ES2165768B1 - Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. - Google Patents
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.Info
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- ES2165768B1 ES2165768B1 ES009901580A ES9901580A ES2165768B1 ES 2165768 B1 ES2165768 B1 ES 2165768B1 ES 009901580 A ES009901580 A ES 009901580A ES 9901580 A ES9901580 A ES 9901580A ES 2165768 B1 ES2165768 B1 ES 2165768B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
Nuevos derivados de quinuclidina y composiciones farmacéuticas que los contienen, teniendo dichos derivados de quinuclidina la fórmula (I): **FIGURA** en donde: C es un fenilo, un compuesto heteroaromático de 4 a 9 átomos de carbono conteniendo uno o más heteroátomos, o un grupo naftalenilo, 5,6,7,8- tetrahidronaftalenllo o bifenilo; R{sup,1}, R{sup,2} y R{sup,3} cada uno independientemente representan un átomo de hidrógeno o halógeno, o un grupo hidroxilo -CN, -NO{sub,2}, o un grupo orgánico. n es un número del 0 al 4; A representa un grupo - CH{sub,2}-, -CH=CR{sup,6}, CR{sup, 6}=CH, CR{sup,6}R{sup, 7}-, -CO-, -O-, -S-, -S(O)-, SO{sub,2} o -NR-{sup, 6}-, en donde R{sup,6} y R{sup,7} cada uno independientemente representan un átomo de hidrógeno, o un grupo orgánico; m es un número del 0 al 8; a condición de que cuando m = 0, A no es -CH{sub,2}-; p es un número del 1 al 2 y la sustitución en el anillo azoniabicíclico puede estar en la posición 2,3 o 4 incluyendo todas las posibilidades de configuraciones de los carbonos asimétricos, B representa un grupo orgánico bicíclico o tricíclico, homocíclico o heterocíclico; y X representa un anión farmacéuticamente aceptable de un ácido mono o polivalente.
Priority Applications (65)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901580A ES2165768B1 (es) | 1999-07-14 | 1999-07-14 | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
AU64330/00A AU779881C (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivates and their use as muscarinic M3 receptor ligands |
HU0202100A HU228594B1 (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives, process for their preparation and medicinal compositions containing the same |
IL14753300A IL147533A0 (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives and medicinal compositions containing the same |
PL357160A PL204024B1 (pl) | 1999-07-14 | 2000-07-07 | Nowe pochodne chinuklidyny, sposób ich wytwarzania, zastosowanie i zawierające je kompozycje farmaceutyczne |
KR1020027000479A KR100773844B1 (ko) | 1999-07-14 | 2000-07-07 | 신규한 퀴누클리딘 유도체 및 그것의 무스카린 엠3 수용체리간드로의 이용 |
CNB008127549A CN1272334C (zh) | 1999-07-14 | 2000-07-07 | 作为毒蕈碱性m3受体配体的奎宁环衍生物及其用途 |
UA2002010323A UA73509C2 (uk) | 1999-07-14 | 2000-07-07 | Хінуклідинові похідні та їх використання як лігандів мускаринового м3-рецептора |
DE60001840A DE60001840D1 (de) | 1999-07-14 | 2000-07-07 | Chinuclidin-derivate und deren verwendung als muscarin-m3-rezeptoren-liganden |
KR1020067027733A KR100854321B1 (ko) | 1999-07-14 | 2000-07-07 | 신규한 퀴누클리딘 유도체 및 그것의 무스카린 엠3 수용체리간드로의 이용 |
SI200030108T SI1200431T1 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
CA2381165A CA2381165C (en) | 1999-07-14 | 2000-07-07 | Novel quinuclidine derivatives and medicinal compositions containing the same |
RU2002103605A RU2264401C3 (ru) | 1999-07-14 | 2000-07-07 | Производные хинуклидина, способ их получения, фармацевтическая композиция, способ лечения и промежуточные вещества |
EP00951361.5A EP1200431B3 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
CNB2006100068921A CN100451018C (zh) | 1999-07-14 | 2000-07-07 | 作为毒蕈碱性m3受体配体的奎宁环衍生物及其用途 |
AT00951361T ATE235492T1 (de) | 1999-07-14 | 2000-07-07 | Chinuclidin-derivate und deren verwendung als muscarin-m3-rezeptoren-liganden |
TR2002/00768T TR200200768T2 (tr) | 1999-07-14 | 2000-07-07 | Yeni kuinüklidin türevleri ve bunu içeren ilaç bileşimleri |
DE60001840.7T DE60001840T4 (de) | 1999-07-14 | 2000-07-07 | Chinuclidin-derivate und deren verwendung als muscarin-m3-rezeptoren-liganden |
CZ2002-121A CZ304292B6 (cs) | 1999-07-14 | 2000-07-07 | Chinuklidinové deriváty, způsob jejich přípravy a použití a farmaceutická kompozice s jejich obsahem |
SK43-2002A SK287480B6 (sk) | 1999-07-14 | 2000-07-07 | Chinuklidínové deriváty, spôsob ich prípravy, liečivé kompozície, ktoré ich obsahujú, a ich použitie |
JP2001509727A JP4030040B2 (ja) | 1999-07-14 | 2000-07-07 | キヌクリジン誘導体およびそれらのムスカリンm3レセプターリガンドとしての使用 |
PCT/EP2000/006469 WO2001004118A2 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic m3 receptor ligands |
BRPI0012434A BRPI0012434B8 (pt) | 1999-07-14 | 2000-07-07 | compostos ésteres de quinuclidina úteis como antagonistas de receptores m3 muscarínicos |
PT00951361T PT1200431E (pt) | 1999-07-14 | 2000-07-07 | Derivados de quinuclidina e sua utilizacao como ligandos de receptores muscarinicos m3 |
KR1020067027730A KR100854315B1 (ko) | 1999-07-14 | 2000-07-07 | 신규한 퀴누클리딘 유도체 및 그것의 무스카린 엠3 수용체리간드로의 이용 |
ES951361T ES2193098T7 (es) | 1999-07-14 | 2000-07-07 | Derivados de quinuclidina y su uso como ligandos de los receptores muscarínicos M3 |
EEP200200017A EE04915B3 (et) | 1999-07-14 | 2000-07-07 | Kinuklidiinderivaadid, nende valmistamismeetod, vaheühendid, farmatseutiline kompositsioon ja nende kasutamine |
DK00951361.5T DK1200431T6 (en) | 1999-07-14 | 2000-07-07 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
PE2000000691A PE20010397A1 (es) | 1999-07-14 | 2000-07-11 | Derivados de quinuclidina como antagonistas de receptores muscarinicos m3 y composiciones farmaceuticas que los contienen |
TW089113865A TWI284644B (en) | 1999-07-14 | 2000-07-12 | Novel quinuclidine derivatives and medicinal compositions containing the same |
MYPI20003178 MY126959A (en) | 1999-07-14 | 2000-07-12 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
EG20000907A EG24066A (en) | 1999-07-14 | 2000-07-12 | Novel quinuclidine derivatives and medicinal compositions containing the same |
ARP000103613A AR029760A1 (es) | 1999-07-14 | 2000-07-13 | Derivados de quinuclidina, proceso para preparar dichos derivados, compuestos intermediarios utilizables en dicho proceso, composiciones farmaceuticas formuladas con dichos derivados y uso de dichos derivados para la produccion de medicamentos para el tratamiento de enfermedades respiratorias, urina |
CO00052873A CO5200759A1 (es) | 1999-07-14 | 2000-07-13 | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen |
UY26244A UY26244A1 (es) | 1999-07-14 | 2000-07-14 | Nuevos derivados de quinuclidina y composiciones farmacéuticas que los contienen. |
ZA200200232A ZA200200232B (en) | 1999-07-14 | 2002-01-10 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands. |
NO20020180A NO329484B3 (no) | 1999-07-14 | 2002-01-14 | Nye kinuklidinderivater og medisinske sammensetninger inneholdende det samme, samt anvendelse derav for fremstilling av medikamenter |
US10/047,464 US6750226B2 (en) | 1999-07-14 | 2002-01-14 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
BG106301A BG65565B1 (bg) | 1999-07-14 | 2002-01-14 | Хинуклидинови производни и тяхното използване като мускаринови м3 рецепторни лиганди |
HK02103992A HK1042487B (en) | 1999-07-14 | 2002-05-29 | Quinuclidine derivatives and their use as muscarinic m3 receptors ligands |
US10/740,264 US7109210B2 (en) | 1999-07-14 | 2003-12-17 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/116,777 US7078412B2 (en) | 1999-07-14 | 2005-04-28 | Quinuclidine derivatives and medicinal compositions containing the same |
AU2005202144A AU2005202144B2 (en) | 1999-07-14 | 2005-05-18 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
RU2005121162/04A RU2306312C2 (ru) | 1999-07-14 | 2005-07-06 | Производные хинуклидина, фармацевтическая композиция и способ лечения респираторных заболеваний |
JP2005203365A JP4951217B2 (ja) | 1999-07-14 | 2005-07-12 | キヌクリジン誘導体およびそれらのムスカリンm3レセプターリガンドとしての使用 |
US11/325,059 US7196098B2 (en) | 1999-07-14 | 2006-01-03 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/324,919 US7214687B2 (en) | 1999-07-14 | 2006-01-03 | Quinuclidine derivatives and medicinal compositions containing the same |
US11/636,181 US7358260B2 (en) | 1999-07-14 | 2006-12-08 | Quinuclidine derivatives and medicinal compositions containing the same |
US12/074,929 US7750023B2 (en) | 1999-07-14 | 2008-03-07 | Quinuclidine derivatives and medicinal compositions containing the same |
US12/787,772 US7897617B2 (en) | 1999-07-14 | 2010-05-26 | Quinuclidine derivatives and medicinal compositions containing the same |
US13/011,131 US8129405B2 (en) | 1999-07-14 | 2011-01-21 | Quinuclidine derivatives and medicinal compositions containing the same |
UY0001033494A UY33494A (es) | 1999-07-14 | 2011-07-08 | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen |
US13/354,873 US8513279B2 (en) | 1999-07-14 | 2012-01-20 | Quinuclidine derivatives and medicinal compositions containing the same |
BE2013C001C BE2013C001I2 (es) | 1999-07-14 | 2013-01-03 | |
CY2013001C CY2013001I2 (el) | 1999-07-14 | 2013-01-07 | Nεα παραγωγα κινουκλιδινης και ιατρικα σκευασματα που τα πepιεχουν |
FR13C0001C FR13C0001I2 (fr) | 1999-07-14 | 2013-01-08 | Derives de quinuclidine et leur utilisation comme ligands des recepteurs m3 muscariniques |
LU92132C LU92132I2 (fr) | 1999-07-14 | 2013-01-16 | Sel d'aclidinium avec anion d'un acide mono ou polyvalent pharmaceutiquement acceptable particulièrement le bromure d'aclidinium |
NO2013002C NO2013002I2 (no) | 1999-07-14 | 2013-01-18 | Aklidiniumsalt med et farmaøytisk akseptabelt anion av en mono-eller polyvalent syre, spesielt aklidiniumbromid |
US13/939,742 US8802699B2 (en) | 1999-07-14 | 2013-07-11 | Quinuclidine derivatives and medicinal compositions containing the same |
US14/311,102 US9056100B2 (en) | 1999-07-14 | 2014-06-20 | Quinuclidine derivatives and medicinal compositions containing the same |
US14/712,866 US9333195B2 (en) | 1999-07-14 | 2015-05-14 | Quinuclidine derivatives and medicinal compositions containing the same |
US15/019,009 USRE46417E1 (en) | 1999-07-14 | 2016-02-09 | Quinuclidine derivatives and their use as muscarinic M3 receptor ligands |
US15/095,036 US9687478B2 (en) | 1999-07-14 | 2016-04-09 | Quinuclidine derivatives and medicinal compositions containing the same |
US15/599,646 US10034867B2 (en) | 1999-07-14 | 2017-05-19 | Quinuclidine derivatives and medicinal compositions containing the same |
US16/045,333 US10588895B2 (en) | 1999-07-14 | 2018-07-25 | Quinuclidine derivatives and medicinal compositions containing the same |
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ES009901580A ES2165768B1 (es) | 1999-07-14 | 1999-07-14 | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
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ES951361T Active ES2193098T7 (es) | 1999-07-14 | 2000-07-07 | Derivados de quinuclidina y su uso como ligandos de los receptores muscarínicos M3 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US9056100B2 (en) | 1999-07-14 | 2015-06-16 | Almirall, S.A. | Quinuclidine derivatives and medicinal compositions containing the same |
US9333195B2 (en) | 1999-07-14 | 2016-05-10 | Almirall, S.A. | Quinuclidine derivatives and medicinal compositions containing the same |
US9254262B2 (en) | 2008-03-13 | 2016-02-09 | Almirall, S.A. | Dosage and formulation |
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