MD20140130A2 - 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2 - Google Patents

4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2

Info

Publication number
MD20140130A2
MD20140130A2 MD20140130A MD20140130A MD20140130A2 MD 20140130 A2 MD20140130 A2 MD 20140130A2 MD 20140130 A MD20140130 A MD 20140130A MD 20140130 A MD20140130 A MD 20140130A MD 20140130 A2 MD20140130 A2 MD 20140130A2
Authority
MD
Moldova
Prior art keywords
pyrrolo
novel
pyrimidines
amino
substituted
Prior art date
Application number
MD20140130A
Other languages
English (en)
Russian (ru)
Inventor
Пол ГАЛАЦИС
Мэтью Меррилл ХЭЙВАРД
Жаклин Хендерсон
Бетэни Лин КОРМОС
Рави Г. КУРУМБЕЙЛ
Антония Фредерик СТЕПАН
Патрик Роберт Верхоест
Трэвис Т. ВЕЙДЖЕР
Лэй ЦЗАН
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20140130(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20140130A2 publication Critical patent/MD20140130A2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Prezenta invenţie se referă la derivaţi noi de 7H-pirolo[2,3-d]pirimidine 4,5-disubstituite cu formula I şi la sărurile farmaceutic acceptabile ale acestoraI ,în care R1, R2, R3, R4 şiR5 au semnificaţiile definite în descriere. Invenţia se referă, de asemenea, la compoziţii farmaceutice care conţin compuşii cu formula I şi la utilizarea acestor compuşi în tratamentul bolilor asociate cu LRRK2, cum ar fi bolile neurodegenerative, inclusiv boala Parkinson sau boala Alzheimer, cancerul, boala Crohn sau lepra.
MD20140130A 2012-06-29 2013-06-19 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2 MD20140130A2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261666299P 2012-06-29 2012-06-29
US201361820828P 2013-05-08 2013-05-08
PCT/IB2013/055039 WO2014001973A1 (en) 2012-06-29 2013-06-19 NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS

Publications (1)

Publication Number Publication Date
MD20140130A2 true MD20140130A2 (ro) 2015-04-30

Family

ID=49029142

Family Applications (1)

Application Number Title Priority Date Filing Date
MD20140130A MD20140130A2 (ro) 2012-06-29 2013-06-19 4-(amino-substituite)-7H-pirolo[2,3-d]pirimidine noi ca inhibitori de LRRK2

Country Status (32)

Country Link
US (2) US9156845B2 (ro)
EP (2) EP3255049A1 (ro)
JP (3) JP6189948B2 (ro)
KR (1) KR20150027267A (ro)
CN (2) CN105732639A (ro)
AP (1) AP3902A (ro)
AR (1) AR091628A1 (ro)
AU (1) AU2013282869B2 (ro)
BR (1) BR112014032913A2 (ro)
CA (1) CA2878054C (ro)
CL (1) CL2014003566A1 (ro)
CO (1) CO7160063A2 (ro)
CR (1) CR20140566A (ro)
DO (1) DOP2014000303A (ro)
EA (1) EA025186B1 (ro)
ES (1) ES2637245T3 (ro)
GE (1) GEP201706620B (ro)
GT (1) GT201400301A (ro)
HK (1) HK1204619A1 (ro)
IL (1) IL236294A (ro)
MD (1) MD20140130A2 (ro)
MX (1) MX2014015769A (ro)
NI (1) NI201400151A (ro)
NZ (1) NZ702571A (ro)
PE (1) PE20150153A1 (ro)
PH (1) PH12014502886A1 (ro)
SG (1) SG11201408044QA (ro)
TN (1) TN2014000537A1 (ro)
TW (1) TWI482774B (ro)
UY (1) UY34883A (ro)
WO (1) WO2014001973A1 (ro)
ZA (1) ZA201409136B (ro)

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