ATE541854T1 - Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellung - Google Patents
Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellungInfo
- Publication number
- ATE541854T1 ATE541854T1 AT04746165T AT04746165T ATE541854T1 AT E541854 T1 ATE541854 T1 AT E541854T1 AT 04746165 T AT04746165 T AT 04746165T AT 04746165 T AT04746165 T AT 04746165T AT E541854 T1 ATE541854 T1 AT E541854T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- production
- aryl
- composition containing
- glucose
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
- C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
- C07D231/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/52—Oxygen atom in position 3 and nitrogen atom in position 5, or vice versa
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003175663 | 2003-06-20 | ||
PCT/JP2004/008695 WO2004113359A1 (ja) | 2003-06-20 | 2004-06-15 | ピラゾール誘導体、それを含有する医薬組成物及びその製造中間体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE541854T1 true ATE541854T1 (de) | 2012-02-15 |
Family
ID=33534874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04746165T ATE541854T1 (de) | 2003-06-20 | 2004-06-15 | Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellung |
Country Status (7)
Country | Link |
---|---|
US (1) | US7576064B2 (de) |
EP (1) | EP1637539B1 (de) |
JP (1) | JP4708187B2 (de) |
AT (1) | ATE541854T1 (de) |
CA (1) | CA2529878C (de) |
ES (1) | ES2377741T3 (de) |
WO (1) | WO2004113359A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004137245A (ja) * | 2002-08-23 | 2004-05-13 | Kissei Pharmaceut Co Ltd | ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
EA015104B1 (ru) | 2003-08-01 | 2011-06-30 | Мицубиси Танабе Фарма Корпорейшн | Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера |
US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
US7375090B2 (en) | 2003-08-26 | 2008-05-20 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof |
CN1950389B (zh) | 2004-03-04 | 2011-01-19 | 橘生药品工业株式会社 | 含氮稠环衍生物,含该衍生物的药物组合物,和其作为药物的用途 |
US7803838B2 (en) | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
DE102004028241B4 (de) * | 2004-06-11 | 2007-09-13 | Sanofi-Aventis Deutschland Gmbh | Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel |
TW200637869A (en) | 2005-01-28 | 2006-11-01 | Chugai Pharmaceutical Co Ltd | The spiroketal derivatives and the use as therapeutical agent for diabetes of the same |
MX2008000011A (es) * | 2005-07-22 | 2008-03-26 | Boehringer Ingelheim Int | Procesos para preparar derivados de pirazol-o-glucosido y nuevos intermediarios de dichos procesos. |
UY30082A1 (es) | 2006-01-11 | 2007-08-31 | Boehringer Ingelheim Int | Forma cristalina de 1-(1-metiletil)-4`-((2-fluoro-4-metoxifenil)metil)-5`- metil-1h-pirazol-3`-o-b-d-glucopiranosido, un metodo para su preparacion y el uso de la misma para preparar medicamentos |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
UY30730A1 (es) | 2006-12-04 | 2008-07-03 | Mitsubishi Tanabe Pharma Corp | Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno |
DK2200606T3 (en) * | 2007-09-10 | 2017-12-04 | Janssen Pharmaceutica Nv | PROCEDURE FOR THE PREPARATION OF RELATIONSHIP USED AS INHIBITORS OF SGLT |
CL2008003653A1 (es) | 2008-01-17 | 2010-03-05 | Mitsubishi Tanabe Pharma Corp | Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica. |
WO2010018438A2 (en) * | 2008-08-11 | 2010-02-18 | Hetero Research Foundation | Tetrazole glycosides |
AP2728A (en) * | 2008-08-28 | 2013-08-31 | Pfizer | Dioxa-bicyclo[3.2.1.] octane-2,3,4-triol derivatives |
US9056850B2 (en) * | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
CN101445528B (zh) * | 2008-12-25 | 2011-06-15 | 天津药物研究院 | 硫代葡萄糖衍生物、其制备方法和用途 |
US20110009347A1 (en) * | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
CN102482250B (zh) | 2009-07-10 | 2014-11-19 | 詹森药业有限公司 | 1-(β-D-吡喃葡糖基)-4-甲基-3-[5-(4-氟苯基)-2-噻吩基甲基]苯的结晶方法 |
EP2488515B1 (de) * | 2009-10-14 | 2017-01-04 | Janssen Pharmaceutica NV | Verfahren zur herstellung von verbindungen die als sglt2 inhibitoren verwendbar sind |
JP5696156B2 (ja) | 2009-11-02 | 2015-04-08 | ファイザー・インク | ジオキサ−ビシクロ[3.2.1]オクタン−2,3,4−トリオール誘導体 |
US20120115799A1 (en) | 2010-05-11 | 2012-05-10 | Wenhua Wang | Pharmaceutical formulations |
EA028946B1 (ru) | 2011-04-13 | 2018-01-31 | Янссен Фармацевтика Нв | Способ получения соединений для применения в качестве ингибиторов sglt2 |
US9035044B2 (en) | 2011-05-09 | 2015-05-19 | Janssen Pharmaceutica Nv | L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
EP2937096B1 (de) * | 2014-04-23 | 2019-08-21 | Julius-Maximilians-Universität Würzburg | Aus RS1 abgeleitete Peptide, die Glukoseabsorption nach einer glukosereichen Mahlzeit herunterregulieren und die Insulinsensitivität steigern |
US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
CN108456182A (zh) * | 2018-01-25 | 2018-08-28 | 于磊 | Sglt2蛋白的抑制剂以及应用 |
US10988462B2 (en) * | 2018-04-04 | 2021-04-27 | Japan Tobacco Inc. | Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2529786A1 (fr) * | 1982-07-12 | 1984-01-13 | Nativelle Sa Ets | Compositions pharmaceutiques a base de derives de la pyrazolone-5, nouveaux produits et procede de preparation |
FR2529891A1 (fr) * | 1982-07-12 | 1984-01-13 | Nativelle Sa Ets | Derives du pyridyl-3 alcoxy-5 pyrazole, procede de preparation et application en therapeutique |
ATE264337T1 (de) * | 1999-08-31 | 2004-04-15 | Kissei Pharmaceutical | Glucopyranosyloxypyrazol-derivate, diese enthaltende arzneimittel und zwischenprodukte zu deren herstellung |
US6555519B2 (en) * | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
AU2002210990A1 (en) | 2000-11-02 | 2002-05-15 | Ajinomoto Co. Inc. | Novel pyrazole derivatives and diabetes remedies containing the same |
PL209375B1 (pl) * | 2000-12-28 | 2011-08-31 | Kissei Pharmaceutical | Pochodne glukopiranozyloksypirazolu, kompozycja farmaceutyczna zawierająca takie pochodne i zastosowanie tych pochodnych do wytwarzania kompozycji farmaceutycznej |
EP1364957B1 (de) * | 2001-02-26 | 2008-12-31 | Kissei Pharmaceutical Co., Ltd. | Glykopyranosyloxypyrazolderivate und deren medizinische verwendung |
US7294618B2 (en) | 2001-02-27 | 2007-11-13 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and medicinal use thereof |
EP1389621A4 (de) | 2001-04-27 | 2005-05-11 | Ajinomoto Kk | N-substituierte pyrazolyl-o-glykosidderivate und diese enthaltendes diabetesmittel |
CA2448741C (en) | 2001-05-30 | 2010-06-22 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate therefor |
JP4115105B2 (ja) * | 2001-07-02 | 2008-07-09 | 協和醗酵工業株式会社 | ピラゾール誘導体 |
JP4284091B2 (ja) * | 2002-03-27 | 2009-06-24 | キッセイ薬品工業株式会社 | 単糖類共輸送担体 |
US20060035844A1 (en) * | 2002-12-04 | 2006-02-16 | Fumiaki Ito | Preventive or remedy for diseases caused by hyperglycemia |
-
2004
- 2004-06-15 EP EP04746165A patent/EP1637539B1/de not_active Not-in-force
- 2004-06-15 US US10/561,217 patent/US7576064B2/en not_active Expired - Fee Related
- 2004-06-15 WO PCT/JP2004/008695 patent/WO2004113359A1/ja active Application Filing
- 2004-06-15 JP JP2005507253A patent/JP4708187B2/ja not_active Expired - Fee Related
- 2004-06-15 AT AT04746165T patent/ATE541854T1/de active
- 2004-06-15 CA CA2529878A patent/CA2529878C/en not_active Expired - Fee Related
- 2004-06-15 ES ES04746165T patent/ES2377741T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
EP1637539A1 (de) | 2006-03-22 |
EP1637539B1 (de) | 2012-01-18 |
US7576064B2 (en) | 2009-08-18 |
EP1637539A4 (de) | 2009-06-17 |
JPWO2004113359A1 (ja) | 2006-07-27 |
CA2529878C (en) | 2012-11-20 |
JP4708187B2 (ja) | 2011-06-22 |
US20070060531A1 (en) | 2007-03-15 |
ES2377741T3 (es) | 2012-03-30 |
CA2529878A1 (en) | 2004-12-29 |
WO2004113359A1 (ja) | 2004-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE541854T1 (de) | Pyrazolderivat, arzneimittelzusammensetzung, die dieses enthält, und zwischenprodukt für dessen herstellung | |
DE60332743D1 (de) | Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, medizinische verwendung davon, und zwischenprodukt für dessen herstellung | |
EP1609798A4 (de) | Kondensiertes heterocyclisches derivat, dieses enthaltende medizinische zusammensetzung und deren medizinische verwendung | |
CA2474578A1 (en) | Novel pyridin- and pyrimidin-derivatives | |
EP1400529A4 (de) | Glucopyranosyloxypyrazol derivat, diese enthaltende medizinische zusammensetzung, dessen medizinische verwendung und zwischenprodukt zu dessen herstellung | |
UY27666A1 (es) | Nuevos derivados de piridina y quinolina | |
ATE264337T1 (de) | Glucopyranosyloxypyrazol-derivate, diese enthaltende arzneimittel und zwischenprodukte zu deren herstellung | |
ATE312114T1 (de) | Glucopyranosyloxy-benzylbenzen-derivate, medizinische zusammensetzung und zwischenprodukte für die herstellung der derivate | |
NO20064412L (no) | Kondensert heterocykelderivat, medisinsk sammensetning inneholdende det samme og medisinsk anvendelse derav | |
WO2002044192A1 (fr) | Derives de glucopyranosyloxybenzylbenzene, compositions medicinales contenant ces derives et produits intermediaires obtenus lors de l'elaboration de ces compositions | |
NO20072389L (no) | Substituerte benzokinolizinderivater | |
WO2003011880A1 (fr) | Derive de glucopyranosyloxybenzylbenzene, composition medicinale contenant ce derive, usage medicinal de cette composition et produit intermediaire pour produire cette composition | |
MY129023A (en) | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same | |
EP1679309A4 (de) | Antistress-arzneimittel und dessen medizinische verwendung | |
ATE427926T1 (de) | Cycloalkylaminderivate | |
EP1726580A4 (de) | Aminophenylpropansäurederivat | |
NO20055887L (no) | Pyrido'2, 1-A-isokinoliderivater som DPP-IV-inhibitorer | |
ATE430743T1 (de) | Benzimidazolsubstituierte thiophenderivate, die auf ikk3 wirken | |
TW200637839A (en) | 1-thio-d-glucitol derivatives | |
ATE398128T1 (de) | Neue purinderivate, deren herstelllung und deren verwendung als arzneimittel | |
EP1634874A4 (de) | Imidazolidinderivate | |
EP1550668A4 (de) | Pyrazolderivat, dieses enthaltende medizinische zusammensetzung, dessen medizinische verwendung und zwischenprodukt für dessen herstellung | |
ATE420853T1 (de) | 5-amidino-2-hydroxybenzolsulfonamidderivate, pharmazeutischen zusammensetzungen, die diese verbindungen enthalten, und zwischenprodukte zu deren herstellung | |
NO20063860L (no) | 7-fenylamino-4-kinolon-3-karboksylsyrederivater, fremgangsmate for fremstilling derav samt deres anvendelse som legemidler | |
MXPA05008190A (es) | Derivado de oligosacarido. |