MX2022012089A - Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos. - Google Patents

Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos.

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Publication number
MX2022012089A
MX2022012089A MX2022012089A MX2022012089A MX2022012089A MX 2022012089 A MX2022012089 A MX 2022012089A MX 2022012089 A MX2022012089 A MX 2022012089A MX 2022012089 A MX2022012089 A MX 2022012089A MX 2022012089 A MX2022012089 A MX 2022012089A
Authority
MX
Mexico
Prior art keywords
antibodies
binding
ion concentration
region variants
concentration dependent
Prior art date
Application number
MX2022012089A
Other languages
English (en)
Inventor
Atsuhiko Maeda
Kenta Haraya
Tatsuhiko Tachibana
Yuji Hori
Tomoyuki Igawa
Yuki Iwayanagi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2022012089A publication Critical patent/MX2022012089A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Abstract

La presente invención se refiere a moléculas además mejoradas a partir de anticuerpos que pueden unirse a antígenos en una manera dependiente de la concentración. Un aspecto no exclusivo alterno proporciona variantes de la región Fc seguras y más ventajosas que tienen unión reducida a ADA pre-existente. Un aspecto no exclusivo alterno proporciona anticuerpos IL-8 novedosos que son superiores como farmacéuticos.
MX2022012089A 2015-02-05 2017-07-06 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos. MX2022012089A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015021371 2015-02-05
JP2015185254 2015-09-18

Publications (1)

Publication Number Publication Date
MX2022012089A true MX2022012089A (es) 2022-11-14

Family

ID=55398349

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017008978A MX2017008978A (es) 2015-02-05 2016-02-04 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos.
MX2022012089A MX2022012089A (es) 2015-02-05 2017-07-06 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos.
MX2021008816A MX2021008816A (es) 2015-02-05 2017-07-06 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos.

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Application Number Title Priority Date Filing Date
MX2017008978A MX2017008978A (es) 2015-02-05 2016-02-04 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, antiocuerpor de union a interleucina 8 (il-8) y usos de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021008816A MX2021008816A (es) 2015-02-05 2017-07-06 Anticuerpos que comprenden un dominio de union al antigeno dependiente de la concentracion ionica, variantes de la region fc, anticuerpos de union a interleucina 8 (il-8) y usos de los mismos.

Country Status (13)

Country Link
US (4) US9969800B2 (es)
EP (2) EP3816179A3 (es)
JP (3) JP2018510842A (es)
KR (3) KR20170110129A (es)
CN (4) CN114773469A (es)
AU (4) AU2016216079A1 (es)
BR (1) BR112017014328A2 (es)
CA (1) CA2974547A1 (es)
EA (1) EA201791754A1 (es)
MX (3) MX2017008978A (es)
SG (2) SG11201706014PA (es)
TW (1) TW202248212A (es)
WO (1) WO2016125495A1 (es)

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DK2009101T3 (en) 2006-03-31 2018-01-15 Chugai Pharmaceutical Co Ltd Antibody modification method for purification of a bispecific antibody
DK2006381T3 (en) 2006-03-31 2016-02-22 Chugai Pharmaceutical Co Ltd PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS
SG10201605394SA (en) 2007-09-26 2016-08-30 Chugai Pharmaceutical Co Ltd Modified Antibody Constant Region
EP3127921A1 (en) 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substition in cdr
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