SG11201604821YA - Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith - Google Patents
Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewithInfo
- Publication number
- SG11201604821YA SG11201604821YA SG11201604821YA SG11201604821YA SG11201604821YA SG 11201604821Y A SG11201604821Y A SG 11201604821YA SG 11201604821Y A SG11201604821Y A SG 11201604821YA SG 11201604821Y A SG11201604821Y A SG 11201604821YA SG 11201604821Y A SG11201604821Y A SG 11201604821YA
- Authority
- SG
- Singapore
- Prior art keywords
- substituted
- compositions
- methods
- treatment therewith
- diaminopyrimidyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919216P | 2013-12-20 | 2013-12-20 | |
PCT/US2014/071449 WO2015095679A1 (en) | 2013-12-20 | 2014-12-19 | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201604821YA true SG11201604821YA (en) | 2016-07-28 |
Family
ID=53399293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201604821YA SG11201604821YA (en) | 2013-12-20 | 2014-12-19 | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
Country Status (16)
Country | Link |
---|---|
US (3) | US9556126B2 (en) |
EP (2) | EP3736268A1 (en) |
JP (1) | JP6483707B2 (en) |
KR (1) | KR20160095159A (en) |
CN (1) | CN106170290A (en) |
AR (1) | AR099376A1 (en) |
AU (1) | AU2014369031A1 (en) |
BR (1) | BR112016014412A2 (en) |
CA (1) | CA2934061A1 (en) |
ES (1) | ES2812605T3 (en) |
IL (1) | IL246252A0 (en) |
MX (1) | MX2016007898A (en) |
RU (1) | RU2016129380A (en) |
SG (1) | SG11201604821YA (en) |
TW (1) | TW201609671A (en) |
WO (1) | WO2015095679A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI681952B (en) | 2011-04-22 | 2020-01-11 | 美商標誌製藥公司 | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
WO2014149819A1 (en) | 2013-03-14 | 2014-09-25 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
WO2015089170A1 (en) | 2013-12-12 | 2015-06-18 | Kalyra Pharmaceuticals, Inc. | Bicyclic alkyl compounds and synthesis |
EP3736268A1 (en) * | 2013-12-20 | 2020-11-11 | Signal Pharmaceuticals, LLC | Process for the preparation of substituted diaminopyrimidyl compounds |
NZ715903A (en) * | 2014-01-30 | 2017-06-30 | Signal Pharm Llc | Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use |
JP6741343B2 (en) | 2014-03-07 | 2020-08-19 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | Propellane derivatives and synthesis |
CA2961605C (en) | 2014-09-17 | 2023-01-10 | Kalyra Pharmaceuticals, Inc. | Bicyclic compounds |
US10697760B2 (en) | 2015-04-15 | 2020-06-30 | General Electric Company | Data acquisition devices, systems and method for analyzing strain sensors and monitoring component strain |
CA2993173C (en) | 2015-07-24 | 2023-10-03 | Celgene Corporation | Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein |
US20190060257A1 (en) * | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
CN105906569B (en) * | 2016-05-24 | 2018-04-24 | 杰达维(上海)医药科技发展有限公司 | A kind of preparation method of pyrimidine derivatives |
CA3060416A1 (en) | 2017-04-21 | 2018-10-25 | Epizyme, Inc. | Combination therapies with ehmt2 inhibitors |
CA3063729A1 (en) | 2017-05-15 | 2018-11-22 | Recurium Ip Holdings, Llc | Analgesic compounds |
JP2021500327A (en) * | 2017-10-18 | 2021-01-07 | エピザイム,インコーポレイティド | How to use EHMT2 inhibitors for immunotherapy |
CN107759477A (en) * | 2017-11-20 | 2018-03-06 | 阿里化学(常州)有限公司 | A kind of preparation method of p-nitrophenyl ethylamine hydrochloride |
CN108395408B (en) * | 2018-03-23 | 2021-03-09 | 杰达维(上海)医药科技发展有限公司 | Drug intermediate and preparation method thereof |
WO2020210521A2 (en) | 2019-04-12 | 2020-10-15 | The Regents Of The University Of California | Compositions and methods for increasing muscle mass and oxidative metabolism |
CN112574123A (en) * | 2019-09-30 | 2021-03-30 | 武汉朗来科技发展有限公司 | JNK inhibitors, pharmaceutical compositions and uses thereof |
CA3166936A1 (en) | 2020-02-04 | 2021-08-12 | Abdelmalik Slassi | Psilocin derivatives as serotonergic psychedelic agents for the treatment of cns disorders |
KR20230130664A (en) * | 2021-01-08 | 2023-09-12 | 캄테크, 인크. | Protective alkyl tryptamines and their therapeutic uses |
KR20240024063A (en) | 2021-05-06 | 2024-02-23 | 엑스사이언티아 에이아이 리미티드 | PKC-theta regulator |
CA3213703A1 (en) | 2021-05-06 | 2022-11-10 | Peter Ray | Pkc-theta modulators |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU73300A (en) | 1998-05-26 | 2003-08-29 | Warner-Lambert Company | Bicyclic pyrimidines and bicyclic 3,4-dihydro-pyrimidines as inhibitors of cellular proliferation |
AU5108000A (en) | 1999-06-10 | 2001-01-02 | Yamanouchi Pharmaceutical Co., Ltd. | Novel nitrogen-contaiing heterocyclic derivatives or salts thereof |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
CA2451128A1 (en) | 2001-06-26 | 2003-01-09 | Bristol-Myers Squibb Company | N-heterocyclic inhibitors of tnf-alpha expression |
JPWO2003082855A1 (en) | 2002-03-28 | 2005-08-04 | 協和醗酵工業株式会社 | Anti-inflammatory agent |
DE602004021558D1 (en) * | 2003-01-17 | 2009-07-30 | Warner Lambert Co | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION |
CA2514612A1 (en) | 2003-01-30 | 2004-08-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta |
AU2005225471B2 (en) | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
WO2006014482A1 (en) | 2004-07-08 | 2006-02-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Pyrimidine derivatives useful as inhibitors of pkc-theta |
EP1794134A1 (en) | 2004-09-29 | 2007-06-13 | Bayer Schering Pharma Aktiengesellschaft | Substituted 2-anilinopyrimidines as cell cycle kinase inhibitors or receptor tyrosine kinase inhibitors, production of said substances and use of the latter as medicaments |
WO2006091737A1 (en) * | 2005-02-24 | 2006-08-31 | Kemia, Inc. | Modulators of gsk-3 activity |
ES2324837T3 (en) | 2005-03-28 | 2009-08-17 | Boehringer Ingelheim International Gmbh | USED PIRIDINE DERIVATIVES AS INHIBITORS OF THE PKC-THETA. |
US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
JP2009521488A (en) | 2005-12-21 | 2009-06-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pyrimidine derivatives useful as inhibitors of PKC-theta |
DE102005062742A1 (en) * | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | New sulfoximine-substituted pyrimidines useful for treating e.g. diseases caused by inflammatory, allergic or proliferative processes, oncological diseases, cancer, eye, autoimmune and neurodegerative diseases |
PE20080068A1 (en) * | 2006-05-15 | 2008-03-17 | Boehringer Ingelheim Int | COMPOUNDS DERIVED FROM PYRIMIDINE AS INHIBITORS OF KINASE AURORA |
DE102007010801A1 (en) | 2007-03-02 | 2008-09-04 | Bayer Cropscience Ag | Use of new and known 2,4-diaminopyrimidine derivatives as fungicides, especially for controlling phytopathogenic fungi |
CA2704266A1 (en) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
WO2009071535A1 (en) | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation |
CL2009000600A1 (en) | 2008-03-20 | 2010-05-07 | Bayer Cropscience Ag | Use of diaminopyrimidine compounds as phytosanitary agents; diaminopyrimidine compounds; its preparation procedure; agent that contains them; procedure for the preparation of said agent; and method for combating pests of animals and / or harmful plant pathogenic fungi. |
JP5302389B2 (en) | 2008-04-29 | 2013-10-02 | エフ.ホフマン−ラ ロシュ アーゲー | JNK's pyrimidinyl pyridone inhibitor |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
WO2010024430A1 (en) * | 2008-09-01 | 2010-03-04 | アステラス製薬株式会社 | 2,4-diaminopyrimidine compound |
JP2012501981A (en) | 2008-09-03 | 2012-01-26 | バイエル・クロップサイエンス・アーゲー | Heterocyclic substituted anilinopyrimidines as fungicides |
CN102203086A (en) | 2008-09-03 | 2011-09-28 | 拜尔农作物科学股份公司 | Thienylamino pyrimidines for use as fungicides |
WO2010025831A1 (en) | 2008-09-03 | 2010-03-11 | Bayer Cropscience Ag | Heterocyclically substituted anilinopyrimidines as fungicides |
EP2331512A1 (en) * | 2008-09-03 | 2011-06-15 | Bayer CropScience AG | Alkoxy-substituted and alkylthio-substituted anilinopyrimidines |
US8377924B2 (en) | 2009-01-21 | 2013-02-19 | Rigel Pharmaceuticals Inc. | Protein kinase C inhibitors and uses thereof |
JP2012148977A (en) | 2009-05-20 | 2012-08-09 | Astellas Pharma Inc | 2,4-diaminopyrimidine compound having aminocyclohexylalkyl group |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
JP2011173853A (en) | 2010-02-26 | 2011-09-08 | Astellas Pharma Inc | 2,4-diaminopyrimidine compound having substituted aminoadamantylalkyl group |
JP2011173854A (en) | 2010-02-26 | 2011-09-08 | Astellas Pharma Inc | 2,4-diaminopyrimidine compound having bicyclo ring-substituted alkyl group |
HUE046617T2 (en) | 2010-11-10 | 2020-03-30 | Genentech Inc | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
RU2013132683A (en) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | INFLUENZA VIRUS REPLICATION INHIBITORS |
TWI681952B (en) | 2011-04-22 | 2020-01-11 | 美商標誌製藥公司 | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith |
GB201108225D0 (en) * | 2011-05-17 | 2011-06-29 | Amakem Nv | Novel KBC inhibitors |
EP2751093A1 (en) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CA2856306A1 (en) | 2011-11-23 | 2013-05-30 | Portola Pharmaceuticals, Inc. | Selective kinase inhibitors |
AR089182A1 (en) | 2011-11-29 | 2014-08-06 | Hoffmann La Roche | AMINOPIRIMIDINE DERIVATIVES AS MODULATORS OF LRRK2 |
AU2012357038B2 (en) * | 2011-12-23 | 2016-05-12 | Cellzome Limited | Pyrimidine-2,4-diamine derivatives as kinase inhibitors |
WO2013164323A1 (en) | 2012-05-03 | 2013-11-07 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease |
MX363118B (en) | 2012-05-03 | 2019-03-11 | Genentech Inc | Pyrazole aminopyrimidine derivatives as lrrk2 modulators. |
WO2014044025A1 (en) | 2012-09-20 | 2014-03-27 | 山东亨利医药科技有限责任公司 | Pyrimidineamide derivative and preparation method and use thereof |
US9145387B2 (en) | 2013-02-08 | 2015-09-29 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
US20150087673A1 (en) | 2013-09-26 | 2015-03-26 | Rigel Pharmaceuticals, Inc. | Methods for using and biomarkers for ampk-activating compounds |
EP3736268A1 (en) * | 2013-12-20 | 2020-11-11 | Signal Pharmaceuticals, LLC | Process for the preparation of substituted diaminopyrimidyl compounds |
-
2014
- 2014-12-19 EP EP20178220.8A patent/EP3736268A1/en active Pending
- 2014-12-19 AR ARP140104825A patent/AR099376A1/en unknown
- 2014-12-19 JP JP2016541143A patent/JP6483707B2/en active Active
- 2014-12-19 SG SG11201604821YA patent/SG11201604821YA/en unknown
- 2014-12-19 TW TW103144680A patent/TW201609671A/en unknown
- 2014-12-19 KR KR1020167019049A patent/KR20160095159A/en not_active Application Discontinuation
- 2014-12-19 AU AU2014369031A patent/AU2014369031A1/en not_active Abandoned
- 2014-12-19 CN CN201480076086.4A patent/CN106170290A/en active Pending
- 2014-12-19 US US14/576,197 patent/US9556126B2/en active Active
- 2014-12-19 EP EP14871136.9A patent/EP3082819B1/en active Active
- 2014-12-19 ES ES14871136T patent/ES2812605T3/en active Active
- 2014-12-19 BR BR112016014412A patent/BR112016014412A2/en not_active Application Discontinuation
- 2014-12-19 CA CA2934061A patent/CA2934061A1/en not_active Abandoned
- 2014-12-19 WO PCT/US2014/071449 patent/WO2015095679A1/en active Application Filing
- 2014-12-19 RU RU2016129380A patent/RU2016129380A/en unknown
- 2014-12-19 MX MX2016007898A patent/MX2016007898A/en unknown
-
2015
- 2015-04-07 US US14/680,530 patent/US9156798B2/en active Active
-
2016
- 2016-06-15 IL IL246252A patent/IL246252A0/en unknown
- 2016-08-19 US US15/241,232 patent/US9783505B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015095679A1 (en) | 2015-06-25 |
CA2934061A1 (en) | 2015-06-25 |
CN106170290A (en) | 2016-11-30 |
US9156798B2 (en) | 2015-10-13 |
IL246252A0 (en) | 2016-07-31 |
KR20160095159A (en) | 2016-08-10 |
US20150175557A1 (en) | 2015-06-25 |
US20160354374A1 (en) | 2016-12-08 |
JP6483707B2 (en) | 2019-03-13 |
US9556126B2 (en) | 2017-01-31 |
AU2014369031A1 (en) | 2016-07-07 |
EP3082819B1 (en) | 2020-06-17 |
EP3082819A1 (en) | 2016-10-26 |
BR112016014412A2 (en) | 2017-08-08 |
TW201609671A (en) | 2016-03-16 |
US9783505B2 (en) | 2017-10-10 |
EP3082819A4 (en) | 2017-08-23 |
ES2812605T3 (en) | 2021-03-17 |
JP2017500325A (en) | 2017-01-05 |
RU2016129380A (en) | 2018-01-25 |
US20150246890A1 (en) | 2015-09-03 |
MX2016007898A (en) | 2016-10-07 |
AR099376A1 (en) | 2016-07-20 |
EP3736268A1 (en) | 2020-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL246252A0 (en) | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith | |
HK1212207A1 (en) | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith | |
IL245184A0 (en) | Prostacyclin compounds, compositions and methods of use thereof | |
IL277069B (en) | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith | |
HK1225654A1 (en) | Compositions and methods for the treatment of presbyopia | |
HUE048666T2 (en) | Agricultural endophyte-plant compositions, and methods of use | |
EP2986140A4 (en) | Compositions, methods, and kits for treatment of pets | |
HK1216175A1 (en) | Therapeutic compounds and compositions | |
HK1220324A1 (en) | Methods, compounds, and compositions for the treatment of angiotensin-related diseases | |
GB201320723D0 (en) | Composition and methods of treatment | |
IL244066A0 (en) | Triazolopyridine compounds, compositions and methods of use thereof | |
PL2988764T3 (en) | Anti-dandruff compositions, and methods of use thereof | |
SG10201705899XA (en) | Prevention & treatment of neuropathy | |
HK1220374A1 (en) | Compositions and methods for the treatment of carboxyhemoglobinemia | |
EP2967055A4 (en) | Biocide compositions, methods of manufacture, and methods of use | |
EP3089745A4 (en) | Compounds, compositions, and methods for the treatment of cancers | |
HK1217715A1 (en) | Compositions and methods for treatment of stroke | |
EP2994156A4 (en) | Compounds, compositions and methods for the treatment of diseases through inhibiting tgf- activity | |
HRP20181445T1 (en) | Compositions and methods for treatment of type 1 diabetes |