EA201000101A1 - Производные пиримидина 934 - Google Patents

Производные пиримидина 934

Info

Publication number
EA201000101A1
EA201000101A1 EA201000101A EA201000101A EA201000101A1 EA 201000101 A1 EA201000101 A1 EA 201000101A1 EA 201000101 A EA201000101 A EA 201000101A EA 201000101 A EA201000101 A EA 201000101A EA 201000101 A1 EA201000101 A1 EA 201000101A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine
derivatives
ring
aili
ephb4
Prior art date
Application number
EA201000101A
Other languages
English (en)
Inventor
Бернар Кристоф Барлам
Ришар Дюкрай
Джейсон Грант Кеттл
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201000101A1 publication Critical patent/EA201000101A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Соединение формулы (I)где один из А, Аили Апредставляет собой N, а другие независимо выбирают из СН или N; кольцо В представляет собой конденсированное 5- или 6-членное карбоциклическое или гетероциклическое кольцо, которое необязательно замещено, как определено в описании, и R, R, R, Rи n имеют значения, указанные в описании. Соединения являются ингибиторами EphB4 или EphA2 и следовательно могут быть полезными в фармацевтических композициях для лечения таких состояний, как злокачественное новообразование.
EA201000101A 2007-07-16 2008-07-14 Производные пиримидина 934 EA201000101A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07301236 2007-07-16
PCT/GB2008/050562 WO2009010789A2 (en) 2007-07-16 2008-07-14 Pyrimidine derivatives 934

Publications (1)

Publication Number Publication Date
EA201000101A1 true EA201000101A1 (ru) 2010-08-30

Family

ID=40260140

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000101A EA201000101A1 (ru) 2007-07-16 2008-07-14 Производные пиримидина 934

Country Status (18)

Country Link
US (1) US7718653B2 (ru)
EP (1) EP2183242A2 (ru)
JP (1) JP2010533700A (ru)
KR (1) KR20100042272A (ru)
CN (1) CN101796046A (ru)
AU (1) AU2008277446A1 (ru)
BR (1) BRPI0814821A2 (ru)
CA (1) CA2693880A1 (ru)
CO (1) CO6260075A2 (ru)
CR (1) CR11220A (ru)
DO (1) DOP2010000022A (ru)
EA (1) EA201000101A1 (ru)
EC (1) ECSP109958A (ru)
MX (1) MX2010000658A (ru)
NI (1) NI201000011A (ru)
SV (1) SV2010003459A (ru)
WO (1) WO2009010789A2 (ru)
ZA (1) ZA201000107B (ru)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
AU2011254550B2 (en) 2010-05-21 2013-11-07 Noviga Research Ab Novel pyrimidine derivatives
CA2830129C (en) 2011-03-24 2016-07-19 Chemilia Ab Novel pyrimidine derivatives
TWI681952B (zh) 2011-04-22 2020-01-11 美商標誌製藥公司 經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
EP2705521B1 (de) 2011-05-03 2021-06-23 Phoenix Contact GmbH & Co. KG Anordnung und verfahren zur kontaklosen energieübertragung mit einer kopplungsminimierten matrix aus planaren sendespulen
CN103222842B (zh) 2013-04-18 2015-09-09 安翰光电技术（武汉）有限公司 一种控制胶囊内窥镜在人体消化道运动的装置及方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
ES2882954T3 (es) 2014-12-16 2021-12-03 Signal Pharm Llc Usos médicos que comprenden métodos para la medición de la inhibición de la quinasa c-Jun N-terminal en la piel
US9796685B2 (en) 2014-12-16 2017-10-24 Signal Pharmaceuticals, Llc Formulations of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-Methylcyclohexylamino)-pyrimidine-5-carboxamide
US20180022710A1 (en) 2015-01-29 2018-01-25 Signal Pharmaceuticals, Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
CA2993173C (en) 2015-07-24 2023-10-03 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法
CA3180623A1 (en) * 2020-05-29 2021-12-02 Changyou MA Pyrimidine compound as axl inhibitor
CN116178433A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的盐及其制备方法和用途
CN116178434A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的单对甲苯磺酸盐及其晶型

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WO2001060816A1 (en) * 2000-02-17 2001-08-23 Amgen Inc. Kinase inhibitors
WO2003074514A1 (en) 2002-03-05 2003-09-12 Astrazeneca Ab Alkylammonium salts of omeprazole and esomeprazole
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PL1660458T3 (pl) * 2003-08-15 2012-07-31 Novartis Ag 2,4-pirymidynodwuaminy stosowane w leczeniu chorób nowotworowych, chorób zapalnych i zaburzeń układu immunologicznego
US7521457B2 (en) * 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
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PE20070362A1 (es) 2005-07-15 2007-04-23 Glaxo Group Ltd COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk)
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
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Also Published As

Publication number Publication date
ZA201000107B (en) 2010-09-29
CO6260075A2 (es) 2011-03-22
SV2010003459A (es) 2010-04-30
AU2008277446A1 (en) 2009-01-22
US20090023719A1 (en) 2009-01-22
US7718653B2 (en) 2010-05-18
EP2183242A2 (en) 2010-05-12
CR11220A (es) 2010-05-20
MX2010000658A (es) 2010-03-26
NI201000011A (es) 2010-12-07
KR20100042272A (ko) 2010-04-23
BRPI0814821A2 (pt) 2015-02-03
ECSP109958A (es) 2010-03-31
DOP2010000022A (es) 2010-02-15
WO2009010789A3 (en) 2009-05-07
JP2010533700A (ja) 2010-10-28
WO2009010789A2 (en) 2009-01-22
CN101796046A (zh) 2010-08-04
CA2693880A1 (en) 2009-01-22

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