EA201790624A1 - Нацеливание цитотоксических клеток с химерными рецепторами для адоптивной иммунотерапии - Google Patents

Нацеливание цитотоксических клеток с химерными рецепторами для адоптивной иммунотерапии

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EA201790624A1
EA201790624A1 EA201790624A EA201790624A EA201790624A1 EA 201790624 A1 EA201790624 A1 EA 201790624A1 EA 201790624 A EA201790624 A EA 201790624A EA 201790624 A EA201790624 A EA 201790624A EA 201790624 A1 EA201790624 A1 EA 201790624A1
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car
receptor
chemeric
receptors
aiming
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EA201790624A
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English (en)
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Грегори Битти
Борис Энгельс
Неераджа Идамаканти
Карл Х. Джун
Андреас Лев
Майкл С. Майлон
Хойцзюань Сун
Эньсю Ван
Цилун У
Original Assignee
Новартис Аг
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания
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Publication of EA201790624A1 publication Critical patent/EA201790624A1/ru

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Abstract

Настоящее изобретение относится к композициям и способам регуляции специфичности и активности эффекторных клеток иммунной системы для применения в иммунотерапии. В одном из вариантов осуществления изобретение относится к типу химерного антигенного рецептора (CAR), где CAR называют "NKR-CAR", который представляет собой конструкцию CAR, содержащую компонент рецептора, встречающийся в природе на естественных киллерных (NK) клетках. В одном из вариантов осуществления NK-рецептор включает, но не ограничивается ими, природный активирующий и ингибирующий рецептор NK-клеток, звестный как иммуноглобулиноподобный рецептор киллерной клетки (KIR).
EA201790624A 2014-09-17 2015-09-17 Нацеливание цитотоксических клеток с химерными рецепторами для адоптивной иммунотерапии EA201790624A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014086694 2014-09-17
CN2014090578 2014-11-07
PCT/US2015/050715 WO2016044605A1 (en) 2014-09-17 2015-09-17 Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy

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EA201790624A1 true EA201790624A1 (ru) 2017-08-31

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US (1) US10577417B2 (ru)
EP (2) EP3967709A1 (ru)
JP (3) JP6839074B2 (ru)
KR (3) KR20210149228A (ru)
CN (2) CN107580628B (ru)
AU (2) AU2015317608B2 (ru)
BR (1) BR112017005390A2 (ru)
CA (1) CA2961636A1 (ru)
DK (1) DK3194443T3 (ru)
EA (1) EA201790624A1 (ru)
ES (1) ES2891332T3 (ru)
MX (2) MX2017003645A (ru)
PL (1) PL3194443T3 (ru)
WO (1) WO2016044605A1 (ru)

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