DE69712172T2 - Propiophenonderivate und Verfahren zu ihrer Herstellung - Google Patents

Propiophenonderivate und Verfahren zu ihrer Herstellung

Info

Publication number
DE69712172T2
DE69712172T2 DE69712172T DE69712172T DE69712172T2 DE 69712172 T2 DE69712172 T2 DE 69712172T2 DE 69712172 T DE69712172 T DE 69712172T DE 69712172 T DE69712172 T DE 69712172T DE 69712172 T2 DE69712172 T2 DE 69712172T2
Authority
DE
Germany
Prior art keywords
preparation
propiophenone derivatives
propiophenone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69712172T
Other languages
English (en)
Other versions
DE69712172D1 (de
Inventor
Kenji Tsujihara
Kunio Saito
Mitsuya Hongu
Mamoru Matsumoto
Akira Oku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of DE69712172D1 publication Critical patent/DE69712172D1/de
Application granted granted Critical
Publication of DE69712172T2 publication Critical patent/DE69712172T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69712172T 1996-12-26 1997-12-17 Propiophenonderivate und Verfahren zu ihrer Herstellung Expired - Lifetime DE69712172T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34740696 1996-12-26

Publications (2)

Publication Number Publication Date
DE69712172D1 DE69712172D1 (de) 2002-05-29
DE69712172T2 true DE69712172T2 (de) 2002-10-31

Family

ID=18390010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69712172T Expired - Lifetime DE69712172T2 (de) 1996-12-26 1997-12-17 Propiophenonderivate und Verfahren zu ihrer Herstellung

Country Status (23)

Country Link
US (1) US6048842A (de)
EP (1) EP0850948B1 (de)
KR (1) KR100407029B1 (de)
CN (1) CN1094942C (de)
AR (1) AR010385A1 (de)
AT (1) ATE216704T1 (de)
AU (1) AU719726B2 (de)
BG (1) BG63546B1 (de)
BR (1) BR9706471B1 (de)
CA (1) CA2225439C (de)
DE (1) DE69712172T2 (de)
DK (1) DK0850948T3 (de)
ES (1) ES2176600T3 (de)
HK (1) HK1014960A1 (de)
HU (1) HU228514B1 (de)
ID (1) ID19290A (de)
IL (1) IL122666A (de)
MY (1) MY119350A (de)
NO (1) NO311804B1 (de)
PT (1) PT850948E (de)
RU (1) RU2156247C2 (de)
TW (1) TW406086B (de)
ZA (1) ZA9711560B (de)

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US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
EP1338603B1 (de) 2000-11-02 2010-01-20 Ajinomoto Co., Inc. Neue pyrazolderivate und diese enthaltende mittel gegen diabetes
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
DE60233655D1 (de) * 2001-04-04 2009-10-22 Ortho Mcneil Janssen Pharm R und retinoid x rezeptorenmodulatoren
DE60231295D1 (de) * 2001-04-04 2009-04-09 Ortho Mcneil Janssen Pharm R und ppar modulatoren
US7956041B2 (en) 2002-04-26 2011-06-07 Ajinomoto Co., Inc. Prophylactic and therapeutic agent of diabetes mellitus
AU2003231517A1 (en) * 2002-04-26 2003-11-10 Ajinomoto Co., Inc. Preventive/remedy for diabetes
EP1528066A4 (de) 2002-08-09 2007-05-02 Taisho Pharmaceutical Co Ltd ARYL-t-THIO-B-GLUCOPYRANOSID DERIVATE UND DIABETESMITTEL, DIE DIESE ENTHALTEN
DE10258008B4 (de) * 2002-12-12 2006-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de) * 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
EP1680414A4 (de) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv Substituierte indazol-o-glukoside
WO2005012243A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indole-o-glucosides
MXPA06001274A (es) * 2003-08-01 2006-04-11 Tanabe Seiyaku Co Compuestos novedosos que poseen actividad inhibitoria contra transporador dependiente de sodio.
EP1679966A4 (de) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv Substituierte benzimidazol-, benzotriazol- und benzimidazolon-o-glukoside
EA009768B1 (ru) * 2003-08-01 2008-04-28 Янссен Фармацевтика Нв Замещенные конденсированные гетероциклические с-гликозиды
FR2862303B1 (fr) * 2003-11-17 2006-01-06 Agronomique Inst Nat Rech Preparations colorantes hydrosolubles jaunes derivees des dihydrochalcones, leur procede des preparation, et leurs utilisations
DE102004028241B4 (de) * 2004-06-11 2007-09-13 Sanofi-Aventis Deutschland Gmbh Neue Fluorglykosidderivate von Pyrazolen, diese Verbindungen enthaltende Arzneimittel und Herstellung dieser Arzneimittel
TW200606129A (en) * 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
KR20090016456A (ko) 2006-05-19 2009-02-13 다이쇼 세이야꾸 가부시끼가이샤 당뇨병 치료용 ｃ-페닐글리시톨 화합물
DE102006028862A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3-Amino-imidazo[1,2-a]pyridinderivate
KR20090023570A (ko) 2006-06-29 2009-03-05 다이쇼 세이야꾸 가부시끼가이샤 Ｃ-페닐 1-티오글루시톨 화합물
US7993687B2 (en) * 2006-07-12 2011-08-09 Julianne Marie Kawa Compositions and methods for management of diabetes
UY30730A1 (es) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
CN101611023A (zh) 2006-12-14 2009-12-23 大正制药株式会社 1－苯基1－硫代－d－山梨醇衍生物
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
DK2200606T3 (en) * 2007-09-10 2017-12-04 Janssen Pharmaceutica Nv PROCEDURE FOR THE PREPARATION OF RELATIONSHIP USED AS INHIBITORS OF SGLT
DE102007048716A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo[1,2-a]pyrimidinderivate
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
DE102008017590A1 (de) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
CN102105153B (zh) 2008-05-22 2014-03-05 百时美施贵宝公司 Sglt2抑制剂的医药用途和含该抑制剂的组合物
EP2334687B9 (de) 2008-08-28 2012-08-08 Pfizer Inc. Dioxabicyclo[3.2.1]octan-2,3,4-triolderivate
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) * 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
PT2451797E (pt) 2009-07-10 2013-06-25 Janssen Pharmaceutica Nv Processo de cristalização para o 1-(β-d-glucopiranosilo)-4-metilo-3-[5-(4-fluorofenilo)-2-tienilometilo]benzeno
EP2298782A1 (de) * 2009-08-26 2011-03-23 Sanofi-Aventis Verfahren zur Herstellung von Pyrazol-glykosid-Derivate
ME02634B (de) * 2009-10-14 2017-06-20 Janssen Pharmaceutica Nv Verfahren zur herstellung von sglt2-hemmenden verbindungen
PT2496583E (pt) 2009-11-02 2015-01-14 Pfizer Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
TWI599360B (zh) 2010-05-11 2017-09-21 健生藥品公司 醫藥調配物
ME02469B (de) 2011-04-13 2017-02-20 Janssen Pharmaceutica Nv Verfahren zur herstellung von sglt2-hemmenden verbindungen
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
EP2774619B1 (de) 2013-03-04 2016-05-18 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
US20160033480A1 (en) * 2013-12-16 2016-02-04 Amy Huimeei Lo Immunovir and Components, Immunovir A, B, C, D Utility and Useful Processes
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen
CN104478956A (zh) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 苯基双o-葡萄糖苷衍生物、其制备方法和用途
CN104497069A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一类胺基苯基s-葡萄糖苷衍生物、其制备方法和用途
CN104497068A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含三氟甲氧基苯s-葡萄糖苷结构的化合物及其用途
CN104478961A (zh) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 含丙烯腈和胺基苯o-葡萄糖苷结构衍生物、其制备方法和用途
CN104497071A (zh) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 一种含丙烯腈基和腈基苯o-葡萄糖苷结构化合物及用途
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN107827753A (zh) * 2017-11-14 2018-03-23 湖北工业大学 一种对甲基二乙酰氧基碘苯的制备方法
CA3105626A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
US20220023252A1 (en) 2020-07-27 2022-01-27 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
AU2022251165A1 (en) 2021-04-01 2023-11-09 Astrazeneca Uk Limited Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
WO2023144722A1 (en) 2022-01-26 2023-08-03 Astrazeneca Ab Dapagliflozin for use in the treatment of prediabetes or reducing the risk of developing type 2 diabetes

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Also Published As

Publication number Publication date
DK0850948T3 (da) 2002-07-29
NO976072D0 (no) 1997-12-23
CA2225439C (en) 2005-06-07
BG63546B1 (bg) 2002-04-30
PT850948E (pt) 2002-08-30
TW406086B (en) 2000-09-21
AR010385A1 (es) 2000-06-07
CN1094942C (zh) 2002-11-27
CA2225439A1 (en) 1998-06-26
ZA9711560B (en) 1998-06-24
IL122666A0 (en) 1998-08-16
KR100407029B1 (ko) 2004-03-30
HU9702534D0 (en) 1998-03-02
CN1190097A (zh) 1998-08-12
BR9706471B1 (pt) 2012-09-04
MY119350A (en) 2005-05-31
HUP9702534A3 (en) 1999-01-28
ID19290A (id) 1998-07-02
NO311804B1 (no) 2002-01-28
BR9706471A (pt) 1999-05-18
ATE216704T1 (de) 2002-05-15
EP0850948A1 (de) 1998-07-01
DE69712172D1 (de) 2002-05-29
AU4841697A (en) 1998-07-02
HU228514B1 (hu) 2013-03-28
IL122666A (en) 2000-06-01
US6048842A (en) 2000-04-11
ES2176600T3 (es) 2002-12-01
BG102148A (en) 1998-09-30
HK1014960A1 (en) 1999-10-08
KR19980064710A (ko) 1998-10-07
NO976072L (no) 1998-06-29
RU2156247C2 (ru) 2000-09-20
EP0850948B1 (de) 2002-04-24
AU719726B2 (en) 2000-05-18
HUP9702534A2 (hu) 1998-07-28

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