmaceutical Glukopyranosyloxypyrazolderivater og anvendelse deraf i medikamenter
CA2438593C (en) 2001-02-26 2010-09-21 Kissei Pharmaceutical Co., Ltd. Glucopyranosyloxypyrazole derivatives and medicinal use thereof
WO2002068440A1 (fr) 2001-02-27 2002-09-06 Kissei Pharmaceutical Co., Ltd. Derives de glycopyranosyloxypyrazole et utilisation medicinale de ceux-ci
JP4190290B2 (ja) 2001-03-02 2008-12-03 ユニバーシティー オブ ウエスタン オンタリオ 放射能標識された化合物のポリマー前駆体、ならびにその作製および使用法
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
DK1385856T3 (da) 2001-04-11 2006-05-15 Bristol Myers Squibb Co Aminosyrekomplekser af C-aryl-glucosider til behandling af diabetes og fremgangsmåder
WO2002088157A1 (fr) 2001-04-27 2002-11-07 Ajinomoto Co., Inc. Derives pyrazolyl-o-glycoside n-substitues et medicament contre le diabete en contenant
GB0112122D0 (en) 2001-05-18 2001-07-11 Lilly Co Eli Heteroaryloxy 3-substituted propanamines
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
WO2003000712A1 (fr) 2001-06-20 2003-01-03 Kissei Pharmaceutical Co., Ltd. Derive heterocyclique azote, composition medicinale contenant ce derive, leur utilisation medicinale et intermediaire associe
JP4115105B2 (ja) 2001-07-02 2008-07-09 協和醗酵工業株式会社 ピラゾール誘導体
WO2003011880A1 (fr) 2001-07-31 2003-02-13 Kissei Pharmaceutical Co., Ltd. Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition
US20030191121A1 (en) 2001-08-09 2003-10-09 Miller Ross A. Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
WO2003020737A1 (en) 2001-09-05 2003-03-13 Bristol-Myers Squibb Company O-pyrazole glucoside sglt2 inhibitors and method of use
ATE312940T1 (de) 2001-10-24 2005-12-15 Michael Burton Chromogenischen enzymsubstraten und verfahren zum nachweis von beta-d-ribofuranosidase-wirksamkeit
BR0213949A (pt) * 2001-11-08 2004-08-31 Sepracor Inc Métodos para o tratamento de depressão e outros distúrbios do snc utilizando metabólitos desmetila e didesmetila de citalopram enanciomericamente enriquecidos
CA2464867C (en) 2001-11-16 2014-01-28 Cutanix Corporation Pharmaceutical and cosmetic compositions containing oxy group-bearing aromatic aldehydes
JP2003238417A (ja) 2002-02-18 2003-08-27 Nippon Shoyaku Kenkyusho:Kk フロレチン配糖体の安定化組成物、該安定化組成物を含有する糖尿病予防・治療剤、および保健食品
US6617313B1 (en) 2002-03-13 2003-09-09 Council Of Scientific And Industrial Research Glucopyranoside and process of isolation thereof from pterocarpus marsupium pharmaceutical composition containing the same and use thereof
US6562791B1 (en) 2002-03-29 2003-05-13 Council Of Scientific And Industrial Research Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof
EP1499616B1 (en) 2002-04-18 2009-06-17 AstraZeneca AB Heterocyclic compounds
JP2003313168A (ja) 2002-04-18 2003-11-06 Kirin Brewery Co Ltd Ｂｃｌ−２阻害活性を有する化合物およびその化合物のスクリーニング方法
DE10231370B4 (de) 2002-07-11 2006-04-06 Sanofi-Aventis Deutschland Gmbh Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
TWI254635B (en) 2002-08-05 2006-05-11 Yamanouchi Pharma Co Ltd Azulene derivative and salt thereof
KR20050056194A (ko) 2002-08-09 2005-06-14 다이쇼 세이야꾸 가부시끼가이샤 선택적인 아릴 5-티오-β-Ｄ-알도헥소피라노시드의 제조방법
WO2004019958A1 (ja) 2002-08-27 2004-03-11 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体、それを含有する医薬組成物及びその医薬用途
EP1551384A4 (en) 2002-10-07 2008-04-09 Encore Pharmaceuticals Inc R-NSAID ESTERS AND ITS USE
DE10258007B4 (de) 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258008B4 (de) 2002-12-12 2006-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
CN101260130A (zh) 2003-01-03 2008-09-10 布里斯托尔-迈尔斯斯奎布公司 制备c-芳基葡糖苷sglt2抑制剂的方法
WO2004076470A2 (en) 2003-02-27 2004-09-10 Bristol-Myers Squibb Company A non-cryogenic process for forming glycosides
JP4222450B2 (ja) 2003-03-14 2009-02-12 アステラス製薬株式会社 Ｃ−グリコシド誘導体又はその塩
JP2004300102A (ja) 2003-03-31 2004-10-28 Kissei Pharmaceut Co Ltd 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途
AU2003902263A0 (en) 2003-05-12 2003-05-29 Fujisawa Pharmaceutical Co., Ltd. Monosaccharide compounds
ATE541854T1 (de) 2003-06-20 2012-02-15 Kissei Pharmaceutical Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellung
EP1653968A4 (en) 2003-07-23 2006-09-06 Synta Pharmaceuticals Corp METHOD FOR MODULATING CALCIUMION RELIEF ACTIVATED CALCIUMION CHANNELS
CA2549015A1 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted fused heterocyclic c-glycosides
WO2005012242A2 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica Nv Substituted benzimidazole-, benztriazole-, and benzimidazolone-o-glucosides
UA86042C2 (en) 2003-08-01 2009-03-25 Янссен Фармацевтика Н.В. Substituted indazole-o-glucosides
AU2004261264A1 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indazole-O-glucosides
CN103214471B (zh) 2003-08-01 2018-02-06 田边三菱制药株式会社 具有钠依赖型葡萄糖转运体抑制活性的化合物的制备方法
CA2549025A1 (en) 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indole-o-glucosides
WO2005058845A2 (en) 2003-12-19 2005-06-30 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
EP2360165A3 (de) 2004-03-16 2012-01-04 Boehringer Ingelheim International GmbH Glucopyranosyl-substituierte Benzol-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
EP1773800A1 (de) 2004-07-27 2007-04-18 Boehringer Ingelheim International GmbH D-glucopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
WO2006018150A1 (de) 2004-08-11 2006-02-23 Boehringer Ingelheim International Gmbh D-xylopyranosyl-phenyl-substituierte cyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
TW200637839A (en) 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
WO2006082523A2 (en) 2005-01-25 2006-08-10 Aurobindo Pharma Limited Pharmaceutical sustained release composition of metformin
AR053329A1 (es) 2005-01-31 2007-05-02 Tanabe Seiyaku Co Derivados de indol utiles como inhibidores de los transportadores de glucosa dependientes del sodio (sglt)
ES2334940T3 (es) 2005-02-23 2010-03-17 Boehringer Ingelheim International Gmbh Derivados de ((hetero)ariletinilbencil)benceno sustituidos con glucopiranosilo y uso de los mismos como inhibidores del cotransportador 2 de glucosa dependiente de sodio (sglt2).
ATE453656T1 (de) 2005-04-15 2010-01-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte (heteroaryloxy- benzyl)-benzen-derivate als sglt-inhibitoren
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
DE602006014411D1 (de) 2005-07-27 2010-07-01 Boehringer Ingelheim Pharma Glucopyranosyl-substituierte ((hetero)cycloalyklethynyl-benzyl)-benzenderivative und deren verwendung als inhibitoren des natriumabhängigen glucose-cotransporters (sglt)
EP1924571B1 (en) 2005-08-30 2010-10-13 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
AR056195A1 (es) 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
JP5430943B2 (ja) 2006-01-25 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連用途のための置換芳香族化合物
JP2007230999A (ja) 2006-01-31 2007-09-13 Kyoto Univ 置換芳香族ニトリル化合物およびその製造方法
TWI418556B (zh) 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp 吲哚衍生物
JP5384343B2 (ja) 2006-08-15 2014-01-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング グルコピラノシル−置換シクロプロピルベンゼン誘導体、そのような化合物を含む医薬組成物、ｓｇｌｔ阻害剤としてのそれらの使用及びそれらの製造方法
CA2664095A1 (en) 2006-09-21 2008-03-27 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted difluorobenzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
WO2008055870A1 (en) 2006-11-06 2008-05-15 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzonitrile derivatives, medicaments containing such compounds, their use and process for their manufacture
JP5337040B2 (ja) 2006-11-09 2013-11-06 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｇｌｔ−２インヒビターとの組み合わせ治療及びそれらの医薬組成物
UY30730A1 (es) 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
EP2099791B1 (en) 2006-12-04 2012-11-21 Janssen Pharmaceutica, N.V. Thienyl-containing glycopyranosyl derivatives as antidiabetics
EP1956023A1 (en) 2007-02-06 2008-08-13 Lonza Ag Method for lithium exchange reactions
TW200904405A (en) 2007-03-22 2009-02-01 Bristol Myers Squibb Co Pharmaceutical formulations containing an SGLT2 inhibitor
US20090047514A1 (en) 2007-08-15 2009-02-19 Allen David P Thermal Activated Pressure Sensitive Adhesive and Method for Producing the Same and Product therewith
PE20090603A1 (es) 2007-08-16 2009-06-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de sglt2 y un inhibidor de dpp iv
EP2187742B1 (en) 2007-08-23 2017-10-25 Theracos Sub, LLC (2s,3r,4r,5s,6r)-2-(4-chloro-3-benzylphenyl)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol derivatives for use in the treatment of diabetes
HUE035130T2 (en) 2007-09-10 2018-05-02 Janssen Pharmaceutica Nv A method for preparing compounds useful as SGLT inhibitors
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
PE20091730A1 (es) 2008-04-03 2009-12-10 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
SI2488515T1 (sl) 2009-10-14 2017-04-26 Janssen Pharmaceutica Nv Postopek za pripravo spojin, ki so uporabne kot inhibitorji SGLT2
JP6227406B2 (ja) 2010-05-11 2017-11-08 ヤンセン ファーマシューティカ エヌ．ベー． ＳＧＬＴの阻害剤としての１−（β−Ｄ−グルコピラノシル）−２−チエニル−メチルベンゼン誘導体を含有する医薬製剤

Also Published As

Publication number Publication date
DK2457908T3 (en) 2017-02-13
ZA201103587B (en) 2012-10-31
HRP20170255T1 (hr) 2017-04-07
SMT201700092B (it) 2017-03-08
CA2946212A1 (en) 2010-04-22
CY1123817T1 (el) 2022-05-27
IL239313A0 (en) 2015-07-30
TW201443033A (zh) 2014-11-16
JP5905926B2 (ja) 2016-04-20
EA201170579A1 (ru) 2011-10-31
TW201613905A (en) 2016-04-16
KR20110086039A (ko) 2011-07-27
RS55577B1 (sr) 2017-05-31
CN103467439B (zh) 2016-11-23
SMT201300058B (it) 2013-07-09
KR101724598B1 (ko) 2017-04-07
TW201026689A (en) 2010-07-16
PT2346888E (pt) 2013-02-27
BRPI0920356A2 (pt) 2015-08-04
CA2946212C (en) 2018-05-22
JP2012505858A (ja) 2012-03-08
EP2346888A2 (en) 2011-07-27
TWI636981B (zh) 2018-10-01
US20100099883A1 (en) 2010-04-22
AU2009305413B2 (en) 2015-07-09
IL212270A0 (en) 2011-07-31
SI2455374T1 (sl) 2021-04-30
DK2455374T3 (da) 2021-02-08
SI2457908T1 (sl) 2017-05-31
US9056850B2 (en) 2015-06-16
JP6123111B2 (ja) 2017-05-10
WO2010043682A2 (en) 2010-04-22
JP2016117758A (ja) 2016-06-30
ES2854598T3 (es) 2021-09-22
EP2457908B1 (en) 2016-11-23
MX2011004054A (es) 2011-05-24
KR101679593B1 (ko) 2016-11-25
DK2346888T3 (da) 2013-03-25
CN103467439A (zh) 2013-12-25
ES2611881T3 (es) 2017-05-11
CL2011000849A1 (es) 2011-08-05
EP2457908B8 (en) 2017-04-05
IL239313A (en) 2017-07-31
CN102264714A (zh) 2011-11-30
CN105541814A (zh) 2016-05-04
WO2010043682A3 (en) 2011-08-11
RS52740B (en) 2013-08-30
HRP20210225T1 (hr) 2021-04-02
PL2455374T3 (pl) 2021-07-12
UA107450C2 (uk) 2015-01-12
HK1224289A1 (zh) 2017-08-18
LT2455374T (lt) 2021-05-10
CA2740853A1 (en) 2010-04-22
EA021373B1 (ru) 2015-06-30
RS61484B1 (sr) 2021-03-31
AR073892A1 (es) 2010-12-09
EP2346888B1 (en) 2013-01-02
TWI588143B (zh) 2017-06-21
ES2399959T3 (es) 2013-04-04
PL2457908T3 (pl) 2017-08-31
KR20160083144A (ko) 2016-07-11
LT2457908T (lt) 2017-03-10
CY1113867T1 (el) 2016-07-27
AU2009305413A1 (en) 2010-04-22
PT2455374T (pt) 2021-01-20
EP2455374A1 (en) 2012-05-23
CY1118708T1 (el) 2017-07-12
SI2346888T1 (sl) 2013-05-31
EP2457908A1 (en) 2012-05-30
BRPI0920356B1 (pt) 2021-09-21
CA2740853C (en) 2017-07-11
PL2346888T3 (pl) 2013-06-28
EP2455374B1 (en) 2020-12-16
JP2014167030A (ja) 2014-09-11
HRP20130254T1 (en) 2013-06-30
HUE030868T2 (en) 2017-06-28
HUE052432T2 (hu) 2021-04-28
NZ592204A (en) 2012-12-21

Similar Documents

Publication Publication Date Title
HRP20170255T1 (hr) Postupak za pripremu spojeva korisnih kao inhibitori sglt-a
HK1144554A1 (en) Process for the preparation of compounds useful as inhibitors of sglt
HK1170241A1 (zh) 可用作 的抑制劑的化合物的製備方法
IL238338A (en) Processes for preparing sglt2 inhibitors