JOP20190230A1 - طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به - Google Patents

طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به

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Publication number
JOP20190230A1
JOP20190230A1 JOP/2019/0230A JOP20190230A JOP20190230A1 JO P20190230 A1 JOP20190230 A1 JO P20190230A1 JO P20190230 A JOP20190230 A JO P20190230A JO P20190230 A1 JOP20190230 A1 JO P20190230A1
Authority
JO
Jordan
Prior art keywords
processes
intermediate compounds
jak inhibitors
related intermediate
preparing
Prior art date
Application number
JOP/2019/0230A
Other languages
English (en)
Inventor
Qiyan Lin
Haisheng Wang
James D Rodgers
Tai-Yuen Yue
Jiacheng Zhou
Brian W Metcalf
David Meloni
Michael Xia
Mei Li
Yongchun Pan
Pingli Liu
Original Assignee
Incyte Corp
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Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of JOP20190230A1 publication Critical patent/JOP20190230A1/ar

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
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    • C07F7/0803—Compounds with Si-C or Si-Si linkages
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    • C07F7/083—Syntheses without formation of a Si-C bond
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

يتعلق الاكتشاف الحالي بطرق لتحضير بايريمدينات [2,3-d] بايرولو بايرازوليل مستبدلة الجزيئات غير منطبقة مرآويا خاصة بالصيغة III والمركبات الوسيطة التوليفية الصناعية المتعلقة بها. البايريمدينات [2,3-d] بايرولو بايرازوليل مستبدلة الجزيئات غير المنطبقة مرآويا مفيدة كمثبطات لعائلة مستقبِل كاينيز جانوس لبروتين كاينيز تايروزين لمعالجة الامراض الالتهابية واضطرابات التشعب النخاعي العظمي وغير ذلك من الامراض.
JOP/2019/0230A 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به JOP20190230A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14499109P 2009-01-15 2009-01-15

Publications (1)

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JOP20190230A1 true JOP20190230A1 (ar) 2017-06-16

Family

ID=42026219

Family Applications (3)

Application Number Title Priority Date Filing Date
JOP/2019/0230A JOP20190230A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2019/0231A JOP20190231A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2010/0010A JO3441B1 (ar) 2009-01-15 2010-01-14 طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به

Family Applications After (2)

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JOP/2019/0231A JOP20190231A1 (ar) 2009-01-15 2009-01-15 طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
JOP/2010/0010A JO3441B1 (ar) 2009-01-15 2010-01-14 طرق لاصلاح مثبطات انزيم jak والمركبات الوسيطة المتعلقة به

Country Status (29)

Country Link
US (9) US8410265B2 (ar)
EP (2) EP2398774B1 (ar)
JP (6) JP5650662B2 (ar)
KR (7) KR102422043B1 (ar)
CN (4) CN108395433A (ar)
AR (2) AR082747A1 (ar)
AU (4) AU2010204772B2 (ar)
BR (3) BRPI1006794B1 (ar)
CA (2) CA3121743A1 (ar)
CL (3) CL2011001668A1 (ar)
CO (1) CO6400137A2 (ar)
EA (3) EA020643B1 (ar)
EC (1) ECSP11011268A (ar)
ES (1) ES2641761T3 (ar)
IL (7) IL214061A (ar)
JO (3) JOP20190230A1 (ar)
MA (1) MA33038B1 (ar)
MX (5) MX357874B (ar)
MY (3) MY186533A (ar)
NZ (5) NZ725585A (ar)
PE (4) PE20160788A1 (ar)
PH (1) PH12016502060B1 (ar)
PL (1) PL2398774T3 (ar)
PT (1) PT2398774T (ar)
SG (3) SG10201913261QA (ar)
TN (1) TN2011000329A1 (ar)
TW (7) TWI710562B (ar)
WO (1) WO2010083283A2 (ar)
ZA (1) ZA201104909B (ar)

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