MD20160053A2 - Derivaţi ai purinei 2,6-substituite şi utilizarea acestora în tratamentul tulburărilor proliferative - Google Patents
Derivaţi ai purinei 2,6-substituite şi utilizarea acestora în tratamentul tulburărilor proliferativeInfo
- Publication number
- MD20160053A2 MD20160053A2 MDA20160053A MD20160053A MD20160053A2 MD 20160053 A2 MD20160053 A2 MD 20160053A2 MD A20160053 A MDA20160053 A MD A20160053A MD 20160053 A MD20160053 A MD 20160053A MD 20160053 A2 MD20160053 A2 MD 20160053A2
- Authority
- MD
- Moldova
- Prior art keywords
- treatment
- purine derivatives
- proliferative disorders
- substituted purine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Prezenta invenţie se referă la compuşi cu formula (I)sau la sărurile farmaceutic acceptabile ale acestora, unde Q, inelul A, inelul B, R1, R2, R3, R4, R5, R6, R7, R8, şi m sunt definiţi în materialele cererii. Derivaţii noi ai purinei sunt utili în tratamentul creşterii anormale a celulelor, precum cancerul, la mamifere. Exemplele de realizare suplimentare se referă la compoziţiile farmaceutice ce conţin compuşii (I) şi la metodele de utilizare a acestor compuşi şi compoziţii în tratamentul creşterii anormale a celulelor la mamifere.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361907322P | 2013-11-21 | 2013-11-21 | |
PCT/IB2014/065935 WO2015075598A1 (en) | 2013-11-21 | 2014-11-10 | 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
MD20160053A2 true MD20160053A2 (ro) | 2016-10-31 |
Family
ID=52004011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20160053A MD20160053A2 (ro) | 2013-11-21 | 2014-11-10 | Derivaţi ai purinei 2,6-substituite şi utilizarea acestora în tratamentul tulburărilor proliferative |
Country Status (39)
Country | Link |
---|---|
US (1) | US9290496B2 (ro) |
EP (1) | EP3071570B1 (ro) |
JP (2) | JP6166845B2 (ro) |
KR (1) | KR101919672B1 (ro) |
CN (1) | CN105916853B (ro) |
AP (1) | AP2016009219A0 (ro) |
AR (1) | AR098492A1 (ro) |
AU (1) | AU2014351433B2 (ro) |
CA (1) | CA2931034C (ro) |
CL (1) | CL2016001151A1 (ro) |
CR (1) | CR20160236A (ro) |
CU (1) | CU24402B1 (ro) |
CY (1) | CY1120478T1 (ro) |
DK (1) | DK3071570T3 (ro) |
DO (1) | DOP2016000115A (ro) |
EA (1) | EA029842B1 (ro) |
ES (1) | ES2681799T3 (ro) |
GE (1) | GEP20186878B (ro) |
GT (1) | GT201600091A (ro) |
HR (1) | HRP20181036T1 (ro) |
HU (1) | HUE039858T2 (ro) |
IL (1) | IL245698B (ro) |
LT (1) | LT3071570T (ro) |
MA (1) | MA39043B1 (ro) |
MD (1) | MD20160053A2 (ro) |
MX (1) | MX2016006397A (ro) |
MY (1) | MY184433A (ro) |
NI (1) | NI201600072A (ro) |
PE (1) | PE20160885A1 (ro) |
PH (1) | PH12016500911A1 (ro) |
PL (1) | PL3071570T3 (ro) |
PT (1) | PT3071570T (ro) |
RS (1) | RS57537B1 (ro) |
SI (1) | SI3071570T1 (ro) |
TN (1) | TN2016000188A1 (ro) |
TW (1) | TWI538913B (ro) |
UA (1) | UA115388C2 (ro) |
UY (1) | UY35845A (ro) |
WO (1) | WO2015075598A1 (ro) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
CA2924362C (en) * | 2013-09-18 | 2018-12-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compound inhibiting activities of btk and/or jak3 kinases |
MX2017014436A (es) * | 2015-05-12 | 2018-08-01 | Kalyra Pharmaceuticals Inc | Compuestos biciclicos. |
CN109937039A (zh) * | 2016-09-30 | 2019-06-25 | 斯坦福国际研究院 | 用于癌症治疗的双重clk/cdk1抑制剂 |
EP3541389A1 (en) | 2016-11-16 | 2019-09-25 | Pfizer Inc | Combination of an egfr t790m inhibitor and a cdk inhibitor for the treatment of non-small cell lung cancer |
WO2018119441A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Egfr proteolysis targeting chimeric molecules and associated methods of use |
ES2910083T3 (es) | 2017-03-10 | 2022-05-11 | Pfizer | Derivados de imidazo[4,5-c]quinolina cíclicos sustituidos |
JP7219223B2 (ja) | 2017-03-10 | 2023-02-07 | ファイザー・インク | LRRK2阻害剤としての新規のイミダゾ[4,5-c]キノリン誘導体 |
EP3814354B1 (en) * | 2018-06-22 | 2023-11-08 | The Royal Institution for the Advancement of Learning / McGill University | Purine compounds and method for the treatment of cancer |
KR20200105631A (ko) * | 2019-02-28 | 2020-09-08 | 보로노이바이오 주식회사 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 |
US20230234954A1 (en) * | 2020-05-20 | 2023-07-27 | Tyk Medicines, Inc. | Compound used as ret kinase inhibitor and application thereof |
AR127031A1 (es) | 2021-09-14 | 2023-12-13 | Boehringer Ingelheim Int | Derivados de 3-fenoxiazetidin-1-il-heteroaril pirrolidina y el uso de estos como medicamento |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
ATE159009T1 (de) | 1991-05-10 | 1997-10-15 | Rhone Poulenc Rorer Int | Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase |
NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
ATE419355T1 (de) | 1992-02-06 | 2009-01-15 | Novartis Vaccines & Diagnostic | Marker für krebs und biosynthetisches bindeprotein dafür |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
GB9314884D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
US5863949A (en) | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
PT821671E (pt) | 1995-04-20 | 2001-04-30 | Pfizer | Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf |
US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
GB9520822D0 (en) | 1995-10-11 | 1995-12-13 | Wellcome Found | Therapeutically active compounds |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
DE69624081T2 (de) | 1995-12-20 | 2003-06-12 | Hoffmann La Roche | Matrix-metalloprotease Inhibitoren |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
ATE227283T1 (de) | 1996-07-13 | 2002-11-15 | Glaxo Group Ltd | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
AU3693697A (en) | 1996-07-13 | 1998-02-09 | Glaxo Group Limited | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors |
KR20000067904A (ko) | 1996-07-18 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 매트릭스 메탈로프로테아제의 포스피네이트계 억제제 |
US6790958B2 (en) | 1996-08-02 | 2004-09-14 | Robert T. Lum | Purine inhibitors of cyclin dependent kinase 2 & IKBA |
US6794390B2 (en) | 1996-08-02 | 2004-09-21 | Cv Therapeutics, Inc. | Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha |
US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
PL331895A1 (en) | 1996-08-23 | 1999-08-16 | Pfizer | Arylosulphonylamino derivatives of hydroxamic acid |
CA2277100C (en) | 1997-01-06 | 2005-11-22 | Pfizer Inc. | Cyclic sulfone derivatives |
CN1113862C (zh) | 1997-02-03 | 2003-07-09 | 辉瑞产品公司 | 芳基磺酰氨基异羟肟酸衍生物 |
JP2000507975A (ja) | 1997-02-07 | 2000-06-27 | ファイザー・インク | N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用 |
NZ336836A (en) | 1997-02-11 | 2001-02-23 | Pfizer | Arylsulfonyl hydroxamic acid derivatives suitable for a broad range of medicinal treatments |
JP2002511852A (ja) | 1997-05-07 | 2002-04-16 | スージェン・インコーポレーテッド | 蛋白質キナーゼ活性の調節剤としての2−インドリノン誘導体 |
AU734009B2 (en) | 1997-05-30 | 2001-05-31 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
JP2001516694A (ja) | 1997-08-07 | 2001-10-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | プロテインキナーゼ、gプロテイン及びポリメラーゼのプリン阻害剤 |
JP4959049B2 (ja) | 1997-08-22 | 2012-06-20 | アストラゼネカ・ユーケイ・リミテッド | 血管新生阻害剤としてのオキシインドリルキナゾリン誘導体 |
EP1017682A4 (en) | 1997-09-26 | 2000-11-08 | Merck & Co Inc | NEW ANGIOGENESIS INHIBITORS |
EA005889B1 (ru) | 1997-11-11 | 2005-06-30 | Пфайзер Продактс Инк. | Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов |
GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
GB9800575D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
PA8469501A1 (es) | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico |
PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
TR200003514T2 (tr) | 1998-05-29 | 2002-05-21 | Sugen Inc. | Pirol ikame edilmiş 2-indolinon protein kinaz inhibitörleri |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
JP3270834B2 (ja) | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
BR0111548A (pt) | 2000-06-22 | 2003-05-06 | Pfizer Prod Inc | Derivados bicìclicos substituìdos para o tratamento de crescimento de célula anormal |
IL154817A0 (en) | 2000-09-15 | 2003-10-31 | Vertex Pharma | Pyrazole derivatives and pharmaceutical compositions containing the same |
AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
US6951848B2 (en) | 2001-03-12 | 2005-10-04 | Millennium Pharmaceuticals, Inc., | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
US20040235867A1 (en) | 2001-07-24 | 2004-11-25 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
WO2003031406A2 (en) | 2001-10-12 | 2003-04-17 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
US6949644B2 (en) | 2001-10-12 | 2005-09-27 | Irm Llc | Methods for the synthesis of substituted purines |
US20060009642A1 (en) | 2001-10-12 | 2006-01-12 | Irm Llc, A Delaware Limited Liability Company | Methods for the synthesis of substituted purines |
CA2502429A1 (en) | 2002-10-31 | 2004-05-21 | Amgen Inc. | Antiinflammation agents |
WO2005016268A2 (en) | 2003-08-08 | 2005-02-24 | Mitochroma Research, Inc. | Alimentary compositions and methods for metabolic modulation |
WO2005020892A2 (en) | 2003-08-08 | 2005-03-10 | Mitochroma Research, Inc. | Pharmaceutical compositions and methods for metabolic modulation |
US20050124637A1 (en) | 2003-08-15 | 2005-06-09 | Irm Llc | Compounds and compositions as inhibitors of receptor tyrosine kinase activity |
US20060029642A1 (en) | 2004-08-03 | 2006-02-09 | Dusan Miljkovic | Methods and compositions for improved chromium complexes |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
FR2876583B1 (fr) | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de derives de purines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
GB0502573D0 (en) | 2005-02-08 | 2005-03-16 | Topotarget As | Therapeutic compounds |
GB0526246D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
US20070253896A1 (en) | 2006-02-07 | 2007-11-01 | Conforma Therapeutics Corporation | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors |
BRPI0621509A2 (pt) | 2006-03-15 | 2011-12-13 | Csir | modulação da atividade de fosforil transferase de glutamina sintetase |
EP2617423A1 (en) | 2006-10-19 | 2013-07-24 | Genzyme Corporation | Purine derivatives for the treatment of cystic diseases |
WO2008057402A2 (en) | 2006-11-02 | 2008-05-15 | Cytovia, Inc. | N-aryl-isoxazolopyrimidin-4-amines and related compounds as activators of caspases and inducers of apoptosis and the use thereof |
EA200900983A1 (ru) * | 2007-01-26 | 2010-02-26 | Айрм Ллк | Соединения и композиции в качестве ингибиторов киназы |
US8404674B2 (en) * | 2007-03-07 | 2013-03-26 | Boehringer Ingelheim International Gmbh | Substituted 9H-purin-2-YL compounds, compositions thereof and uses thereof |
MX2010001650A (es) | 2007-08-10 | 2010-08-02 | Glaxosmithkline Llc | Entidades quimicas biciclicas que contienen nitrogeno para el tratamiento de infecciones virales. |
KR20100068286A (ko) | 2007-10-17 | 2010-06-22 | 노파르티스 아게 | 아데노신 a1 수용체 리간드로서의 퓨린 유도체 |
US9089572B2 (en) | 2008-01-17 | 2015-07-28 | California Institute Of Technology | Inhibitors of p97 |
US20110251172A1 (en) | 2008-08-13 | 2011-10-13 | Rivkin Alexey A | Purine derivatives for treatment of alzheimer's disease |
AR073397A1 (es) * | 2008-09-23 | 2010-11-03 | Palau Pharma Sa | Derivados de (r) -3- (n,n-dimetilamino) pirrolidina |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
US8426428B2 (en) * | 2008-12-05 | 2013-04-23 | Principia Biopharma, Inc. | EGFR kinase knockdown via electrophilically enhanced inhibitors |
WO2010118367A2 (en) | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
US9908884B2 (en) * | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
FR2945747A1 (fr) * | 2009-05-25 | 2010-11-26 | Centre Nat Rech Scient | Composition pharmaceutique antitumorale comprenant un inhibiteur de cdks et un inhibiteur de la croissance cellulaire |
TW201111385A (en) | 2009-08-27 | 2011-04-01 | Biocryst Pharm Inc | Heterocyclic compounds as janus kinase inhibitors |
US9139592B2 (en) | 2010-06-14 | 2015-09-22 | Trt Pharma Inc. | Modulators of Nrf2 and uses thereof |
EP2585464A2 (en) | 2010-06-22 | 2013-05-01 | University Of Central Florida Research Foundation, Inc. | Substituted 2-(9h-purin-9-yl) acetic acid analogues as inhibitors of stat3 |
CN104814970A (zh) * | 2010-10-14 | 2015-08-05 | 阿里亚德医药股份有限公司 | 抑制egfr导致的癌症中细胞增殖的方法 |
JP5956999B2 (ja) * | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
EP2637502B1 (en) * | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutant-selective egfr inhibitors and uses thereof |
WO2012151561A1 (en) * | 2011-05-04 | 2012-11-08 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
US8762299B1 (en) | 2011-06-27 | 2014-06-24 | Google Inc. | Customized predictive analytical model training |
JP5914667B2 (ja) | 2011-09-22 | 2016-05-11 | ファイザー・インク | ピロロピリミジンおよびプリン誘導体 |
CN103159742B (zh) | 2011-12-16 | 2015-08-12 | 北京韩美药品有限公司 | 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用 |
EP2802568A1 (en) | 2012-01-13 | 2014-11-19 | Acea Biosciences, Inc. | Heterocyclic compounds and uses as anticancer agents. |
RU2015137596A (ru) | 2013-03-14 | 2017-04-17 | Пфайзер Инк. | Комбинация ингибитора EGFR T790М и ингибитора EGFR для лечения немелкоклеточного рака легкого |
US10884952B2 (en) | 2016-09-30 | 2021-01-05 | Intel Corporation | Enforcing memory operand types using protection keys |
-
2014
- 2014-10-11 UA UAA201605505A patent/UA115388C2/uk unknown
- 2014-11-10 LT LTEP14806447.0T patent/LT3071570T/lt unknown
- 2014-11-10 DK DK14806447.0T patent/DK3071570T3/en active
- 2014-11-10 MD MDA20160053A patent/MD20160053A2/ro not_active Application Discontinuation
- 2014-11-10 TN TN2016000188A patent/TN2016000188A1/fr unknown
- 2014-11-10 EP EP14806447.0A patent/EP3071570B1/en active Active
- 2014-11-10 GE GEAP201414151A patent/GEP20186878B/en unknown
- 2014-11-10 JP JP2016532623A patent/JP6166845B2/ja not_active Expired - Fee Related
- 2014-11-10 PE PE2016000650A patent/PE20160885A1/es unknown
- 2014-11-10 RS RS20180909A patent/RS57537B1/sr unknown
- 2014-11-10 AP AP2016009219A patent/AP2016009219A0/en unknown
- 2014-11-10 ES ES14806447.0T patent/ES2681799T3/es active Active
- 2014-11-10 SI SI201430806T patent/SI3071570T1/sl unknown
- 2014-11-10 CN CN201480073530.7A patent/CN105916853B/zh active Active
- 2014-11-10 CU CU2016000073A patent/CU24402B1/es unknown
- 2014-11-10 MX MX2016006397A patent/MX2016006397A/es unknown
- 2014-11-10 EA EA201600337A patent/EA029842B1/ru not_active IP Right Cessation
- 2014-11-10 KR KR1020167016053A patent/KR101919672B1/ko active IP Right Grant
- 2014-11-10 MA MA39043A patent/MA39043B1/fr unknown
- 2014-11-10 HU HUE14806447A patent/HUE039858T2/hu unknown
- 2014-11-10 AU AU2014351433A patent/AU2014351433B2/en active Active
- 2014-11-10 PT PT148064470T patent/PT3071570T/pt unknown
- 2014-11-10 MY MYPI2016701796A patent/MY184433A/en unknown
- 2014-11-10 PL PL14806447T patent/PL3071570T3/pl unknown
- 2014-11-10 WO PCT/IB2014/065935 patent/WO2015075598A1/en active Application Filing
- 2014-11-10 CA CA2931034A patent/CA2931034C/en active Active
- 2014-11-19 UY UY0001035845A patent/UY35845A/es not_active Application Discontinuation
- 2014-11-20 TW TW103140297A patent/TWI538913B/zh not_active IP Right Cessation
- 2014-11-20 AR ARP140104368A patent/AR098492A1/es unknown
- 2014-11-20 US US14/548,749 patent/US9290496B2/en active Active
-
2016
- 2016-05-13 CL CL2016001151A patent/CL2016001151A1/es unknown
- 2016-05-17 PH PH12016500911A patent/PH12016500911A1/en unknown
- 2016-05-18 IL IL24569816A patent/IL245698B/en active IP Right Grant
- 2016-05-19 DO DO2016000115A patent/DOP2016000115A/es unknown
- 2016-05-20 CR CR20160236A patent/CR20160236A/es unknown
- 2016-05-20 NI NI201600072A patent/NI201600072A/es unknown
- 2016-05-20 GT GT201600091A patent/GT201600091A/es unknown
-
2017
- 2017-06-23 JP JP2017122759A patent/JP2017214390A/ja active Pending
-
2018
- 2018-07-05 HR HRP20181036TT patent/HRP20181036T1/hr unknown
- 2018-07-25 CY CY20181100779T patent/CY1120478T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD20160053A2 (ro) | Derivaţi ai purinei 2,6-substituite şi utilizarea acestora în tratamentul tulburărilor proliferative | |
PH12018500065A1 (en) | Oxysterols and methods of use thereof | |
PH12016502378A1 (en) | Substituted dihydroisoquinolinone compounds | |
PH12015502615B1 (en) | Chemical compounds | |
JO3674B1 (ar) | مشتقات ثنائية الحلقة جديدة، عملية لتحضيرها وتركيبات صيدلية تحتوي عليها | |
TN2015000281A1 (fr) | Lactames condenses aryliques et heteroaryliques | |
PH12018500061A1 (en) | Oxysterols and methods of use thereof | |
MY190243A (en) | Hydroxyacid derivatives, a process for their preparation and pharmaceutical compositions containing them | |
IN2015DN01156A (ro) | ||
EA201490673A1 (ru) | Производные пирролопиримидина и пурина | |
MX2016010056A (es) | 6-heteroariloxi o 6-ariloxi-quinolina-2-carboxamidas y metodos de uso. | |
MD20170011A2 (ro) | Compuşi imidazopiridazinici | |
TW201613864A (en) | Novel compounds | |
TR201819805T4 (tr) | Flavaglin türevleri̇. | |
PH12016501997A1 (en) | Cycloalkyl-linked diheterocycle derivatives | |
MX2015012600A (es) | Compuestos de tetrahidroisoquinolina-2-il-(quinazolina-4-il) metanona como inhibidores del crecimiento de células cancerígenas. | |
GB2527958A (en) | Pregnane-oximino-aminoalkylethers and process for preparation thereof, useful as antidiabetic and antidyslipidemic agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Abandonment or withdrawal of application (patent for invention) |