PE20161573A1 - Ciclopropilamina como inhibidor de la lsd1 - Google Patents

Ciclopropilamina como inhibidor de la lsd1

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Publication number
PE20161573A1
PE20161573A1 PE2016001466A PE2016001466A PE20161573A1 PE 20161573 A1 PE20161573 A1 PE 20161573A1 PE 2016001466 A PE2016001466 A PE 2016001466A PE 2016001466 A PE2016001466 A PE 2016001466A PE 20161573 A1 PE20161573 A1 PE 20161573A1
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PE
Peru
Prior art keywords
halo
aryl
alkyl
methyl
ring
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PE2016001466A
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English (en)
Inventor
Joel R Courter
Liangxing Wu
Bo Shen
Chunhong He
Ding-Quan Qian
xiaozhao Wang
Wenqing Yao
Fenglei Zhang
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Incyte Corp
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52589819&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161573(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20161573A1 publication Critical patent/PE20161573A1/es

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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
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    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4468Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4965Non-condensed pyrazines
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CICLOPROPILAMINAS DE FORMULA (I) DONDE EL ANILLO A ES ARILO C6-C10 O HETEROARILO DE 5-10 MIEMBROS QUE COMPRENDE DE 1 A 4 HETEROATOMOS SELECCIONADOS DE N, O Y S; EL ANILLO B ES HETEROCICLOALQUILO DE 4-10 MIEMBROS QUE COMPRENDE DE 1 A 3 HETEROATOMOS SELECCIONADOS DE N, O Y S; EL ANILLO C ES ARILO C6-C10, CICLOALQUILO C3-C10, ENTRE OTROS; L ES ALQUILENO C1-C4, -C(=O)-, ENTRE OTROS; R1 ES HALO, ALQUILO C1-C6, ENTRE OTROS; R2 ES HALO, CN, ENTRE OTROS; R3 ES HALO, ALQUENILO C2-C6, ENTRE OTROS; R4 ES ALQUILO C1-C6, ARILO C6-C10, ENTRE OTROS; R5 Y R6 SON H, HALO, CIANOALQUILO C1-C4, ENTRE OTROS; q ES DE 0 A 2; RZ ES H, ALQUILO C1-C6, ENTRE OTROS; m ES DE 0 A 2; n Y p SON DE 0 A 3. SON COMPUESTOS PREFERIDOS: ACIDO-4-[(3-{[(TRANS-2-FENILCICLOPROPIL)AMINO]METIL}AZETIDIN-1-IL)METIL]BENZOICO; N-{[1-(4-FLUOROBENCIL)AZETIDIN-3-IL]METIL}-TRANS-2-FENILCICLOPROPANAMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA DESMETILASA 1 ESPECIFICA DE LISINAS (LSD1) SIENDO UTILES EN EL TRATAMIENTO DE LEUCEMIA LINFOCITICA AGUDA, LEUCEMIA MIELOIDE AGUDA
PE2016001466A 2014-02-13 2015-02-12 Ciclopropilamina como inhibidor de la lsd1 PE20161573A1 (es)

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US201461939488P 2014-02-13 2014-02-13
US201462061283P 2014-10-08 2014-10-08

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