CA2603830A1 - Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors - Google Patents

Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors Download PDF

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Publication number
CA2603830A1
CA2603830A1 CA002603830A CA2603830A CA2603830A1 CA 2603830 A1 CA2603830 A1 CA 2603830A1 CA 002603830 A CA002603830 A CA 002603830A CA 2603830 A CA2603830 A CA 2603830A CA 2603830 A1 CA2603830 A1 CA 2603830A1
Authority
CA
Canada
Prior art keywords
pyrazinones
pyridino
pde
inhibitors
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA002603830A
Other languages
French (fr)
Inventor
Andrew Simon Bell
Brent Virgil Mischke
Alan George Benson
Dafydd Rhys Owen
Yvette Marlene Fobian
Michael John Palmer
John Major Molyneaux
Joseph Blair Moon
Christopher Phillips
David Louis Brown
John Keith Walker
Michael Brent Tollefson
Todd Michael Maddux
David Graham Brown
John Nicholas Freskos
Steven Edward Heasley
Donald Joseph Rogier Jr
Robert Owen Hughes
Eric Jon Jacobsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Publication of CA2603830A1 publication Critical patent/CA2603830A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Compounds of Formula (I), wherein R2, Y6, R6A, R6, and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
CA002603830A 2005-05-24 2006-05-17 Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors Pending CA2603830A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68413005P 2005-05-24 2005-05-24
PCT/IB2006/001386 WO2006126081A2 (en) 2005-05-24 2006-05-17 Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors

Publications (1)

Publication Number Publication Date
CA2603830A1 true CA2603830A1 (en) 2006-11-30

Family

ID=37046762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002603830A Pending CA2603830A1 (en) 2005-05-24 2006-05-17 Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors

Country Status (2)

Country Link
CA (1) CA2603830A1 (en)
WO (1) WO2006126081A2 (en)

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ES2459047T3 (en) 2008-08-05 2014-05-07 Daiichi Sankyo Company, Limited Imidazopyridin-2-one derivatives
CN101747282A (en) 2008-12-10 2010-06-23 上海特化医药科技有限公司 Phenyl pyrimidone compounds, pharmaceutical compositions and preparation methods and uses thereof
CA2830027C (en) 2011-03-31 2016-04-26 Pfizer Inc. Novel bicyclic pyridinones
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
JP6043355B2 (en) 2011-08-31 2016-12-14 ファイザー・インク Hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compound
ES2585262T3 (en) 2012-05-04 2016-10-04 Pfizer Inc Hexahydropyran [3,4-d] [1,3] thiazin-2-amine heterocyclic compounds substituted as inhibitors of PPA, BACE1 and BACE2
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UA110688C2 (en) 2012-09-21 2016-01-25 Пфайзер Інк. Bicyclic pirydynony
CA2893256A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
MX2015010714A (en) 2013-02-19 2016-06-14 Pfizer Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders.
ES2742078T3 (en) 2013-10-04 2020-02-13 Pfizer Novel bicyclic pyridones as gamma-secretase modulators
DK3126361T3 (en) 2014-04-01 2020-01-02 Pfizer CHROMEN AND 1,1A, 2,7B-TETRAHYDROCYCLOPROPA [C] CHROMEN-PYRIDOPYRAZINE DIONS AS GAMMA SECRETASE MODULATORS
MA39866A (en) 2014-04-10 2017-02-15 Pfizer 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
EP3172210B1 (en) 2014-07-24 2020-01-15 Pfizer Inc Pyrazolopyrimidine compounds
DK3177624T3 (en) 2014-08-06 2019-07-01 Pfizer IMIDAZOPYRIDAZINE COMPOUNDS
MX368391B (en) 2015-02-03 2019-09-30 Pfizer Novel cyclopropabenzofuranyl pyridopyrazinediones.
PL3310784T3 (en) 2015-06-17 2021-03-08 Pfizer Inc. Tricyclic compounds and their use as phosphodiesterase inhibitors.
WO2017051303A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
AU2016325665A1 (en) 2015-09-24 2018-03-08 Pfizer Inc. N-[2-(2-amino-6,6-disubstituted-4, 4a, 5, 6-tetrahydropyrano [3,4-d][1,3] thiazin-8a (8h)-yl) -1, 3-thiazol-4-yl] amides
AU2017223132B2 (en) 2016-02-23 2019-12-05 Pfizer Inc. 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
AU2017286868B2 (en) 2016-07-01 2021-11-11 Pfizer Inc. 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
MX2019015371A (en) 2017-06-22 2020-07-20 Pfizer Dihydro-pyrrolo-pyridine derivatives.
CN109400463B (en) * 2017-08-16 2021-10-22 北京颖泰嘉和生物科技股份有限公司 Preparation method of 2-n-propoxyacetyl chloride
EP3768669B1 (en) 2018-03-23 2023-01-25 Pfizer Inc. Piperazine azaspiro derivaves
MA54758A (en) 2019-01-18 2022-04-27 Astrazeneca Ab PCSK9 INHIBITORS AND METHODS OF USE THEREOF

Family Cites Families (4)

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GB9413975D0 (en) * 1994-07-11 1994-08-31 Fujisawa Pharmaceutical Co New heterobicyclic derivatives
GB9526558D0 (en) * 1995-12-27 1996-02-28 Fujisawa Pharmaceutical Co Heterobicyclic derivatives
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
JP4166991B2 (en) * 2001-02-26 2008-10-15 田辺三菱製薬株式会社 Pyridopyrimidine or naphthyridine derivatives

Also Published As

Publication number Publication date
WO2006126081A3 (en) 2007-01-18
WO2006126081A2 (en) 2006-11-30

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