BR112018068702A2 - inibidores bicíclicos em ponte de menin-mll e métodos de uso - Google Patents
inibidores bicíclicos em ponte de menin-mll e métodos de usoInfo
- Publication number
- BR112018068702A2 BR112018068702A2 BR112018068702A BR112018068702A BR112018068702A2 BR 112018068702 A2 BR112018068702 A2 BR 112018068702A2 BR 112018068702 A BR112018068702 A BR 112018068702A BR 112018068702 A BR112018068702 A BR 112018068702A BR 112018068702 A2 BR112018068702 A2 BR 112018068702A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- menin
- mll
- bridged bicyclic
- bicyclic inhibitors
- Prior art date
Links
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 101710169972 Menin Proteins 0.000 abstract 2
- 102100030550 Menin Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000027450 oncoproteins Human genes 0.000 abstract 1
- 108091008819 oncoproteins Proteins 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
o presente relatório provê métodos para a inibição da interação de menin com mll1, mll2 e oncoproteínas de fusão de mll. os métodos são úteis para o tratamento de leucemia, cânceres sólidos, diabetes e outras doenças dependentes da atividade de mll1, mll2, proteínas de fusão de mll e/ou menin. são também providas composições para uso nestes métodos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662309362P | 2016-03-16 | 2016-03-16 | |
US201662431387P | 2016-12-07 | 2016-12-07 | |
PCT/US2017/022535 WO2017161002A1 (en) | 2016-03-16 | 2017-03-15 | Bridged bicyclic inhibitors of menin-mll and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018068702A2 true BR112018068702A2 (pt) | 2019-01-15 |
Family
ID=59851929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018068702A BR112018068702A2 (pt) | 2016-03-16 | 2017-03-15 | inibidores bicíclicos em ponte de menin-mll e métodos de uso |
Country Status (17)
Country | Link |
---|---|
US (2) | US10752639B2 (pt) |
EP (1) | EP3429585B1 (pt) |
JP (1) | JP7000333B2 (pt) |
KR (1) | KR102419524B1 (pt) |
CN (1) | CN109640987B (pt) |
AU (1) | AU2017235462B2 (pt) |
BR (1) | BR112018068702A2 (pt) |
CA (1) | CA3015845A1 (pt) |
HK (1) | HK1258821A1 (pt) |
IL (1) | IL261625B (pt) |
MA (1) | MA43823A (pt) |
MX (1) | MX2018011092A (pt) |
PH (1) | PH12018501955A1 (pt) |
SG (1) | SG11201807834WA (pt) |
TW (1) | TWI743096B (pt) |
WO (1) | WO2017161002A1 (pt) |
ZA (1) | ZA201805845B (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
MA43823A (fr) | 2016-03-16 | 2018-11-28 | Kura Oncology Inc | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
CN109152784B (zh) | 2016-03-16 | 2021-12-28 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
MX2018013433A (es) | 2016-05-02 | 2019-07-18 | Univ Michigan Regents | Piperidinas como inhibidores de menina. |
MX2019002962A (es) | 2016-09-14 | 2019-07-04 | Janssen Pharmaceutica Nv | Inhibidores espirobiciclicos de la interaccion de menina-mll. |
TWI753016B (zh) | 2016-09-14 | 2022-01-21 | 比利時商健生藥品公司 | Menin-mll相互作用之稠合二環抑制劑 |
WO2018109088A1 (en) | 2016-12-15 | 2018-06-21 | Janssen Pharmaceutica Nv | Azepane inhibitors of menin-mll interaction |
JP7142010B2 (ja) | 2016-12-15 | 2022-09-26 | ヤンセン ファーマシューティカ エヌ.ベー. | メニン-mll相互作用のアゼパン阻害剤 |
CN110691779B (zh) | 2017-03-24 | 2023-10-10 | 库拉肿瘤学公司 | 治疗血液***恶性肿瘤和尤因肉瘤的方法 |
KR20190133224A (ko) | 2017-03-31 | 2019-12-02 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 공유 메닌 억제제로서의 피페리딘 |
US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
US11649251B2 (en) | 2017-09-20 | 2023-05-16 | Kura Oncology, Inc. | Substituted inhibitors of menin-MLL and methods of use |
US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
CN110204552B (zh) * | 2018-02-28 | 2021-08-17 | 中国科学院上海药物研究所 | 一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途 |
WO2019189732A1 (ja) | 2018-03-30 | 2019-10-03 | 大日本住友製薬株式会社 | 光学活性な架橋型環状2級アミン誘導体 |
WO2020069027A1 (en) * | 2018-09-26 | 2020-04-02 | Kura Oncology, Inc. | Treatment of hematological malignancies with inhibitors of menin |
CN110964016B (zh) * | 2018-09-29 | 2021-05-28 | 南京药捷安康生物科技有限公司 | 氨基降茨烷衍生物及其制备方法与应用 |
BR112021007421A2 (pt) * | 2018-12-06 | 2021-08-03 | Daiichi Sankyo Company, Limited | derivado de cicloalcano-1,3-diamina |
TW202043205A (zh) | 2018-12-31 | 2020-12-01 | 美商拜歐米富士恩有限公司 | Menin-mll相互作用之抑制劑 |
EP3924329A2 (en) | 2019-02-15 | 2021-12-22 | Bristol-Myers Squibb Company | Substituted amide compounds useful as farnesoid x receptor modulators |
CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
JP2023522166A (ja) * | 2020-04-07 | 2023-05-29 | シンダックス ファーマシューティカルズ, インコーポレイテッド | メニン阻害剤とcyp3a4阻害剤との組合せ、およびその使用方法 |
JP2024518434A (ja) | 2021-05-08 | 2024-05-01 | ヤンセン ファーマシューティカ エヌ.ベー. | 置換スピロ誘導体 |
EP4334320A1 (en) | 2021-05-08 | 2024-03-13 | JANSSEN Pharmaceutica NV | Substituted spiro derivatives |
JP2024517945A (ja) | 2021-05-14 | 2024-04-23 | シンダックス ファーマシューティカルズ, インコーポレイテッド | メニン-mll相互作用の阻害剤 |
WO2022253167A1 (en) | 2021-06-01 | 2022-12-08 | Janssen Pharmaceutica Nv | SUBSTITUTED PHENYL-1H-PYRROLO [2, 3-c] PYRIDINE DERIVATIVES |
BR112023025436A2 (pt) | 2021-06-03 | 2024-02-27 | Janssen Pharmaceutica Nv | Piridazinas ou 1,2,4-triazinas substituídas por aminas espirocíclicas |
EP4355747A1 (en) | 2021-06-17 | 2024-04-24 | JANSSEN Pharmaceutica NV | (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cancer |
CA3229150A1 (en) | 2021-08-20 | 2023-02-23 | Biomea Fusion, Inc. | Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cance |
WO2023220098A1 (en) * | 2022-05-09 | 2023-11-16 | Syndax Pharmaceuticals, Inc. | Menin-mll inhibitors for the treatment of cancer |
WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US949A (en) | 1838-09-27 | Improvement in roller cotton-gins for ginning long-staple and other kinds of cotton | ||
US5861A (en) | 1848-10-17 | Locking umbrella and parasol | ||
US510A (en) | 1837-12-07 | soeel | ||
US5863A (en) | 1848-10-17 | Matthias p | ||
US1007727A (en) | 1908-02-17 | 1911-11-07 | Oscar F Onken | Auxiliary table-top. |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
DE4239169A1 (de) | 1992-11-21 | 1994-05-26 | Merck Patent Gmbh | Cyclobutan - Benzol - Derivate |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
JP3053222B2 (ja) | 1995-04-20 | 2000-06-19 | ファイザー・インコーポレーテッド | Mmpおよびtnf抑制剤としてのアリールスルホニルヒドロキサム酸誘導体 |
ES2183905T3 (es) | 1995-12-20 | 2003-04-01 | Hoffmann La Roche | Inhibidores de metaloproteasa de matriz. |
JP3195756B2 (ja) | 1996-07-04 | 2001-08-06 | 公子 吉水 | 潤滑補助体 |
PT923585E (pt) | 1996-07-18 | 2002-08-30 | Pfizer | Inibidores a base de fosfinato de metaloproteases de matriz |
JP3333870B2 (ja) | 1996-07-26 | 2002-10-15 | 国土交通省北陸地方整備局長 | 草刈機 |
US6153609A (en) | 1996-08-23 | 2000-11-28 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
US5866562A (en) | 1996-10-25 | 1999-02-02 | Bayer Aktiengesellschaft | Ring-bridged bis-quinolines |
DK0950059T3 (da) | 1997-01-06 | 2004-11-01 | Pfizer | Cycliske sulfonderivater |
PL335027A1 (en) | 1997-02-03 | 2000-03-27 | Pfizer Prod Inc | Derivatives of arylsulphonylamino hydroxamic acid |
EP0966438A1 (en) | 1997-02-07 | 1999-12-29 | Pfizer Inc. | N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases |
IL131123A0 (en) | 1997-02-11 | 2001-01-28 | Pfizer | Arylsulfonyl hydroxamic acid derivatives |
JPH10330377A (ja) | 1997-06-02 | 1998-12-15 | Kyowa Hakko Kogyo Co Ltd | ピペリジン誘導体 |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8474101A1 (es) | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
US7074801B1 (en) | 2001-04-26 | 2006-07-11 | Eisai Co., Ltd. | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof |
CN101100472A (zh) | 2001-04-30 | 2008-01-09 | 美国拜尔公司 | 4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用 |
WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
WO2004030671A2 (en) | 2002-10-02 | 2004-04-15 | Merck Patent Gmbh | Use of 4-amino-quinazolines as anti cancer agents |
WO2004030672A1 (en) | 2002-10-02 | 2004-04-15 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
US7612078B2 (en) | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
US20050222175A1 (en) | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
BRPI0408988A (pt) | 2003-03-31 | 2006-03-28 | Predix Pharmaceuticals Holding | composto de piperidinilamino-tieno[2,3-d]pirimidina |
JP5335191B2 (ja) | 2003-08-22 | 2013-11-06 | デンドレオン コーポレイション | Trp−p8発現に関連する疾患の処置をするための組成物および方法 |
US20050123906A1 (en) | 2003-11-06 | 2005-06-09 | Rana Tariq M. | Protein modulation |
EP1768964A1 (en) | 2004-07-06 | 2007-04-04 | Angion Biomedica Corporation | Quinazoline modulators of hepatocyte growth factor / c-met activity for the treatment of cancer |
JP4981794B2 (ja) * | 2005-06-03 | 2012-07-25 | アボット・ラボラトリーズ | シクロブチルアミン誘導体 |
US20060281769A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
US20060281771A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using aminoquinoline and aminoquinazoline kinase modulators |
WO2007026024A2 (en) | 2005-09-02 | 2007-03-08 | Tibotec Pharmaceuticals Ltd. | Benzodiazepines as hcv inhibitors |
ATE444345T1 (de) | 2005-09-19 | 2009-10-15 | Merck Patent Gmbh | Cyclobutan- und spiroä3.3üheptanverbindungen |
FR2891829A1 (fr) | 2005-10-12 | 2007-04-13 | Sanofi Aventis Sa | Derives de la 4-amino-quinazoline, leur preparation et leur application en therapeutique |
JP2009521479A (ja) | 2005-12-21 | 2009-06-04 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
AU2007236116A1 (en) | 2006-04-07 | 2007-10-18 | Develogen Aktiengesellschaft | Thienopyrimidines having MnKl /Mnk2 inhibiting activity for pharmaceutical compositions |
EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
WO2008070303A2 (en) | 2006-10-19 | 2008-06-12 | The University Of Chicago | Therapeutics to inhibit mll-menin interaction for treating leukemia |
EP1947103A1 (en) | 2007-01-22 | 2008-07-23 | 4Sc Ag | Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments |
WO2008099019A1 (en) | 2007-02-16 | 2008-08-21 | Tibotec Pharmaceuticals Ltd. | 6-hydroxy-dibenzodiazepinones useful as hepatitis c virus inhibitors |
FR2913017A1 (fr) | 2007-02-23 | 2008-08-29 | Cerep Sa | Derives de piperidine et piperazine comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire |
US8309726B2 (en) | 2007-03-19 | 2012-11-13 | Council Of Scientific & Industrial Research | Substituted piperazine compounds of formula 8 |
WO2008135232A1 (en) | 2007-05-02 | 2008-11-13 | Riccardo Cortese | Use and compositions of purine derivatives for the treatment of proliferative disorders |
US20080293699A1 (en) | 2007-05-25 | 2008-11-27 | Burnham Institute For Medical Research | Inhibitors of thapsigargin-induced cell death |
WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
US20110124649A1 (en) | 2007-11-09 | 2011-05-26 | The Johns Hopkins University | Inhibitors of human methionine aminopeptidase 1 and methods of treating disorders |
WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
US8193203B2 (en) | 2008-05-22 | 2012-06-05 | Allergan, Inc. | Bicyclic compounds having activity at the CXCR4 receptor |
DE102008027574A1 (de) * | 2008-06-10 | 2009-12-17 | Merck Patent Gmbh | Neue Pyrrolidinderivate als MetAP-2 Inhibitoren |
EP2328871B1 (en) | 2008-08-25 | 2020-04-01 | Novartis AG | Hedgehog pathway modulators |
EP2320904A4 (en) | 2008-09-10 | 2011-09-14 | Kalypsys Inc | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE |
EP2451813B1 (en) | 2009-07-08 | 2014-10-01 | Leo Pharma A/S | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors |
EP2459533A4 (en) | 2009-07-30 | 2013-01-16 | Univ Singapore | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEIN CARBOXYL METHYLTRANERASE WITH POTENTIAL ANTICANCING ACTIVITY |
AU2010289321A1 (en) | 2009-09-04 | 2012-04-05 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
SG183233A1 (en) | 2010-02-22 | 2012-09-27 | Merck Patent Gmbh | Hetarylaminonaphthyridines |
MX2013001970A (es) | 2010-08-20 | 2013-08-09 | Hutchison Medipharma Ltd | Compuestos de pirrolopirimidina y usos de los mismos. |
WO2013019966A1 (en) * | 2011-08-04 | 2013-02-07 | Allergan, Inc. | Aromatic bycyclic derivatives as cxcr4 receptor modulators |
GB201114212D0 (en) | 2011-08-18 | 2011-10-05 | Ucb Pharma Sa | Therapeutic agents |
AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
CN103833759A (zh) * | 2012-11-23 | 2014-06-04 | 华东理工大学 | 作为blk、flt3抑制剂的蝶啶酮衍生物及其应用 |
JP2016512514A (ja) | 2013-03-13 | 2016-04-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | チエノピリミジン及びチエノピリジン化合物を含有する組成物並びにそれらの使用方法 |
EP2968285A4 (en) | 2013-03-13 | 2016-12-21 | Flatley Discovery Lab | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS |
US9212180B2 (en) * | 2013-06-12 | 2015-12-15 | The Regents Of The University Of Michigan | Menin-MLL inhibitors and methods of use thereof |
ES2702951T3 (es) * | 2014-04-04 | 2019-03-06 | Syros Pharmaceuticals Inc | Inhibidores de quinasas dependientes de ciclina 7 (cdk7) |
WO2015191701A1 (en) | 2014-06-10 | 2015-12-17 | The Trustees Of The University Of Pennsylvania | Scaffolds for inhibitors of menin-mll interactions |
WO2016040330A1 (en) * | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
WO2016197027A1 (en) | 2015-06-04 | 2016-12-08 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with mll proteins |
JP2018538330A (ja) | 2015-12-22 | 2018-12-27 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | menin−MLL相互作用の阻害剤 |
AU2017212572A1 (en) | 2016-01-26 | 2018-08-23 | Memorial Sloan-Kettering Cancer Center | Targeting chromatin regulators inhibits leukemogenic gene expression in NPM1 mutant leukemia |
MA43823A (fr) | 2016-03-16 | 2018-11-28 | Kura Oncology Inc | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
CN109152784B (zh) | 2016-03-16 | 2021-12-28 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
MX2018013433A (es) | 2016-05-02 | 2019-07-18 | Univ Michigan Regents | Piperidinas como inhibidores de menina. |
WO2017207387A1 (en) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction |
SI3468966T1 (sl) | 2016-06-10 | 2021-03-31 | Vitae Pharmaceuticals, Llc | Zaviralci interakcije menin-MLL |
WO2018024602A1 (en) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro[4.4]nonanes |
TWI753016B (zh) | 2016-09-14 | 2022-01-21 | 比利時商健生藥品公司 | Menin-mll相互作用之稠合二環抑制劑 |
WO2018050686A1 (en) | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-mll interaction |
KR102536029B1 (ko) | 2016-09-16 | 2023-05-23 | 비타이 파마슈티컬즈, 엘엘씨 | 메닌-mll 상호작용의 억제제 |
-
2017
- 2017-03-15 MA MA043823A patent/MA43823A/fr unknown
- 2017-03-15 KR KR1020187029700A patent/KR102419524B1/ko active IP Right Grant
- 2017-03-15 WO PCT/US2017/022535 patent/WO2017161002A1/en active Application Filing
- 2017-03-15 US US16/082,645 patent/US10752639B2/en active Active
- 2017-03-15 BR BR112018068702A patent/BR112018068702A2/pt not_active Application Discontinuation
- 2017-03-15 TW TW106108619A patent/TWI743096B/zh active
- 2017-03-15 SG SG11201807834WA patent/SG11201807834WA/en unknown
- 2017-03-15 CA CA3015845A patent/CA3015845A1/en active Pending
- 2017-03-15 MX MX2018011092A patent/MX2018011092A/es unknown
- 2017-03-15 JP JP2018544323A patent/JP7000333B2/ja active Active
- 2017-03-15 AU AU2017235462A patent/AU2017235462B2/en active Active
- 2017-03-15 CN CN201780030449.4A patent/CN109640987B/zh active Active
- 2017-03-15 EP EP17767444.7A patent/EP3429585B1/en active Active
-
2018
- 2018-08-30 ZA ZA2018/05845A patent/ZA201805845B/en unknown
- 2018-09-05 IL IL261625A patent/IL261625B/en unknown
- 2018-09-11 PH PH12018501955A patent/PH12018501955A1/en unknown
-
2019
- 2019-01-23 HK HK19101198.7A patent/HK1258821A1/zh unknown
-
2020
- 2020-07-13 US US16/927,844 patent/US11555041B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20210107917A1 (en) | 2021-04-15 |
EP3429585A1 (en) | 2019-01-23 |
US20190092783A1 (en) | 2019-03-28 |
AU2017235462A1 (en) | 2018-09-27 |
EP3429585B1 (en) | 2021-11-24 |
MX2018011092A (es) | 2018-11-22 |
TW201742870A (zh) | 2017-12-16 |
CN109640987A (zh) | 2019-04-16 |
JP2019508426A (ja) | 2019-03-28 |
TWI743096B (zh) | 2021-10-21 |
MA43823A (fr) | 2018-11-28 |
IL261625B (en) | 2021-08-31 |
KR102419524B1 (ko) | 2022-07-08 |
HK1258821A1 (zh) | 2019-11-22 |
US11555041B2 (en) | 2023-01-17 |
AU2017235462B2 (en) | 2021-07-01 |
KR20180127406A (ko) | 2018-11-28 |
JP7000333B2 (ja) | 2022-02-10 |
SG11201807834WA (en) | 2018-10-30 |
WO2017161002A1 (en) | 2017-09-21 |
PH12018501955A1 (en) | 2019-06-17 |
ZA201805845B (en) | 2023-03-29 |
US10752639B2 (en) | 2020-08-25 |
CA3015845A1 (en) | 2017-09-21 |
IL261625A (en) | 2018-10-31 |
CN109640987B (zh) | 2022-12-02 |
EP3429585A4 (en) | 2019-10-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018068702A2 (pt) | inibidores bicíclicos em ponte de menin-mll e métodos de uso | |
BR112018068703A2 (pt) | inibidores substituídos de menin-mll e métodos de uso | |
MY186712A (en) | Methods and compositions for inhibiting the interaction of menin with mll proteinss | |
MX2021010482A (es) | Compuestos y metodos para la degradacion mejorada de proteinas especificas. | |
BR112015022602A2 (pt) | composições compreendendo compostos de tienopirimidina e tienopiridina e métodos de uso dos mesmos | |
CO2018011668A2 (es) | Neoantígenos y métodos de su uso | |
WO2018119441A8 (en) | Egfr proteolysis targeting chimeric molecules and associated methods of use | |
MX2021012926A (es) | Moduladores de la proteolisis basados en imida y metodos de uso asociados. | |
BR112016027722A8 (pt) | compostos contendo grupo autoimulativo e seu uso | |
MX2017012805A (es) | Complejo de unión a antígenos con actividad agonista y métodos de uso. | |
MX2018000360A (es) | Moduladores basados en mdm2 de proteolisis y metodos de uso asociados. | |
CL2021001735A1 (es) | Inhibidores irreversibles de la interacción menina-mll. | |
MX2017015605A (es) | Moduladores de proteolisis basados en imida y metodos de uso asociados. | |
BR112017007170A2 (pt) | anticorpos anti-ox40 humanizados e suas utilizações | |
MX2022009478A (es) | Compuestos y metodos para degradacion mejorada de proteinas y otros polipeptidos elegidos como blanco mediante una ubiquitina ligasa e3. | |
TR201909887T4 (tr) | ERK inhibitörleri olarak tieno[2,3-c]pirol-4-on türevleri. | |
BR112016016916A8 (pt) | uso de um anticorpo que se liga à calicreína plasmática ativa para tratamento de angiodema hereditário (hae) | |
BR112019017403A2 (pt) | composições e métodos para o tratamento de câncer | |
MX2018005399A (es) | Nuevo polipeptido con afinidad por pd-l1. | |
MX2017000083A (es) | Compuestos de platino, composiciones y usos de estos. | |
BR112019007365A2 (pt) | métodos e composições para imunoterapia com tusc2 | |
WO2017075170A8 (en) | Methods of measuring factor d activity and potency of factor d inhibitors | |
EP3925979A3 (en) | Fgfr-tacc fusion proteins and methods thereof | |
BR112019003834A2 (pt) | compostos contendo monoterpenoides / fenilpropanóides e métodos de sua fabricação e uso como herbicidas | |
EA201892082A1 (ru) | Мостиковые бициклические ингибиторы менин-mll и способы применения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |