JPH09508016A - 細菌レセプター構造体 - Google Patents
細菌レセプター構造体Info
- Publication number
- JPH09508016A JPH09508016A JP7518984A JP51898495A JPH09508016A JP H09508016 A JPH09508016 A JP H09508016A JP 7518984 A JP7518984 A JP 7518984A JP 51898495 A JP51898495 A JP 51898495A JP H09508016 A JPH09508016 A JP H09508016A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- receptor
- bacterial
- proteins
- streptococcus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/882—Staphylococcus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/882—Staphylococcus
- Y10S435/883—Staphylococcus aureus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.天然細菌レセプターのドメインの表面露出アミノ酸の変異誘発により得るこ とができ、かつ前記天然細菌レセプターの基本構造および安定性を実質的に失う ことなく得られる新規タンパク質。 2.前記新規タンパク質のレパートリーを具体化するタンパク質ライブラリーか ら選抜された、請求項1記載のタンパク質。 3.ファージ-コートタンパク質に融合されており、そして前記細胞レセプター が好ましくはグラム陽性細菌に由来する、請求項1または2記載のタンパク質。 4.前記細菌レセプターが黄色ぶどう球菌、化膿連鎖球菌〔グループA〕、連鎖 球菌グループC、G、L、ウシグループG連鎖球菌、ストレプトコッカス・ズー エピデミカス〔グループC〕、ストレプトコッカス・ズーピデミカスS212、化 膿連鎖球菌〔グループA〕、連鎖球菌グループA、C、G、ペプトストレプトコ ッカス・マグナス、ストレプトコッカス・アガラクティエ〔グループB〕より選 択される請求項3記載のタンパク質。 5.前記細菌レセプターが連鎖球菌プロテインAまたは連鎖球菌プロテインGに 由来する、請求項4記載のタンパク質。 6.前記細菌レセプターが、Fc〔IgG〕レセプタータイプI、タイプII、タイプI II、タイプIV、タイプVおよびタイプVI、フィブロネクチンレセプター、Mプロ テイン、プラスミンレセプター、コラーゲンレセプター、フィブリノーゲンレセ プターまたはプロテインL〔K軽鎖〕、プロテインH〔ヒトIgG〕、プロテイン B〔ヒトIgA、A1〕、プロテインArp〔ヒトIgA〕より選択されるレセプターに 由来する、請求項4または5記載のタンパク質。 7.前記レセプターがぶどう球菌プロテインAのFc〔IgG〕レセプタータイプI または連鎖球菌プロテインGの血清アルブミンレセプターに由来する、請求項5 記載のタンパク質。 8.前記レセプターがIgG結合性ドメインZ、C1、および血清アルブミン結合 性ドメインB2A3に由来する、請求項7記載のタンパク質。 9.前記置換に、原細菌レセプターのアミノ酸残基のうち最高で約50%が関与す る、前記請求項のいずれかに記載のタンパク質。 10.前記置換に、原細菌レセプターのアミノ酸残基のうち最高で約25%が関与す る、請求項9記載のタンパク質。 11.前記置換に、最高でも、原細菌レセプターの相互作用機能に参加する実質的 に全部が関与する、請求項1〜7のいずれかに記載のタンパク質。 12.前記置換が部位特異的変異誘発により得られたものである、前記請求項のい ずれかに記載のタンパク質。 13.前記置換が相互作用相手としてのタンパク質、脂質、炭水化物および無機物 質より選択された物質に対する特異的相互作用能を創出するためのものである、 前記請求項のいずれかに記載のタンパク質。 14.前記物質が相互作用相手としての炭水化物例えば血液型決定因子、および病 原体特異的オリゴ糖より選択される、請求項13記載のタンパク質。 15.前記物質が相互作用相手としてのIGF−I、IGF−II、hGH、第VIII因子、イ ンスリンおよびアポリポタンパク質およびそれらのそれぞれの受容体より選択さ れる、請求項13記載のタンパク質。 16.前記置換がウイルスコートタンパク質、細菌抗原、ビオチンおよび細胞マー カー例えばCD34、CD4より選択される物質に対する特異的相互作用能を創出する ためのものである、請求項13記載のタンパク質。 17.前記置換が抗体断片、例えばFv、scFv、FabおよびFcに対する特異的相互作 用能を創出するためのものである、請求項13記載のタンパク質。 18.前記置換が有機リガンドに対する特異的相互作用能を創出するためのもので ある、請求項12記載のタンパク質。 19.次の諸段階、すなわち a)請求項1に従って得られた新規レセプター構造体のレパートリーを所望の 相互作用機能に基づく選抜手順にかける;そして b)選抜されたレセプター構造体を単離する 段階より成る人工細菌レセプター構造体の製造方法。 20.次の諸段階、すなわち a1)新規レセプター構造体の前記レパートリーからのものであってファージ− コートタンパク質に融合されたタンパク質をそれぞれの表面に有するファージ粒 子を組換えDNA法により調製する; a2)段階a1)で得られたファージ粒子のプールからパンニングを行って所望の 結合特性を示す特定ファージクローンを選抜する;そして b)前記特定ファージクローンを前記結合特性と関連する相互作用を用いて単 離する 段階より成る請求項19記載の方法。 21.次の諸段階、すなわち a)前記ライブラリーのタンパク質を、特定タンパク質変種とそれをコートす るプラスミドとの間に相互作用を生じる特定プラスミド担持オペレーター領域に 対する親和性を有するレプレッサータンパク質に融合させることによって組換え DNA法により融合タンパク質を調製する;および b)前記相互作用を用いて選抜されたタンパク質を単離する 段階より成る、非分泌性のタンパク質に関係したレセプター構造を選抜するた めの請求項19記載の方法。 22.次の諸段階、すなわち a1)新規レセプター構造体の前記レパートリーからのものであって、細菌細胞 において機能する細胞壁アンカリングドメインに融合されたタンパク質をそれぞ れの表面に有する前記細菌細胞を組換えDNA法により調製する; a2)段階a1)で得られた細菌細胞のプールからパンニングを行って所望の結合 特性を示す特定細菌クローンを選抜する;および b)前記結合特性と関連する相互作用を用いて前記特定クローンを単離する 段階より成る、請求項19記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9400088-2 | 1994-01-14 | ||
SE9400088A SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Bacterial receptor structures |
PCT/SE1995/000034 WO1995019374A1 (en) | 1994-01-14 | 1995-01-16 | Bacterial receptor structures |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005138021A Division JP2005263810A (ja) | 1994-01-14 | 2005-05-11 | 細菌レセプター構造体 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09508016A true JPH09508016A (ja) | 1997-08-19 |
JP4089920B2 JP4089920B2 (ja) | 2008-05-28 |
Family
ID=20392561
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51898495A Expired - Lifetime JP4089920B2 (ja) | 1994-01-14 | 1995-01-16 | 細菌レセプター構造体 |
JP2005138021A Pending JP2005263810A (ja) | 1994-01-14 | 2005-05-11 | 細菌レセプター構造体 |
JP2007195296A Expired - Lifetime JP4373461B2 (ja) | 1994-01-14 | 2007-07-27 | 細菌レセプター構造体 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005138021A Pending JP2005263810A (ja) | 1994-01-14 | 2005-05-11 | 細菌レセプター構造体 |
JP2007195296A Expired - Lifetime JP4373461B2 (ja) | 1994-01-14 | 2007-07-27 | 細菌レセプター構造体 |
Country Status (12)
Country | Link |
---|---|
US (2) | US5831012A (ja) |
EP (1) | EP0739353B1 (ja) |
JP (3) | JP4089920B2 (ja) |
AT (1) | ATE279439T1 (ja) |
AU (1) | AU696186B2 (ja) |
CA (1) | CA2181042C (ja) |
DE (1) | DE69533644T2 (ja) |
ES (1) | ES2225838T3 (ja) |
NZ (1) | NZ278991A (ja) |
PT (1) | PT739353E (ja) |
SE (1) | SE9400088D0 (ja) |
WO (1) | WO1995019374A1 (ja) |
Cited By (9)
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JP2001520397A (ja) * | 1997-10-20 | 2001-10-30 | ディバーシス リミテッド | 種々のリガンドによるファージ提示ライブラリーのスクリーニング方法 |
JP2002527107A (ja) * | 1998-10-21 | 2002-08-27 | アフィボディ・テクノロジー・スウェーデン・アーベー | アフィニティ分離の方法及びそれに用いるリガンド |
JP2002542259A (ja) * | 1999-04-19 | 2002-12-10 | ビオヴィトルム・アクチボラゲット | ヒト第viii因子の少なくとも1ドメインと相互作用するスタフィロコッカスタンパク質a(spa)由来のbまたはzドメインの誘導体 |
JP2003518075A (ja) * | 1999-12-24 | 2003-06-03 | ジェネンテック・インコーポレーテッド | 生理活性化合物の消失半減期延長のための方法及び組成物 |
JP2004504062A (ja) * | 2000-07-19 | 2004-02-12 | ゴット‐エー‐ジーン・エービー | 修飾ウイルス |
JP2007537700A (ja) * | 2003-07-04 | 2007-12-27 | アフィボディ・アーベー | Her2に対する結合親和性を有するポリペプチド |
JP2009519013A (ja) * | 2005-12-05 | 2009-05-14 | アフィボディ・アーベー | ポリペプチド |
JP2014508118A (ja) * | 2010-12-21 | 2014-04-03 | ザ ユニバーシティ オブ ウエスタン オンタリオ | プロテインaの新規アルカリ抵抗性変異体及びアフィニティークロマトグラフィーにおけるその使用 |
JP2020517275A (ja) * | 2017-04-18 | 2020-06-18 | アブクロン・インコーポレイテッドAbclon Inc. | タンパク質の純度及び抗原に対する親和性が向上したポリペプチド、その抗体または抗原結合断片との複合体、及びこれらの製造方法 |
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US6534628B1 (en) | 2003-03-18 |
DE69533644D1 (de) | 2004-11-18 |
AU1548795A (en) | 1995-08-01 |
WO1995019374A1 (en) | 1995-07-20 |
JP4373461B2 (ja) | 2009-11-25 |
EP0739353B1 (en) | 2004-10-13 |
SE9400088D0 (sv) | 1994-01-14 |
PT739353E (pt) | 2005-01-31 |
CA2181042C (en) | 2008-04-15 |
DE69533644T2 (de) | 2005-02-17 |
US5831012A (en) | 1998-11-03 |
WO1995019374A9 (en) | 2006-04-13 |
CA2181042A1 (en) | 1995-07-20 |
ES2225838T3 (es) | 2005-03-16 |
JP4089920B2 (ja) | 2008-05-28 |
JP2007308509A (ja) | 2007-11-29 |
NZ278991A (en) | 1997-04-24 |
JP2005263810A (ja) | 2005-09-29 |
EP0739353A1 (en) | 1996-10-30 |
ATE279439T1 (de) | 2004-10-15 |
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