ES2183492T3 - Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2183492T3
ES2183492T3 ES99401565T ES99401565T ES2183492T3 ES 2183492 T3 ES2183492 T3 ES 2183492T3 ES 99401565 T ES99401565 T ES 99401565T ES 99401565 T ES99401565 T ES 99401565T ES 2183492 T3 ES2183492 T3 ES 2183492T3
Authority
ES
Spain
Prior art keywords
new
pharmaceutical compositions
compositions containing
preparation procedure
nitron
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99401565T
Other languages
English (en)
Inventor
Solo Goldstein
Alain Dhainaut
Andre Tizot
Brian Lockhart
Pierre Lestage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Application granted granted Critical
Publication of ES2183492T3 publication Critical patent/ES2183492T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE: W REPRESENTA UN GRUPO ARILO, ARILALQUILO, HETEROARILO O HETEROARILALQUILO, ESTANDO CADA UNO DE ESTOS GRUPOS OPCIONALMENTE SUSTITUIDO, R 1 REPRESENTA UN GRUPO ALQUILO, ALQUENILO, ALQUINILO, ARILO, CICLOALQUILO, ARILALQUILO, CICLOALQUILALQUILO, ESTANDO CADA UNO DE ESTOS GRUPOS OPCIONALMENTE SUSTITUIDO, R 2 ES TAL COMO SE DEFINE EN LA DESCRIPCION, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO O A UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTO.
ES99401565T 1998-06-26 1999-06-24 Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2183492T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9808116A FR2780404B1 (fr) 1998-06-26 1998-06-26 Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2183492T3 true ES2183492T3 (es) 2003-03-16

Family

ID=9527896

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99401565T Expired - Lifetime ES2183492T3 (es) 1998-06-26 1999-06-24 Nuevos derivados de nitrono,su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (17)

Country Link
US (1) US6034250A (es)
EP (1) EP0967207B1 (es)
JP (1) JP2000026428A (es)
CN (1) CN1153766C (es)
AT (1) ATE223904T1 (es)
AU (1) AU747203B2 (es)
BR (1) BR9903282A (es)
CA (1) CA2274621C (es)
DE (1) DE69902851T2 (es)
DK (1) DK0967207T3 (es)
ES (1) ES2183492T3 (es)
FR (1) FR2780404B1 (es)
HU (1) HUP9902199A1 (es)
NO (1) NO312722B1 (es)
NZ (1) NZ336460A (es)
PT (1) PT967207E (es)
ZA (1) ZA994201B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096899A (en) * 1998-04-14 2000-08-01 The Regents Of The University Of Michigan Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom
US20050026811A1 (en) * 2003-05-20 2005-02-03 Mjalli Adnan M. M. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
CN1496271B (zh) * 2001-02-16 2010-04-28 阿斯比奥制药株式会社 伴随有aop-1基因或aop-1的表达减少的疾病的治疗方法以及该疾病的治疗药
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
ATE529110T1 (de) * 2002-03-05 2011-11-15 Transtech Pharma Inc Mono- und bicyclische azolderivate die die interaktion von liganden mit rage hemmen
WO2003082216A2 (en) * 2002-03-28 2003-10-09 Oxis International, Inc. Neuroprotectant methods, compositions, and screening methods thereof
CN101468970B (zh) * 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease
JP5885620B2 (ja) * 2012-08-22 2016-03-15 四国化成工業株式会社 ２−（２−フリル）イミダゾール化合物及び酸化防止剤
FR3012460B1 (fr) 2013-10-25 2015-12-11 Michelin & Cie Composition de caoutchouc comprenant un elastomere dienique portant des fonctions imidazole reparties de facon aleatoire le long de la chaine
FR3012458B1 (fr) * 2013-10-25 2015-10-30 Michelin & Cie Composition de caoutchouc comprenant un additif compose 1,3-dipolaire portant une fonction imidazole
FR3012451B1 (fr) 2013-10-25 2016-11-11 Michelin & Cie Compose 1,3-dipolaire portant une fonction imidazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0643403B2 (ja) * 1986-01-25 1994-06-08 四国化成工業株式会社 イミダゾール―アルドキシム化合物の合成方法
US4803282A (en) * 1986-08-27 1989-02-07 Pennwalt Corporation Alpha-substituted ketonitrone derivatives
EP0590072B1 (en) * 1991-06-18 2001-12-05 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
JP3887020B2 (ja) * 1995-11-17 2007-02-28 フロリダ インターナショナル ユニバーシティー アズレニルニトロンスピントラッピング剤、ならびにその製造方法および使用方法

Also Published As

Publication number Publication date
JP2000026428A (ja) 2000-01-25
CA2274621A1 (fr) 1999-12-26
DE69902851T2 (de) 2003-05-28
ATE223904T1 (de) 2002-09-15
AU747203B2 (en) 2002-05-09
PT967207E (pt) 2002-12-31
HUP9902199A1 (hu) 2000-06-28
DK0967207T3 (da) 2003-01-20
EP0967207B1 (fr) 2002-09-11
NZ336460A (en) 2000-05-26
AU3680099A (en) 2000-01-13
FR2780404B1 (fr) 2001-04-13
CN1153766C (zh) 2004-06-16
DE69902851D1 (de) 2002-10-17
HU9902199D0 (en) 1999-08-30
EP0967207A1 (fr) 1999-12-29
CA2274621C (fr) 2004-01-20
NO993122L (no) 1999-12-27
CN1245169A (zh) 2000-02-23
BR9903282A (pt) 2000-04-18
NO993122D0 (no) 1999-06-23
ZA994201B (en) 2000-01-11
US6034250A (en) 2000-03-07
NO312722B1 (no) 2002-06-24
FR2780404A1 (fr) 1999-12-31

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