EA201590693A1 - Ингибиторы gdf-8 - Google Patents

Ингибиторы gdf-8

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Publication number
EA201590693A1
EA201590693A1 EA201590693A EA201590693A EA201590693A1 EA 201590693 A1 EA201590693 A1 EA 201590693A1 EA 201590693 A EA201590693 A EA 201590693A EA 201590693 A EA201590693 A EA 201590693A EA 201590693 A1 EA201590693 A1 EA 201590693A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gdf
inhibitors
methods
patient
disorder
Prior art date
Application number
EA201590693A
Other languages
English (en)
Inventor
Сомасехар Бхамидипати
Марина Гельман
Пиньгюй Дин
Раджиндер Сингх
Джеффри Клаф
Тодд Кинселла
Дональд Пайан
Original Assignee
Ригель Фармасьютикалс, Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49474701&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201590693(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ригель Фармасьютикалс, Инк. filed Critical Ригель Фармасьютикалс, Инк.
Publication of EA201590693A1 publication Critical patent/EA201590693A1/ru

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems

Abstract

Описаны ингибиторы GDF-8 формулы (I)и их фармацевтически приемлемые соли, где значения n, R, R, R, R, X и Z определены в настоящем документе. Также представлены содержащие их фармацевтические композиции. Такие соединения и композиции применимы в способах ингибирования GDF-8 в клетке и в способах лечения пациента, страдающего от заболевания или нарушения, при котором пациент смог бы ощутить терапевтический эффект от увеличения массы или силы мышечной ткани.
EA201590693A 2012-10-05 2013-10-04 Ингибиторы gdf-8 EA201590693A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261710449P 2012-10-05 2012-10-05
PCT/US2013/063585 WO2014055955A1 (en) 2012-10-05 2013-10-04 Gdf-8 inhibitors

Publications (1)

Publication Number Publication Date
EA201590693A1 true EA201590693A1 (ru) 2015-08-31

Family

ID=49474701

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590693A EA201590693A1 (ru) 2012-10-05 2013-10-04 Ингибиторы gdf-8

Country Status (20)

Country Link
US (3) US9145433B2 (ru)
EP (1) EP2903978B1 (ru)
JP (2) JP6457942B2 (ru)
KR (1) KR20150072412A (ru)
CN (1) CN104837832B (ru)
AU (1) AU2013326867B2 (ru)
BR (1) BR112015007182A2 (ru)
CA (1) CA2887203A1 (ru)
CL (1) CL2015000851A1 (ru)
EA (1) EA201590693A1 (ru)
IL (1) IL238031A0 (ru)
MA (1) MA38050B1 (ru)
MX (1) MX2015004151A (ru)
PE (1) PE20150767A1 (ru)
PH (1) PH12015500719A1 (ru)
SA (1) SA515360229B1 (ru)
SG (1) SG11201502527UA (ru)
TN (1) TN2015000121A1 (ru)
WO (1) WO2014055955A1 (ru)
ZA (1) ZA201503041B (ru)

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RU2729999C1 (ru) * 2016-07-29 2020-08-13 Шанхай Инли Фармасьютикал Ко., Лтд Азотсодержащее гетероциклическое ароматическое соединение, способ его получения, фармацевтическая композиция на его основе и его применение

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