MX347656B - Inversion de los efectos del micro-ambiente de tumor utilizando receptores de citocina quimericos. - Google Patents

Inversion de los efectos del micro-ambiente de tumor utilizando receptores de citocina quimericos.

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Publication number
MX347656B
MX347656B MX2013011742A MX2013011742A MX347656B MX 347656 B MX347656 B MX 347656B MX 2013011742 A MX2013011742 A MX 2013011742A MX 2013011742 A MX2013011742 A MX 2013011742A MX 347656 B MX347656 B MX 347656B
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MX
Mexico
Prior art keywords
reversing
effects
cells
tumor microenvironment
cytokine receptors
Prior art date
Application number
MX2013011742A
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English (en)
Other versions
MX2013011742A (es
Inventor
Marie Leen Ann
F Vera Juan
Original Assignee
Baylor College Medicine
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Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Publication of MX2013011742A publication Critical patent/MX2013011742A/es
Publication of MX347656B publication Critical patent/MX347656B/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
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Abstract

La presente invención se refiere a una célula del sistema inmune que comprende un receptor de citosina quimérico, caracterizada porque comprende un exodominio de unión a citosina y un endodominio de transducción de señal, en donde el exodominio es el exodominio del receptor IL4 y el endodominio es el endodominio del receptor IL7 o el exodominio es el exodominio del receptor IL13 y el endodominio es el endodominio del receptor IL2, en donde la célula es una célula T primaria, linfocito T, o una célula NK.
MX2013011742A 2011-04-08 2012-04-05 Inversion de los efectos del micro-ambiente de tumor utilizando receptores de citocina quimericos. MX347656B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161473457P 2011-04-08 2011-04-08
PCT/US2012/032322 WO2012138858A1 (en) 2011-04-08 2012-04-05 Reversing the effects of the tumor microenvironment using chimeric cytokine receptors

Publications (2)

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MX2013011742A MX2013011742A (es) 2014-03-27
MX347656B true MX347656B (es) 2017-05-08

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US (2) US10548921B2 (es)
EP (2) EP2694640B1 (es)
JP (3) JP6066991B2 (es)
CN (2) CN107164330A (es)
AU (3) AU2012240135B2 (es)
CA (1) CA2832569A1 (es)
DK (1) DK2694640T3 (es)
ES (1) ES2649967T3 (es)
HK (1) HK1245840A1 (es)
MX (1) MX347656B (es)
NO (1) NO2724929T3 (es)
NZ (3) NZ723731A (es)
WO (1) WO2012138858A1 (es)

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US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
US8956860B2 (en) 2009-12-08 2015-02-17 Juan F. Vera Methods of cell culture for adoptive cell therapy
KR102062407B1 (ko) 2010-12-09 2020-01-03 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도
JP2015519080A (ja) * 2012-06-11 2015-07-09 ウィルソン ウォルフ マニュファクチャリング コーポレイションＷｉｌｓｏｎ Ｗｏｌｆ Ｍａｎｕｆａｃｔｕｒｉｎｇ Ｃｏｒｐｏｒａｔｉｏｎ 養子細胞療法のための改良型細胞培養方法
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
NZ750426A (en) * 2013-02-06 2020-06-26 Celgene Corp Modified t lymphocytes having improved specificity
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