ECSP13012985A - Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y métodos de tratamiento con las mismas - Google Patents

Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y métodos de tratamiento con las mismas

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Publication number
ECSP13012985A
ECSP13012985A ECSP13012985A ECSP13012985A EC SP13012985 A ECSP13012985 A EC SP13012985A EC SP13012985 A ECSP13012985 A EC SP13012985A EC SP13012985 A ECSP13012985 A EC SP13012985A
Authority
EC
Ecuador
Prior art keywords
same
compositions
methods
diaminocarbonitrile
diaminocarboxamide
Prior art date
Application number
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English (en)
Inventor
Mercedes Delgado
Jan Elsner
Paul Erdman
Brydon L Bennett
Robert Hilgraf
Laurie Ann Lebrun
Meg Mccarrick
Mehran F Moghaddam
Mark A Nagy
Stephen Norris
David A Paisner
Marianne Sloss
Yoshitakax Satoh
Won Hyung Yoon
Original Assignee
Signal Pharm Llc
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Filing date
Publication date
Application filed by Signal Pharm Llc filed Critical Signal Pharm Llc
Publication of ECSP13012985A publication Critical patent/ECSP13012985A/es

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
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Abstract

En la presente se proveen Compuestos de Diaminopirimidina teniendo las siguientes estructuras:en donde R1, R2, R3 y R4 son como se define en la presente, composiciones que comprenden una cantidad efectiva de un Compuesto de Diaminopirimidina, y métodos para tratar o prevenir trastornos fibróticos del hígado o una condición tratable o prevenible por inhibición de una vía de JNK.
ECSP13012985 2011-04-22 2013-10-21 Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y métodos de tratamiento con las mismas ECSP13012985A (es)

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US201161478076P 2011-04-22 2011-04-22
US201161555339P 2011-11-03 2011-11-03

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ECSP13012985A true ECSP13012985A (es) 2013-11-29

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ECSP13012985 ECSP13012985A (es) 2011-04-22 2013-10-21 Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y métodos de tratamiento con las mismas

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Publication number Priority date Publication date Assignee Title
SG10201702654VA (en) 2011-04-22 2017-06-29 Signal Pharm Llc Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith
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