PA8474101A1
(es)
|
1998-06-19 |
2000-09-29 |
Pfizer Prod Inc |
Compuestos de pirrolo [2,3-d] pirimidina
|
EP1065207A1
(en)
*
|
1999-07-02 |
2001-01-03 |
Aventis Pharma Deutschland GmbH |
Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
|
DE19948417A1
(de)
*
|
1999-10-07 |
2001-04-19 |
Morphochem Ag |
Imidazol-Derivate und ihre Verwendung als Arzneimittel
|
JP2003511378A
(ja)
|
1999-10-07 |
2003-03-25 |
アムジエン・インコーポレーテツド |
トリアジン系キナーゼ阻害薬
|
DK1235830T3
(da)
|
1999-12-10 |
2004-03-29 |
Pfizer Prod Inc |
Pyrrolo[2,3-d]pyrimidin-forbindelser som proteinkinaseinhibitorer
|
CA2397774A1
(en)
*
|
2000-01-24 |
2001-07-26 |
Genzyme Corporation |
Jak/stat pathway inhibitors and the uses thereof
|
EP1782800B1
(en)
*
|
2000-01-24 |
2013-12-18 |
Genzyme Corporation |
Methods for detecting JAK3 inhibitors
|
MY137020A
(en)
*
|
2000-04-27 |
2008-12-31 |
Abbott Lab |
Diazabicyclic central nervous system active agents
|
EE200200711A
(et)
*
|
2000-06-26 |
2004-06-15 |
Pfizer Products Inc. |
Pürrolo[2,3-d]pürimidiinühendid kui immunosupressiivsed vahendid
|
US6864255B2
(en)
|
2001-04-11 |
2005-03-08 |
Amgen Inc. |
Substituted triazinyl amide derivatives and methods of use
|
US6881737B2
(en)
|
2001-04-11 |
2005-04-19 |
Amgen Inc. |
Substituted triazinyl acrylamide derivatives and methods of use
|
US7301023B2
(en)
*
|
2001-05-31 |
2007-11-27 |
Pfizer Inc. |
Chiral salt resolution
|
GB0115393D0
(en)
*
|
2001-06-23 |
2001-08-15 |
Aventis Pharma Ltd |
Chemical compounds
|
MXPA03011998A
(es)
*
|
2001-06-23 |
2005-07-01 |
Aventis Pharma Inc |
Pirrolopirimidinas como inhibidores de protein cinasa.
|
GB0119249D0
(en)
|
2001-08-07 |
2001-10-03 |
Novartis Ag |
Organic compounds
|
US7323469B2
(en)
|
2001-08-07 |
2008-01-29 |
Novartis Ag |
7H-pyrrolo[2,3-d]pyrimidine derivatives
|
GT200200234A
(es)
|
2001-12-06 |
2003-06-27 |
|
Compuestos cristalinos novedosos
|
US6642381B2
(en)
*
|
2001-12-27 |
2003-11-04 |
Hoffman-La Roche Inc. |
Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors
|
MXPA04006614A
(es)
|
2002-01-07 |
2004-10-04 |
Eisai Co Ltd |
Deazapurinas y usos de las mismas.
|
GB0202679D0
(en)
*
|
2002-02-05 |
2002-03-20 |
Glaxo Group Ltd |
Novel compounds
|
EP1388541A1
(en)
*
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
EP1572213A1
(en)
|
2002-11-26 |
2005-09-14 |
Pfizer Products Inc. |
Method of treatment of transplant rejection
|
WO2004093812A2
(en)
*
|
2003-04-22 |
2004-11-04 |
Irm Llc |
Compounds that induce neuronal differentiation in embryonic stem cells
|
US7169918B2
(en)
*
|
2003-10-27 |
2007-01-30 |
Genelabs Technologies, Inc. |
Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
|
US20050165029A1
(en)
*
|
2004-01-13 |
2005-07-28 |
Ambit Biosciences Corporation |
Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
|
GB0403606D0
(en)
*
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
WO2005117909A2
(en)
*
|
2004-04-23 |
2005-12-15 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
EP1768662A2
(en)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
MXPA06015237A
(es)
|
2004-06-29 |
2007-12-10 |
Amgen Inc |
Pirrolo[2-3-d]pirimidinas que modulan la actividad de ack1 y lck.
|
US7465726B2
(en)
|
2004-08-02 |
2008-12-16 |
Osi Pharmaceuticals, Inc. |
Substituted pyrrolo[2.3-B]pyridines
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
MY179032A
(en)
|
2004-10-25 |
2020-10-26 |
Cancer Research Tech Ltd |
Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
|
AR054416A1
(es)
|
2004-12-22 |
2007-06-27 |
Incyte Corp |
Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas.
|
FR2880626B1
(fr)
*
|
2005-01-13 |
2008-04-18 |
Aventis Pharma Sa |
Derives de la purine, compositions les contenant et utilisation
|
WO2006091450A1
(en)
*
|
2005-02-18 |
2006-08-31 |
Lexicon Genetics Incorporated |
4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds
|
EP1891066B1
(en)
|
2005-05-13 |
2010-12-22 |
Irm, Llc |
Compounds and compositions as protein kinase inhibitors
|
KR20080026654A
(ko)
|
2005-07-14 |
2008-03-25 |
아스텔라스세이야쿠 가부시키가이샤 |
헤테로시클릭 야누스 키나제 3 억제제
|
CN102127078A
(zh)
|
2005-07-14 |
2011-07-20 |
安斯泰来制药株式会社 |
Janus激酶3的杂环类抑制剂
|
EP1926735A1
(en)
|
2005-09-22 |
2008-06-04 |
Incyte Corporation |
Tetracyclic inhibitors of janus kinases
|
AU2006297351A1
(en)
*
|
2005-09-30 |
2007-04-12 |
Vertex Pharmaceuticals Incorporated |
Deazapurines useful as inhibitors of janus kinases
|
AU2015201850B2
(en)
*
|
2005-12-13 |
2017-03-02 |
Incyte Holdings Corporation |
Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
|
MY162590A
(en)
*
|
2005-12-13 |
2017-06-30 |
Incyte Holdings Corp |
Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors
|
KR20090007319A
(ko)
*
|
2006-03-11 |
2009-01-16 |
베르날리스 (알 앤드 디) 리미티드 |
Hsp90 억제제로서 사용되는 피롤로피리미딘 유도체
|
MX2008012860A
(es)
*
|
2006-04-05 |
2009-01-07 |
Vertex Pharma |
Desazapurinas de utilidad como inhibidores de janus cinasas.
|
GB0608176D0
(en)
*
|
2006-04-25 |
2006-06-07 |
Astex Therapeutics Ltd |
Pharmaceutical Compounds
|
JP5606734B2
(ja)
*
|
2006-04-25 |
2014-10-15 |
アステックス、セラピューティックス、リミテッド |
医薬化合物
|
WO2008012635A2
(en)
*
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
US20080161320A1
(en)
*
|
2006-09-11 |
2008-07-03 |
Xiong Cai |
Fused bicyclic pyrimidines as ptk inhibitors containing a zinc binding moiety
|
KR20090077914A
(ko)
*
|
2006-09-11 |
2009-07-16 |
쿠리스 인코퍼레이션 |
항증식제로서의 다작용성 소분자
|
WO2008075007A1
(en)
*
|
2006-12-21 |
2008-06-26 |
Cancer Research Technology Limited |
Morpholino-substituted bicycloheteroaryl compounds and their use as anti cancer agents
|
AR064416A1
(es)
*
|
2006-12-21 |
2009-04-01 |
Cancer Rec Tech Ltd |
Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
|
US8513270B2
(en)
|
2006-12-22 |
2013-08-20 |
Incyte Corporation |
Substituted heterocycles as Janus kinase inhibitors
|
MX2009007426A
(es)
|
2007-01-12 |
2009-07-17 |
Astellas Pharma Inc |
Compuesto de piridina condensado.
|
PE20090996A1
(es)
*
|
2007-04-02 |
2009-07-15 |
Palau Pharma Sa |
Derivados de pirrolopirimidina como inhibidores de cinasa jak3
|
UA99284C2
(ru)
|
2007-05-11 |
2012-08-10 |
Елі Ліллі Енд Компані |
ИНГИБИТОРЫ р70 S6-КИНАЗЫ
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
EP3495369B1
(en)
*
|
2007-06-13 |
2021-10-27 |
Incyte Holdings Corporation |
Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile
|
GB0713602D0
(en)
*
|
2007-07-12 |
2007-08-22 |
Syngenta Participations Ag |
Chemical compounds
|
JP5536647B2
(ja)
*
|
2007-07-27 |
2014-07-02 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ピロロピリミジン
|
CN101772502A
(zh)
*
|
2007-08-08 |
2010-07-07 |
莱西肯医药有限公司 |
作为激酶抑制剂用于治疗癌和炎症的(7H-吡咯并[2,3-d]嘧啶-4-基)哌嗪类化合物
|
WO2009030871A1
(en)
*
|
2007-09-07 |
2009-03-12 |
Vernalis R & D Ltd |
Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
|
CN101861321B
(zh)
|
2007-10-11 |
2013-02-06 |
阿斯利康(瑞典)有限公司 |
作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物
|
CA2704599C
(en)
|
2007-11-16 |
2015-05-12 |
Incyte Corporation |
4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
|
SI2288610T1
(sl)
|
2008-03-11 |
2016-11-30 |
Incyte Holdings Corporation |
Derivati azetidina in ciklobutana kot inhibitorji jak
|
EP2297153B1
(en)
|
2008-04-21 |
2015-05-27 |
Lexicon Pharmaceuticals, Inc. |
Limk2 inhibitors, compositions comprising them, and methods of their use
|
CA2722326A1
(en)
|
2008-04-24 |
2009-10-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
JP4884570B2
(ja)
|
2008-08-20 |
2012-02-29 |
ファイザー・インク |
ピロロ[2,3−d]ピリミジン化合物
|
US8385364B2
(en)
*
|
2008-09-24 |
2013-02-26 |
Nec Laboratories America, Inc. |
Distributed message-passing based resource allocation in wireless systems
|
CL2009001884A1
(es)
*
|
2008-10-02 |
2010-05-14 |
Incyte Holdings Corp |
Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
|
JOP20190230A1
(ar)
*
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
DE102009005193A1
(de)
*
|
2009-01-20 |
2010-07-22 |
Merck Patent Gmbh |
Neue heterocyclische Verbindungen als MetAP-2 Inhibitoren
|
WO2010085597A1
(en)
|
2009-01-23 |
2010-07-29 |
Incyte Corporation |
Macrocyclic compounds and their use as kinase inhibitors
|
WO2010093808A1
(en)
|
2009-02-11 |
2010-08-19 |
Reaction Biology Corp. |
Selective kinase inhibitors
|
CA2759026C
(en)
|
2009-04-20 |
2019-01-15 |
Auspex Pharmaceuticals, Inc. |
Piperidine inhibitors of janus kinase 3
|
EA025520B1
(ru)
|
2009-05-22 |
2017-01-30 |
Инсайт Холдингс Корпорейшн |
N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
|
MX2011012262A
(es)
|
2009-05-22 |
2012-01-25 |
Incyte Corp |
3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il] octano-o heptano-nitrilo como inhibidores de cinasas janus (jak).
|
CA2767079A1
(en)
|
2009-07-08 |
2011-01-13 |
Leo Pharma A/S |
Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors
|
TWI466885B
(zh)
*
|
2009-07-31 |
2015-01-01 |
Japan Tobacco Inc |
含氮螺環化合物及其醫藥用途
|
TW201111385A
(en)
*
|
2009-08-27 |
2011-04-01 |
Biocryst Pharm Inc |
Heterocyclic compounds as janus kinase inhibitors
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
NZ598985A
(en)
|
2009-09-04 |
2013-07-26 |
Biogen Idec Inc |
Bruton's tyrosine kinase inhibitors
|
JP5792171B2
(ja)
*
|
2009-09-04 |
2015-10-07 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
白血病を治療するための組成物および方法
|
PT2486041E
(pt)
|
2009-10-09 |
2013-11-14 |
Incyte Corp |
Derivados hidroxilo, ceto e glucuronido de 3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentil-propanonitrilo
|
IN2012DN02577A
(no)
|
2009-10-15 |
2015-08-28 |
Pfizer |
|
US9074143B2
(en)
*
|
2009-12-11 |
2015-07-07 |
Uop Llc |
Process for producing hydrocarbon fuel
|
JP5739446B2
(ja)
|
2009-12-18 |
2015-06-24 |
ファイザー・インク |
ピロロ[2,3−d]ピリミジン化合物
|
JP2013518882A
(ja)
|
2010-02-05 |
2013-05-23 |
ファイザー・インク |
JAK阻害剤としてのピロロ[2,3−d]ピリミジン尿素化合物
|
EA023444B1
(ru)
*
|
2010-02-18 |
2016-06-30 |
Инсайт Холдингс Корпорейшн |
Циклобутановые и метилциклобутановые производные, композиции на их основе и способы их применения
|
SI3354652T1
(sl)
|
2010-03-10 |
2020-08-31 |
Incyte Holdings Corporation |
Derivati piperidin-4-il azetidina kot inhibitorji JAK1
|
SG10201910912TA
(en)
|
2010-05-21 |
2020-01-30 |
Incyte Corp |
Topical Formulation for a JAK Inhibitor
|
US9586961B2
(en)
|
2010-07-09 |
2017-03-07 |
Leo Pharma A/S |
Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof
|
WO2012022045A1
(en)
*
|
2010-08-20 |
2012-02-23 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
CN102372717B
(zh)
*
|
2010-08-20 |
2014-06-18 |
和记黄埔医药(上海)有限公司 |
吡咯并嘧啶类化合物及其用途
|
SG187742A1
(en)
*
|
2010-08-20 |
2013-03-28 |
Hutchison Medipharma Ltd |
Pyrrolopyrimidine compounds and uses thereof
|
TWI401258B
(zh)
*
|
2010-09-08 |
2013-07-11 |
Hutchison Medipharma Ltd |
吡咯並嘧啶類化合物及其用途
|
BR112013012502A2
(pt)
|
2010-11-19 |
2019-03-06 |
Incyte Corporation |
pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak
|
US9034884B2
(en)
|
2010-11-19 |
2015-05-19 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
|
EP2651417B1
(en)
|
2010-12-16 |
2016-11-30 |
Calchan Limited |
Ask1 inhibiting pyrrolopyrimidine derivatives
|
WO2012088682A1
(en)
*
|
2010-12-29 |
2012-07-05 |
Shanghai Fochon Pharmaceutical Co Ltd. |
2-(3-aminopiperidin-1-yl)-[1,2,4]triazolo[1,5-c]pyrimidine-5,7(3h,6h)-dione derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
|
CN103298817A
(zh)
*
|
2011-01-07 |
2013-09-11 |
利奥制药有限公司 |
作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途
|
DE102011008352A1
(de)
*
|
2011-01-12 |
2012-07-12 |
Merck Patent Gmbh |
5-([1,2,3]Triazol-4-yl)-7H-pyrrolo-[2,3-d]pyrimidinderivate
|
US9139590B2
(en)
|
2011-02-04 |
2015-09-22 |
Duquesne University Of The Holy Spirit |
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient
|
WO2012112847A1
(en)
|
2011-02-18 |
2012-08-23 |
Novartis Pharma Ag |
mTOR/JAK INHIBITOR COMBINATION THERAPY
|
AU2012232658B2
(en)
|
2011-03-22 |
2016-06-09 |
Advinus Therapeutics Limited |
Substituted fused tricyclic compounds, compositions and medicinal applications thereof
|
US9402847B2
(en)
|
2011-04-01 |
2016-08-02 |
Astrazeneca Ab |
Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide
|
MY165963A
(en)
|
2011-06-20 |
2018-05-18 |
Incyte Holdings Corp |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
CN103987388A
(zh)
*
|
2011-06-29 |
2014-08-13 |
默沙东公司 |
二肽基肽酶-iv抑制剂的新晶形
|
CN103732596B
(zh)
*
|
2011-07-08 |
2016-06-01 |
诺华股份有限公司 |
吡咯并嘧啶衍生物
|
EP2741747A1
(en)
|
2011-08-10 |
2014-06-18 |
Novartis Pharma AG |
JAK P13K/mTOR COMBINATION THERAPY
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為jak抑制劑之環己基氮雜環丁烷衍生物
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
US9089574B2
(en)
|
2011-11-30 |
2015-07-28 |
Emory University |
Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
|
CA2856646C
(en)
|
2011-11-30 |
2020-01-14 |
Astrazeneca Ab |
Combination treatment of cancer
|
US8993756B2
(en)
|
2011-12-06 |
2015-03-31 |
Merck Sharp & Dohme Corp. |
Pyrrolopyrimidines as janus kinase inhibitors
|
AU2013204533B2
(en)
|
2012-04-17 |
2017-02-02 |
Astrazeneca Ab |
Crystalline forms
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
MD20140130A2
(ro)
*
|
2012-06-29 |
2015-04-30 |
Pfizer Inc. |
4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2
|
JP6318156B2
(ja)
*
|
2012-09-06 |
2018-04-25 |
プレキシコン インコーポレーテッドPlexxikon Inc. |
キナーゼをモジュレートするための化合物および方法、ならびにその指標
|
JP2015529242A
(ja)
|
2012-09-21 |
2015-10-05 |
アドヴィヌス セラピューティクス リミテッドAdvinus Therapeutics Limited |
置換された縮合三環式化合物、組成物およびその医薬用途
|
US20150284394A1
(en)
*
|
2012-10-26 |
2015-10-08 |
Hoffmann-La Roche Inc. |
Inhibitors of bruton's tyrosine kinase
|
CN102936251A
(zh)
*
|
2012-11-05 |
2013-02-20 |
上海毕得医药科技有限公司 |
一种吡咯并[2,3-d]嘧啶衍生物的制备方法
|
SG11201503695XA
(en)
|
2012-11-15 |
2015-06-29 |
Incyte Corp |
Sustained-release dosage forms of ruxolitinib
|
EP2958921B1
(en)
|
2013-02-22 |
2017-09-20 |
Pfizer Inc |
Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus kinases (jak)
|
EA030705B1
(ru)
|
2013-03-06 |
2018-09-28 |
Инсайт Холдингс Корпорейшн |
Способы и промежуточные соединения при получении ингибитора jak
|
WO2014139388A1
(en)
*
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
ES2792549T3
(es)
|
2013-08-07 |
2020-11-11 |
Incyte Corp |
Formas de dosificación de liberación sostenida para un inhibidor de JAK1
|
SI3318565T1
(sl)
|
2013-12-05 |
2021-07-30 |
Pfizer Inc. |
Pirolo(2,3-D)pirimidinil, pirolo(2,3-B)pirazinil in pirolo(2,3-D)piridinil akrilamidi
|
CA2933767C
(en)
|
2013-12-17 |
2018-11-06 |
Pfizer Inc. |
Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
|
WO2015184305A1
(en)
|
2014-05-30 |
2015-12-03 |
Incyte Corporation |
TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
|
WO2016024185A1
(en)
|
2014-08-12 |
2016-02-18 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
|
US10246464B2
(en)
|
2014-09-09 |
2019-04-02 |
The Regents Of The University Of Michigan |
Thienopyrimidine and thienopyridine compounds and methods of use thereof
|
CN105524067A
(zh)
*
|
2014-09-28 |
2016-04-27 |
江苏柯菲平医药股份有限公司 |
4-取代吡咯并[2,3-d]嘧啶化合物及其用途
|
EP3288943B1
(en)
|
2015-05-01 |
2022-09-28 |
Pfizer Inc. |
Pyrrolo[2,3-b]pyrazinyl acrylamides and epoxides thereof as inhibitors of janus kinase
|
EP3302057A4
(en)
|
2015-06-04 |
2018-11-21 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
TWI703150B
(zh)
|
2015-06-04 |
2020-09-01 |
美商庫拉腫瘤技術股份有限公司 |
用於抑制menin及mll蛋白之交互作用的方法及組合物
|
ES2927324T3
(es)
*
|
2015-07-31 |
2022-11-04 |
Taiho Pharmaceutical Co Ltd |
Compuestos de pirrolo[2,3-d]pirimidina o sus sales
|
KR101771219B1
(ko)
*
|
2015-08-21 |
2017-09-05 |
양지화학 주식회사 |
야누스 키나제 1 선택적 억제제 및 그 의약 용도
|
AU2016322813B2
(en)
|
2015-09-14 |
2021-04-01 |
Pfizer Inc. |
Novel imidazo (4,5-c) quinoline and imidazo (4,5-c)(1,5) naphthyridine derivatives as LRRK2 inhibitors
|
US10045981B2
(en)
|
2015-11-24 |
2018-08-14 |
Jakpharm, Llc |
Selective kinase inhibitors
|
CN107098908B
(zh)
*
|
2016-02-23 |
2021-01-08 |
欣凯医药科技(上海)有限公司 |
一种吡咯并嘧啶类化合物的制备方法和应用
|
EP3429591B1
(en)
|
2016-03-16 |
2023-03-15 |
Kura Oncology, Inc. |
Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use
|
BR112018068702A2
(pt)
|
2016-03-16 |
2019-01-15 |
Kura Oncology Inc |
inibidores bicíclicos em ponte de menin-mll e métodos de uso
|
CN107513069A
(zh)
*
|
2016-06-16 |
2017-12-26 |
正大天晴药业集团股份有限公司 |
手性吡咯并嘧啶化合物的制备方法
|
CN107513067A
(zh)
|
2016-06-16 |
2017-12-26 |
北京赛林泰医药技术有限公司 |
含有取代环戊基的吡咯并嘧啶化合物
|
CA3031443A1
(en)
|
2016-07-21 |
2018-01-25 |
Biogen Ma Inc. |
Succinate of pyrimidinyl derivatives and solid forms thereof as bruton's tyrosine kinase inhibitors
|
WO2018140648A1
(en)
|
2017-01-25 |
2018-08-02 |
Eric Jon Jacobsen |
Pyrrolopyrimidine itk inhibitors for treating inflammation and cancer
|
JP7101176B2
(ja)
*
|
2017-02-03 |
2022-07-14 |
レオ ファーマ アクティーゼルスカブ |
新規JAKキナーゼ阻害剤としての5-(7H-ピロロ[2,3-d]ピリミジン-4-イル)-5-アザスピロ[2.5]オクタン-8-カルボン酸誘導体
|
WO2018175746A1
(en)
|
2017-03-24 |
2018-09-27 |
Kura Oncology, Inc. |
Methods for treating hematological malignancies and ewing's sarcoma
|
CN108794480A
(zh)
*
|
2017-04-28 |
2018-11-13 |
天津药物研究院有限公司 |
吡咯并嘧啶类化合物、其制备方法和用途
|
WO2018226976A1
(en)
|
2017-06-08 |
2018-12-13 |
Kura Oncology, Inc. |
Methods and compositions for inhibiting the interaction of menin with mll proteins
|
TW201920170A
(zh)
|
2017-09-20 |
2019-06-01 |
美商庫拉腫瘤技術股份有限公司 |
經取代之menin-mll 抑制劑及使用方法
|
BR112020008850A2
(pt)
|
2017-11-03 |
2020-10-20 |
Aclaris Therapeutics, Inc. |
composto, composição farmacêutica e método para tratar uma doença mediada por jak1 e jak3
|
US10800775B2
(en)
|
2017-11-03 |
2020-10-13 |
Aclaris Therapeutics, Inc. |
Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
|
US10596161B2
(en)
|
2017-12-08 |
2020-03-24 |
Incyte Corporation |
Low dose combination therapy for treatment of myeloproliferative neoplasms
|
PL3746429T3
(pl)
|
2018-01-30 |
2022-06-20 |
Incyte Corporation |
Procesy do otrzymywania (1-(3-fluoro-2-(trifluorometylo)izonikotynoilo)piperydyn-4-onu)
|
WO2019191684A1
(en)
|
2018-03-30 |
2019-10-03 |
Incyte Corporation |
Treatment of hidradenitis suppurativa using jak inhibitors
|
EP3833350A4
(en)
|
2018-08-10 |
2022-05-18 |
Aclaris Therapeutics, Inc. |
PYRROLOPYRIMIDINE TKI INHIBITORS
|
GB201818750D0
(en)
*
|
2018-11-16 |
2019-01-02 |
Institute Of Cancer Res Royal Cancer Hospital |
Lox inhibitors
|
CN109394768B
(zh)
*
|
2018-12-10 |
2019-08-23 |
牡丹江医学院 |
一种治疗湿疹的药物及其制备方法
|
EP3946606A1
(en)
|
2019-03-27 |
2022-02-09 |
Insilico Medicine IP Limited |
Bicyclic jak inhibitors and uses thereof
|
JP2022531088A
(ja)
|
2019-05-02 |
2022-07-06 |
アクラリス セラピューティクス,インコーポレイテッド |
Jak阻害剤としての置換ピロロピリジン
|
KR102503349B1
(ko)
|
2019-05-14 |
2023-02-23 |
프로벤션 바이오, 인코포레이티드 |
제1형 당뇨병을 예방하기 위한 방법 및 조성물
|
KR20220107213A
(ko)
|
2019-11-22 |
2022-08-02 |
인사이트 코포레이션 |
Alk2 억제제 및 jak2 억제제를 포함하는 병용 요법
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
WO2023055731A1
(en)
*
|
2021-09-28 |
2023-04-06 |
Sanford Burnham Prebys Medical Discovery Institute |
Inhibitors of serine/threonine protein kinase stk3 or stk4 and uses thereof
|