EP2377530A3 - Modulation von Neurogenese durch PDE-Hemmung - Google Patents
Modulation von Neurogenese durch PDE-Hemmung Download PDFInfo
- Publication number
- EP2377530A3 EP2377530A3 EP10013573A EP10013573A EP2377530A3 EP 2377530 A3 EP2377530 A3 EP 2377530A3 EP 10013573 A EP10013573 A EP 10013573A EP 10013573 A EP10013573 A EP 10013573A EP 2377530 A3 EP2377530 A3 EP 2377530A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- neurogenesis
- modulation
- pde inhibition
- pde
- stimulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72936605P | 2005-10-21 | 2005-10-21 | |
| US78460506P | 2006-03-21 | 2006-03-21 | |
| US80759406P | 2006-07-17 | 2006-07-17 | |
| EP06826395A EP1940389A2 (de) | 2005-10-21 | 2006-10-20 | Modulation von neurogenese durch pde-hemmung |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06826395.3 Division | 2006-10-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2377530A2 EP2377530A2 (de) | 2011-10-19 |
| EP2377530A3 true EP2377530A3 (de) | 2012-06-20 |
Family
ID=37963343
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06826395A Withdrawn EP1940389A2 (de) | 2005-10-21 | 2006-10-20 | Modulation von neurogenese durch pde-hemmung |
| EP10013573A Withdrawn EP2377530A3 (de) | 2005-10-21 | 2006-10-20 | Modulation von Neurogenese durch PDE-Hemmung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP06826395A Withdrawn EP1940389A2 (de) | 2005-10-21 | 2006-10-20 | Modulation von neurogenese durch pde-hemmung |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7985756B2 (de) |
| EP (2) | EP1940389A2 (de) |
| JP (1) | JP2009512711A (de) |
| AU (1) | AU2006304787A1 (de) |
| CA (1) | CA2625153A1 (de) |
| WO (1) | WO2007047978A2 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ565683A (en) * | 2005-07-08 | 2011-04-29 | Braincells Inc | Methods for identifying agents and conditions that modulate neurogenesis in human neural cells |
| US20110275664A1 (en) * | 2005-09-26 | 2011-11-10 | The Regents Of The University Of Colorado,A Body Corporate | Method for treating drug and behavioral addictions |
| AU2006294758A1 (en) * | 2005-09-26 | 2007-04-05 | Medicinova, Inc. | Use of ibudilast for treating drug and behavioral addictions |
| US20070197592A1 (en) * | 2005-12-12 | 2007-08-23 | Sandra Boom | Use of Paliperidone for the Treatment of Substance Abuse |
| US7858611B2 (en) | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
| EP2382975A3 (de) * | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| US20090197823A1 (en) * | 2006-05-09 | 2009-08-06 | Braincells, Inc. | Aliskiren modulation of neurogenesis |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| US7622256B2 (en) | 2006-05-31 | 2009-11-24 | Avigen, Inc. | Method for selecting compounds that modulate MIF-induced expression of ICAM-1 and/or VCAM-1 |
| AU2007256633B2 (en) | 2006-06-06 | 2013-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| ME01901B (me) * | 2006-07-05 | 2014-12-20 | Astrazeneca Ab | Kombinacija inhibitora HMG-CoA reduktaze atorvastatina ili simvastatina sa fosfodiesteraza 4 inhibitorom, kao što je roflumilast za lečenje inflamatornih pulmonarnih oboljenja |
| US20080103105A1 (en) * | 2006-09-22 | 2008-05-01 | Braincells, Inc. | HMG CoA REDUCTASE MEDIATED MODULATION OF NEUROGENESIS |
| CA2675132A1 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation of neurogenesis with use of modafinil |
| WO2008097861A2 (en) * | 2007-02-02 | 2008-08-14 | Braincells, Inc. | MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS |
| CN101917992A (zh) * | 2007-03-27 | 2010-12-15 | 奥默罗斯公司 | 用于治疗运动障碍的pde7抑制剂的用途 |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| AU2008254907A1 (en) * | 2007-05-15 | 2008-11-27 | Helicon Therapeutics, Inc. | Methods of identifying genes involved in memory formation using small interfering RNA(siRNA) |
| PL2187882T3 (pl) | 2007-07-11 | 2013-05-31 | Medicinova Inc | Leczenie postępującej choroby neurodegeneracyjnej ibudilastem |
| WO2009017625A1 (en) * | 2007-07-27 | 2009-02-05 | Avigen, Inc. | Treatment of depression, phychosis, and anxiety |
| CA2707218A1 (en) * | 2007-12-06 | 2009-06-11 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2009076529A1 (en) | 2007-12-11 | 2009-06-18 | Research Development Foundation | Small molecules for neuronal differentiation of embryonic stem cells |
| EP2236511A4 (de) | 2007-12-21 | 2011-04-13 | Alla Chem Llc | Liganden von alpha-adrenoceptoren und von dopamin-, histamin-, imidazolin- und serotoninrezeptoren und anwendung davon |
| CA2740385A1 (en) | 2008-12-06 | 2010-06-10 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EA201170772A1 (ru) | 2008-12-06 | 2012-03-30 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| MX2011005932A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
| US8555875B2 (en) | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| EP2379076B1 (de) * | 2008-12-23 | 2014-11-12 | The Trustees of Columbia University in the City of New York | Phosphodiesterase-hemmer und ihre verwendungen |
| US8355927B2 (en) | 2010-11-05 | 2013-01-15 | Genomind, Llc | Neuropsychiatric test reports |
| WO2011111066A2 (en) * | 2010-03-12 | 2011-09-15 | Connexios Life Sciences Pvt. Ltd. | Composition and uses thereof |
| WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
| AU2013201989B2 (en) * | 2010-11-08 | 2016-01-07 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| CN103547267A (zh) * | 2010-11-08 | 2014-01-29 | 奥默罗斯公司 | 使用pde7抑制剂治疗成瘾和冲动控制障碍 |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| WO2012123406A1 (en) * | 2011-03-17 | 2012-09-20 | Algiax Pharmaceuticals Gmbh | Novel use of imidazotriazinones |
| WO2012149535A1 (en) * | 2011-04-29 | 2012-11-01 | Genomind, Llc | The use of angiotensin ii (at ii) type 1 receptor antagonist in the therapeutic treatment of autism |
| WO2013024164A1 (en) * | 2011-08-18 | 2013-02-21 | Shire Ag | Combinations of a 5-ht4 receptor agonist and a pde4 inhibitor for use in therapy |
| WO2013033246A2 (en) | 2011-08-29 | 2013-03-07 | Braincells, Inc. | Novel benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof |
| EP2785183B1 (de) * | 2011-11-14 | 2018-12-19 | Merck Sharp & Dohme Corp. | Triazolpyridinon-pde10-inhibitoren |
| US20140044813A1 (en) * | 2012-08-09 | 2014-02-13 | Kemin Industries, Inc. | Plant Extracts for Improving Cognitive Health and Function |
| WO2015106032A1 (en) * | 2014-01-08 | 2015-07-16 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
| US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN107205993B (zh) | 2014-12-06 | 2021-03-09 | 细胞内治疗公司 | 有机化合物 |
| KR102557603B1 (ko) | 2014-12-06 | 2023-07-19 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| GB2536650A (en) | 2015-03-24 | 2016-09-28 | Augmedics Ltd | Method and system for combining video-based and optic-based augmented reality in a near eye display |
| RU2735834C2 (ru) | 2015-06-22 | 2020-11-09 | Сосьете Де Продюи Нестле С.А. | Композиции и способы для усиления нейрогенеза у животных |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2017196857A1 (en) * | 2016-05-10 | 2017-11-16 | Medicinova, Inc. | Treatment of alcoholism and depression and/or dysphoric mood using ibudilast |
| CA3023014C (en) * | 2017-11-06 | 2023-09-26 | Stalicla Sa | Pharmaceutical composition for treatment of autism |
| US11839614B2 (en) * | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
| US11766296B2 (en) | 2018-11-26 | 2023-09-26 | Augmedics Ltd. | Tracking system for image-guided surgery |
| CN111803487B (zh) * | 2019-04-10 | 2022-12-02 | 成都百裕制药股份有限公司 | 银杏萜内酯在制备预防和/或治疗吉兰-巴雷综合征药物中的用途 |
| EP3936125A4 (de) * | 2019-04-10 | 2022-07-06 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Verwendung von ginkgo-terpenlacton zur herstellung eines arzneimittels zur verhinderung von schuppen oder zur behandlung von guillain-barré-strohl-syndrom |
| US11382712B2 (en) | 2019-12-22 | 2022-07-12 | Augmedics Ltd. | Mirroring in image guided surgery |
| US11839622B1 (en) | 2020-01-15 | 2023-12-12 | Randall Lewarchik | Consumable nutraceutical composition |
| WO2022047070A1 (en) * | 2020-08-27 | 2022-03-03 | University Of Central Florida Research Foundation, Inc. | Combination drug treatment to increase neurogenesis for neurological disorders |
| JP2024503727A (ja) * | 2021-01-20 | 2024-01-26 | アルト ニューロサイエンス，インコーポレーテッド | うつ病及び関連する状態の治療のための併用薬物戦略としてのｃＡＭＰシグナル伝達の強化 |
| US11896445B2 (en) | 2021-07-07 | 2024-02-13 | Augmedics Ltd. | Iliac pin and adapter |
| WO2024013505A1 (en) * | 2022-07-13 | 2024-01-18 | Healx Ltd | Ibudilast and gaboxadol for the treatment of fragile x syndrome |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004002461A2 (en) * | 2002-06-26 | 2004-01-08 | Pfizer Limited | Combination of pde5 inhibitors with angiotensin ii receptor antagonists |
| WO2004045592A2 (en) * | 2002-11-20 | 2004-06-03 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US20050004046A1 (en) * | 2003-06-13 | 2005-01-06 | Praag Henriette Van | Method for increasing cognitive function and neurogenesis |
| EP1579862A1 (de) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern |
| WO2006050057A2 (en) * | 2004-10-28 | 2006-05-11 | Celgene Corporation | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury |
Family Cites Families (713)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3121076A (en) | 1964-02-11 | Benzodiazepinones and processes | ||
| US3109843A (en) | 1963-11-05 | Process for preparing | ||
| US666073A (en) | 1900-10-29 | 1901-01-15 | Harry Simmons | Sectional legal-blank file. |
| GB235187A (en) | 1924-06-07 | 1926-06-03 | Robert Howe Gould | Improvements in burglar and like alarms |
| US1873732A (en) | 1928-12-28 | 1932-08-23 | Abbott Lab | Bactericide applicable to acid-fast bacteria |
| US3371085A (en) | 1959-12-10 | 1968-02-27 | Hoffmann La Roche | 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones |
| US3136815A (en) | 1959-12-10 | 1964-06-09 | Hoffmann La Roche | Amino substituted benzophenone oximes and derivatives thereof |
| US3454554A (en) | 1960-10-14 | 1969-07-08 | Colgate Palmolive Co | Aminoalkyliminodibenzyl compounds |
| US3116203A (en) | 1962-03-14 | 1963-12-31 | Hoffmann La Roche | Oleaginous systems |
| NL298071A (de) | 1963-06-04 | |||
| CH449645A (de) | 1963-07-09 | 1968-01-15 | Ciba Geigy | Verfahren zur Herstellung neuer Aminosäuren |
| CH427803A (de) | 1963-12-06 | 1967-01-15 | Geigy Ag J R | Verfahren zur Herstellung eines neuen Isoxazolderivates |
| NL129434C (de) | 1966-03-12 | |||
| US3397209A (en) | 1966-11-25 | 1968-08-13 | Geigy Chem Corp | 3-hydroxy-5-isoxazole-carboxamide |
| US3885046A (en) | 1969-12-04 | 1975-05-20 | Burroughs Wellcome Co | Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression |
| BE759838A (fr) | 1969-12-04 | 1971-06-03 | Wellcome Found | Cetones a activite biologique |
| FR2077918B1 (de) | 1970-02-24 | 1973-04-06 | Berthier Laboratoires | |
| US3758528A (en) | 1970-03-13 | 1973-09-11 | Science Union & Cie | Tricyclic compounds |
| US3821249A (en) | 1970-03-13 | 1974-06-28 | En Nom Collectif Science Union | Dibenzothiazefin derivatives |
| US3819631A (en) | 1970-12-15 | 1974-06-25 | May & Baker Ltd | Azapurinones |
| OA04285A (fr) | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
| US3932407A (en) | 1973-11-19 | 1976-01-13 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| USRE31617E (en) | 1972-02-04 | 1984-06-26 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| US4036840A (en) | 1972-06-07 | 1977-07-19 | Icn Pharmaceuticals | 2-Substituted-s-triazolo[1,5a]pyrimidines |
| GB1457873A (en) | 1973-01-04 | 1976-12-08 | Allen & Hanburys Ltd | Imidazotriazines |
| GB1422263A (en) | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| US4051236A (en) | 1973-02-15 | 1977-09-27 | E. R. Squibb & Sons, Inc. | Inhibition of blood platelet aggregation |
| US4194009A (en) | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| US4314081A (en) | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
| US4280957A (en) | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| AR208414A1 (es) | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
| US4093617A (en) | 1974-11-12 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines |
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US3960927A (en) | 1975-03-18 | 1976-06-01 | Richardson-Merrell Inc. | Olefinic derivatives of amino acids |
| NL7503310A (nl) | 1975-03-20 | 1976-09-22 | Philips Nv | Verbindingen met antidepressieve werking. |
| NL189199C (nl) | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| FR2319338A1 (fr) | 1975-08-01 | 1977-02-25 | Synthelabo | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| YU96177A (en) | 1976-04-24 | 1982-08-31 | Wuelfing Johann A | Process for obtaining adenine derivatives |
| USRE30511E (en) | 1977-02-03 | 1981-02-10 | American Cyanamid Company | Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones |
| US4107307A (en) | 1977-02-03 | 1978-08-15 | American Cyanamid Company | Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones |
| CA1095906A (en) | 1977-02-14 | 1981-02-17 | Davis L. Temple, Jr. | Heterocyclopyrimidines, compositions and therapeutic process |
| US4404380A (en) | 1977-02-14 | 1983-09-13 | Mead Johnson & Company | Triazolopyrimidines |
| US4096257A (en) | 1977-05-23 | 1978-06-20 | American Cyanamid Company | Substituted imidazo [1,2-d]-as-triazines |
| US4107309A (en) | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
| IN148482B (de) | 1977-06-03 | 1981-03-07 | Pfizer | |
| DK270378A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
| US4370328A (en) | 1977-11-03 | 1983-01-25 | Pfizer Inc. | Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines |
| CA1086735A (en) | 1977-11-03 | 1980-09-30 | John C. Danilewicz | Piperidino-quinazolines |
| IL56369A (en) | 1978-01-20 | 1984-05-31 | Erba Farmitalia | Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them |
| US4146718A (en) | 1978-04-10 | 1979-03-27 | Bristol-Myers Company | Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides |
| JPS5510608A (en) | 1978-07-07 | 1980-01-25 | Kokusai Denshin Denwa Co Ltd <Kdd> | Coordinate reader |
| US4366156A (en) | 1979-03-05 | 1982-12-28 | Mead Johnson & Company | Antiallergic methods using diazaheterocyclopurines |
| CA1143728A (en) | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| US4536518A (en) | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| JPS5668695A (en) | 1979-11-10 | 1981-06-09 | Sankyo Co Ltd | Enzyme inhibitor griseolic acid and its preparation |
| US4642345A (en) | 1980-08-14 | 1987-02-10 | Mead Johnson & Company | 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones |
| US4301176A (en) | 1980-08-18 | 1981-11-17 | Warner-Lambert Company | Method of administering calcium valproate |
| US4361583A (en) | 1980-08-19 | 1982-11-30 | Synthelabo | Analgesic agent |
| FR2492258A1 (fr) | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
| FR2492382A1 (fr) | 1980-10-22 | 1982-04-23 | Synthelabo | Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique |
| US4489078A (en) | 1980-11-24 | 1984-12-18 | Mead Johnson & Company | Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators |
| US4338317A (en) | 1981-03-16 | 1982-07-06 | Mead Johnson & Company | Phenoxyethyl-1,2,4,-triazol-3-one antidepressants |
| US4383999A (en) | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
| FR2508035A1 (fr) | 1981-06-23 | 1982-12-24 | Fabre Sa Pierre | Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central |
| LU83729A1 (fr) | 1981-11-04 | 1983-09-01 | Galephar | Sels d'acide valproique,leur preparation et leur utilisation |
| US4513135A (en) | 1982-03-05 | 1985-04-23 | Eli Lilly And Company | Diaryl-pyrazine derivatives affecting GABA binding |
| CH655110A5 (de) | 1982-09-03 | 1986-03-27 | Otsuka Pharma Co Ltd | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten. |
| US4490371A (en) | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
| US4663320A (en) | 1983-02-16 | 1987-05-05 | Syntex (U.S.A.) Inc. | (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof |
| US4900836A (en) | 1983-06-23 | 1990-02-13 | American Cyanamid Company | (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
| US4626538A (en) | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
| US4521422A (en) | 1983-06-23 | 1985-06-04 | American Cyanamid Company | Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4761501A (en) | 1983-10-26 | 1988-08-02 | American Home Products Corporation | Substituted phenylacetamides |
| US4593029A (en) | 1984-02-15 | 1986-06-03 | Syntex (U.S.A.) Inc. | Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones |
| GB8425872D0 (en) | 1984-10-12 | 1984-11-21 | Ciba Geigy Ag | Chemical compounds |
| CA1272408A (en) | 1985-02-13 | 1990-08-07 | Goro Mizuno | Display device |
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| DK288385D0 (da) | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| ZW20586A1 (en) | 1985-10-17 | 1988-05-25 | Smith Kline French Lab | Chemical compounds |
| US4670434A (en) | 1985-11-14 | 1987-06-02 | Syntex (U.S.A.) Inc. | (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors |
| US4775674A (en) | 1986-05-23 | 1988-10-04 | Bristol-Myers Company | Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors |
| FR2600650B1 (fr) | 1986-06-27 | 1988-09-09 | Synthelabo | Procede de preparation d'imidazopyridines et composes intermediaires |
| US4701459A (en) | 1986-07-08 | 1987-10-20 | Bristol-Myers Company | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation |
| US5093525A (en) | 1986-07-10 | 1992-03-03 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists |
| US5312840A (en) | 1986-07-10 | 1994-05-17 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US5502255A (en) | 1986-07-10 | 1996-03-26 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US4709094A (en) | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
| US4761416A (en) | 1986-07-25 | 1988-08-02 | Syntex (U.S.A.) Inc. | N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds |
| US4739056A (en) | 1986-11-26 | 1988-04-19 | Syntex (U.S.A.) Inc. | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds |
| US4786648A (en) | 1986-12-08 | 1988-11-22 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| US4710508A (en) | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| US5081242A (en) | 1986-12-22 | 1992-01-14 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones |
| US4766118A (en) | 1986-12-22 | 1988-08-23 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use |
| US4721784A (en) | 1986-12-22 | 1988-01-26 | Ortho Pharmaceutical Corporation | 6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones |
| US4956388A (en) | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| US4929734A (en) | 1987-03-31 | 1990-05-29 | Warner-Lambert Company | Tetrahydropyridine oxime compounds |
| GB8714789D0 (en) | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
| US4981858A (en) | 1987-08-13 | 1991-01-01 | State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research | Optical isomers |
| US5319115A (en) | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
| USRE35517E (en) | 1987-08-25 | 1997-05-20 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US5120723A (en) | 1987-08-25 | 1992-06-09 | University Of Southern California | Method, compositions, and compounds for modulating brain excitability |
| US5232917A (en) | 1987-08-25 | 1993-08-03 | University Of Southern California | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series |
| US5412096A (en) | 1987-10-05 | 1995-05-02 | Yamanouchi Pharmaceutical Co., Ltd. | Hydrochloride salts of heterocyclic spiro compounds |
| ES2074441T3 (es) | 1987-10-05 | 1995-09-16 | Yamanouchi Pharma Co Ltd | Compuestos espiro heterociclicos y su preparacion. |
| IE63906B1 (en) | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
| US4831031A (en) | 1988-01-22 | 1989-05-16 | Pfizer Inc. | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity |
| US5091431A (en) | 1988-02-08 | 1992-02-25 | Schering Corporation | Phosphodiesterase inhibitors |
| US4957916A (en) | 1988-08-05 | 1990-09-18 | Janssen Pharmaceutica N.V. | Antipsychotic 3-piperazinylbenzazole derivatives |
| GB8820266D0 (en) | 1988-08-26 | 1988-09-28 | Smith Kline French Lab | Compounds |
| US4861891A (en) | 1988-08-31 | 1989-08-29 | Pfizer Inc. | Antidepressant N-substituted nicotinamide compounds |
| FR2636625B1 (fr) | 1988-09-01 | 1990-11-09 | Jouveinal Sa | Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese |
| DE8817121U1 (de) | 1988-11-22 | 1993-02-04 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
| US5286864A (en) | 1988-11-22 | 1994-02-15 | Boehringer Ingelheim Kg | Quinuclidines, their use as medicaments and processes for their preparation |
| US5043345A (en) | 1989-02-22 | 1991-08-27 | Novo Nordisk A/S | Piperidine compounds and their preparation and use |
| US4981870A (en) | 1989-03-07 | 1991-01-01 | Pfizer Inc. | Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants |
| US4971972A (en) | 1989-03-23 | 1990-11-20 | Schering Corporation | Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion |
| SG48315A1 (en) | 1989-04-13 | 1998-04-17 | Beecham Group Plc | Novel compounds |
| US5278170A (en) | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
| AU642881B2 (en) | 1989-05-02 | 1993-11-04 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Methods for treating anxiety with sigma receptor ligands |
| US4956368A (en) | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
| US5109002A (en) | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
| WO1991006297A1 (en) | 1989-10-27 | 1991-05-16 | The Du Pont Merck Pharmaceutical Company | (n-phthalimidoalkyl) piperidines |
| US4943573A (en) | 1989-11-01 | 1990-07-24 | Bristol-Myers Squibb Company | Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility |
| US4963561A (en) | 1990-02-28 | 1990-10-16 | Sterling Drug Inc. | Imidazopyridines, their preparation and use |
| US5010086A (en) | 1990-02-28 | 1991-04-23 | Sterling Drug Inc. | Imidazopyridines, compositions and use |
| US5149817A (en) | 1990-03-05 | 1992-09-22 | Shionogi & Co., Ltd. | Teirahydropyridine derivatives |
| US5169855A (en) | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
| US5574070A (en) | 1990-05-25 | 1996-11-12 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US5116995A (en) | 1990-05-25 | 1992-05-26 | Taisho Pharmaceutical Co., Ltd. | Carbazole compounds |
| US5612211A (en) | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| FR2663328B1 (fr) | 1990-06-14 | 1994-08-05 | Sanofi Sa | Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| US5095015A (en) | 1990-07-24 | 1992-03-10 | Neurogen Corporation | Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands |
| FR2663934B1 (fr) | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
| JP2935541B2 (ja) | 1990-06-28 | 1999-08-16 | サントリー株式会社 | 縮合複素環化合物 |
| US5086054A (en) | 1990-07-31 | 1992-02-04 | Sri International | Novel arylcycloalkanepolyalkylamines |
| DK198590D0 (da) | 1990-08-21 | 1990-08-21 | Novo Nordisk As | Heterocykliske forbindelser, deres fremstilling og anvendelse |
| GB9019095D0 (en) | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
| US5185446A (en) | 1990-09-04 | 1993-02-09 | Neurogen Corporation | Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands |
| AU652968B2 (en) | 1990-10-09 | 1994-09-15 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands |
| US5356914A (en) | 1990-10-12 | 1994-10-18 | Beecham Group P.L.C. | 1,2,5,6-tetrahydropyridine oxime derivatives |
| US5139802A (en) | 1990-10-15 | 1992-08-18 | Nestec S.A. | Oxidation of tea |
| EP0481262B1 (de) | 1990-10-15 | 1995-02-15 | Societe Des Produits Nestle S.A. | Behandlung von schwarzem Tee |
| US6268496B1 (en) | 1990-10-31 | 2001-07-31 | Neurogen Corporation | Certain imidazoquinoxalines: a new class of GABA brain receptor ligands |
| US5130430A (en) | 1990-10-31 | 1992-07-14 | Neurogen Corporation | 2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands |
| US5744602A (en) | 1990-10-31 | 1998-04-28 | Neurogen Corporation | Certain imidazoquinoxalines; a new class of GABA brain receptor ligands |
| US5116837A (en) | 1990-12-21 | 1992-05-26 | Ortho Pharmaceutical Corporation | 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines |
| US5180729A (en) | 1991-02-22 | 1993-01-19 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists for treatment of ***e abuse |
| US5162341A (en) | 1991-02-22 | 1992-11-10 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists for treatment of amphetamine abuse |
| ATE130851T1 (de) | 1991-03-14 | 1995-12-15 | Basf Ag | Substituierte n-phenylpiperidine und arzneimittel daraus. |
| US5231099A (en) | 1991-04-15 | 1993-07-27 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs |
| US5137895A (en) | 1991-04-29 | 1992-08-11 | A. H. Robins Company, Incorporated | 3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols |
| WO1992020683A1 (en) | 1991-05-15 | 1992-11-26 | Yamanouchi Pharmaceutical Co., Ltd. | (-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane l-tartrate |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| PT100639A (pt) | 1991-06-27 | 1993-09-30 | Univ Virginia Commonwealth | Metodo para o tratamento terapeutico com compostos que sao ligandos ao receptor sigma e compostos ai utilizados, nomeadamente derivados fenilalquil-amina, aminotetralina,piperazina e piperidina |
| US5182290A (en) | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain oxazoloquinolinones; a new class of GABA brain receptor ligands |
| US5182386A (en) | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
| CA2118938A1 (en) | 1991-09-13 | 1993-04-01 | Kelvin W. Gee | Novel gabaa receptor with steroid binding sites |
| PT100905A (pt) | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US5585490A (en) | 1991-10-08 | 1996-12-17 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands |
| PH31245A (en) | 1991-10-30 | 1998-06-18 | Janssen Pharmaceutica Nv | 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives. |
| WO1993009094A1 (en) | 1991-10-30 | 1993-05-13 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
| US5212310A (en) | 1991-12-19 | 1993-05-18 | Neurogen Corporation | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands |
| US5243049A (en) | 1992-01-22 | 1993-09-07 | Neurogen Corporation | Certain pyrroloquinolinones: a new class of GABA brain receptor ligands |
| MX9300875A (es) | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
| US6225115B1 (en) | 1992-03-04 | 2001-05-01 | Synaptic Pharmaceutical Corporation | DNA encoding taurine and GABA transporters and uses thereof |
| US5298657A (en) | 1992-03-20 | 1994-03-29 | Cambridge Neuroscience Inc. | Preparation of substituted guanidines |
| US5294612A (en) | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
| AU4117493A (en) | 1992-04-08 | 1994-11-21 | Neurogen Corporation | Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands |
| US5367077A (en) | 1992-04-08 | 1994-11-22 | Neurogen Corporation | Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands |
| US5266698A (en) | 1992-04-30 | 1993-11-30 | Neurogen Corporation | Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands |
| ES2060547B1 (es) | 1992-06-04 | 1995-06-16 | Ferrer Int | Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina". |
| GB9212693D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9212673D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| JP2683783B2 (ja) | 1992-07-10 | 1997-12-03 | 雪印乳業株式会社 | シェーグレン症候群治療剤 |
| JP2657760B2 (ja) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | ４−アミノキナゾリン誘導体およびそれを含有する医薬品 |
| US5928947A (en) | 1992-07-27 | 1999-07-27 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5306819A (en) | 1992-08-27 | 1994-04-26 | Neurogen Corporation | Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands |
| ZA937382B (en) | 1992-10-06 | 1994-04-29 | Warner Lambert Co | Novel composition for peroral therapy of cognitionimpairment and a process therefor |
| GB9222253D0 (en) | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| US5668283A (en) | 1992-11-12 | 1997-09-16 | Neurogen Corporation | Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands |
| US5286860A (en) | 1992-11-12 | 1994-02-15 | Neurogen Corporation | Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands |
| US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
| US5622977A (en) | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
| GB9226830D0 (en) | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
| WO1994015937A1 (en) | 1993-01-06 | 1994-07-21 | Neurogen Corporation | Certain aryl substituted imidazopyrazinones a new class of gaba brain receptor ligands |
| US5362860A (en) | 1993-02-01 | 1994-11-08 | Warner-Lambert Company | Neutral stabilization complex for CI-979 HCl, a cognition activator |
| US5424301A (en) | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
| US6013799A (en) | 1993-03-03 | 2000-01-11 | Neurogen Corporation | Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands |
| GB9304919D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| DK0690850T3 (da) | 1993-03-26 | 1998-02-09 | Schering Corp | 2-Substituerede morpholin- og thiomorpholinderivater som GABAB-antagonister |
| US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| DE69435286D1 (de) | 1993-05-24 | 2010-05-20 | Purdue Pharma Ltd | Verfahren und zusammensetzungen zum hervorrufen von schlaf |
| US5750702A (en) | 1993-10-27 | 1998-05-12 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands |
| ES2204920T3 (es) | 1993-05-27 | 2004-05-01 | Cenes Limited | Guanidinas substituidas terapeuticas. |
| GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
| US6087346A (en) | 1993-06-23 | 2000-07-11 | Cambridge Neuroscience, Inc. | Sigma receptor ligands and the use thereof |
| WO1995001338A1 (de) | 1993-07-02 | 1995-01-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
| WO1995001997A1 (en) | 1993-07-09 | 1995-01-19 | Smithkline Beecham Corporation | RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN |
| ES2074946B1 (es) | 1993-07-19 | 1996-06-16 | Ferrer Int | Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida. |
| CN1042029C (zh) | 1993-07-28 | 1999-02-10 | 参天制药株式会社 | 1,4－(二苯基烷基)哌嗪衍生物及含有它的药物组合物 |
| US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| US5484944A (en) | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
| DK0730587T3 (da) | 1993-11-26 | 2000-04-10 | Pfizer | 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler |
| US5502072A (en) | 1993-11-26 | 1996-03-26 | Pfizer Inc. | Substituted oxindoles |
| AU687452B2 (en) | 1993-11-26 | 1998-02-26 | Pfizer Inc. | Isoxazoline compounds as antiinflammatory agents |
| US5849760A (en) | 1993-12-09 | 1998-12-15 | Institut De Recherche Jouveinal | 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors |
| US5500420A (en) | 1993-12-20 | 1996-03-19 | Cornell Research Foundation, Inc. | Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia |
| EP0738268B1 (de) | 1993-12-22 | 2004-03-03 | Celltech R&D Limited | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
| GB9326699D0 (en) | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| GB9326173D0 (en) | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
| US7060450B1 (en) | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
| GB9401090D0 (en) | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
| KR100338287B1 (ko) | 1994-02-14 | 2002-11-30 | 푸르듀 파머 리미티드 | 감마-아미노부티르산a수용체의알로오스테리조절용안드로스탄및프레그난 |
| US5939545A (en) | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
| US5696148A (en) | 1994-03-14 | 1997-12-09 | Novo Nordisk A/S | Indole compounds and their use in treating diseases of the central nervous system |
| US5783575A (en) | 1994-03-14 | 1998-07-21 | Novo Nordisk A/S | Antagonists, their preparation and use |
| CA2185670A1 (en) | 1994-03-14 | 1995-09-21 | Palle Jakobsen | Heterocyclic compounds, their preparation and use |
| US5637617A (en) | 1994-04-01 | 1997-06-10 | The Regents Of The University Of California | Methods for use of GABAa receptor GABAergic compounds |
| GB9409705D0 (en) | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
| GB9410877D0 (en) | 1994-05-31 | 1994-07-20 | Bayer Ag | Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| JP2852608B2 (ja) | 1994-06-27 | 1999-02-03 | 雪印乳業株式会社 | 口腔乾燥症治療剤 |
| US5750566A (en) | 1994-08-12 | 1998-05-12 | Eli Lilly And Company | Synthetic excitatory amino acids |
| CN1043993C (zh) | 1994-08-29 | 1999-07-07 | 山之内制药株式会社 | 萘啶衍生物及其医药组合物 |
| WO1996010570A1 (en) | 1994-09-30 | 1996-04-11 | Pfizer Inc. | NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES |
| US5554645A (en) | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| DE4436509A1 (de) | 1994-10-13 | 1996-04-18 | Hoechst Schering Agrevo Gmbh | Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
| JP3993651B2 (ja) | 1994-10-21 | 2007-10-17 | アスビオファーマ株式会社 | シクロプロパクロメンカルボン酸誘導体 |
| US5473077A (en) | 1994-11-14 | 1995-12-05 | Eli Lilly And Company | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists |
| KR100394548B1 (ko) | 1994-11-23 | 2004-02-05 | 퍼듀 파머 리미티드 | Gaba수용체의알로스테릭조절을위한안드로스탄및프레그난계열화합물 |
| GB9423911D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| GB9503601D0 (en) | 1995-02-23 | 1995-04-12 | Merck Sharp & Dohme | Method of treatment and method of manufacture of medicament |
| US5698560A (en) | 1995-03-01 | 1997-12-16 | Kyowa Hakko Kogyo Co., Ltd. | Imidazoquinazoline derivatives |
| US5488055A (en) | 1995-03-10 | 1996-01-30 | Sanofi Winthrop Inc. | Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof |
| WO1996033194A1 (en) | 1995-04-21 | 1996-10-24 | Neurosearch A/S | Benzimidazole compounds and their use as modulators of the gaba a receptor complex |
| EP0823905A1 (de) | 1995-05-05 | 1998-02-18 | Novo Nordisk A/S | Neue heterocyclische chemie |
| DE19518082A1 (de) | 1995-05-17 | 1996-11-21 | Merck Patent Gmbh | 4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one |
| PT828728E (pt) | 1995-05-18 | 2003-06-30 | Altana Pharma Ag | Di-hidrobenzofuranos de fenilo |
| AU705723B2 (en) | 1995-05-18 | 1999-05-27 | Altana Pharma Ag | Cyclohexyl dihydrobenzofuranes |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| US5637725A (en) | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| US5637724A (en) | 1995-06-05 | 1997-06-10 | Neurogen Corporation | Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands |
| CA2223996A1 (en) | 1995-06-06 | 1996-12-19 | Cocensys, Inc. | Neuroactive steroids of the androstane and pregnane series |
| US5534522A (en) | 1995-06-07 | 1996-07-09 | Warner-Lambert Company | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
| US5910590A (en) | 1995-06-07 | 1999-06-08 | Neurogen Corporation | Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands |
| GB9514464D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Medicaments |
| NZ305940A (en) | 1995-07-26 | 1999-05-28 | Pfizer | N-(aroyl)glycine hydroxamic acid derivatives and related compounds that inhibit the production of tnf and are useful in treating asthma |
| US20010018074A1 (en) | 1995-07-29 | 2001-08-30 | Smithkline Beecham P.L.C. | Process for preparing solid dosage forms of very low-dose drugs |
| JPH11509846A (ja) | 1995-07-31 | 1999-08-31 | ノボ ノルディスク アクティーゼルスカブ | ヘテロ環式化合物、それらの調製及び使用 |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| HUP9901051A2 (hu) | 1995-11-06 | 2000-03-28 | H. Lundbeck A/S | 5-(2-Etil-2H-tetrazol-5-il)-1,2,3,6-tetrahidro-1-metil-piridin alkalmazása traumás agykárosodások kezelésére alkalmas gyógyászati készítmények előállítására |
| US5800539A (en) | 1995-11-08 | 1998-09-01 | Emory University | Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| US5912248A (en) | 1995-11-16 | 1999-06-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| IT1276153B1 (it) | 1995-11-17 | 1997-10-27 | Roberto Pellicciari | Derivati di glicina ad attivita' antagonista dei recettori metabotropi del glutammato |
| GB9603723D0 (en) | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
| US5710170A (en) | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
| GB9526245D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526246D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| US5804686A (en) | 1996-01-19 | 1998-09-08 | Neurogen Corporation | fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| US6211365B1 (en) | 1996-01-19 | 2001-04-03 | Neurogen Corporation | Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands |
| EE03523B1 (et) | 1996-01-31 | 2001-10-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine |
| GB9604926D0 (en) | 1996-03-08 | 1996-05-08 | Sandoz Ltd | Organic compounds |
| US5792766A (en) | 1996-03-13 | 1998-08-11 | Neurogen Corporation | Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands |
| US5677309A (en) | 1996-03-22 | 1997-10-14 | Neurogen Corporation | 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands |
| EP0888300A1 (de) | 1996-03-22 | 1999-01-07 | Neurogen Corporation | Kondensierte pyrrolcarboxamide als gaba-gehirn-rezeptor-liganden |
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| FR2746800B1 (fr) | 1996-03-29 | 1998-06-05 | Jouveinal Inst Rech | Diazepino-indoles inhibiteurs de phosphodiesterases 4 |
| US6297273B1 (en) | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| FR2754260B1 (fr) | 1996-10-04 | 1998-10-30 | Adir | Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5723462A (en) | 1996-04-26 | 1998-03-03 | Neurogen Corporation | Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands |
| AP1147A (en) | 1996-05-03 | 2003-02-25 | Pfizer | Substituted indazole derivatives and related compounds. |
| YU49898A (sh) | 1996-05-10 | 2000-03-21 | Icos Corporation | Hemijska jedinjenja |
| DE69738949D1 (de) | 1996-05-20 | 2008-10-09 | Darwin Discovery Ltd | Chinolincarboxamide als tnf-inhibitoren und als pde-iv inhibitoren |
| BR9709113A (pt) | 1996-05-20 | 1999-08-03 | Darwin Discovery Ltd | Benzofurano carboxamidas e seu uso terapêutico |
| BR9709105A (pt) | 1996-05-20 | 1999-08-03 | Darwin Discovery Ltd | Sulfonamidas de quinolina como inibidoras de tnf e como inobidoras de pde-iv |
| EP0934307B1 (de) | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituierte azabicyclische verbindungen und ihre verwendung als inhibitoren des tnf und der cyclischen amp phosphodiestrase |
| EA002274B1 (ru) | 1996-06-25 | 2002-02-28 | Пфайзер Инк. | Призводные замещенного индазола и их применение в качестве ингибиторов фосфодиэстеразы (фдэ) типа iv и фактора некроза опухоли (фно) |
| US6017924A (en) | 1996-06-27 | 2000-01-25 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| WO1998000391A1 (fr) | 1996-06-28 | 1998-01-08 | Nippon Chemiphar Co., Ltd. | Derives de cyclopropylglycine et agoniste du recepteur du l-glutamate du type a regulation metabolique |
| GB9614718D0 (en) | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
| DE19628621A1 (de) | 1996-07-16 | 1998-01-22 | Byk Gulden Lomberg Chem Fab | Neue 4-substituierte Benzofurane |
| AU723098B2 (en) | 1996-07-25 | 2000-08-17 | Merck Sharp & Dohme Limited | Substituted triazolo-pyridazine derivatives as ligands for GABA receptors |
| EP0915877A1 (de) | 1996-07-25 | 1999-05-19 | MERCK SHARP & DOHME LTD. | Substituierte triazolo-pyridazinderivate als inverse agonisten des gaba-a alpha-5 rezeptor subtyps |
| US20020127271A1 (en) | 1996-07-25 | 2002-09-12 | Smithkline Beecham P.L.C. | Formulation for the treatment and/or prophylaxis of dementia |
| AU3967297A (en) | 1996-08-01 | 1998-02-25 | Cocensys, Inc. | Use of gaba and nmda receptor ligands for the treatment of migraine headache |
| DE69737631T3 (de) | 1996-08-12 | 2011-08-18 | Mitsubishi Tanabe Pharma Corp. | MEDIKAMENTE ENTHALTEND Rho-KINASE INHIBITOREN |
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| DE69717827T2 (de) | 1996-08-19 | 2003-09-04 | Altana Pharma Ag | Benzofuran-4-carboxamide |
| SI0920426T1 (en) | 1996-08-26 | 2004-04-30 | Altana Pharma Ag | New thiazole derivatives with phosphodiesterase-inhibiting effect |
| US6312753B1 (en) | 1996-09-06 | 2001-11-06 | Mars, Incorporated | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses |
| US6015913A (en) | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
| US20010003588A1 (en) | 1996-09-12 | 2001-06-14 | Smithkline Beecham Corporation | Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride |
| US5885834A (en) | 1996-09-30 | 1999-03-23 | Epstein; Paul M. | Antisense oligodeoxynucleotide against phosphodiesterase |
| ES2196308T3 (es) | 1996-10-02 | 2003-12-16 | Janssen Pharmaceutica Nv | Derivado de 2-cianoiminoimidazol que inhiben la pde iv. |
| AU4920397A (en) | 1996-10-11 | 1998-05-11 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| DE19642451A1 (de) | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| GB9621789D0 (en) | 1996-10-18 | 1996-12-11 | Lilly Industries Ltd | Pharmaceutical compounds |
| NZ334868A (en) | 1996-10-21 | 2001-02-23 | Neurosearch As | 1-Phenyl-benzimidazole compounds and their use as BAGA-a receptor modulators |
| US5921749A (en) | 1996-10-22 | 1999-07-13 | Siemens Westinghouse Power Corporation | Vane segment support and alignment device |
| GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| US6069151A (en) | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
| EP0946541B1 (de) | 1996-11-06 | 2003-07-30 | Darwin Discovery Limited | Chinoline und deren therapeutische verwendung |
| WO1998021207A1 (de) | 1996-11-12 | 1998-05-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | (2,3-dihydrobenzofuranyl)-thiazole als phosphodiesterasehemmer |
| PT941221E (pt) | 1996-11-20 | 2003-07-31 | Altana Pharma Ag | Dihidrobenzofuranos substituidos como inibidores de fosfodiesterase (pde) |
| GB9625184D0 (en) | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2276455C (en) | 1997-01-15 | 2006-10-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinones |
| GB9702524D0 (en) | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| ES2302350T3 (es) | 1997-02-28 | 2008-07-01 | Nycomed Gmbh | Combinacion sinergica de inhibidores de pde y agonistas de adenilatociclasa o agonistas de guanililciclasa. |
| ES2131463B1 (es) | 1997-04-08 | 2000-03-01 | Lilly Sa | Derivados de ciclopropilglicina con propiedades farmaceuticas. |
| CA2225060A1 (en) | 1997-04-09 | 1998-10-09 | Peter Suilun Fong | Interactive talking dolls |
| GB9708945D0 (en) | 1997-05-01 | 1997-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| US6387673B1 (en) | 1997-05-01 | 2002-05-14 | The Salk Institute For Biological Studies | Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds |
| US6043252A (en) | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
| ATE221887T1 (de) | 1997-05-08 | 2002-08-15 | Merck Sharp & Dohme | Substituierte 1,2,4-triazolo(3,4,-a)phthalazin- derivate als gaba-alpha 5-liganden |
| ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| ATE273007T1 (de) | 1997-05-29 | 2004-08-15 | Lundbeck & Co As H | Behandlung der schizophrenie und der psychose |
| GB9713707D0 (en) | 1997-06-27 | 1997-09-03 | Merck Sharp & Dohme | Therapeutic agents |
| CA2296310A1 (en) | 1997-07-18 | 1999-01-28 | Werner Tuckmantel | Bicyclic metabotropic glutamate receptor ligands |
| US6825211B1 (en) | 1997-07-18 | 2004-11-30 | Georgetown University | Bicyclic metabotropic glutamate receptor ligands |
| US6121279A (en) | 1997-07-25 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| ES2137113B1 (es) | 1997-07-29 | 2000-09-16 | Almirall Prodesfarma Sa | Nuevos derivados de triazolo-piridazinas heterociclicos. |
| GB9715977D0 (en) | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| US6107295A (en) | 1997-08-01 | 2000-08-22 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Arylalkanoyl pyridazines |
| HUP0001054A3 (en) | 1997-08-06 | 2001-01-29 | Daiichi Asubio Pharma Co Ltd | 1-aryl-1,8-naphthyridin-4-one derivative as type iv phosphodiesterase inhibitor |
| US6143760A (en) | 1997-08-25 | 2000-11-07 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands |
| US6207842B1 (en) | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| GB9721437D0 (en) | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| US5932465A (en) | 1997-10-16 | 1999-08-03 | Icos Corporation | Phosphodiesterase 8A |
| US6127363A (en) | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| US6156753A (en) | 1997-10-28 | 2000-12-05 | Vivus, Inc. | Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| UA64769C2 (uk) | 1997-11-07 | 2004-03-15 | Х. Луннбек А/С | Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування |
| GB2346877B (en) | 1997-11-12 | 2001-12-05 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
| WO1999025353A1 (en) | 1997-11-13 | 1999-05-27 | Merck Sharp & Dohme Limited | Therapeutic uses of triazolo-pyridazine derivatives |
| US6429207B1 (en) | 1997-11-21 | 2002-08-06 | Nps Pharmaceuticals, Inc. | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases |
| JP2002508377A (ja) | 1997-12-12 | 2002-03-19 | ユーロ−セルティーク，エス．エイ． | ３−置換アデニンの製造 |
| IT1296985B1 (it) | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| EP1047697A1 (de) | 1998-01-14 | 2000-11-02 | MERCK SHARP & DOHME LTD. | Triazolo-pyridazin-derivate als liganden für gaba-rezeptoren |
| GB9801202D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801234D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| CA2315763A1 (en) | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9801208D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801210D0 (en) | 1998-01-21 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| GB9801397D0 (en) | 1998-01-22 | 1998-03-18 | Merck Sharp & Dohme | Therapeutic agents |
| WO1999038867A1 (fr) | 1998-01-29 | 1999-08-05 | Suntory Limited | Derives de 1-cycloalkyle-1,8-naphthyridine-4-one presentant une activite inhibitrice de la phosphodiesterase iv |
| CA2321224A1 (en) | 1998-02-23 | 1999-08-26 | Icos Corporation | Phosphodiesterase 10 |
| AU2881199A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands |
| WO1999043682A1 (en) | 1998-02-26 | 1999-09-02 | Neurogen Corporation | 2-(het-)aryl-4-(cyclic amino substituted) heteroaryl fused pyridine derivatives, their preparation and their use as (ant-)agonists for gaba (a) brain receptors |
| AU2879799A (en) | 1998-02-26 | 1999-09-15 | Neurogen Corporation | 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands |
| EP1056724B1 (de) | 1998-02-26 | 2005-05-25 | Neurogen Corporation | Substituierte cycloalkyl-4-oxonicotinische karboxamide; gaba gehirn-rezeptorligande |
| US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
| US6805883B2 (en) | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| ATE251624T1 (de) | 1998-03-13 | 2003-10-15 | Univ British Columbia | Granulatimide-derivate zur behandlung von krebs |
| GB9806102D0 (en) | 1998-03-20 | 1998-05-20 | Merck Sharp & Dohme | Therapeutic agents |
| FR2776660B1 (fr) | 1998-03-27 | 2000-05-12 | Parke Davis | Diazepino-indoles de phosphodiesterases iv |
| EP1071655A1 (de) | 1998-04-17 | 2001-01-31 | Kenneth Curry | Cubanderivate als metabotropische glutamatrezeptor-antagonisten und verfahren zu ihrer herstellung |
| JP3721077B2 (ja) | 1998-04-20 | 2005-11-30 | ファイザー・インク | 性的不全を治療するためのピラゾロピリミジノンｃＧＭＰＰＤＥ５阻害剤 |
| BR9910029A (pt) | 1998-04-28 | 2000-12-26 | Dresden Arzneimittel | Hidróxi indóis, sua aplicação como inibidores da fosfodiesterase 4 e processo para sua preparação |
| SI1075477T1 (en) | 1998-05-05 | 2003-08-31 | Altana Pharma Ag | Novel Benzonaphthyridine-N-oxides |
| AU4198299A (en) | 1998-05-21 | 1999-12-06 | Rae R. Matsumoto | Compounds and uses thereof |
| EP0967284A1 (de) | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterasen |
| US6897305B2 (en) | 1998-06-08 | 2005-05-24 | Theravance, Inc. | Calcium channel drugs and uses |
| EP1086096B1 (de) | 1998-06-10 | 2003-07-23 | ALTANA Pharma AG | Benzamide mit tetrahydrofuranyloxy-substituenten als inhibitoren der phosphodiesterase 4 |
| DE19826841A1 (de) | 1998-06-16 | 1999-12-23 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| WO1999065904A1 (en) | 1998-06-16 | 1999-12-23 | Merck Sharp & Dohme Limited | Triazolo-pyridine derivatives as ligands for gaba receptors |
| GB9813006D0 (en) | 1998-06-16 | 1998-08-12 | Merck Sharp & Dohme | Therapeutic agents |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| US6376485B1 (en) | 1998-07-06 | 2002-04-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzoxazoles with PDE-inhibiting activity |
| ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| US6177569B1 (en) | 1998-08-25 | 2001-01-23 | Neurogen Corporation | Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands |
| CN1348363A (zh) | 1998-08-27 | 2002-05-08 | 布里斯托尔-米尔斯·斯奎布公司 | 新的药物盐形式 |
| CA2341865C (en) | 1998-08-31 | 2006-01-17 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
| CH694053A5 (de) | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
| ES2224747T3 (es) | 1998-09-03 | 2005-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Compuestos heterociclicos que contienen oxigeno. |
| AU1025899A (en) | 1998-09-16 | 2000-04-03 | Icos Corporation | Carboline derivatives as cgmp phosphodiesterase inhibitors |
| JP2002526488A (ja) | 1998-09-24 | 2002-08-20 | 三菱化学株式会社 | ヒドロキシフラボン誘導体 |
| AR023052A1 (es) | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
| US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
| AU6111699A (en) | 1998-10-08 | 2000-05-01 | Smithkline Beecham Plc | Novel method and compounds |
| ES2291043T3 (es) | 1998-10-16 | 2008-02-16 | MERCK SHARP & DOHME LIMITED | Derivados de pirazolotriazina como ligandos para receptores de gaba. |
| DE19850701A1 (de) | 1998-11-04 | 2000-05-11 | Merck Patent Gmbh | Benzoylpyridazine |
| CA2349700A1 (en) | 1998-11-12 | 2000-05-18 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
| PE20001236A1 (es) | 1998-11-13 | 2000-11-10 | Lilly Co Eli | Moduladores del receptor de aminoacidos excitadores |
| SE9804064D0 (sv) | 1998-11-25 | 1998-11-25 | A & Science Invest Ab | Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells |
| US6130333A (en) | 1998-11-27 | 2000-10-10 | Monsanto Company | Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use |
| GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
| AU2217200A (en) | 1998-12-23 | 2000-07-12 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| EP1141278B1 (de) | 1998-12-30 | 2008-02-27 | Oligos Etc. Inc. | Therapeutische pde4d phosphodiesterase inhibitoren |
| US6500828B1 (en) | 1999-01-27 | 2002-12-31 | Merck Sharp & Dohme Ltd. | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| US6342496B1 (en) | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
| US6498176B1 (en) | 1999-03-04 | 2002-12-24 | Smithklinebeecham Corporation | 3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors |
| TW575561B (en) | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
| DE19915365A1 (de) | 1999-04-06 | 2000-10-12 | Merck Patent Gmbh | Tetrahydropyridazin-Derivate |
| FR2792938B1 (fr) | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
| DE60020962T2 (de) | 1999-04-28 | 2006-05-24 | Georgetown University | Liganden für metabotropische Glutamat-Rezeptoren |
| US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| US6943166B1 (en) | 1999-04-30 | 2005-09-13 | Lilly Icos Llc. | Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction |
| US6316472B1 (en) | 1999-05-13 | 2001-11-13 | Merck Frosst Canada & Co. | Heterosubstituted pyridine derivatives as PDE 4 inhibitors |
| US6448246B1 (en) | 1999-05-25 | 2002-09-10 | Neurogen Corporation | Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands |
| US6498180B1 (en) | 1999-06-03 | 2002-12-24 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
| CA2376432A1 (en) | 1999-06-10 | 2000-12-21 | Takeda Chemical Industries, Ltd. | Novel protein and dna thereof |
| US6146876A (en) | 1999-06-11 | 2000-11-14 | Millennium Pharmaceuticals, Inc. | 22025, a novel human cyclic nucleotide phosphodiesterase |
| US6297256B1 (en) | 1999-06-15 | 2001-10-02 | Neurogen Corporation | Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands |
| DE19928146A1 (de) | 1999-06-19 | 2000-12-21 | Merck Patent Gmbh | Thienopyrimidine |
| FR2795724B1 (fr) | 1999-07-02 | 2002-12-13 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| KR20020020788A (ko) | 1999-07-21 | 2002-03-15 | 후지야마 아키라 | 벤즈이미다졸론 유도체 및 포스포디에스테라제억제제로서의 이의 용도 |
| GB9918180D0 (en) | 1999-08-02 | 1999-10-06 | Smithkline Beecham Plc | Novel compositions |
| US6821975B1 (en) | 1999-08-03 | 2004-11-23 | Lilly Icos Llc | Beta-carboline drug products |
| US20050137206A1 (en) | 1999-08-05 | 2005-06-23 | Yevich Joseph P. | Method for treatment of anxiety and depression |
| ATE254614T1 (de) | 1999-08-06 | 2003-12-15 | Hoffmann La Roche | Tetrahydro-benzo(d)azepine und deren verwendung als metabotrope glutamatrezeptor-antagonisten |
| AU6525300A (en) | 1999-08-13 | 2001-03-13 | Sepracor, Inc. | Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof |
| US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| GB9919957D0 (en) | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| JP2003508402A (ja) | 1999-08-27 | 2003-03-04 | リガンド・ファーマシューティカルズ・インコーポレイテッド | アンドロゲン受容体モジュレーター化合物および方法 |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| WO2001016133A2 (en) | 1999-08-27 | 2001-03-08 | Ligand Pharmaceuticals Incorporated | 8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators |
| US6956049B1 (en) | 1999-08-31 | 2005-10-18 | Merck & Co., Inc. | Methods of modulating processes mediated by excitatory amino acid receptors |
| GB9921150D0 (en) | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB9921351D0 (en) | 1999-09-09 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
| IL148291A0 (en) | 1999-09-16 | 2002-09-12 | Tanabe Seiyaku Co | Aromatic nitrogen-containing 6-membered cyclic compounds |
| TWI265925B (en) | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
| US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| AU779874B2 (en) | 1999-10-15 | 2005-02-17 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives |
| US7491742B2 (en) | 1999-10-21 | 2009-02-17 | Merck Patent Gmbh | Imidazole derivatives as phosphodiesterase VII inhibitors |
| US6534287B1 (en) | 1999-10-25 | 2003-03-18 | Nps Pharmaceuticals, Inc. | Human metabotropic glutamate receptor |
| AR029185A1 (es) | 1999-10-25 | 2003-06-18 | Yamanouchi Pharma Co Ltd | Derivado de naftiridina |
| DE19953025A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Pyrrolderivate als Phosphodiesterase VII-Hemmer |
| DE19953414A1 (de) | 1999-11-06 | 2001-05-10 | Merck Patent Gmbh | Imidazopyridinderivate als Phospodiesterase VII-Hemmer |
| DE19954707A1 (de) | 1999-11-13 | 2001-05-17 | Merck Patent Gmbh | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| FR2801216A1 (fr) | 1999-11-23 | 2001-05-25 | Centre Nat Rech Scient | Utilisation de derives d'indirubine pour la fabrication de medicaments |
| KR101026205B1 (ko) | 1999-11-23 | 2011-03-31 | 메틸진 인코포레이티드 | 히스톤 디아세틸라제의 억제제 |
| GB9927687D0 (en) | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| WO2001042244A1 (fr) | 1999-12-08 | 2001-06-14 | Grelan Pharmaceutical Co., Ltd. | Nouveaux derives 1,8-naphtyridin-2(1h)-one |
| ATE253918T1 (de) | 1999-12-08 | 2003-11-15 | Centre Nat Rech Scient | Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel |
| AU1734401A (en) | 1999-12-09 | 2001-06-18 | Mitsubishi Pharma Corporation | Carboxyamido derivatives |
| GB9929687D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| US6680336B2 (en) | 1999-12-15 | 2004-01-20 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| GB9929685D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| US6376489B1 (en) | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| AU784748B2 (en) | 1999-12-17 | 2006-06-08 | Novartis Vaccines And Diagnostics, Inc. | Bicyclic inhibitors of glycogen synthase kinase 3 |
| AU782858B2 (en) | 1999-12-17 | 2005-09-01 | Novartis Vaccines And Diagnostics, Inc. | Pyrazine based inhibitors of glycogen synthase kinase 3 |
| AU2400401A (en) | 1999-12-22 | 2001-07-03 | Tanabe Seiyaku Co., Ltd. | Novel phosphodiesterases and genes thereof |
| US6372777B1 (en) | 1999-12-23 | 2002-04-16 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6313156B1 (en) | 1999-12-23 | 2001-11-06 | Icos Corporation | Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors |
| US6362213B1 (en) | 1999-12-23 | 2002-03-26 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6348602B1 (en) | 1999-12-23 | 2002-02-19 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6569885B1 (en) | 1999-12-23 | 2003-05-27 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6258833B1 (en) | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US6294561B1 (en) | 1999-12-23 | 2001-09-25 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| GB0000564D0 (en) | 2000-01-11 | 2000-03-01 | Merck Sharp & Dohme | Therapeutic agents |
| KR20020071029A (ko) | 2000-01-31 | 2002-09-11 | 화이자 프로덕츠 인크. | Ｐｄｅ４ 이소자임 억제제로 유용한 피리미딘카르복스아미드 |
| AU2001233156A1 (en) | 2000-02-01 | 2001-08-14 | Human Genome Sciences, Inc. | Bcl-2-like polynucleotides, polypeptides, and antibodies |
| AU2001234420A1 (en) | 2000-02-03 | 2001-08-14 | Eli Lilly And Company | Potentiators of glutamate receptors |
| AU2001230026A1 (en) | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
| US20010039275A1 (en) | 2000-02-04 | 2001-11-08 | Bowler Andrew Neil | Use of 2,4-diaminothiazole derivatives |
| GB0003254D0 (en) | 2000-02-11 | 2000-04-05 | Darwin Discovery Ltd | Heterocyclic compounds and their therapeutic use |
| FR2804959B1 (fr) | 2000-02-15 | 2006-04-28 | Centre Nat Rech Scient | Utilisation de derives de paullones pour la fabrication de medicaments |
| IL151533A0 (en) | 2000-02-29 | 2003-04-10 | Mitsubishi Pharma Corp | Novel cyclic amide derivatives |
| GB0005700D0 (en) | 2000-03-09 | 2000-05-03 | Glaxo Group Ltd | Therapy |
| US6555572B2 (en) | 2000-03-16 | 2003-04-29 | Inflazyme Pharmaceuticals Ltd. | Benzylated PDE4 inhibitors |
| AU2001262150A1 (en) | 2000-03-23 | 2001-10-03 | Mitsubishi Pharma Corporation | 2-(nitrogen-heterocyclic)pyrimidone derivatives |
| WO2001070243A2 (en) | 2000-03-23 | 2001-09-27 | Nexell Therapeutics Inc. | A method for treating early breast cancer |
| WO2001070727A1 (en) | 2000-03-23 | 2001-09-27 | Sanofi-Synthelabo | 2-(arylalkylamino)pyrimidone derivatives and 2-(heteroarylalkylamino)pyrimidone derivatives |
| EP1136482A1 (de) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-Amino-3-(alkyl)-pyrimidonderivate als GSK3beta-Hemmer |
| EP1136486A1 (de) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-(Indanylamino)pyrimidon und 2-(Tetrahydronaphtalenylamino)pyrimidinon Derivate |
| JP2005289808A (ja) | 2000-03-23 | 2005-10-20 | Sanofi-Aventis | ３−置換−４−ピリミドン誘導体 |
| ATE347557T1 (de) | 2000-03-23 | 2006-12-15 | Takeda Pharmaceutical | Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung |
| EP1136485A1 (de) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | Aminophenylpyrimidonderivate |
| WO2001070675A2 (en) | 2000-03-24 | 2001-09-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| GB0007193D0 (en) | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
| US6683192B2 (en) | 2000-03-30 | 2004-01-27 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| US6761987B2 (en) | 2000-03-31 | 2004-07-13 | Plug Power Inc. | Fuel cell system having an energy source backup |
| GB0007842D0 (en) | 2000-03-31 | 2000-05-17 | Spruce Barbara | Sigma receptor ligands and their medical uses |
| GB0008264D0 (en) | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
| GB0008696D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
| WO2001076507A2 (en) | 2000-04-11 | 2001-10-18 | The University Of Miami | Use of oxygen carriers to improve grafted cell survival in neural transplantation |
| DE60139550D1 (de) | 2000-04-14 | 2009-09-24 | Mars Inc | Zusammensetzungen und methoden zur verbesserung der vaskulären gesundheit |
| CA2306170A1 (en) | 2000-04-18 | 2001-10-18 | Kenneth Curry | Novel amino, carboxy derivatives of barbituric acid |
| AU4878601A (en) | 2000-04-20 | 2001-11-07 | Mitsubishi Corporation | Aromatic amide compounds |
| DK1286964T3 (da) | 2000-05-11 | 2007-10-01 | Univ Madrid Autonoma | Heterocykliske inhibitorer glycogensynthasekinase GSK-3 |
| AU2001256039A1 (en) | 2000-05-11 | 2001-11-20 | Kenneth Curry | Novel spiro(2.4)heptane amino carboxy compounds and derivatives thereof |
| UA72611C2 (uk) | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
| UA74826C2 (en) | 2000-05-17 | 2006-02-15 | Ortho Mcneil Pharm Inc | ?-carboline derivatives as phosphodiesterase inhibitors |
| JP2004501109A (ja) | 2000-05-24 | 2004-01-15 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体に対するリガンドとしての３−フェニル−イミダゾ−ピリミジン誘導体 |
| WO2001091588A1 (fr) | 2000-05-30 | 2001-12-06 | Societe Des Produits Nestle S.A. | Composition primaire contenant un compose bioactif lipophile |
| US7081481B2 (en) | 2000-05-31 | 2006-07-25 | Eli Lilly And Company | Excitatory amino acid receptor modulators |
| JP2003535864A (ja) | 2000-06-07 | 2003-12-02 | アルミラル プロデスファルマ ソシエダ アノニマ | ６−フェニルピロロピリミジンジオン誘導体 |
| JP2004501920A (ja) | 2000-06-23 | 2004-01-22 | リリー アイコス リミテッド ライアビリティ カンパニー | 環状ｇｍｐ特異的ホスホジエステラーゼ阻害剤 |
| US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| US6399641B1 (en) | 2000-07-13 | 2002-06-04 | Hoffmann-La Roche Inc. | 2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists |
| GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| HUP0301431A2 (hu) | 2000-07-27 | 2003-08-28 | F. Hoffmann-La Roche Ag. | 3-Indolil-4-fenil-1H-pirrol-2,5-dion-származékok, mint glikogén szintáz kináz-3béta inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| GT200100147A (es) | 2000-07-31 | 2002-06-25 | Derivados de imidazol | |
| AU2001289751A1 (en) | 2000-08-01 | 2002-02-13 | Bayer Aktiengesellschaft | Selective pde 2 inhibitors, used as medicaments for improving cognition |
| US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
| IL154425A0 (en) | 2000-08-24 | 2003-09-17 | Univ Tennessee Res H Corp | Selective androgen receptor modulators and methods of use thereof |
| AP2001002266A0 (en) | 2000-08-31 | 2001-09-30 | Pfizer Prod Inc | Pyrazole derivatives. |
| JP2004507546A (ja) | 2000-09-01 | 2004-03-11 | サノフィ−サンテラボ | ２−ピリジニル−６，７，８，９−テトラヒドロピリミド［１，２−ａ］ピリミジン−４−オンおよび７−ピリジニル−２，３−ジヒドロイミダゾ［１，２−ａ］ピリミジン−５（１Ｈ）−オン誘導体 |
| EP1184384A1 (de) | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 1-Alkyl, 1-(Heteroaryl)alkyl und 1-(Aryl)alkyl-7-pyridin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-on Derivate |
| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
| JP2004514656A (ja) | 2000-09-06 | 2004-05-20 | カイロン コーポレイション | グリコゲンシンターゼキナーゼ３のインヒビター |
| AU2001288972A1 (en) | 2000-09-11 | 2002-03-26 | Sepracor, Inc. | Antipsychotic sulfonamide-heterocycles, and methods of use thereof |
| US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6613776B2 (en) | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| EP1317450B1 (de) | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazolverbindungen als protein-kinasehemmer |
| US20040115309A1 (en) | 2000-09-22 | 2004-06-17 | Harris Patricia Anna | Food supplement |
| GB0023983D0 (en) | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| JP3830746B2 (ja) | 2000-09-29 | 2006-10-11 | スガツネ工業株式会社 | ヒンジ装置 |
| DE60138658D1 (de) | 2000-09-29 | 2009-06-18 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine Amidgruppe zur Behandlung von Malaria |
| JP4975941B2 (ja) | 2000-09-29 | 2012-07-11 | トポターゲット ユーケー リミテッド | （ｅ）−ｎ−ヒドロキシ−３−（３−スルファモイル−フェニル）アクリルアミド化合物及びその治療用途 |
| EE05195B1 (et) | 2000-10-02 | 2009-08-17 | Janssen Pharmaceutica N.V. | Kinoliini ja kinolinooni derivaadid glutamaatretseptori antagonistidena, nende saamine ja kasutamine ravimite valmistamiseks ning neid sisaldav farmatseutiline kompositsioon |
| EP1193261A1 (de) | 2000-10-02 | 2002-04-03 | Warner-Lambert Company | Thiadiazole und ihre Verwendung als Phosphodiesterase-7 Inhibitoren |
| AU2002210385A1 (en) | 2000-10-16 | 2002-04-29 | Novo-Nordisk A/S | Furazanyl-triazole derivates for the treatment of diseases |
| US20020103192A1 (en) | 2000-10-26 | 2002-08-01 | Curtin Michael L. | Inhibitors of histone deacetylase |
| GB0027561D0 (en) | 2000-11-10 | 2000-12-27 | Merck Sharp & Dohme | Therapeutic agents |
| GB0117277D0 (en) | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| ES2251518T3 (es) | 2000-11-10 | 2006-05-01 | MERCK SHARP & DOHME LTD. | Derivados de imidazo-triazina como ligandos para receptores gaba. |
| AU2954102A (en) | 2000-11-14 | 2002-05-27 | Byk Gulden Lomberg Chem Fab | (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors |
| AR035659A1 (es) | 2000-12-07 | 2004-06-23 | Hoffmann La Roche | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos |
| US6930114B2 (en) | 2000-12-13 | 2005-08-16 | Bayer Pharmaceuticals Corporation | Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors |
| US6900215B2 (en) | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| US6720445B2 (en) | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
| NZ526471A (en) | 2000-12-21 | 2005-08-26 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| US6562995B1 (en) | 2000-12-21 | 2003-05-13 | Beacon Laboratories, Inc. | Delta dicarbonyl compounds and methods for using the same |
| PT1345609E (pt) | 2000-12-22 | 2005-08-31 | Hoffmann La Roche | Derivados de tetra-hidro-(benzo ou tieno)-azepina-pirazina como antagonistas de mglur 1 |
| AR035513A1 (es) | 2000-12-23 | 2004-06-02 | Hoffmann La Roche | Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos |
| US6974824B2 (en) | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| AR035417A1 (es) | 2001-01-27 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| IL156412A0 (en) | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| SK8942003A3 (en) | 2001-01-31 | 2004-10-05 | Pfizer Prod Inc | Ether derivatives useful as inhibitors |
| HUP0400637A2 (hu) | 2001-01-31 | 2004-06-28 | Pfizer Products Inc. | Nikotinamid-biaril-származékok, amelyek PDE4 izozimek inhibitoraiként alkalmazhatók és ezeket tartalmazó gyógyszerkészítmények |
| US6559159B2 (en) | 2001-02-01 | 2003-05-06 | Research Triangle Institute | Kappa opioid receptor ligands |
| US6617357B2 (en) | 2001-03-06 | 2003-09-09 | Smithkline Beecham Corporation | Compounds and their use as PDE inhibitors |
| US20020177594A1 (en) | 2001-03-14 | 2002-11-28 | Curtin Michael L. | Inhibitors of histone deacetylase |
| WO2002076953A1 (en) | 2001-03-21 | 2002-10-03 | Warner-Lambert Company Llc | New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors |
| US6900329B2 (en) | 2001-03-21 | 2005-05-31 | Schering Corporation | MCH antagonists and their use in the treatment of obesity |
| WO2002088079A2 (en) | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| WO2002089782A2 (en) | 2001-05-09 | 2002-11-14 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| HUP0400037A2 (hu) | 2001-05-25 | 2004-04-28 | Pfizer Inc. | Obstruktív légúti megbetegedések kezelésére szolgáló PDE4 inhibitor és antikolinerg hatóanyag-kombináció és ezt tartalmazó gyógyszerkészítmény |
| ES2276942T3 (es) | 2001-05-25 | 2007-07-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Combinacion de un inhibidor de pde4 y tiotropio o un derivado del mismo para tratar vias respiratorias obstructivas y otras enfermedades inflamatorias. |
| US6762179B2 (en) | 2001-05-31 | 2004-07-13 | Vertex Pharmaceuticals Incorporated | Thiazole compounds useful as inhibitors of protein kinase |
| KR20040007672A (ko) | 2001-06-12 | 2004-01-24 | 에스케이 주식회사 | 신규한 페닐알킬디아민 및 아미드 유사체 |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| US7087614B2 (en) | 2001-06-19 | 2006-08-08 | Bristol-Myers Squibb Co. | Pyrimidine inhibitors of phosphodiesterase (PDE) 7 |
| DE10130167A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Imidazotriazine |
| SE0102440D0 (sv) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compound |
| JP2003029331A (ja) | 2001-07-13 | 2003-01-29 | Sano Fuji Koki Co Ltd | 反射型液晶プロジェクタ |
| US6821976B2 (en) | 2001-07-24 | 2004-11-23 | Bristol-Myers Squibb Company | S-6-hydroxy-buspirone |
| JP2004538315A (ja) | 2001-08-03 | 2004-12-24 | ノボ・ノルデイスク・エー／エス | 新規の２，４−ジアミノチアゾール誘導体 |
| EP1285922A1 (de) | 2001-08-13 | 2003-02-26 | Warner-Lambert Company | 1-alkyl oder 1-cycloalkyltriazolo[4,3-a]chinazolin-5-one als phosphodiesterase Inhibitoren |
| JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
| WO2003024448A2 (en) | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| IL160402A0 (en) | 2001-09-21 | 2004-07-25 | Sanofi Synthelabo | Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido {1,2-a} pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo{1,2-pyrimidin-5 (1h) one derivatives |
| EP1295884A1 (de) | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on Derivate |
| EP1295885A1 (de) | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | Substituierte 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)onderivate |
| ATE307815T1 (de) | 2001-09-21 | 2005-11-15 | Sanofi Aventis | Substituierte 2-pyrimidinyl-6,7,8,9- tetrahydropyrimido(1,2-a)pyrimidin-4-on- und 7- pyrimidinyl-2,3-dihydroimidazo(1,2-a)pyrimidin- 5(1h)onderivate gegen neurodegenerative erkrankungen |
| DE10148618B4 (de) | 2001-09-25 | 2007-05-03 | Schering Ag | Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel |
| EP1432710A1 (de) | 2001-09-26 | 2004-06-30 | Bayer Pharmaceuticals Corporation | 1,8-naphthyridinderivate als antidiabetika |
| KR20040047877A (ko) | 2001-10-02 | 2004-06-05 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 제제로서 벤즈이미다졸리디논 유도체 |
| WO2004089942A2 (en) | 2001-10-02 | 2004-10-21 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| US6951849B2 (en) | 2001-10-02 | 2005-10-04 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| US7029163B2 (en) | 2002-10-07 | 2006-04-18 | Advanced Biomaterial Systems, Inc. | Apparatus for mixing and dispensing components |
| US6924311B2 (en) | 2001-10-17 | 2005-08-02 | X-Ceptor Therapeutics, Inc. | Methods for affecting various diseases utilizing LXR compounds |
| JP4643141B2 (ja) | 2001-10-25 | 2011-03-02 | シェーリング コーポレイション | 肥満治療用のｍｃｈアンタゴニスト |
| KR20040048920A (ko) | 2001-11-01 | 2004-06-10 | 얀센 파마슈티카 엔.브이. | 글리코겐 신타아제 키나제 3-베타 저해제(ｇｓｋ저해제)로서의 헤테로아릴 아민 |
| ATE375331T1 (de) | 2001-11-01 | 2007-10-15 | Janssen Pharmaceutica Nv | Amidderivate als inhibitoren der glycogensynthasekinase-3-beta |
| DE60225709T2 (de) | 2001-11-01 | 2009-05-07 | Janssen Pharmaceutica N.V. | Aminobenzamidderivate als inhibitoren der glycogensynthasekinase-3- |
| WO2003042213A1 (en) | 2001-11-14 | 2003-05-22 | Ortho-Mcneil Pharmaceutical Corporation | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors |
| FR2832711B1 (fr) | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
| GB0128287D0 (en) | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
| WO2003048137A1 (en) | 2001-11-30 | 2003-06-12 | Merck & Co., Inc. | Metabotropic glutamate receptor-5 modulators |
| BR0207215A (pt) | 2001-12-13 | 2004-02-10 | Daiichi Suntory Pharma Co Ltd | Derivados de pirazolopiriminona tendo ação de inibição de pde7 |
| JP4286146B2 (ja) | 2001-12-18 | 2009-06-24 | メルク エンド カムパニー インコーポレーテッド | メタボトロピックグルタミン酸受容体−５のヘテロアリール置換ピラゾール系調節剤 |
| DE60222698T2 (de) | 2001-12-18 | 2008-06-19 | Merck & Co., Inc. | Heteroarylsubstituierte triazolmodulatoren des metabotropen glutamatarezeptors 5 |
| US20040259917A1 (en) | 2001-12-19 | 2004-12-23 | Cosford Nicholas D.P. | Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 |
| AU2002353186A1 (en) | 2001-12-19 | 2003-06-30 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| SE0104341D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| AU2002364906B2 (en) | 2001-12-21 | 2007-08-16 | Merck & Co., Inc. | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 |
| WO2003055877A1 (en) | 2001-12-21 | 2003-07-10 | Astrazeneca Ab | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 |
| TW200301123A (en) | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| DE10163991A1 (de) | 2001-12-24 | 2003-07-03 | Merck Patent Gmbh | Pyrrolo-pyrimidine |
| ES2311642T3 (es) | 2001-12-27 | 2009-02-16 | Taisho Pharmaceutical Co., Ltd | Derivados de 6-fluorobicicli 3.1.0 hexano. |
| KR20100008799A (ko) | 2001-12-28 | 2010-01-26 | 아카디아 파마슈티칼스 인코포레이티드 | 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물 |
| US7550459B2 (en) | 2001-12-28 | 2009-06-23 | Acadia Pharmaceuticals, Inc. | Tetrahydroquinoline analogues as muscarinic agonists |
| ES2251624T3 (es) | 2001-12-28 | 2006-05-01 | Acadia Pharmaceuticals Inc. | Analogos de la tetrahidroquinolina como los agonistas muscarinicos. |
| US20050107432A1 (en) | 2002-01-22 | 2005-05-19 | Yoichi Iimura | Sigma receptor binder containing indanone derivative |
| TW200302726A (en) | 2002-01-31 | 2003-08-16 | Ono Pharmaceutical Co | Nitrogen-containing bicyclic compound and medicament containing same as active ingredient |
| WO2003068235A1 (en) | 2002-02-11 | 2003-08-21 | Pfizer Limited | Nicotinamide derivatives useful as pde4 inhibitors |
| AU2003245700A1 (en) | 2002-02-12 | 2003-09-04 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| CN1646535A (zh) | 2002-02-22 | 2005-07-27 | 帝人株式会社 | 吡咯并嘧啶衍生物 |
| TW200306191A (en) | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
| EP1340759A1 (de) | 2002-02-28 | 2003-09-03 | Sanofi-Synthelabo | 1-Alkyl, 1-(Heteroaryl)alkyl und 1-(Aryl)alkyl-7-pyrimidin-4-ylimidazo[1,2-a]pyrimidin-5(1H)-on Derivate |
| BR0308109A (pt) | 2002-02-28 | 2005-01-04 | Sanofi Aventis | Derivados 2-piridinil e 2-pirimidinil-6,7,8,9-tetraidro-pirimido[1,2-a] pirimidin-4-ona substituìdos com hetero arila |
| KR100974770B1 (ko) | 2002-03-05 | 2010-08-06 | 일라이 릴리 앤드 캄파니 | 키나제 억제제로서의 퓨린 유도체 |
| JP2005530707A (ja) | 2002-03-08 | 2005-10-13 | イーライ・リリー・アンド・カンパニー | キナーゼ阻害物質 |
| WO2003076437A1 (de) | 2002-03-11 | 2003-09-18 | Schering Aktiengesellschaft | Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel |
| AU2003213783B2 (en) | 2002-03-12 | 2007-01-25 | Merck Sharp & Dohme Corp. | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 |
| DE60321324D1 (de) | 2002-03-13 | 2008-07-10 | Janssen Pharmaceutica Nv | Sulfonylaminoderivate als neue inhibitoren von histondeacetylase |
| ES2322252T3 (es) | 2002-03-13 | 2009-06-18 | Janssen Pharmaceutica Nv | Aminoderivados como nuevos inhibidores de histona-desacetilasa. |
| CN101450934B (zh) | 2002-03-13 | 2012-10-10 | 詹森药业有限公司 | 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物 |
| JP4674045B2 (ja) | 2002-03-13 | 2011-04-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体 |
| ATE361671T1 (de) | 2002-03-20 | 2007-06-15 | Nestle Sa | Kakaoextrakt mit niedrigem fettgehalt |
| US7514107B2 (en) | 2002-03-21 | 2009-04-07 | Mars, Incorporated | Treatment of diseases involving defective gap junctional communication |
| GB0206723D0 (en) | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel compounds |
| GB0207249D0 (en) | 2002-03-27 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| GB0207246D0 (en) | 2002-03-27 | 2002-05-08 | Glaxo Group Ltd | Novel compounds |
| SE0302546D0 (sv) | 2003-09-24 | 2003-09-24 | Astrazeneca Ab | New compounds |
| SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| PE20040079A1 (es) | 2002-04-03 | 2004-04-19 | Novartis Ag | Derivados de indolilmaleimida |
| MXPA04009490A (es) | 2002-04-03 | 2005-06-08 | Topo Target Uk Ltd | Compuesto de acido carbamico que comprenden un enlace de piperazina como inhibidores de histona desacetilasa. |
| SE0201194D0 (sv) | 2002-04-19 | 2002-04-19 | Astrazeneca Ab | New compounds |
| AU2003225295A1 (en) | 2002-05-08 | 2003-11-11 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
| CA2488602A1 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| CA2488798A1 (en) | 2002-06-05 | 2003-12-18 | Janssen Pharmaceutica N.V. | Substituted pyrrolines as kinase inhibitors |
| US6800625B2 (en) | 2002-06-19 | 2004-10-05 | Janssen Pharmaceutica N.V. | Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors |
| ES2392426T3 (es) | 2002-07-18 | 2012-12-10 | Janssen Pharmaceutica Nv | Inhibidores de quinasas con triazina sustituida |
| JP2006504656A (ja) | 2002-07-19 | 2006-02-09 | メモリー・ファーマシューティカルズ・コーポレイション | Ｎ−置換されたアニリン及びジフェニルアミンアナログを含むホスホジエステラーゼ４インヒビター |
| EP1551841A1 (de) | 2002-07-23 | 2005-07-13 | SmithKline Beecham Corporation | Pyrazolopyrimidine als kinaseinhibitoren |
| AU2003254051A1 (en) | 2002-07-23 | 2004-02-09 | Smithkline Beecham Corporation | Pyrazolopyrimidines as kinase inhibitors |
| WO2004009597A2 (en) | 2002-07-23 | 2004-01-29 | Smithkline Beecham Corporation | Pyrazolopyrimidines as protein kinase inhibitors |
| PT1532145E (pt) | 2002-08-02 | 2007-01-31 | Vertex Pharma | Composiçoes de pirazole úteis como inibidores de gsk-3 |
| CN100415747C (zh) | 2002-08-08 | 2008-09-03 | 记忆药物公司 | 磷酸二酯酶4抑制剂 |
| US7277877B2 (en) | 2002-08-14 | 2007-10-02 | Sony Corporation | System and method for selecting a music channel |
| DE10239042A1 (de) | 2002-08-21 | 2004-03-04 | Schering Ag | Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel |
| US6822418B2 (en) | 2002-08-23 | 2004-11-23 | International Rectifier Corporation | Position estimation and demagnetization detection of a permanent magnet motor |
| KR101088922B1 (ko) | 2002-09-04 | 2011-12-01 | 파마코페이아, 엘엘씨. | 사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘 |
| NZ539161A (en) | 2002-09-04 | 2006-05-26 | Schering Corp | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| CN1219408C (zh) | 2002-09-13 | 2005-09-14 | 华为技术有限公司 | 一种关口归属位置寄存器及用户路由信息交互方法 |
| EP1400244A1 (de) | 2002-09-17 | 2004-03-24 | Warner-Lambert Company LLC | Neue spirokondensierte Chinazolinone und ihre Verwendung als Phosphodiesteraseinhibitoren |
| CA2500587A1 (en) | 2002-10-04 | 2004-04-22 | The Regents Of The University Of California | Screening and therapeutic methods relating to neurogenesis |
| JP2006506383A (ja) | 2002-10-21 | 2006-02-23 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ３のインヒビター |
| GB0226583D0 (en) | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
| FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| ES2209650B2 (es) | 2002-12-09 | 2006-11-01 | Laboratorios Del Dr. Esteve, S.A. | Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones. |
| WO2004053071A2 (en) | 2002-12-09 | 2004-06-24 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
| GB0229581D0 (en) | 2002-12-19 | 2003-01-22 | Cyclacel Ltd | Use |
| TW200418806A (en) | 2003-01-13 | 2004-10-01 | Fujisawa Pharmaceutical Co | HDAC inhibitor |
| US7179832B2 (en) | 2003-01-23 | 2007-02-20 | Crystalgenomics, Inc. | Glycogen synthase kinase 3β inhibitor, composition and process for the preparation thereof |
| CA2513824A1 (en) | 2003-01-31 | 2004-08-19 | Astrazeneca Ab | Saturated quinoxaline derivatives and their use as metabotropic glutamate receptor ligands |
| WO2004072063A1 (en) | 2003-02-07 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl substituted pyrolls useful as inhibitors of protein kinases |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| EP1454909B1 (de) | 2003-03-07 | 2008-08-20 | Sanofi Aventis | 8'-pyridinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a) pyrimidin-6-one und 8'-pyrimidinyl-dihydrospiro-(cycloalkyl)-pyrimido(1,2-a)pyrimidin-6-one Derivate und deren Benutzung gegen neurodegenerative Krankheiten |
| EP1454910A1 (de) | 2003-03-07 | 2004-09-08 | Sanofi-Synthelabo | Substitutierte Pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidonederivate |
| EP1454908B1 (de) | 2003-03-07 | 2008-02-27 | Sanofi-Aventis | Substituierte Pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinonderivate |
| EP1454900A1 (de) | 2003-03-07 | 2004-09-08 | Sanofi-Synthelabo | Verfahren zur herstellung von pyridinyl und pyrimidinyl mono-fluorierten beta-keto Estern |
| TWI292318B (en) | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| ATE423102T1 (de) | 2003-03-12 | 2009-03-15 | Vertex Pharma | 4-substituirte-5-cyano-1h-pyrimidin-6-(th)iones als als gsk-3-hemmer |
| KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| EP1460076A1 (de) | 2003-03-21 | 2004-09-22 | Sanofi-Synthelabo | Substituierte 8-Perfluoro-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-on-Derivate |
| MXPA05010293A (es) | 2003-03-27 | 2005-11-17 | Pfizer Prod Inc | 4-amino[1,2,4]triazolo[4,3-a]quinoxalinas sustituidas. |
| CA2520125A1 (en) | 2003-03-28 | 2004-10-14 | Acadia Pharmaceuticals Inc. | Muscarinic m1 receptor agonists for pain management |
| ES2290741T3 (es) | 2003-04-04 | 2008-02-16 | Dynogen Pharmaceuticals Inc. | Metodo de tratamiento de trastornos del tracto urinario inferior. |
| US20040199842A1 (en) | 2003-04-04 | 2004-10-07 | Sartschev Ronald A. | Test system with high accuracy time measurement system |
| WO2004094375A2 (en) | 2003-04-16 | 2004-11-04 | Memory Pharmaceuticals Corporation | 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors |
| EP1622577A4 (de) | 2003-04-17 | 2007-09-26 | Univ Leland Stanford Junior | Prävention von neurogenese-defiziten mit entzündungshemmenden mitteln |
| AU2004237412B2 (en) | 2003-05-08 | 2010-03-11 | Merck Serono Sa | Pyridinyl acetonitriles |
| GB0311859D0 (en) | 2003-05-22 | 2003-06-25 | Merck Sharp & Dohme | Therapeutic agents |
| WO2004106343A2 (en) | 2003-05-30 | 2004-12-09 | Ufc Limited | Agelastatin derivatives of antitumour and gsk-3beta-inhibiting alkaloids |
| AU2004251178A1 (en) | 2003-06-13 | 2005-01-06 | Janssen Pharmaceutica N.V. | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
| BRPI0411874A (pt) | 2003-06-23 | 2006-08-08 | Pionner Hi Bred International | potencial de staygreen controlado em plantas por gene simples obtido por engenharia genética |
| DE602004016850D1 (de) | 2003-06-27 | 2008-11-13 | Pfizer Prod Inc | Pyrazoloä3,4-büpyridin-6-one als gsk-3 inhibitoren |
| MXPA05013628A (es) | 2003-06-27 | 2006-02-24 | Pfizer Prod Inc | Pirazolo[3,4-b]piridin-6-onas como inhibidores de gsk-3. |
| GB0315657D0 (en) | 2003-07-03 | 2003-08-13 | Astex Technology Ltd | Pharmaceutical compounds |
| TWI372050B (en) | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| US7842835B2 (en) | 2003-07-07 | 2010-11-30 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| GB0315966D0 (en) | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
| DK1658292T3 (da) | 2003-07-16 | 2007-11-12 | Janssen Pharmaceutica Nv | Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer |
| EP1781659B1 (de) | 2003-07-16 | 2008-11-05 | Janssen Pharmaceutica N.V. | Triazolopyrimidin derivate als inhibitoren von glycogen synthase kinase-3 |
| KR101204247B1 (ko) | 2003-07-22 | 2012-11-22 | 아스텍스 테라퓨틱스 리미티드 | 3,4-이치환된 1ｈ-피라졸 화합물 및 그의 시클린 의존성키나제 (ｃｄｋ) 및 글리코겐 합성효소 키나제-3(ｇｓｋ-3) 조정제로서 용도 |
| MXPA06000705A (es) | 2003-07-25 | 2006-04-11 | Hoffmann La Roche | Combinacion de antagonista del receptor 2 de glutamato metabotropico (mglur2) e inhibidor de acetilcolinesterasa (ache) para tratar trastornos neurologicos agudos y/o cronicos. |
| AU2004261484A1 (en) | 2003-07-30 | 2005-02-10 | Cyclacel Limited | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
| WO2005012298A1 (en) | 2003-07-30 | 2005-02-10 | Cyclacel Limited | Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors |
| JP2007519393A (ja) | 2003-08-05 | 2007-07-19 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | 神経系細胞アッセイ |
| WO2005017697A2 (en) | 2003-08-15 | 2005-02-24 | Blackboard Inc. | Content system and associated methods |
| EP1661896A4 (de) | 2003-08-26 | 2008-07-16 | Teijin Pharma Ltd | Pyrrolopyrimidinethionderivat |
| TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| ATE378047T1 (de) | 2003-09-12 | 2007-11-15 | Serono Lab | Benzothiazol-derivate zur behandlung von diabetes |
| WO2005026155A1 (en) | 2003-09-12 | 2005-03-24 | Applied Research Systems Ars Holding N.V. | Benzimidazole acetonitriles |
| CA2534319A1 (en) | 2003-09-12 | 2005-03-24 | Applied Research Systems Ars Holding N.V. | Benzoxazole acetonitriles |
| DE602004008098T8 (de) | 2003-10-10 | 2008-04-17 | Pfizer Products Inc., Groton | Substituierte 2h-[1,2,4]triazolo[4,3-a]pyrazine als gsk-3-inhibitoren |
| AU2004280257A1 (en) | 2003-10-10 | 2005-04-21 | Mars, Incorporated | Treatment of diseases involving ErbB2 kinase overexpression |
| DE10349423A1 (de) | 2003-10-16 | 2005-06-16 | Schering Ag | Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| CA2542880A1 (en) | 2003-10-21 | 2005-05-12 | Cyclacel Limited | Pyrimidin-4-yl-3, 4-thione compounds and their use in therapy |
| WO2005051919A1 (en) | 2003-11-26 | 2005-06-09 | Pfizer Products Inc. | Aminopyrazole derivatives as gsk-3 inhibitors |
| US7855195B2 (en) | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| WO2005066151A2 (en) | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20050159470A1 (en) | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
| KR101157881B1 (ko) | 2003-12-22 | 2012-07-06 | 아카디아 파마슈티칼스 인코포레이티드 | 무스카린 작용제로서의 아미노 치환된 디아릴［ａ,ｄ］사이클로헵텐 유사체, 및 신경정신 질환의 치료 방법 |
| EP1718280A4 (de) | 2004-01-30 | 2010-08-18 | Mars Inc | Verfahren und zusammensetzungen zur krebsbehandlung |
| TWI301760B (en) | 2004-02-27 | 2008-10-11 | Merz Pharma Gmbh & Co Kgaa | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
| WO2005108367A1 (en) | 2004-05-03 | 2005-11-17 | Envivo Pharmaceuticals, Inc. | Compounds for treatment of neurodegenerative diseases |
| JP2009507081A (ja) * | 2005-09-07 | 2009-02-19 | ブレインセルス，インコーポレイティド | ＨＤａｃ阻害による神経発生の調整 |
-
2006
- 2006-10-20 JP JP2008536840A patent/JP2009512711A/ja active Pending
- 2006-10-20 US US11/551,667 patent/US7985756B2/en not_active Expired - Fee Related
- 2006-10-20 EP EP06826395A patent/EP1940389A2/de not_active Withdrawn
- 2006-10-20 AU AU2006304787A patent/AU2006304787A1/en not_active Abandoned
- 2006-10-20 WO PCT/US2006/041131 patent/WO2007047978A2/en active Application Filing
- 2006-10-20 EP EP10013573A patent/EP2377530A3/de not_active Withdrawn
- 2006-10-20 CA CA002625153A patent/CA2625153A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004002461A2 (en) * | 2002-06-26 | 2004-01-08 | Pfizer Limited | Combination of pde5 inhibitors with angiotensin ii receptor antagonists |
| WO2004045592A2 (en) * | 2002-11-20 | 2004-06-03 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US20050004046A1 (en) * | 2003-06-13 | 2005-01-06 | Praag Henriette Van | Method for increasing cognitive function and neurogenesis |
| EP1579862A1 (de) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Verwendung von PDE III Ihibitoren zur Reduktion der Herzgrösse in an Herzversagen leidenden Säugern |
| WO2006050057A2 (en) * | 2004-10-28 | 2006-05-11 | Celgene Corporation | Methods and compositions using pde4 modulators for treatment and management of central nervous system injury |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006304787A1 (en) | 2007-04-26 |
| US7985756B2 (en) | 2011-07-26 |
| WO2007047978A3 (en) | 2007-08-09 |
| CA2625153A1 (en) | 2007-04-26 |
| EP2377530A2 (de) | 2011-10-19 |
| EP1940389A2 (de) | 2008-07-09 |
| JP2009512711A (ja) | 2009-03-26 |
| WO2007047978A2 (en) | 2007-04-26 |
| US20070208029A1 (en) | 2007-09-06 |
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